Kanin Wichapong

Post doc

Dr Kanin Wichapong received his PhD degree in chemistry from Chulalongkorn University, Bangkok, Thailand. After completion of his PhD, he went back and worked as a postdoctoral researcher at Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany where he also carried out parts of his PhD. During his PhD and post-doc period, he worked on computational and physical chemistry subjects by applying in silico drug discovery and design technologies (e.g. virtual screening and molecular docking) to identify and develop novel inhibitors against different target proteins.

To broaden his research horizons with respect to new research fields in a new science environment, in December 2012 he moved to work at the Department of Biochemistry, Maastricht University. His main research focusses on applications of in silico approaches (such as molecular docking, molecular dynamics simulations, and binding free energy calculation) to study and investigate protein-protein interactions as well as to identify and design novel compounds (small compounds or peptides) to modulate protein-protein interactions. The identified bioactive compounds can be further developed as drugs to treat for several related diseases (e.g. cardiovascular diseases and cancer).

 

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.301

  • 2020
    • Santovito, D., Egea, V., Bidzhekov, K., Natarelli, L., Mourao, A., Blanchet, X., Wichapong, K., Aslani, M., Brunssen, C., Horckmans, M., Hristov, M., Geerlof, A., Lutgens, E., Daemen, M. J. A. P., Hackeng, T., Ries, C., Chavakis, T., Morawietz, H., Naumann, R., ... Weber, C. (2020). Autophagy unleashes noncanonical microRNA functions. Autophagy, 16(12), 2294-2296. https://doi.org/10.1080/15548627.2020.1830523
    • Miller, M. C., Cai, C., Wichapong, K., Bhaduri, S., Pohl, N. L. B., Linhardt, R. J., Gabius, H-J., & Mayo, K. H. (2020). Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides. Scientific Reports, 10(1), [15708]. https://doi.org/10.1038/s41598-020-72645-9
    • Santovito, D., Egea, V., Bidzhekov, K., Natarelli, L., Mourao, A., Blanchet, X., Wichapong, K., Aslani, M., Brunssen, C., Horckmans, M., Hristov, M., Geerlof, A., Lutgens, E., Daemen, M. J. A. P., Hackeng, T. M., Ries, C., Chavakis, T., Morawietz, H., Naumann, R., ... Weber, C. (2020). Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Science Translational Medicine, 12(546), [2294]. https://doi.org/10.1126/scitranslmed.aaz2294
    • Eckardt, V., Miller, M. C., Blanchet, X., Duan, R., Leberzammer, J., Duchene, J., Soehnlein, O., Megens, R. T. A., Ludwig, A-K., Dregni, A., Faussner, A., Wichapong, K., Ippel, H., Dijkgraaf, I., Kaltner, H., Doering, Y., Bidzhekov, K., Hackeng, T. M., Weber, C., ... Mayo, K. H. (2020). Chemokines and galectins form heterodimers to modulate inflammation. Embo Reports, 21(4), [47852]. https://doi.org/10.15252/embr.201947852
  • 2019
    • Sang, Y., Huskens, D., Wichapong, K., de Laat, B., Nicolaes, G. A. F., & Roest, M. (2019). A Synthetic Triple Helical Collagen Peptide as a New Agonist for Flow Cytometric Measurement of GPVI-Specific Platelet Activation. Thrombosis and Haemostasis, 119(12), 2005-2013. https://doi.org/10.1055/s-0039-1697660
    • Silvestre-Roig, C., Braster, Q., Wichapong, K., Lee, E. Y., Marie Teulon, J., Berrebeh, N., Winter, J., Adrover, J. M., Santos, G. S., Froese, A., Lemnitzer, P., Ortega-Gomez, A., Chevre, R., Marschner, J., Schumski, A., Winter, C., Perez-Olivares, L., Pan, C., Paulin, N., ... Soehnlein, O. (2019). Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature, 569(7755), 236-240. https://doi.org/10.1038/s41586-019-1167-6
    • Wichapong, K., Poelman, H., Ercig, B., Hrdinova, J., Liu, X., Lutgens, E., & Nicolaes, G. A. F. (2019). Rational modulator design by exploitation of protein-protein complex structures. Future Medicinal Chemistry, 11(9), 1015-1033. https://doi.org/10.4155/fmc-2018-0433
  • 2018
    • Miller, M. C., Ludwig, A-K., Wichapong, K., Kaltner, H., Kopitz, J., Gabius, H-J., & Mayo, K. H. (2018). Adhesion/growth-regulatory galectins tested in combination: evidence for formation of hybrids as heterodimers. Biochemical Journal, 475, 1003-1018. https://doi.org/10.1042/BCJ20170658
    • Ercig, B., Wichapong, K., Reutelingsperger, C. P. M., Vanhoorelbeke, K., Voorberg, J., & Nicolaes, G. A. F. (2018). Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura. Thrombosis and Haemostasis, 118(1), 28-41. https://doi.org/10.1160/TH17-06-0404
  • 2017
    • von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., ... Weber, C. (2017). Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Science Translational Medicine, 9(384), [eaah6650]. https://doi.org/10.1126/scitranslmed.aah6650
  • 2016
    • Wichapong, K., Alard, J. -E., Ortega-Gomez, A., Weber, C., Hackeng, T. M., Soehnlein, O., & Nicolaes, G. A. F. (2016). Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1). Journal of Medicinal Chemistry, 59(9), 4289-4301. https://doi.org/10.1021/acs.jmedchem.5b01952
  • 2015
    • Alard, J-E., Ortega-Gomez, A., Wichapong, K., Bongiovanni, D., Horckmans, M., Megens, R. T. A., Leoni, G., Ferraro, B., Rossaint, J., Paulin, N., Ng, J., Ippel, H., Suylen, D., Hinkel, R., Blanchet, X., Gaillard, F., D'Amico, M., von Hundelshausen, P., Zarbock, A., ... Soehnlein, O. (2015). Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Science Translational Medicine, 7(317), [317ra196]. https://doi.org/10.1126/scitranslmed.aad5330
    • Du, J., Wichapong, K., Hackeng, T. M., & Nicolaes, G. A. F. (2015). Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding. Thrombosis and Haemostasis, 113(2), 373-384. https://doi.org/10.1160/TH14-02-0180