Judith Cosemans

Associate professor

Dr Judith Cosemans holds a master’s degree in Biological Health Sciences with specialisation in molecular biology from Maastricht University. She became fascinated to unravel the role of platelets in arterial thrombosis during her PhD research, which focussed on the dynamic regulation of thrombus stability. After finishing her PhD in 2009, she executed an award-winning postdoc project to develop flow chamber technology as a compatible alternative for experimental animal models of arterial thrombosis.

Dr Cosemans subsequently obtained two personal grants from the Dutch Heart Foundation (2011, 2015) and a Vidi grant from the Netherlands Organisation for Scientific Research (NWO, 2016). These grants facilitate her current research line, which lies on the interface of platelet signalling and vascular biology.

Her team aims to:
• provide novel mechanistic insight into the pathophysiology of thrombosis in the heart and in the brain
• develop better diagnostic tools and novel druggable targets to prevent recurrentthrombotic events

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2012
    • Westein, E., de Witt, S., Lamers, M., Cosemans, J. M. E. M., & Heemskerk, J. W. M. (2012). Monitoring in vitro thrombus formation with novel microfluidic devices. Platelets, 23(7), 501-509. https://doi.org/10.3109/09537104.2012.709653
  • 2011
    • Nergiz-Unal, R., Lamers, M. M. E., Van Kruchten, R., Luiken, J. J., Cosemans, J. M. E. M., Glatz, J. F. C., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2011). Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein. Journal of Thrombosis and Haemostasis, 9(9), 1835-1846. https://doi.org/10.1111/j.1538-7836.2011.04416.x
    • Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D., & Poole, A. W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood, 118(2), 416-424. https://doi.org/10.1182/blood-2010-10-312199
    • Heemskerk, J. W. M., Harper, M. T., Cosemans, J. M. E. M., & Poole, A. W. (2011). Unravelling the different functions of protein kinase C isoforms in platelets. Febs Letters, 585(12), 1711-1716. https://doi.org/10.1016/j.febslet.2011.05.017
    • Cosemans, J. M. E. M., Schols, S. E. M., Stefanini, L., de Witt, S., Feijge, M. A. H., Hamulyak, K., Deckmyn, H., Bergmeier, W., & Heemskerk, J. W. M. (2011). Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood, 117(2), 651-660. https://doi.org/10.1182/blood-2010-01-262683
  • 2010
    • Cosemans, J. M. E. M., Van Kruchten, R., Olieslagers, S., Schurgers, L. J., Verheyen, F. K., Munnix, I. C. A., Waltenberger, J., Angelillo-Scherrer, A., Hoylaerts, M. F., Carmeliet, P., & Heemskerk, J. W. M. (2010). Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. Journal of Thrombosis and Haemostasis, 8(8), 1797-1808. https://doi.org/10.1111/j.1538-7836.2010.03935.x
    • Gilio, K., Harper, M. T., Cosemans, J. M. E. M., Konopatskaya, O., Munnix, I. C. A., Prinzen, L., Leitges, M., Liu, Q., Molkentin, J. D., Heemskerk, J. W. M., & Poole, A. W. (2010). Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen. Journal of Biological Chemistry, 285(30), 23408-23417. https://doi.org/10.1074/jbc.M110.136176
    • Berny, M. A., Munnix, I. C. A., Auger, J. M., Schols, S. E. M., Cosemans, J. M. E. M., Panizzi, P., Bock, P. E., Watson, S. P., McCarty, O. J. T., & Heemskerk, J. W. M. (2010). Spatial Distribution of Factor Xa, Thrombin, and Fibrin(ogen) on Thrombi at Venous Shear. PLOS ONE, 5(4), 8. https://doi.org/10.1371/journal.pone.0010415
    • Nergiz-Unal, R., Cosemans, J. M. E. M., Feijge, M. A. H., van der Meijden, P. E. J., Storey, R. F., van Giezen, J. J. J., Egbrink, M. G. A. O., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2010). Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques. PLOS ONE, 5(4), 13. https://doi.org/10.1371/journal.pone.0010130