Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2021
    • Eck, R. J., Hulshof, L., Wiersema, R., Thio, C. H. L., Hiemstra, B., van den Oever, N. C. G., Gans, R. O. B., van der Horst, I. C. C., Meijer, K., & Keus, F. (2021). Incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients: data from two prospective cohort studies. Critical Care, 25(1), Article 27. https://doi.org/10.1186/s13054-021-03457-0
    • Ariës, M. J. H., van den Bergh, J. P., Beudel, M., Boersma, W., Dormans, T., Douma, R. A., Eerens, A., Elbers, P. W. G., Fleuren, L. M., Gritters van den Oever, N. C., de Haan, L., van der Horst, I. J. C. C., Hu, S., Hubers, D., Janssen, M. L. F., de Kruif, M., Kubben, P. L., van Kuijk, S. M. J., Noordzij, P. G., ... Wyers, C. E. (2021). Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf. Nederlands Tijdschrift voor Geneeskunde, 165(3), Article D5085. https://www.ntvg.nl/artikelen/klinisch-beloop-van-covid-19-nederland
    • Driessen, R. G. H., Heijnen, N. F. L., Hulsewe, R. P. M. G., Holtkamp, J. W. M., Winkens, B., van de Poll, M. C. G., van der Horst, I. C. C., Bergmans, D. C. J. J., & Schnabel, R. M. (2021). Early ICU-mortality in sepsis - causes, influencing factors and variability in clinical judgement: a retrospective cohort study. Infectious Diseases, 53(1), 61-68. https://doi.org/10.1080/23744235.2020.1821912
    • van Dam, P. M. E. L., Zelis, N., van Kuijk, S. M. J., Linkens, A. E. M. J. H., Bruggemann, R. A. G., Spaetgens, B., van der Horst, I. C. C., & Stassen, P. M. (2021). Performance of prediction models for short-term outcome in COVID-19 patients in the emergency department: a retrospective study. Annals of Medicine, 53(1), 402-409. https://doi.org/10.1080/07853890.2021.1891453
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., van de Ven, P. M., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., ... van Royen, N. (2021). Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy. Resuscitation, 158, 14-22. https://doi.org/10.1016/j.resuscitation.2020.10.026
    • Sanfilippo, F., Huang, S., Herpain, A., Balik, M., Chew, M. S., Clau-Terre, F., Corredor, C., De Backer, D., Fletcher, N., Geri, G., Mekontso-Dessap, A., McLean, A., Morelli, A., Orde, S., Petrinic, T., Slama, M., van der Horst, I. C. C., Vignon, P., Mayo, P., & Vieillard-Baron, A. (2021). The PRICES statement: an ESICM expert consensus on methodology for conducting and reporting critical care echocardiography research studies. Intensive Care Medicine, 47(1), 1-13. https://doi.org/10.1007/s00134-020-06262-5
    • Blokzijl, F., Keus, F., Houterman, S., Dieperink, W., Van Der Horst, I. C. C., Reneman, M. F., Absalom, A. R., & Mariani, M. A. (2021). Does postoperative cognitive decline after coronary bypass affect quality of life?Open Heart, 8(1), Article e001569. https://doi.org/10.1136/openhrt-2020-001569
    • Ottenhoff, M. C., Ramos, L. A., Potters, W., Janssen, M. L. F., Hubers, D., Hu, S., Fridgeirsson, E. A., Pina-Fuentes, D., Thomas, R., van der Horst, I. C. C., Herff, C., Kubben, P., Elbers, P. W. G., Marquering, H. A., Welling, M., Simsek, S., de Kruif, M. D., Dormans, T., Fleuren, L. M., ... Dutch COVID-PREDICT research group (2021). Predicting mortality of individual patients with COVID-19: a multicentre Dutch cohort. BMJ Open, 11(7), Article e047347. https://doi.org/10.1136/bmjopen-2020-047347
  • 2020
    • Smit, M. R., de Vos, J., Pisani, L., Hagens, L. A., Almondo, C., Heijnen, N. F. L., Schnabel, R. M., van der Horst, I. C., Bergmans, D. C. J. J., Schultz, M. J., Bos, L. D. J., & DARTS Consortium (2020). Comparison Of Linear And Sector Array Probe For Handheld Lung Ultrasound In Invasively Ventilated Icu Patients. Ultrasound in Medicine and Biology, 46(12), 3249-3256. https://doi.org/10.1016/j.ultrasmedbio.2020.08.016
    • Vlaar, A. P. J., de Bruin, S., Busch, M., Timmermans, S. A. M. E. G., van Zeggeren, I. E., Koning, R., ter Horst, L., Bulle, E. B., van Baarle, F. E. H. P., van de Poll, M. C. G., Kemper, E. M., van der Horst, I. C. C., Schultz, M. J., Horn, J., Paulus, F., Bos, L. D., Wiersinga, W. J., Witzenrath, M., Rueckinger, S., ... van de Beek, D. (2020). Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial. The Lancet Rheumatology, 2(12), E764-E773. https://doi.org/10.1016/s2665-9913(20)30341-6
    • Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M. M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R. R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., Stoel, M., ... van Royen, N. (2020). Coronary Angiography After Cardiac Arrest Without ST Segment Elevation: One-Year Outcomes of the COACT Randomized Clinical Trial. JAMA Cardiology, 5(12), 1358-1365. https://doi.org/10.1001/jamacardio.2020.3670
    • Bruggemann, R. A. G., Spaetgens, B., Gietema, H. A., Brouns, S. H. A., Stassen, P. M., Magdelijns, F. J., Rennenberg, R. J., Henry, R. M. A., Mulder, M. M. G., van Bussel, B. C. T., Schnabel, R. M., van der Horst, I. C. C., Wildberger, J. E., Stehouwer, C. D. A., & ten Cate, H. (2020). The prevalence of pulmonary embolism in patients with COVID-19 and respiratory decline: A three-setting comparison. Thrombosis Research, 196, 486-490. https://doi.org/10.1016/j.thromres.2020.10.012
    • Schiffer, V. M. M. M., Janssen, E. B. N. J., van Bussel, B. C. T., Jorissen, L. L. M., Tas, J., Sels, J.-W. E. M., Bergmans, D. C. J. J., Dinh, T. H. T., van Kuijk, S. M. J., Hana, A., Mehagnoul-Schipper, J., Scheeren, C. I. E., Mesotten, D., Stessel, B., Marx, G., Hof, A. W. J. V. T., Spaanderman, M. E. A., van Mook, W. N. K. A., van der Horst, I. C. C., & Ghossein-Doha, C. (2020). The "sex gap" in COVID-19 trials: a scoping review. EClinicalMedicine, 29-30, Article 100652. https://doi.org/10.1016/j.eclinm.2020.100652
    • Busch, M. H., Timmermans, S. A. M. E. G., Nagy, M., Visser, M., Huckriede, J., Aendekerk, J. P., de Vries, F., Potjewijd, J., Jallah, B., Ysermans, R., Oude Lashof, A. M. L., Breedveld, P. H., van de Poll, M. C. G., van de Horst, I. C. C., van Bussel, B. C. T., Theunissen, R. O. M. F. I. H., Spronk, H. M. H., Damoiseaux, J. G. M. C., ten Cate, H., ... van Paassen, P. (2020). Neutrophils and Contact Activation of Coagulation as Potential Drivers of COVID-19. Circulation, 142(18), 1787-1790. https://doi.org/10.1161/CIRCULATIONAHA.120.050656
    • Wiersema, R., Kaufmann, T., van der Veen, H. N., de Haas, R. J., Franssen, C. F. M., Koeze, J., van der Horst, I. C. C., Keus, F., & SICS Study Group (2020). Diagnostic accuracy of arterial and venous renal Doppler assessment for acute kidney injury in critically ill patients: A prospective study. Journal of Critical Care, 59, 57-62. https://doi.org/10.1016/j.jcrc.2020.05.012
    • van den Akker, E. B., Trompet, S., Barkey Wolf, J. J. H., Beekman, M., Suchiman, H. E. D., Deelen, J., Asselbergs, F. W., Boersma, E., Cats, D., Elders, P. M., Geleijnse, J. M., Ikram, M. A., Kloppenburg, M., Mei, H., Meulenbelt, I., Mooijaart, S. P., Nelissen, R. G. H. H., Netea, M. G., Penninx, B. W. J. H., ... Slagboom, P. E. (2020). Metabolic Age Based on the BBMRI-NL 1 H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circulation: Genomic and Precision Medicine, 13(5), 541-547. Article 002610. https://doi.org/10.1161/CIRCGEN.119.002610
    • Streng, A. S., Delnoij, T. S. R., Mulder, M. M. G., Sels, J. W. E. M., Wetzels, R. J. H., Verhezen, P. W. M., Olie, R. H., Kooman, J. P., van Kuijk, S. M. J., Brandts, L., Ten Cate, H., Lorusso, R., van der Horst, I. C. C., van Bussel, B. C. T., & Henskens, Y. M. C. (2020). Monitoring of Unfractionated Heparin in Severe COVID-19: An Observational Study of Patients on CRRT and ECMO. TH open : companion journal to thrombosis and haemostasis, 4(4), e365-e375. https://doi.org/10.1055/s-0040-1719083
    • Posma, R. A., Wessels, A. M. A., Dieperink, W., Roggeveld, J., Leuvenink, H. G. D., van der Horst, I. C. C., den Dunnen, W. F. A., Nijsten, M. W., & Touw, D. J. (2020). Renal Trapping in Accidental Metformin Intoxication. Kidney International Reports, 5(9), 1525-1528. https://doi.org/10.1016/j.ekir.2020.06.009
    • Wynants, L., Van Calster, B., Collins, G. S., Riley, R. D., Heinze, G., Schuit, E., Albu, E., Arshi, B., Bellou, V., Bonten, M. M. J., Dahly, D. L., Damen, J. A., Debray, T. P. A., de Jong, V. M. T., De Vos, M., Dhiman, P., Ensor, J., Gao, S., Haller, M. C., ... van Royen, F. S. (2020). Update to living systematic review (vol 369, m1328, 2020). BMJ, 369, Article m2204. https://doi.org/10.1136/bmj.m2204
    • Pool, R., Hagenbeek, F. A., Hendriks, A. M., van Dongen, J., Willemsen, G., de Geus, E., van Dijk, K. W., Verhoeven, A., Suchiman, H. E., Beekman, M., Slagboom, P. E., Harms, A. C., Hankemeier, T., Boomsma, D. I., Suchiman, H. E. D., Amin, N., Beulens, J. W., van der Bom, J. A., Bomer, N., ... BBMRI Metabolomics Consortium (2020). Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data. Twin Research and Human Genetics, 23(3), 145-155. Article 1832427420000535. https://doi.org/10.1017/thg.2020.53
    • Kaufmann, T., Cox, E. G. M., Wiersema, R., Hiemstra, B., Eck, R. J., Koster, G., Scheeren, T. W. L., Keus, F., Saugel, B., van der Horst, I. C. C., & SICS Study Group (2020). Non-invasive oscillometric versus invasive arterial blood pressure measurements in critically ill patients: A post hoc analysis of a prospective observational study. Journal of Critical Care, 57, 118-123. https://doi.org/10.1016/j.jcrc.2020.02.013
    • Kaufmann, T., van der Horst, I. C. C., & Scheeren, T. W. L. (2020). This is your toolkit in hemodynamic monitoring. Current Opinion in Critical Care, 26(3), 303-312. https://doi.org/10.1097/MCC.0000000000000727
    • Cox, E. G. M., Wiersema, R., Wong, A. R., van der Horst, I. C. C., & SICS Study Group (2020). Six versus eight and twenty-eight scan sites for B-line assessment: differences in examination time and findings. Intensive Care Medicine, 46(5), 1063-1064. https://doi.org/10.1007/s00134-020-06004-7
    • Huang, S., Sanfilippo, F., Herpain, A., Balik, M., Chew, M., Clau-Terre, F., Corredor, C., De Backer, D., Fletcher, N., Geri, G., Mekontso-Dessap, A., McLean, A., Morelli, A., Orde, S., Petrinic, T., Slama, M., van der Horst, I. C. C., Vignon, P., Mayo, P., & Vieillard-Baron, A. (2020). Systematic review and literature appraisal on methodology of conducting and reporting critical-care echocardiography studies: a report from the European Society of Intensive Care Medicine PRICES expert panel. Annals of Intensive Care, 10(1), Article 49. https://doi.org/10.1186/s13613-020-00662-y
    • Wiersema, R., Jukarainen, S., Eck, R. J., Kaufmann, T., Koeze, J., Keus, F., Pettila, V., van der Horst, I. C. C., & Vaara, S. T. (2020). Different applications of the KDIGO criteria for AKI lead to different incidences in critically ill patients: a post hoc analysis from the prospective observational SICS-II study. Critical Care, 24(1), Article 164. https://doi.org/10.1186/s13054-020-02886-7
    • Wiersema, R., Jukarainen, S., Vaara, S. T., Poukkanen, M., Lakkisto, P., Wong, H., Linder, A., van der Horst, I. C. C., & Pettila, V. (2020). Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery. Critical Care, 24(1), Article 150. https://doi.org/10.1186/s13054-020-02866-x
    • Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H. C., Kaas-Hansen, B. S., van der Horst, I. C. C., Lange, T., Wetterslev, J., Perner, A., & Moller, M. H. (2020). Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial. Intensive Care Medicine, 46(4), 717-726. https://doi.org/10.1007/s00134-019-05903-8
    • van Beek, D. E. C., Kuijpers, Y. A. M., Königs, M. H. H., van der Horst, I. C. C., & Scheeren, T. W. L. (2020). Low serum albumin levels and new-onset atrial fibrillation in the ICU: a prospective cohort study. Journal of Critical Care, 56, 26-30. https://doi.org/10.1016/j.jcrc.2019.11.011
    • Keuning, B. E., Kaufmann, T., Wiersema, R., Granholm, A., Pettila, V., Moller, M. H., Christiansen, C. F., Forte, J. C., Snieder, H., Keus, F., Pleijhuis, R. G., van der Horst, I. C. C., & HEALICS consortium (2020). Mortality prediction models in the adult critically ill: A scoping review. Acta Anaesthesiologica Scandinavica, 64(4), 424-442. https://doi.org/10.1111/aas.13527
    • Posma, R. A., Froslev, T., Jespersen, B., van der Horst, I. C. C., Touw, D. J., Thomsen, R. W., Nijsten, M. W., & Christiansen, C. F. (2020). Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study. Annals of Intensive Care, 10(1), Article 36. https://doi.org/10.1186/s13613-020-00652-0
    • Gerardu, V. C. A., & van der Horst, I. C. C. (2020). In networks we trust. Netherlands Journal of Critical Care, 28(2), 76-77. https://nvic.nl/sites/nvic.nl/files/Nieuws%20aanmaken/NJCC%202020-2%20Vol%2028%2076-77%20In%20netwrorks%20we%20trust.pdf
    • Kjaer, M. B. N., Meyhoff, T. S., Madsen, M. B., Hjortrup, P. B., Moller, M. H., Egerod, I., Wetterslev, J., Lange, T., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Pettila, V., van der Horst, I. C. C., Ostermann, M., Mouncey, P., Cecconi, M., Ferrer, R., Malbrain, M. L. N. G., ... Perner, A. (2020). Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial. Acta Anaesthesiologica Scandinavica, 64(3), 410-416. https://doi.org/10.1111/aas.13519
    • Hiemstra, B., Eck, R. J., Keus, F., & van der Horst, I. C. C. (2020). The authors reply. Critical Care Medicine, 48(2), E154-E154. https://doi.org/10.1097/CCM.0000000000004121
    • Cox, E. G. M., Koster, G., Baron, A., Kaufmann, T., Eck, R. J., Veenstra, T. C., Hiemstra, B., Wong, A., Kwee, T. C., Tulleken, J. E., Keus, F., Wiersema, R., van Der Horst, W. C. C., Dieperink, W., Bleijendaal, R., Cawale, Y. F., Clement, R. P., Dijkhuizen, D., Haker, A., ... SICS Study Group (2020). Should the ultrasound probe replace your stethoscope? A SICS-I sub-study comparing lung ultrasound and pulmonary auscultation in the critically ill. Critical Care, 24(1), Article 14. https://doi.org/10.1186/s13054-019-2719-8
    • Koster, G., Kaufmann, T., Hiemstra, B., Wiersema, R., Vos, M. E., Dijkhuizen, D., Wong, A. R., Scheeren, T. W. L., Hummel, Y. M., Keus, F., & van der Horst, I. C. C. (2020). Feasibility of cardiac output measurements in critically ill patients by medical students. Critical Ultrasound Journal, 12(1), Article 1. https://doi.org/10.1186/s13089-020-0152-5
    • Hagenbeek, F. A., Pool, R., van Dongen, J., Draisma, H. H. M., Jan Hottenga, J., Willemsen, G., Abdellaoui, A., Fedko, I. O., den Braber, A., Visser, P. J., de Geus, E. J. C. N., Willems van Dijk, K., Verhoeven, A., Suchiman, H. E., Beekman, M., Slagboom, P. E., van Duijn, C. M., Harms, A. C., Hankemeier, T., ... BBMRI Metabolomics Consortium (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nature Communications, 11(1), Article 39. https://doi.org/10.1038/s41467-019-13770-6
    • Tas, J., van Gassel, R. J. J., Heines, S. J. H., Mulder, M. M. G., Heijnen, N. F. L., Acampo-de Jong, M. J., Bels, J. L. M., Bennis, F. C., Koelmann, M., Groven, R. V. M., Donkers, M. A., van Rosmalen, F., Hermans, B. J. M., Meex, S. J. R., Mingels, A., Bekers, O., Savelkoul, P., Oude Lashof, A. M. L., Wildberger, J., ... van Bussel, B. C. T. (2020). Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht). BMJ Open, 10(9), Article 040175. https://doi.org/10.1136/bmjopen-2020-040175
  • 2019
    • Wiersema, R., Eck, R. J., Haapio, M., Koeze, J., Poukkanen, M., Keus, F., van der Horst, I. C. C., Pettila, V., & Vaara, S. T. (2019). Burden of acute kidney injury and 90-day mortality in critically ill patients. Bmc Nephrology, 21(1), Article 1. https://doi.org/10.1186/s12882-019-1645-y
    • Hiemstra, B., Keus, F., Wetterslev, J., Gluud, C., & van der Horst, I. C. C. (2019). DEBATE-statistical analysis plans for observational studies. BMC Medical Research Methodology, 19(1), Article 233. https://doi.org/10.1186/s12874-019-0879-5
    • Eck, R. J., Bult, W., Wetterslev, J., Gans, R. O. B., Meijer, K., van Der Horst, I. C. C., & Keus, F. (2019). Low Dose Low-Molecular-Weight Heparin for Thrombosis Prophylaxis: Systematic Review with Meta-Analysis and Trial Sequential Analysis. Journal of Clinical Medicine, 8(12), Article 2039. https://doi.org/10.3390/jcm8122039
    • Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., Stoel, M., ... van Royen, N. (2019). Coronary Angiography after Cardiac Arrest without ST-Segment Elevation. New England Journal of Medicine, 380(15), 1397-1407. https://doi.org/10.1056/NEJMoa1816897
    • Kaufmann, T., Forte, J. C., Hiemstra, B., Wiering, M. A., Grzegorczyk, M., Epema, A. H., van der Horst, I. C. C., & SICS Study Group (2019). A Bayesian Network Analysis of the Diagnostic Process and its Accuracy to Determine How Clinicians Estimate Cardiac Function in Critically Ill Patients: Prospective Observational Cohort Study. JMIR Medical Informatics, 7(4), 214-224. Article 15358. https://doi.org/10.2196/15358
  • 2016
    • Hassell, M. E. C. J., Delewi, R., Lexis, C. P. H., Smulders, M. W., Hirsch, A., Wagner, G., Bekkers, S. C. A. M., van der Horst, I. C. C., Zijlstra, F., van Rossum, A. C., Piek, J. J., van der Harst, P., & Nijveldt, R. (2016). The relationship between terminal QRS distortion on initial ECG and final infarct size at 4 months in conventional ST- segment elevation myocardial infarct patients. Journal of Electrocardiology, 49(3), 292-299. https://doi.org/10.1016/j.jelectrocard.2016.03.009
  • 2012
    • Willemsen, S., Hartog, J. W. L., van Veldhuisen, D. J., van der Meer, P., Roze, J. F., Jaarsma, T., Schalkwijk, C., van der Horst, I. C. C., Hillege, H. L., & Voors, A. A. (2012). The role of advanced glycation end-products and their receptor on outcome in heart failure patients with preserved and reduced ejection fraction. American Heart Journal, 164(5), 742-U146. https://doi.org/10.1016/j.ahj.2012.07.027
  • 2011
    • Lexis, C. P. H., van der Horst, I. C. C., Rahel, B. M., Lexis, M. A. S., Kampinga, M. A., Gu, Y. L., de Smet, B. J. G. L., & Zijlstra, F. (2011). Impact of Chronic Total Occlusions on Markers of Reperfusion, Infarct Size, and Long-Term Mortality: A Substudy from the TAPAS-Trial. Catheterization and Cardiovascular interventions, 77(4), 484-491. https://doi.org/10.1002/ccd.22664