Frauke Swieringa

Post doc

Dr Frauke Swieringa graduated from the bachelor study Molecular Life Sciences at Maastricht University, after which she specialised in Clinical Molecular Sciences. She carried out her graduate internship, focussing on the identification of blood platelet-reactive sites in collagen, at the Department of Biochemistry at Maastricht University and at the University of Cambridge (UK). After obtaining her (cum laude) diploma in 2010, she started her PhD research at CARIM at the Department of Biochemistry at Maastricht University.  She conducted research in the field of platelets, thrombosis and haemostasis. After being awarded a Humboldt research Fellowship in 2016 she worked as a post-doctoral researcher at the Leibniz Institute for Analytical Sciences – ISAS in Dortmund, Germany, focussing on platelet proteomics in disease.

Since 2018, she is again working at Maastricht University. The current focus of her research is uncovering the complexity of platelet (dys)functions in thrombosis and haemostasis using microscopy-based platelet phenotyping and advanced platelet proteomics. She aims to develop a diagnostic and predictive platform for platelet-related disorders based on the combined characterisation of platelet function and proteomics.

Department of Biochemistry   
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number:4.320
T: +31(0)43 388 15 37

  • 2020
    • van Geffen, J. P., Swieringa, F., van Kuijk, K., Tullemans, B. M. E., Solari, F. A., Peng, B., Clemetson, K. J., Farndale, R. W., Dubois, L. J., Sickmann, A., Zahedi, R. P., Ahrends, R., Biessen, E. A. L., Sluimer, J. C., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2020). Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome. Scientific Reports, 10(1), [21407]. https://doi.org/10.1038/s41598-020-78522-9
    • Brouns, S. L. N., van Geffen, J. P., Campello, E., Swieringa, F., Spiezia, L., van Oerle, R., Provenzale, I., Verdoold, R., Farndale, R. W., Clemetson, K. J., Spronk, H. M. H., van der Meijden, P. E. J., Cavill, R., Kuijpers, M. J. E., Castoldi, E., Simioni, P., & Heemskerk, J. W. M. (2020). Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation. Scientific Reports, 10(1), 11910. [11910]. https://doi.org/10.1038/s41598-020-68438-9
  • 2019
    • Provenzale, I., Brouns, S. L. N., van der Meijden, P. E. J., Swieringa, F., & Heemskerk, J. W. M. (2019). Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis. Micromachines, 10(11), [787]. https://doi.org/10.3390/mi10110787
    • van Geffen, A., Brouns, S., Batista, J., McKinney, H., Kempster, C., Nagy, M., Sivapalaratnam, S., Baaten, C., Bourry, N., Frontini, M., Jurk, K., Krause, M., Pilliteri, D., Swieringa, F., Verdoold, R., Cavill, R., Kuijpers, M., Ouwehand, W. H., Downes, K., & Heemskerk, J. (2019). High-throughput elucidation of thrombus formation reveals sources of platelet function variability. Haematologica-the Hematology Journal, 104(6), 1256-1267. https://doi.org/10.3324/haematol.2018.198853
  • 2018
    • Baaten, C. C. F. M. J., Meacham, S., de Witt, S. M., Feijge, M. A. H., Adams, D. J., Akkerman, J-W. N., Cosemans, J. M. E. M., Grassi, L., Jupe, S., Kostadima, M., Mattheij, N. J. A., Prins, M. H., Ramirez-Solis, R., Soehnlein, O., Swieringa, F., Weber, C., White, J. K., Ouwehand, W. H., & Heemskerk, J. W. M. (2018). A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding. Blood, 132(24), E35-E46. https://doi.org/10.1182/blood-2018-02-831982
    • Baaten, C. C. F. M. J., Swieringa, F., Misztal, T., Mastenbroek, T. G., Feijge, M. A. H., Bock, P. E., Donners, M. M. P. C., Collins, P. W., Li, R., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2018). Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects. Blood advances, 2(18), 2320-2331. https://doi.org/10.1182/bloodadvances.2017011544
    • Lepropre, S., Kautbally, S., Octave, M., Ginion, A., Onselaer, M-B., Steinberg, G. R., Kemp, B. E., Hego, A., Wera, O., Brouns, S., Swieringa, F., Giera, M., Darley-Usmar, V. M., Ambroise, J., Guigas, B., Heemskerk, J., Bertrand, L., Oury, C., Beauloye, C., & Horman, S. (2018). AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation. Blood, 132(11), 1180-1192. https://doi.org/10.1182/blood-2018-02-831503
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., ten Cate, H., Holloway, G. P., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica-the Hematology Journal, 103(9), 1557-1567. https://doi.org/10.3324/haematol.2017.185165
    • Swieringa, F., Spronk, H. M. H., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Integrating platelet and coagulation activation in fibrin clot formation. Research and practice in thrombosis and haemostasis, 2(3), 450-460. https://doi.org/10.1002/rth2.12107
    • Thomassen, S., Mastenbroek, T. G., Swieringa, F., Winckers, K., Feijge, M. A. H., Schrijver, R., Cosemans, J. M. E. M., Maroney, S. A., Mast, A. E., Hackeng, T. M., & Heemskerk, J. W. M. (2018). Suppressive Role of Tissue Factor Pathway Inhibitor-alpha in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength. Thrombosis and Haemostasis, 118(3), 502-513. https://doi.org/10.1055/s-0038-1627453
  • 2017
  • 2016
    • Baig, A. A., Haining, E. J., Geuss, E., Beck, S., Swieringa, F., Wanitchakool, P., Schuhmann, M. K., Stegner, D., Kunzelmann, K., Kleinschnitz, C., Heemskerk, J. W. M., Braun, A., & Nieswandt, B. (2016). TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice: Brief Report. Arteriosclerosis Thrombosis and Vascular Biology, 36(11), 2152-2157. https://doi.org/10.1161/ATVBAHA.116.307727
    • Solari, F. A., Mattheij, N. J. A., Burkhart, J. M., Swieringa, F., Collins, P. W., Cosemans, J. M. E. M., Sickmann, A., Heemskerk, J. W. M., & Zahedi, R. P. (2016). Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome. Molecular & Cellular Proteomics, 15(10), 3154-3169. https://doi.org/10.1074/mcp.M116.060368
    • van Geffen, A., Swieringa, F., & Heemskerk, J. W. M. (2016). Platelets and coagulation in thrombus formation: aberrations in the Scott syndrome. Thrombosis Research, 141(suppl 2), S12-S16. https://doi.org/10.1016/S0049-3848(16)30355-3
    • Mattheij, N. J. A., Swieringa, F., Mastenbroek, T. G., Berny-Lang, M. A., May, F., Baaten, C. C. F. M. J., van der Meijden, P. E. J., Henskens, Y. M. C., Beckers, E. A. M., Suylen, D. P. L., Nolte, M. W., Hackeng, T. M., McCarty, O. J. T., Heemskerk, J. W. M., & Cosemans, J. M. E. M. (2016). Coated platelets function in platelet-dependent fibrin formation via integrin alpha(IIb)beta(3) and transglutaminase factor XIII. Haematologica-the Hematology Journal, 101(4), 427-436. https://doi.org/10.3324/haematol.2015.131441
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R., van Oerle, R., ten Cate, H., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2016). Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy. Thrombosis Research, 140S1, S171-S171. https://doi.org/10.1016/s0049-3848(16)30125-6
    • Swieringa, F., Baaten, C. C. F. M. J., Verdoold, R., Mastenbroek, T. G., Rijnveld, N., van der Laan, K. O., Breel, E. J., Collins, P. W., Lance, M. D., Henskens, Y. M. C., Cosemans, J. M. E. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2016). Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow. Arteriosclerosis Thrombosis and Vascular Biology, 36(4), 692-699. https://doi.org/10.1161/ATVBAHA.115.306537
  • 2015
    • Mastenbroek, T. G., Feijge, M. A. H., Kremers, R. M. W., van den Bosch, M. T. J., Swieringa, F., De Groef, L., Moons, L., Bennett, C., Ghevaert, C., Johnson, J. L., van der Meijden, P. E. J., & Cosemans, J. M. E. M. (2015). Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity. Arteriosclerosis Thrombosis and Vascular Biology, 35(12), 2554-2561. https://doi.org/10.1161/ATVBAHA.115.306153
    • Baaten, C. C. F. M. J., Veenstra, L. F., Wetzels, R., van Geffen, J. P., Swieringa, F., de Witt, S. M., Henskens, Y. M. C., Crijns, H., Nylander, S., van Giezen, J. J. J., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2015). Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication. Haematologica-the Hematology Journal, 100(9), 1131-1138. https://doi.org/10.3324/haematol.2014.122457
    • Swieringa, F., Lance, M. D., Fuchs, B., Feijge, M. A. H., Solecka, B. A., Verheijen, L. P. J., Hughes, K. R., Van Oerle, R., Deckmyn, H., Kannicht, C., Heemskerk, J. W. M., & Van der Meijden, P. E. J. (2015). Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding. Journal of Thrombosis and Haemostasis, 13(8), 1503-1513. https://doi.org/10.1111/jth.13007
    • Swieringa, F., Kuijpers, M. J. E., Lamers, M. M. E., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2015). Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow. Haematologica-the Hematology Journal, 100(6), 748-756. https://doi.org/10.3324/haematol.2014.116863
    • Whyte, C. S., Swieringa, F., Mastenbroek, T. G., Lionikiene, A. S., Lance, M. D., van der Meijden, P. E. J., Heemskerk, J. W. M., & Mutch, N. J. (2015). Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow. Blood, 125(16), 2568-2578. https://doi.org/10.1182/blood-2014-09-599480
  • 2014
    • Swieringa, F., Kuijpers, M. J. E., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2014). Targeting platelet receptor function in thrombus formation: The risk of bleeding. Blood Reviews, 28(1), 9-21. https://doi.org/10.1016/j.blre.2013.12.001
  • 2013
    • van Kruchten, R., Mattheij, N. J. A., Saunders, C., Feijge, M. A. H., Swieringa, F., Wolfs, J. L. N., Collins, P. W., Heemskerk, J. W. M., & Bevers, E. M. (2013). Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation. Blood, 121(10), 1850-1857. https://doi.org/10.1182/blood-2012-09-454314
  • 2012
    • van der Meijden, P. E. J., Feijge, M. A. H., Swieringa, F., Gilio, K., Nergiz-Unal, R., Hamulyak, K., & Heemskerk, J. W. M. (2012). Key role of integrin alpha(IIb)beta(3) signaling to Syk kinase in tissue factor-induced thrombin generation. Cellular and Molecular Life Sciences, 69(20), 3481-3492. https://doi.org/10.1007/s00018-012-1033-2