Gerry Nicolaes

Associate professor

Dr Gerry Nicolaes received a Masters’ degree in Chemistry from the Utrecht University with majors in clinical chemistry, biochemistry and protein engineering and enzymology. He obtained a PhD from the Maastricht University on the regulation of thrombin formation in normal and hypercoagulable plasma (with Prof. H.C. Hemker) and later spent several years at the laboratory of Prof. B. Dahlbäck at the Lund University (Sweden), focussing on the use of molecular biological technologies in blood coagulation research.

Dr Nicolaes received a Vidi grant by the Netherlands Organisation for Scientific Research (NWO) to establish a research line that uses structural bioinformatics to rationally approach the structure-function study of proteins involved in coagulation and inflammation. In addition to protein structure-function research, in recent years, in silico drug design and optimisation of biologically active molecules for use in therapy or diagnosis has become one of the major research focusses.

His research interests are within the fields of thrombosis and haemostasis, and in particular on the overlap with the fields of inflammation and atherosclerosis. In this respect, extracellular histones and their role in systemic inflammatory disease and sepsis have evolved into a major research focus.

He is the president of the Netherlands Society on Biomolecular Modelling.

Dr Nicolaes has published more than 80 peer reviewed research papers, has been a co-promotor of 7 successful PhD students and currently supervises 7 more PhD students. He is inventor of several granted patents.

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.352

  • 2014
    • Nicolaes, G. A. F., Kulharia, M., Voorberg, J., Kaijen, P. H., Wroblewska, A., Wielders, S., Schrijver, R., Sperandio, O., & Villoutreix, B. O. (2014). Rational design of small molecules targeting the C2 domain of coagulation factor VIII. Blood, 123(1), 113-120. https://doi.org/10.1182/blood-2013-05-503227
    • Du, J., Bleylevens, I. W. M., Bitorina, A., Wichapong, K., & Nicolaes, G. A. F. (2014). Optimization of compound ranking for structure-based virtual ligand screening using an established FRED-Surflex consensus approach. Chemical Biology & Drug Design, 83(1), 37-51. https://doi.org/10.1111/cbdd.12202
  • 2013
    • Schuijt, T. J., Bakhtiari, K., Daffre, S., DePonte, K., Wielders, S. J. H., Marquart, J. A., Hovius, J. W., van der Poll, T., Fikrig, E., Bunce, M. W., Camire, R. M., Nicolaes, G. A. F., Meijers, J. C. M., & van 't Veer, C. (2013). Factor Xa Activation of Factor V Is of Paramount Importance in Initiating the Coagulation System: Lessons From a Tick Salivary Protein. Circulation, 128(3), 254-266. https://doi.org/10.1161/CIRCULATIONAHA.113.003191
  • 2012
    • Sanders, M. P. A., Barbosa, A. J. M., Zarzycka, B., Nicolaes, G. A. F., Klomp, J. P. G., de Vlieg, J., & Del Rio, A. (2012). Comparative Analysis of Pharmacophore Screening Tools. Journal of Chemical Information and Modeling, 52(6), 1607-1620. https://doi.org/10.1021/ci2005274
    • Mencarelli, C., Bode, G. H., Losen, M., Kulharia, M., Molenaar, P. C., Veerhuis, R., Steinbusch, H. W. M., De Baets, M. H., Nicolaes, G. A. F., & Martinez-Martinez, P. (2012). Goodpasture Antigen-binding Protein/Ceramide Transporter Binds to Human Serum Amyloid P-Component and Is Present in Brain Amyloid Plaques. Journal of Biological Chemistry, 287(18), 14897-14911. https://doi.org/10.1074/jbc.M111.299545
  • 2011
    • Wildhagen, K. C. A. A., Lutgens, E., Loubele, S. T. G. B., ten Cate, H., & Nicolaes, G. A. F. (2011). The structure-function relationship of activated protein C Lessons from natural and engineered mutations. Thrombosis and Haemostasis, 106(6), 1034-1045. https://doi.org/10.1160/TH11-08-0522
    • Ungethum, L., Kenis, H., Nicolaes, G. A., Autin, L., Stoilova-McPhie, S., & Reutelingsperger, C. P. M. (2011). Engineered Annexin A5 Variants Have Impaired Cell Entry for Molecular Imaging of Apoptosis Using Pretargeting Strategies. Journal of Biological Chemistry, 286(3), 1903-1910. https://doi.org/10.1074/jbc.M110.163527
    • Gerards, M., van den Bosch, B. J. C., Danhauser, K., Serre, V., van Weeghel, M., Wanders, R. J. A., Nicolaes, G. A. F., Sluiter, W., Schoonderwoerd, K., Scholte, H. R., Prokisch, H., Rötig, A., de Coo, I. F. M., & Smeets, H. J. M. (2011). Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene. Brain, 134(Pt 1), 210-219. https://doi.org/10.1093/brain/awq273
  • 2010
    • Nicolaes, G. A. F., Bock, P. E., Segers, K., Wildhagen, K. C. A. A., Dahlback, B., & Rosing, J. (2010). Inhibition of Thrombin Formation by Active Site Mutated (S360A) Activated Protein C. Journal of Biological Chemistry, 285(30), 22888-22898. https://doi.org/10.1074/jbc.M110.131029
    • Liu, Z., Lin, L., Yuan, C., Nicolaes, G. A. F., Chen, L., Meehan, E. J., Furie, B., Furie, B. C., & Huang, M. (2010). Trp(2313)-His(2315) of Factor VIII C2 Domain Is Involved in Membrane Binding STRUCTURE OF A COMPLEX BETWEEN THE C2 DOMAIN AND AN INHIBITOR OF MEMBRANE BINDING. Journal of Biological Chemistry, 285(12), 8824-8829. https://doi.org/10.1074/jbc.M109.080168
  • 1997
    • Rosing, J., Tans, G., Nicolaes, G. A. F., Thomassen, M. C. G. L. D., van Oerle, R., van der Ploeg, P. M. E. N., Heijnen, P., Hamulyak, K., & Hemker, H. C. (1997). Oral contraceptives and venous thrombosis: Different sensitives to activated protein C in women using second-and third-generation oral contraceptives. British Journal of Haematology, 97(1), 233-238. https://doi.org/10.1046/j.1365-2141.1997.192707.x