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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Longer and better lives for patients with atrial fibrillation

Longer and better lives for patients with atrial fibrillation

15 April 2024

An international panel of experts published recommendations to improve management of atrial fibrillation (AF).

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Carim Maastricht
Carim Maastricht

Marijke Kuijpers

Associate professor

Dr Marijke Kuijpers studied Biological Health Sciences at Maastricht University, after which she could start on a joint PhD project of the Department of Biochemistry and Physiology, studying studied platelet receptors and procoagulant activity in thrombus formation. After obtaining her PhD, she received a Kootstra fellowship, and started on a post-doc project from the Dutch Heart Foundation to investigate the role of platelets and coagulation in thrombus formation on ruptured atherosclerotic plaques.

Since 2011, she has been working as a scientific researcher in the Laboratory on Cell Biochemistry of Thrombosis and Haemostasis, chaired by Prof. Johan Heemskerk, within the Department of Biochemistry. Furthermore, she is connected to the Thrombosis Expertise Center (TEC) from Maastrich UMC+, which main aim is to improve translational research.

The current focus of her research is (hyper)active platelet function under pathologic circumstances: cancer, atherosclerosis, thrombosis, hyperlipidemia (diabetes type 2, Alzheimer). Main research questions are: the full characterisation gain-of-function platelet phenotypes and exploration of the underlying signaling mechanisms. She has a particular interest in the effects of tyrosine kinase inhibitors, often used as anti-cancer treatment, on platelet functions in vitro and in patients. Furthermore, she is part of the EU Horizon2020 TAPAS, investigating whether targeting platelet adhesion receptors can lead to better anti-thrombotic treatment without bleeding.

Marijke-kuipers

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.320

  • 2024
    • Jooss, N. J., Diender, M. G., Fernandez, D. I., Huang, J., Heubel-Moenen, F. C. J., van der Veer, A., Kuijpers, M. J. E., Poulter, N. S., Henskens, Y. M. C., te Loo, M., & Heemskerk, J. W. M. (2024). Restraining of glycoprotein VI- and integrin a2ß1-dependent thrombus formation by platelet PECAM1. Cellular and Molecular Life Sciences, 81(1), Article 44. https://doi.org/10.1007/s00018-023-05058-2
    • Provenzale, I., Solari, F. A., Schoenichen, C., Brouns, S. L. N., Fernandez, D. I., Kuijpers, M. J. E., van Der Meijden, P. E. J., Gibbins, J. M., Sickmann, A., Jones, C., & Heemskerk, J. W. M. (2024). Endothelium-mediated regulation of platelet activation: Involvement of multiple protein kinases. Faseb Journal, 38(4), Article e23468. https://doi.org/10.1096/fj.202300360RR
    • Melo, S. F., Nondonfaz, A., Aqil, A., Pierrard, A., Hulin, A., Delierneux, C., Ditkowski, B., Gustin, M., Legrand, M., Tullemans, B. M. E., Brouns, S. L. N., Nchimi, A., Carrus, R., Dejosé, A., Heemskerk, J. W. M., Kuijpers, M. J. E., Ritter, J., Steinseifer, U., Clauser, J. C., ... Oury, C. (2024). Design, manufacturing and testing of a green non-isocyanate polyurethane prosthetic heart valve. Biomaterials Science. Advance online publication. https://doi.org/10.1039/d3bm01911j
    • Fernández, D. I., Troitiño, S., Sobota, V., Tullemans, B. M. E., Zou, J., van den Hurk, H., García, Á., Honarnejad, S., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2024). Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics. Scientific Reports, 14(1), Article 6229. Advance online publication. https://doi.org/10.1038/s41598-024-56799-4
  • 2023
    • Oury, C., Meyers, S., Jacques, N., Leeten, K., Jiang, Z., Musumeci, L., Lox, M., Debuisson, M., Goffin, E., Pirotte, B., Delvenne, P., Nchimi, A., Hubert, C., Heptia, M., Hubert, P., Kuijpers, M. J. E., Vanassche, T., Martinod, K., Verhamme, P., & Lancellotti, P. (2023). Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice. JACC: Basic to Translational Science, 8(11), 1439-1453. https://doi.org/10.1016/j.jacbts.2023.02.003
    • Schönichen, C., Montague, S. J., Brouns, S. L. N., Burston, J. J., Cosemans, J. M. E. M., Jurk, K., Kehrel, B. E., Koenen, R. R., Ní Áinle, F., O'Donnell, V. B., Soehnlein, O., Watson, S. P., Kuijpers, M. J. E., Heemskerk, J. W. M., & Nagy, M. (2023). Antagonistic Roles of Human Platelet Integrin aIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow. Arteriosclerosis Thrombosis and Vascular Biology, 43(9), 1700-1712. https://doi.org/10.1161/ATVBAHA.122.318767
    • Fernandez, D. I., Diender, M., Hermida-Nogueira, L., Huang, J., Veiras, S., Henskens, Y. M. C., te Loo, M. W. M., Heemskerk, J. W. M., Kuijpers, M. J. E., & Garcia, A. (2023). Role of SHP2 (PTPN11) in glycoprotein VI-dependent thrombus formation: Improved platelet responsiveness by the allosteric drug SHP099 in Noonan syndrome patients. Thrombosis Research, 228(1), 105-116. https://doi.org/10.1016/j.thromres.2023.06.001
    • Antunes-Ferreira, M., D'Ambrosi, S., Arkani, M., Post, E., In 't Veld, S. G. J. G., Ramaker, J., Zwaan, K., Kucukguzel, E. D., Wedekind, L. E., Griffioen, A. W., Egbrink, M. O., Kuijpers, M. J. E., van den Broek, D., Noske, D. P., Hartemink, K. J., Sabrkhany, S., Bahce, I., Sol, N., Bogaard, H.-J., ... Wurdinger, T. (2023). Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management. Scientific Reports, 13(1), Article 9359. https://doi.org/10.1038/s41598-023-35818-w
    • Sabrkhany, S., Kuijpers, M. J. E., Van Kuijk, S. M. J., Griffioen, A. W., & Oude Egbrink, M. G. A. (2023). Age- and gender-matched controls needed for platelet-based biomarker studies. Haematologica-the Hematology Journal, 108(6), 1667-1670. https://doi.org/10.3324/haematol.2022.281726
    • Zhang, P., Solari, F. A., Heemskerk, J. W. M., Kuijpers, M. J. E., Sickmann, A., Walter, U., & Jurk, K. (2023). Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets. International Journal of Molecular Sciences, 24(9), Article 7776. https://doi.org/10.3390/ijms24097776
  • 2022
    • In 't Veld, S. G. J. G., Arkani, M., Post, E., Antunes-Ferreira, M., D'Ambrosi, S., Vessies, D. C. L., Vermunt, L., Vancura, A., Muller, M., Niemeijer, A.-L. N., Tannous, J., Meijer, L. L., Le Large, T. Y. S., Mantini, G., Wondergem, N. E., Heinhuis, K. M., van Wilpe, S., Smits, A. J., Drees, E. E. E., ... Wurdinger, T. (2022). Detection and localization of early- and late-stage cancers using platelet RNA. Cancer Cell, 40(9), 999-1009.e6. https://doi.org/10.1016/j.ccell.2022.08.006
    • Navarro, S., Starke, A., Heemskerk, J. W. M., Kuijpers, M. J. E., Stegner, D., & Nieswandt, B. (2022). Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function. International journal of molecular sciences, 23(15), Article 8610. https://doi.org/10.3390/ijms23158610
    • Tullemans, B. M. E., Brouns, S. L. N., Swieringa, F., Sabrkhany, S., van den Berkmortel, F. W. P. J., Peters, N. A. J. B., de Bruijn, P., Koolen, S. L. W., Heemskerk, J. W. M., Aarts, M. J. B., & Kuijpers, M. J. E. (2022). Quantitative and qualitative changes in platelet traits of sunitinib-treated patients with renal cell carcinoma in relation to circulating sunitinib levels: a proof-of-concept study. BMC Cancer, 22(1), Article 653. https://doi.org/10.1186/s12885-022-09676-0
    • Tamer, F., Tullemans, B. M. E., Kuijpers, M. J. E., Claushuis, T. A. M., & Heemskerk, J. W. M. (2022). Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis. Thrombosis and Haemostasis, 122(06), 879-894. https://doi.org/10.1055/a-1683-5599
    • Kuijpers, M. J. E., Heemskerk, J. W. M., & Jurk, K. (2022). Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation. International journal of molecular sciences, 23(10), Article 5825. https://doi.org/10.3390/ijms23105825
    • Veninga, A., Baaten, C. C. F. M. J., De Simone, I., Tullemans, B. M. E., Kuijpers, M. J. E., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2022). Effects of Platelet Agonists and Priming on the Formation of Platelet Populations. Thrombosis and Haemostasis, 122(05), 726-738. https://doi.org/10.1055/s-0041-1735972
    • Peters, L. J. F., Baaten, C. C. F. M. J., Maas, S. L., Lu, C., Nagy, M., Jooss, N. J., Bidzhekov, K., Santovito, D., Moreno-Andrés, D., Jankowski, J., Biessen, E. A. L., Döring, Y., Heemskerk, J. W. M., Weber, C., Kuijpers, M. J. E., & van der Vorst, E. P. C. (2022). MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Biomedicines, 10(5), Article 983. https://doi.org/10.3390/biomedicines10050983
    • Karel, M. F. A., Tullemans, B. M. E., D'Italia, G., Lemmens, T. P., Claushuis, T. A. M., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2022). Corrigendum to "The effect of Bruton's tyrosine kinase inhibitor ibrutinib on atherothrombus formation under stenotic flow conditions" [Thromb. Res. 212 (2022) 72-80]. Thrombosis Research, 213, 113-113. https://doi.org/10.1016/j.thromres.2022.03.012
    • Karel, M. F. A., Tullemans, B. M. E., D'Italia, G., Lemmens, T. P., Claushuis, T. A. M., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2022). The effect of Bruton's tyrosine kinase inhibitor ibrutinib on atherothrombus formation under stenotic flow conditions. Thrombosis Research, 212, 72-80. https://doi.org/10.1016/j.thromres.2022.02.020
    • Brouns, S. L. N., Tullemans, B. M. E., Bulato, C., Perrella, G., Campello, E., Spiezia, L., van Geffen, J. P., Kuijpers, M. J. E., van Oerle, R., Spronk, H. M. H., van der Meijden, P. E. J., Simioni, P., & Heemskerk, J. W. M. (2022). Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow. Research and practice in thrombosis and haemostasis, 6(2), Article e12678. https://doi.org/10.1002/rth2.12678
    • Fernandez, D. I., Provenzale, I., Cheung, H. Y. F., van Groningen, J., Tullemans, B. M. E., Veninga, A., Dunster, J. L., Honarnejad, S., van den Hurk, H., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2022). Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation. iScience, 25(1), Article 103718. https://doi.org/10.1016/j.isci.2021.103718
    • Navarro, S., Stegner, D., Nieswandt, B., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2022). Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation. International journal of molecular sciences, 23(1), Article 358. https://doi.org/10.3390/ijms23010358
    • Tullemans, B. M. E., Fernandez, D. I., Veninga, A., Baaten, C. C. F. M. J., Peters, L. J. F., Aarts, M. J. B., Eble, J. A., Campello, E., Spiezia, L., Simioni, P., van der Vorst, E. P. C., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2022). Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin. Thrombosis and Haemostasis, 122(01), 92-104. https://doi.org/10.1055/s-0041-1730312
  • 2021
    • Fernandez, D. I., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2021). Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity. Platelets, 32(7), 863-871. https://doi.org/10.1080/09537104.2020.1859103
    • Tullemans, B. M. E., Veninga, A., Fernandez, D. I., Aarts, M. J. B., Eble, J. A., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2021). Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment. International Journal of Molecular Sciences, 22(20), Article 11199. https://doi.org/10.3390/ijms222011199
    • D'Ambrosi, S., Visser, A., Antunes-Ferreira, M., Poutsma, A., Giannoukakos, S., Sol, N., Sabrkhany, S., Bahce, I., Kuijpers, M. J. E., Egbrink, M. G. A. O., Griffioen, A. W., Best, M. G., Koppers-Lalic, D., Oudejans, C., & Wurdinger, T. (2021). The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer. Cancers, 13(18), Article 4644. https://doi.org/10.3390/cancers13184644
    • Coenen, D. M., Heinzmann, A. C. A., Oggero, S., Albers, H. J., Nagy, M., Hague, P., Kuijpers, M. J. E., Vanderwinden, J. M., van der Meer, A. D., Perretti, M., Koenen, R. R., & Cosemans, J. M. E. M. (2021). Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. Cells, 10(8), Article 1998. https://doi.org/10.3390/cells10081998
    • Lacy, M., Buerger, C., Shami, A., Ahmadsei, M., Winkels, H., Nitz, K., van Tiel, C. M., Seijkens, T. T. P., Kusters, P. J. H., Karshovka, E., Prange, K. H. M., Wu, Y., Brouns, S. L. N., Unterlugauer, S., Kuijpers, M. J. E., Reiche, M. E., Steffens, S., Edsfeldt, A., Megens, R. T. A., ... Lutgens, E. (2021). Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nature Communications, 12(1), Article 3754. https://doi.org/10.1038/s41467-021-23909-z
    • Sabrkhany, S., Kuijpers, M. J. E., Egbrink, M. G. A. O., & Griffioen, A. W. (2021). Platelets as messengers of early-stage cancer. Cancer and Metastasis Reviews, 40(2), 563-573. https://doi.org/10.1007/s10555-021-09956-4
    • Dickhout, A., Tullemans, B. M. E., Heemskerk, J. W. M., Thijssen, V. L. J. L., Kuijpers, M. J. E., & Koenen, R. R. (2021). Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro. PLOS ONE, 16(1), Article e0244736. https://doi.org/10.1371/journal.pone.0244736
    • Tullemans, B., Karel, M., Léopold, V., ten Brink, M. S., Baaten, C., Maas, S. L., de Vos, A. F., Eble, J. A., Nijziel, M. R., van der Vorst, E., Cosemans, J., Heemskerk, J., Claushuis, T. A. M., & Kuijpers, M. (2021). Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function. eJHaem, 2(4), 685–699. https://doi.org/10.1002/jha2.269
  • 2020
    • van Geffen, J. P., Swieringa, F., van Kuijk, K., Tullemans, B. M. E., Solari, F. A., Peng, B., Clemetson, K. J., Farndale, R. W., Dubois, L. J., Sickmann, A., Zahedi, R. P., Ahrends, R., Biessen, E. A. L., Sluimer, J. C., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2020). Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome. Scientific Reports, 10(1), Article 21407. https://doi.org/10.1038/s41598-020-78522-9
    • Mastenbroek, T. G., Karel, M. F. A., Nagy, M., Chayoua, W., Korsten, E. I. J., Coenen, D. M., Debets, J., Konings, J., Brouns, A. E., Leenders, P. J. A., van Essen, H., van Oerle, R., Heitmeier, S., Spronk, H. M., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2020). Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery. Scientific Reports, 10(1), Article 19360. https://doi.org/10.1038/s41598-020-76377-8
    • Brouns, S. L. N., van Geffen, J. P., Campello, E., Swieringa, F., Spiezia, L., van Oerle, R., Provenzale, I., Verdoold, R., Farndale, R. W., Clemetson, K. J., Spronk, H. M. H., van der Meijden, P. E. J., Cavill, R., Kuijpers, M. J. E., Castoldi, E., Simioni, P., & Heemskerk, J. W. M. (2020). Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation. Scientific Reports, 10(1), Article 11910. https://doi.org/10.1038/s41598-020-68438-9
    • Kroone, C., Vos, M., Rademakers, T., Kuijpers, M., Hoogenboezem, M., van Buul, J., Heemskerk, J. W. M., Ruf, W., van Hylckama Vlieg, A., Versteeg, H. H., Goumans, M.-J., de Vries, C. J. M., Kurakula, K., & INVENT Consortium (2020). LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis. Haematologica-the Hematology Journal, 105(6), 1677-1685. https://doi.org/10.3324/haematol.2018.203026
    • Sternkopf, M., Nagy, M., Baaten, C. C. F. M. J., Kuijpers, M. J. E., Tullemans, B. M. E., Wirth, J., Theelen, W., Mastenbroek, T. G., Lehrke, M., Winnerling, B., Baerts, L., Marx, N., De Meester, I., Doring, Y., Cosemans, J. M. E. M., Daiber, A., Steven, S., Jankowski, J., Heemskerk, J. W. M., & Noels, H. (2020). Native, Intact Glucagon-Like Peptide 1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions. Arteriosclerosis Thrombosis and Vascular Biology, 40(3), E65-E77. https://doi.org/10.1161/atvbaha.119.313645
    • Karel, M. F. A., Hechler, B., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2020). Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations. Platelets, 31(4), 439-446. https://doi.org/10.1080/09537104.2019.1708884
  • 2019
    • Nagy, M., van Geffen, J. P., Stegner, D., Adams, D. J., Braun, A., de Witt, S. M., Elvers, M., Geer, M. J., Kuijpers, M. J. E., Kunzelmann, K., Mori, J., Oury, C., Pircher, J., Pleines, I., Poole, A. W., Senis, Y. A., Verdoold, R., Weber, C., Nieswandt, B., ... Baaten, C. C. F. M. J. (2019). Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. Frontiers in Cardiovascular Medicine, 6, Article 99. https://doi.org/10.3389/fcvm.2019.00099
    • Jooss, N. J., De Simone, I., Provenzale, I., Fernández, D. I., Brouns, S. L. N., Farndale, R. W., Henskens, Y. M. C., Kuijpers, M. J. E., Ten Cate, H., van der Meijden, P. E. J., Cavill, R., & Heemskerk, J. W. M. (2019). Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces. International journal of molecular sciences, 20(11), Article 2788. https://doi.org/10.3390/ijms20112788
    • van Geffen, A., Brouns, S., Batista, J., McKinney, H., Kempster, C., Nagy, M., Sivapalaratnam, S., Baaten, C., Bourry, N., Frontini, M., Jurk, K., Krause, M., Pilliteri, D., Swieringa, F., Verdoold, R., Cavill, R., Kuijpers, M., Ouwehand, W. H., Downes, K., & Heemskerk, J. (2019). High-throughput elucidation of thrombus formation reveals sources of platelet function variability. Haematologica-the Hematology Journal, 104(6), 1256-1267. https://doi.org/10.3324/haematol.2018.198853
    • Sabrkhany, S., Kuijpers, M. J. E., Griffioen, A. W., & Egbrink, M. G. A. O. (2019). Platelets: the holy grail in cancer blood biomarker research?Angiogenesis, 22(1), 1-2. https://doi.org/10.1007/s10456-018-9651-4
    • Kiouptsi, K., Jaeckel, S., Pontarollo, G., Grill, A., Kuijpers, M. J. E., Wilms, E., Weber, C., Sommer, F., Nagy, M., Neideck, C., Jansen, Y., Ascher, S., Formes, H., Karwot, C., Bayer, F., Kollar, B., Subramaniam, S., Molitor, M., Wenzel, P., ... Reinhardt, C. (2019). The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. Mbio, 10(5), Article e02298-19. https://doi.org/10.1128/mBio.02298-19
  • 2018
    • Tullemans, B. M. E., Nagy, M., Sabrkhany, S., Griffioen, A. W., Egbrink, M. G. A. O., Aarts, M., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2018). Tyrosine Kinase Inhibitor Pazopanib Inhibits Platelet Procoagulant Activity in Renal Cell Carcinoma Patients. Frontiers in Cardiovascular Medicine, 5, Article 142. https://doi.org/10.3389/fcvm.2018.00142
    • Hofmann, I., Geer, M. J., Vogtle, T., Crispin, A., Campagna, D. R., Barr, A., Calicchio, M. L., Heising, S., van Geffen, J. P., Kuijpers, M. J. E., Heemskerk, J. W. M., Eble, J. A., Schmitz-Abe, K., Obeng, E. A., Douglas, M., Freson, K., Pondarre, C., Favier, R., Jarvis, G. E., ... Senis, Y. A. (2018). Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice. Blood, 132(13), 1399-1412. https://doi.org/10.1182/blood-2017-08-802769
    • Geer, M. J., van Geffen, J. P., Gopalasingam, P., Vogtle, T., Smith, C. W., Heising, S., Kuijpers, M. J. E., Tullemans, B. M. E., Jarvis, G. E., Eble, J. A., Jeeves, M., Overduin, M., Heemskerk, J. W. M., Mazharian, A., & Senis, Y. A. (2018). Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis. Blood, 132(13), 1413-1425. https://doi.org/10.1182/blood-2017-10-802975
    • Tullemans, B. M. E., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2018). Acquired platelet antagonism: off-target antiplatelet effects of malignancy treatment with tyrosine kinase inhibitors. Journal of Thrombosis and Haemostasis, 16(9), 1686-1699. https://doi.org/10.1111/jth.14225
    • Sabrkhany, S., Kuijpers, M. J. E., Knol, J. C., Damink, S. W. M. O., Dingemans, A.-M. C., Verheul, H. M., Piersma, S. R., Pham, T. V., Griffioen, A. W., Egbrink, M. G. A. O., & Jimenez, C. R. (2018). Exploration of the platelet proteome in patients with early-stage cancer. Journal of Proteomics, 177, 65-74. https://doi.org/10.1016/j.jprot.2018.02.011
    • Mori, J., Nagy, Z., Di Nunzio, G., Smith, C. W., Geer, M. J., Al Ghaithi, R., van Geffen, J. P., Heising, S., Boothman, L., Tullemans, B. M. E., Correia, J. N., Tee, L., Kuijpers, M. J. E., Harrison, P., Heemskerk, J. W. M., Jarvis, G. E., Tarakhovsky, A., Weiss, A., Mazharian, A., & Senis, Y. A. (2018). Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148. Blood, 131(10), 1122-1144. https://doi.org/10.1182/blood-2017-02-768077
  • 2017
    • Sabrkhany, S., Kuijpers, M. J. E., van Kuijk, S. M. J., Sanders, L., Pineda, S., Damink, S. W. M. O., Dingemans, A.-M. C., Griffioen, A. W., & Egbrink, M. G. A. O. (2017). A combination of platelet features allows detection of early-stage cancer. European Journal of Cancer, 80, 5-13. https://doi.org/10.1016/j.ejca.2017.04.010
    • van der Vorst, E. P. C., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., Aliyev, T., Huitema, L. F. A., Tas, S. W., Wolfs, I. M. J., Kuijpers, M. J. E., Gijbels, M. J., Schalkwijk, C. G., Koonen, D. P. Y., Abdollahi-Roodsaz, S., McDaniels, K., Wang, C.-C., Leitges, M., Lawrence, T., ... Donners, M. M. P. C. (2017). High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappa B/STAT1-IRF1 Signaling. Cell Metabolism, 25(1), 197-207. https://doi.org/10.1016/j.cmet.2016.10.013
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