Hugo ten Cate


Prof. Hugo ten Cate graduated in Medicine at the University of Amsterdam in 1987. The title of his PhD thesis was 'Clinical and experimental studies with a low molecular weight heparinoid'. Hugo had his post-doctoral training at the laboratory of Prof. Robert Rosenberg and Dr Kenneth Bauer at the Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). He completed his internal medicine training in 1996 and became a general internist in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, Prof. Pieter Reitsma). He received a Clinical Established Investigator grant from the Dutch Heart Foundation in 1998.

In 2002, Hugo ten Cate was appointed Professor of Clinical Thrombosis and Haemostasis at CARIM. In addition, Prof. ten Cate was appointed adjunct professor at the Center for Thrombosis and Haemostasis (CTH) at Gutenberg University Medical Center, Mainz, Germany in 2017

Since the transfer to CARIM in 2002 his research focus shifted from coagulation-inflammation research in sepsis models, to the broader field of cardiovascular (CV) disease (atherothrombosis and 'thrombo-inflammation'). A specific focus of current research is the pleiotropic actions of coagulation proteases in atherosclerosis, atherothrombosis and ischemia reperfusion injury. Clinical research is aimed at chronic thrombotic disease including peripheral artery disease, high risk patients with coronary disease on antithrombotic medication and, together with Dr Arina ten Cate-Hoek, on venous thrombosis and post thrombotic syndrome (PTS). He is workpackage leader in CVON consortia RACE-5 (coagulation and its impact on atrial fibrillation) and CONTRAST (acute ischemic stroke) and involved in the ITN consortia TAPAS and TICARDIO. His group has an ongoing target finding programme with Bayer (steered from CARIM by Dr Henri Spronk and Prof. Hugo ten Cate) as well as with 2M (on POC development).

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.344
T: +31(0)43 388 42 62

  • 2023
    • Iding, A. F. J., Limpens, T. M. P., Ten Cate, H., & Ten Cate-Hoek, A. J. (2023). Chronic inflammatory diseases increase the risk of post-thrombotic syndrome: A prospective cohort study. European journal of internal medicine. Advance online publication.
    • Jacobs, L. M. C., Wintjens, M. S. J. N., Nagy, M., Willems, L., ten Cate, H., Spronk, H. M. H., van Kuijk, S. M. J., Ghossein-Doha, C., Netea, M. G., Groh, L. A., van Petersen, A. S., & Warle, M. C. (2023). Biomarkers of sustained systemic inflammation and microvascular dysfunction associated with post-COVID-19 condition symptoms at 24 months after SARS-CoV-2-infection. Frontiers in Immunology, 14, Article 1182182.
    • Heuts, S., Ceulemans, A., Kuiper, G. J. A. J. M., Schreiber, J. U., van Varik, B. J., Olie, R. H., Ten Cate, H., Maessen, J. G., Milojevic, M., & Maesen, B. (2023). Optimal management of cardiac surgery patients using direct oral anticoagulants: recommendations for clinical practice. European Journal of Cardio-Thoracic Surgery, 64(4), Article ezad340.
    • V. Kock, R., Berend, K., Florquin, S., & ten Cate, H. (2023). Pitfalls in anticoagulant-related nephropathy. Clinical Nephrology.
    • Baidildinova, G., Pallares Robles, A., ten Cate, V., Kremers, B. M. M., Heitmeier, S., ten Cate, H., Mees, B. M. E., Spronk, H. M. H., Wild, P. S., ten Cate-Hoek, A. J., & Jurk, K. (2023). Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease. Thrombosis Research, 230, 105-118.
    • Olie, R. H., Winckers, K., Rocca, B., & Ten Cate, H. (2023). Oral Anticoagulants Beyond Warfarin. Annual Review of Pharmacology and Toxicology, 64. Advance online publication.
    • Alnima, T., Meijer, R. I., Spronk, H. M. H., Warlé, M., & Cate, H. T. (2023). Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease. Cardiovascular Diabetology, 22(1), Article 257.
    • van Voorst, H., Hoving, J. W., Koopman, M. S., Daems, J. D., Peerlings, D., Buskens, E., Lingsma, H. F., Beenen, L. F. M., de Jong, H. W. A. M., Berkhemer, O. A., van Zwam, W. H., Roos, Y. B. W. E. M., van Walderveen, M. A. A., van den Wijngaard, I., Dippel, D. W. J., Yoo, A. J., Campbell, B. C. V., Kunz, W. G., Emmer, B. J., ... MR CLEAN Registry Investigators (2023). Cost-effectiveness of CT perfusion for the detection of large vessel occlusion acute ischemic stroke followed by endovascular treatment: a model-based health economic evaluation study. European Radiology.
    • Verheugt, F. W. A., Fox, K. A. A., Virdone, S., Ambrosio, G., Gersh, B. J., Haas, S., Pieper, K. S., Kayani, G., Camm, A. J., Parkhomenko, A., Misselwitz, F., Ragy, APH., Ten Cate, H., Keltai, M., Kakkar, A. K., & GARFIELD-AF Investigators (2023). Outcomes of Oral Anticoagulation in Atrial Fibrillation Patients with or without Comorbid Vascular Disease: Insights from the GARFIELD-AF Registry. The American Journal of Medicine. Advance online publication.
    • Sun, S., Campello, E., Zou, J., Konings, J., Huskens, D., Wan, J., Fernández, D. I., Reutelingsperger, C., Ten Cate, H., Toffanin, S., Bulato, C., de Groot, P. G., de Laat, B., Simioni, P., Heemskerk, J. W. M., & Roest, M. (2023). Crucial roles of red blood cells and platelets in whole blood thrombin generation. Blood advances.
    • Gigante, B., Levy, J. H., van Gorp, E., Bartoloni, A., Bochaton-Piallat, M-L., Bäck, M., Ten Cate, H., Christersson, C., Ferreiro, J. L., Geisler, T., Lutgens, E., Schulman, S., Storey, R. F., Thachil, J., Vilahur, G., Liaw, P. C., & Rocca, B. (2023). Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis. European Heart Journal, 44(32), 3040-3058.
    • Schultinge, L., Hulshof, A. M., van Neerven, D., Mulder, M. M. G., Sels, J. W. E. M., Hulsewe, H. P. M. G., Kuiper, G. J. A. J. M., Olie, R. H., ten Cate, H., van der Horst, I. C. C., van Bussel, B. C. T., & Henskens, Y. M. C. (2023). Applications of rotational thromboelastometry in heparin monitoring in critical COVID-19 disease: Observations in the Maastricht Intensive Care COVID cohort. Thrombosis Update, 12, Article 100140.
    • Luu, I. H. Y., Buijs, J., Krdzalic, J., de Kruif, M. D., Mostard, G. J. M., ten Cate, H., Dormans, T. P. J., Mostard, R. L. M., Leers, M. P. G., & van Twist, D. J. L. (2023). Pulmonary embolism in hospitalized COVID-19 patients: Short- and long-term clinical outcomes. Thrombosis Update, 12, Article 100142.
    • Musgrave, K. M., Scott, J., Sendama, W., Gardner, A. I., Dewar, F., Lake, C. J., Spronk, H. M. H., van Oerle, R., Visser, M., ten Cate, H., Kesteven, P., Fuller, A., McDonald, D., Knill, C., Hulme, G., Filby, A., Wright, S. E., Roy, A. I., Ruchaud-Sparagano, M-H., ... Rostron, A. J. (2023). Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis. Thrombosis Research, 228, 10-20.
    • Gigante, B., & Cate, H. T. (2023). Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale. Nature Reviews Cardiology, 20(8), 511-512.
    • Iding, A. F. J., Kremers, B. M. M., Pallares Robles, A., ten Cate, H., & ten Cate-Hoek, A. J. (2023). Residual Venous Obstruction as an Indicator of Clinical Outcomes following Deep Vein Thrombosis: A Management Study. Thrombosis and Haemostasis, 123(08), 763-772.
    • Douxfils, J., ten Cate, H., & Pola, R. (2023). Insights in thrombosis: 2022. Frontiers in cardiovascular medicine, 10, Article 1240626.
    • Robles, A. P., ten Cate, V., Lenz, M., Schulz, A., Prochaska, J. H., Rapp, S., Koeck, T., Leineweber, K., Heitmeier, S., Opitz, C. F., Held, M., Espinola-Klein, C., Lackner, K. J., Muenzel, T., V. Konstantinides, S., ten Cate-Hoek, A., ten Cate, H., & Wild, P. S. (2023). Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification. Thrombosis Research, 227, 71-81.
    • Willems, R. A. L., Michiels, N., Lanting, V. R., Bouwense, S., van den Broek, B. L. J., Graus, M., Klok, F. A., Koerkamp, B. G., de Laat, B., Roest, M., Wilmink, J. W., van Es, N., Mieog, J. S. D., ten Cate, H., & de Vos-Geelen, J. (2023). Venous Thromboembolism and Primary Thromboprophylaxis in Perioperative Pancreatic Cancer Care. Cancers, 15(14), Article 3546.
    • Nagy, M., Robles, A. P., Visser, M., Koeck, T., ten Cate, V., ten Cate-Hoek, A. J., Schwers, S., Heitmeier, S., ten Cate, H., Wild, P. S., & Spronk, H. M. H. (2023). Predictive value for increased activated factor XI activity in acute venous thromboembolism. Journal of Thrombosis and Haemostasis, 21(6), 1610-1622.
    • Braeken, D. C. W., Bavalia, R., Henskens, Y. M. C., Cate, H. T., Hengeveld, R. C. C., Hutten, B. A., Middeldorp, S., Coppens, M., & Stroobants, A. K. (2023). Clinical characteristics of patients with direct oral anticoagulant (DOAC) levels outside expected ranges: A retrospective chart study. Thrombosis Update, 11, Article 100139.
    • Barakzie, A., Jansen, A. J. G., ten Cate, H., & de Maat, M. P. M. (2023). Coagulation biomarkers for ischemic stroke. Research and practice in thrombosis and haemostasis, 7(4), Article 100160.
    • De Simone, I., Baaten, C. C. F. M. J., Gibbins, J. M., Ten Cate, H., Heemskerk, J. W. M., Jones, C. I., & van der Meijden, P. E. J. (2023). Repeated platelet activation and the potential of previously activated platelets to contribute to thrombus formation. Journal of Thrombosis and Haemostasis, 21(5), 1289-1306.
    • Schreurs, R. H. P., ten Cate-Hoek, A. J., ten Cate, H., & Joore, M. A. (2023). Budget Impact of Three Improvement Targets for Compression Therapy for Patients with Deep Venous Thrombosis in The Netherlands. PharmacoEconomics - open, 7, 479-491.
    • Busch, M. H., Timmermans, S. A. M. E. G., Van Kuijk, S. M. J., Aendekerk, J. P., Ysermans, R., Van Doorn, D. P. C., Potjewijd, J., Van de Poll, M. C. G., Van der Horst, I. C. C., Damoiseaux, J. G. M. C., Spronk, H. M. H., Cate, H. T., Reutelingsperger, C. P., Nagy, M., & Van Paassen, P. (2023). Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19. Haematologica-the Hematology Journal, 108(5), 1417-1422.
    • van Twist, D. J. L., Luu, I. H. Y., & Ten Cate, H. (2023). Aspirin for Thromboprophylaxis after a Fracture. New England Journal of Medicine, 388(16), Article e57.
    • Arita, V. A., Van de Lande, M. E., Ekrami, N. K., Nguyen, B. O., Van Melle, J. M., Geelhoed, B., De With, R. R., Weberndorfer, V., Erkuner, O., Hillege, H., Linz, D., Ten Cate, H., Spronk, H. M. H., Koldenhof, T., Tieleman, R. G., Schotten, U., Crijns, H. J. G. M., Van Gelder, I. C., & Rienstra, M. (2023). Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation: data from the RACE V study. EP Europace, 25, 1323-1331.
    • Luu, I. H. Y., Frijns, T., Buijs, J., Krdzalic, J., de Kruif, M. D., Mostard, G. J. M., ten Cate, H., Martens, R. J. H., Mostard, R. L. M., Leers, M. P. G., & van Twist, D. J. L. (2023). Systematic screening versus clinical gestalt in the diagnosis of pulmonary embolism in COVID-19 patients in the emergency department. PLOS ONE, 18(3), Article e0283459.
    • Akbalut, C., Arisz, R., Baaten, C., Baildildinova, G., Barakzie, A., Bauersachs, R., Ten Berg, J. M., van den Broek, W., de Boer, H. C., Broker, V., Buka, R., Ten Cate, H., Cate, A. T., De Luca, C., De Simone, I., Dignat-George, F., Freson, K., Gazzaniga, G., van Gorp, E., ... van Zonneveld, A-J. (2023). Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis. Advance online publication.
    • Turpie, A. G. G., Farjat, A. E., Haas, S., Ageno, W., Weitz, J. I., Goldhaber, S. Z., Goto, S., Angchaisuksiri, P., Kayani, G., Lopes, R. D., Chiang, C-E., Gibbs, H., Tse, E., Verhamme, P., Ten Cate, H., Muntaner, J., Schellong, S., Bounameaux, H., Prandoni, P., ... GARFIELD-VTE Investigators (2023). 36-month clinical outcomes of patients with venous thromboembolism: Garfield-vte. Thrombosis Research, 222, 31-39.
    • Iding, A. F. J., Robles, A. P., Ten Cate, V., Ten Cate, H., Wild, P. S., & Ten Cate-Hoek, A. J. (2023). Exploring phenotypes of deep vein thrombosis in relation to clinical outcomes beyond recurrence. Journal of Thrombosis and Haemostasis, 21(5), 1238-1247. Advance online publication.
    • Willems, L. H., Jacobs, L. M. C., Groh, L. A., ten Cate, H., Spronk, H. M. H., Wilson-Storey, B., Hannink, G., van Kuijk, S. M. J., Ghossein-Doha, C., Nagy, M., Thijssen, D. H. J., van Petersen, A. S., & Warle, M. C. (2023). Vascular Function, Systemic Inflammation, and Coagulation Activation 18 Months after COVID-19 Infection: An Observational Cohort Study. Journal of Clinical Medicine, 12(4), Article 1413.
    • Nguyen, B. O., Weberndorfer, V., Crijns, H. J. G. M., Geelhoed, B., Ten Cate, H., Spronk, H., Kroon, A., De With, R., Al-Jazairi, M., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., Luermans, J., de Groot, J., Allaart, C. P., Elvan, A., De Melis, M., Scheerder, C., ... Rienstra, M. (2023). Prevalence and determinants of atrial fibrillation progression in paroxysmal atrial fibrillation. Heart, 109(3), 186-194.
    • Kremers, B. M. M., Daemen, J. H. C., ten Cate, H., Spronk, H. M. H., Mees, B. M. E., & Cate-Hoek, A. J. T. (2023). Inadequate response to antiplatelet therapy in patients with peripheral artery disease: a prospective cohort study. Thrombosis Journal, 21(1), Article 5.
    • Prandoni, P., Haas, S., Fluharty, M. E., Schellong, S., Gibbs, H., Tse, E., Carrier, M., Jacobson, B., ten Cate, H., Panchenko, E., Verhamme, P., Pieper, K., Kayani, G., Kakkar, L. A., & GARFIELD-VTE Investigators (2023). Incidence and predictors of post-thrombotic syndrome in patients with proximal DVT in a real-world setting: findings from the GARFIELD-VTE registry. Journal of Thrombosis and Thrombolysis. Advance online publication.
    • Iding, A. F. J., Kremers, B. M. M., Nagy, M., Robles, A. P., Ten Cate, H., Spronk, H. M. H., & Ten Cate-Hoek, A. J. (2023). Translational insights into mechanisms underlying residual venous obstruction and the role of factor XI, P-selectin and GPVI in recurrent venous thromboembolism. Thrombosis Research, 221, 58-64.
    • Iding, A., Cate-Hoek, A. T., & Cate, H. T. (2023). Determining 'thrombogenicity' in patients with coronary artery disease; what's next?European Heart Journal, 44(19), 1729–1731.
  • 2022
    • Baidildinova, G., Ten Cate, V., Nagler, M., Panova-Noeva, M., Rapp, S., Köck, T., Prochaska, J. H., Heitmeier, S., Gerdes, C., Schwers, S., Konstantinides, S. V., Münzel, T., Espinola-Klein, C., Lackner, K. J., Spronk, H. M. N., Ten Cate, H., van der Meijden, P. E. J., Leineweber, K., Wild, P. S., & Jurk, K. (2022). Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism. Thrombosis Research, 220, 75-87.
    • Ghossein-Doha, C., Wintjens, M. S. J. N., Janssen, E. B. N. J., Klein, D., Heemskerk, S. C. M., Asselbergs, F. W., Birnie, E., Bonsel, G. J., van Bussel, B. C. T., Cals, J. W. L., Ten Cate, H., Haagsma, J., Hemmen, B., van der Horst, I. C. C., Kietselaer, B. L. J. H., Klok, F. A., de Kruif, M. D., Linschoten, M., van Santen, S., ... van Kuijk, S. M. J. (2022). Prevalence, pathophysiology, prediction and health-related quality of life of long COVID: study protocol of the longitudinal multiple cohort CORona Follow Up (CORFU) study. BMJ Open, 12(11), Article e065142.
    • Nagy, M., van der Meijden, P. E. J., Glunz, J., Schurgers, L., Lutgens, E., Ten Cate, H., Heitmeier, S., & Spronk, H. M. H. (2022). Integrating Mechanisms in Thrombotic Peripheral Arterial Disease. Pharmaceuticals, 15(11), Article 1428.
    • Wauthier, L., Favresse, J., Hardy, M., Douxfils, J., Le Gal, G., Roy, P-M., van Es, N., Ay, C., Ten Cate, H., Vander Borght, T., Dupont, M. V., Lecompte, T., Lippi, G., & Mullier, F. (2022). D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review. Diagnostics, 12(11), Article 2770.
    • Kremers, B. M. M., Posma, J. N., Heitmeier, S., Glunz, J., Ten Cate, H., Pallares Robles, A., Daemen, J. H. C., Ten Cate-Hoek, A. J., Mees, B. M. E., & Spronk, H. M. H. (2022). Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease. Scientific Reports, 12(1), Article 18388.
    • Willers, A., Swol, J., Van Kuijk, S. M. J., Buscher, H., McQuilten, Z., Ten Cate, H., Rycus, P. T., McKellar, S., Lorusso, R., & Tonna, J. E. (2022). HEROES V-A-HEmoRrhagic cOmplications in veno-arterial Extracorporeal life Support-Development and internal validation of a multivariable prediction model in adult patients. Artificial Organs, 46(11), 2266-2283.
    • Willems, L. H., Thijssen, D. H. J., Groh, L. A., Kooijman, N. I., Ten Cate, H., Spronk, H. M. H., Donders, A. R. T., Van der Vijver-Coppen, R. J., van Hoek, F., Nagy, M., Reijnen, M. M. P. J., & Warle, M. C. (2022). Dual pathway inhibition as compared to acetylsalicylic acid monotherapy in relation to endothelial function in peripheral artery disease, a phase IV clinical trial. Frontiers in cardiovascular medicine, 9, Article 979819.
    • van de Berg, T. W., Mulder, M. M. G., Alnima, T., Nagy, M., van Oerle, R., Beckers, E. A. M., Hackeng, T. M., Hulshof, A. M., Sels, J. W. E. M., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Dutch COVID & Thrombosis Coalition (2022). Serial thrombin generation and exploration of alternative anticoagulants in critically ill COVID-19 patients: Observations from Maastricht Intensive Care COVID Cohort. Frontiers in cardiovascular medicine, 9, Article 929284.
    • van Paridon, P. C. S., Panova-Noeva, M., van Oerle, R., Schulz, A., Prochaska, J. H., Arnold, N., Schmidtmann, I., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., ten Cate, H., Wild, P. S., & Spronk, H. M. H. (2022). Lower levels of vWF are associated with lower risk of cardiovascular disease. Research and practice in thrombosis and haemostasis, 6(7), Article e12797.
    • Haas, S., Farjat, A. E., Pieper, K., Ageno, W., Angchaisuksiri, P., Bounameaux, H., Goldhaber, S. Z., Goto, S., Mantovani, L., Prandoni, P., Schellong, S., Turpie, A. G. G., Weitz, J. I., MacCallum, P., Cate, H. T., Panchenko, E., Carrier, M., Jerjes-Sanchez, C., Gibbs, H., ... GARFIELD-VTE Investigators (2022). On-treatment Comparative Effectiveness of Vitamin K Antagonists and Direct Oral Anticoagulants in GARFIELD-VTE, and Focus on Cancer and Renal Disease. TH open : companion journal to thrombosis and haemostasis, 6(4), e354-e364.
    • Ten Cate, H. (2022). Editorial: Insights in thrombosis: 2021. Frontiers in cardiovascular medicine, 9, Article 1021626.
    • De Simone, I., Baaten, C. C. F. M. J., Jandrot-Perrus, M., Gibbins, J. M., Ten Cate, H., Heemskerk, J. W. M., Jones, C. I., & van der Meijden, P. E. J. (2022). Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1. International journal of molecular sciences, 23(18), Article 10203.