Monika Stoll


Prof. Monika Stoll graduated from University of Giessen, Germany, where she received her Diploma in Biology in 1991, before finishing a PhD in Pharmacology in 1995 at University of Heidelberg, Germany. She then assumed a post-doctoral fellowship at the Medical College of Wisconsin, USA, where she discovered her interest in complex genetics and genomics. In 2003, she became Professor and Director of the Division Genetic Epidemiology at the Leibniz-Institute for Arteriosclerosis Research, and starting 2014, at the Institute of Human Genetics of the University of Muenster, Germany. In October 2013 she assumed a part-time position as Visiting Professor in Cardiovascular Genetics at Maastricht University. In 2015, she was appointed as Extraordinary Professor of Genetic Epidemiology and Statistical Genetics. In October 2016, she was appointed as Vice-Rector for Research of the University of Muenster.

Prof. Stoll is engaged in research in complex genetics and genetic epidemiology particularly relating to cardiovascular diseases and inflammation. Current research projects address the genetic and genomic basis of arrhythmogenic diseases and heart failure. She is involved in a number of large research networks, such as the EU-funded Horizon2020 consortium CATCH-ME, CVON RACE-V, CVON-PREDICT2 and the ITN TRAIN-HEART, and is responsible for all aspects of next generation sequencing approaches and the analysis thereof in the context of the pathogenesis of cardiovascular diseases. In addition, her group is running a core facility for genomics which supports high-density arrays and next generation sequencing applications and a (bio)informatics infrastructure for management and analysis of such large data sets.

Department of Biochemistry
Department of Genetic Epidemiology and Statistical Genetics
Universiteitssingel 60, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2023
    • Young, W. J., Haessler, J., Benjamins, J. W., Repetto, L., Yao, J., Isaacs, A., Harper, A. R., Ramirez, J., Garnier, S., van Duijvenboden, S., Baldassari, A. R., Concas, M. P., Duong, T. V., Foco, L., Isaksen, J. L., Mei, H., Noordam, R., Nursyifa, C., Richmond, A., ... Et al. (2023). Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nature Communications, 14(1), Article 1411.
    • Winters, J., Isaacs, A., Zeemering, S., Kawczynski, M., Maesen, B., Maessen, J., Bidar, E., Boukens, B., Hermans, B., van Hunnik, A., Casadei, B., Fabritz, L., Chua, W., Sommerfeld, L., Guasch, E., Mont, L., Batlle, M., Hatem, S., Kirchhof, P., ... Schotten, U. (2023). Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium. Journal of the American Heart Association, 12(22), Article 031220.
    • Limperger, V., Kenet, G., Kiesau, B., Koether, M., Schmeiser, M., Langer, F., Juhl, D., Shneyder, M., Franke, A., Klostermeier, U. C., Mesters, R., Ruehle, F., Stoll, M., Steppat, D., Kowalski, D., Rocke, A., Kuta, P., Bajorat, T., Torge, A., ... Nowak-Goettl, U. (2023). Role of prothrombin 19,911 A > G polymorphism, blood group and male gender in patients with venous thromboembolism: results of a german cohort study (vol 51, pg 494, 2020). Journal of Thrombosis and Thrombolysis, 56(1), 212-212.
    • Juni, R. P., Kocken, J. M. M., Abreu, R. C., Ottaviani, L., Davalan, T., Duygu, B., Poels, E. M., Vasilevich, A., Hegenbarth, J. C., Appari, M., Bitsch, N., Olieslagers, S., Schrijvers, D. M., Stoll, M., Heineke, J., de Boer, J., de Windt, L. J., & da Costa, P. A. (2023). MicroRNA-216a is essential for cardiac angiogenesis. Molecular Therapy, 31(6), 1807-1828.
    • Isaacs, A., Barysenka, A., ter Bekke, R. M. A., den Enden, A. T. J. M. H., van den Wijngaard, A., Volders, P. G. A., & Stoll, M. (2023). Standing genetic variation affects phenotypic heterogeneity in an SCN5A-mutation founder population with excess sudden cardiac death. Heart Rhythm, 20(5), 720-727.
    • Herrera-Rivero, M., Hofer, E., Maceski, A., Leppert, D., Benkert, P., Kuhle, J., Schmidt, R., Khalil, M., Wiendl, H., Stoll, M., & Berger, K. (2023). Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum. Frontiers in Neurology, 14, Article 1145737.
    • Schulz, C., Lemoine, M. D., Mearini, G., Koivumaeki, J., Sani, J., Schwedhelm, E., Kirchhof, P., Ghalawinji, A., Stoll, M., Hansen, A., Eschenhagen, T., & Christ, T. (2023). PITX2 Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillation. Circulation-Arrhythmia and Electrophysiology, 16(3), Article e011602.
    • de Boer, M., Hekkert, M. T., Chang, J., van Thiel, B. S., Martens, L., Bos, M. M., de Kleijnen, M. G. J., Ridwan, Y., Octavia, Y., van Deel, E. D., Blonden, L. A., Brandt, R. M. C., Barnhoorn, S., Bautista-Nino, P. K., Krabbendam-Peters, I., Wolswinkel, R., Arshi, B., Ghanbari, M., Kupatt, C., ... Duncker, D. J. (2023). DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice. Aging Cell, 22(3), Article e13768.
    • Fontaine, M. A. C., Jin, H., Gagliardi, M., Rousch, M., Wijnands, E., Stoll, M., Li, X., Schurgers, L., Reutelingsperger, C., Schalkwijk, C., van den Akker, N. M. S., Molin, D. G. M., Gullestad, L., Eritsland, J., Hoffman, P., Skjelland, M., Andersen, G. Ø., Aukrust, P., Karel, J., ... Biessen, E. A. L. (2023). Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair. Advanced Science, 10(5), Article 2203053.
  • 2022
    • Hegenbarth, J. C., De Majo, F., Spano, G., Olieslagers, S., Esfandyari, D., Tiburcy, M., Zimmermann, W. H., Stoll, M., & de Windt, L. (2022). Machine learning-assisted integration of single cell transcriptomic data identifies potential cardiomyocyte maturation genes. Journal of Molecular and Cellular Cardiology, 173, S47-S47.
    • Zeemering, S., Isaacs, A., Winters, J., Maesen, B., Bidar, E., Dimopoulou, C., Guasch, E., Batlle, M., Haase, D., Hatem, S. N., Kara, M., Kääb, S., Mont, L., Sinner, M. F., Wakili, R., Maessen, J., Crijns, H. J. G. M., Fabritz, L., Kirchhof, P., ... Schotten, U. (2022). Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis, inflammation, and endothelial dysfunction. Heart Rhythm, 19(12), 2115-2124.
    • Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J-W., Haessler, J., Lyytikäinen, L-P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., ... Munroe, P. B. (2022). Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nature Communications, 13(1), Article 5144.
    • Ottaviani, L., Juni, R. P., de Abreu, R. C., Sansonetti, M., Sampaio-Pinto, V., Halkein, J., Hegenbarth, J. C., Ring, N., Knoops, K., Kocken, J. M. M., Jesus, C. D., Ernault, A. C., El Azzouzi, H., Rühle, F., Olieslagers, S., Fernandes, H., Ferreira, L., Braga, L., Stoll, M., ... da Costa Martins, P. A. (2022). Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells. Molecular Therapy, 30(6), 2257-2273.
    • Christ, A., Goossens, P. G., Wijnands, E., Jin, H., Legein, B., Oth, T., Isaacs, A., Stoll, M., Vanderlocht, J., Lutgens, E., Daemen, M. J. A. P., Zenke, M., & Biessen, E. A. L. (2022). Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77. Biomedicines, 10(5), Article 1152.
    • Jauch-Speer, S-L., Herrera-Rivero, M., Ludwig, N., Véras De Carvalho, B. C., Martens, L., Wolf, J., Imam Chasan, A., Witten, A., Markus, B., Schieffer, B., Vogl, T., Rossaint, J., Stoll, M., Roth, J., & Fehler, O. (2022). C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9. Elife, 11, Article 75594.
    • Limperger, V., Torge, A., Kiesau, B., Langer, F., Kenet, G., Mesters, R., Juhl, D., Stoll, M., Shneyder, M., Kowalski, D., Bajorat, T., Rocke, A., Kuta, P., Lasarow, L., Spengler, D., Junker, R., & Nowak-Göttl, U. (2022). Validation of a predictive model for identifying an increased risk for recurrence in adolescents and young adults with a first provoked thromboembolism. Blood Cells Molecules and Diseases, 94, Article 102651.
    • Witten, A., Martens, L., Schäfer, A-C., Troidl, C., Pankuweit, S., Vlacil, A-K., Oberoi, R., Schieffer, B., Grote, K., Stoll, M., & Markus, B. (2022). Monocyte subpopulation profiling indicates CDK6-derived cell differentiation and identifies subpopulation-specific miRNA expression sets in acute and stable coronary artery disease. Scientific Reports, 12(1), Article 5589.
    • Herrera-Rivero, M., Gandhi, S., Witten, A., Ghalawinji, A., Schotten, U., & Stoll, M. (2022). Cardiac chamber-specific genetic alterations suggest candidate genes and pathways implicating the left ventricle in the pathogenesis of atrial fibrillation. Genomics, 114(2), Article 110320.
    • Simons, C. C. J. M., Offermans, N. S. M., Stoll, M., van den Brandt, P. A., & Weijenberg, M. P. (2022). Empirical Investigation of Genomic Clusters Associated with Height and the Risk of Postmenopausal Breast and Colorectal Cancer in the Netherlands Cohort Study. American Journal of Epidemiology, 191(3), 413-429.
    • Grabowski, K., Herlan, L., Witten, A., Qadri, F., Eisenreich, A., Lindner, D., Schadlich, M., Schulz, A., Subrova, J., Mhatre, K. N., Primessnig, U., Plehm, R., van Linthout, S., Escher, F., Bader, M., Stoll, M., Westermann, D., Heinzel, F. R., & Kreutz, R. (2022). Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Hypertension Research, 45(2), 292-307.
    • Simons, C. C. J. M., Schouten, L. J., Godschalk, R. W. L., Van Schooten, F. J., Stoll, M., Van Steen, K., van den Brandt, P. A., & Weijenberg, M. P. (2022). Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study. Biodata Mining, 15(1), Article 2.
  • 2021
    • Gandhi, S., Witten, A., De Majo, F., Gilbers, M., Maessen, J., Schotten, U., de Windt, L. J., & Stoll, M. (2021). Evolutionarily conserved transcriptional landscape of the heart defining the chamber specific physiology. Genomics, 113(6), 3782-3792.
    • Martens, L., Ruehle, F., Witten, A., Meder, B., Katus, H. A., Arbustini, E., Hasenfuss, G., Sinner, M. F., Kaeaeb, S., Pankuweit, S., Angermann, C., Bornberg-Bauer, E., & Stoll, M. (2021). A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy. Rna Biology, 18, 409-415.
    • De Majo, F., Martens, L., Hegenbarth, J. C., Ruhle, F., Hamczyk, M. R., Nevado, R. M., Andres, V., Hilbold, E., Bar, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A. S., Stoll, M., & De Windt, L. J. (2021). Genomic instability in the naturally and prematurely aged myocardium. Proceedings of the National Academy of Sciences of the United States of America, 118(36), Article e2022974118.
    • Herrera-Rivero, M., Stoll, M., Hegenbarth, J. C., Ruhle, F., Limperger, V., Junker, R., Franke, A., Hoffmann, P., Shneyder, M., Stach, M., & Nowak-Gottl, U. (2021). Single- and Multimarker Genome-Wide Scans Evidence Novel Genetic Risk Modifiers for Venous Thromboembolism. Thrombosis and Haemostasis, 121(09), 1169-1180.
    • Iding, A. F. J., Witten, A., Isaacs, A., Castoldi, E., ten Cate, H., Stoll, M., & ten Cate-Hoek, A. J. (2021). Leukocyte gene expression in post-thrombotic syndrome. Thrombosis Research, 202, 40-42.
    • Gilbers, M. D., Bidar, E., Maesen, B., Zeemering, S., Isaacs, A., Crijns, H., van Gelder, I., Rienstra, M., Verheule, S., Maessen, J., Stoll, M., & Schotten, U. (2021). Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Tissue Bank Project: study design. Netherlands Heart Journal, 29(5), 280-287.
    • Fabritz, L., Crijns, H. J. G. M., Guasch, E., Goette, A., Häusler, K. G., Kotecha, D., Lewalter, T., Meyer, C., Potpara, T. S., Rienstra, M., Schnabel, R. B., Willems, S., Breithardt, G., Camm, A. J., Chan, A., Chua, W., de Melis, M., Dimopoulou, C., Dobrev, D., ... Kirchhof, P. (2021). Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference. EP Europace, 23(3), 329-344.
    • Limperger, V., Kenet, G., Kiesau, B., Koether, M., Schmeiser, M., Langer, F., Juhl, D., Shneyder, M., Franke, A., Klostermeier, U. K., Mesters, R., Ruehle, F., Stoll, M., Steppat, D., Kowalski, D., Rocke, A., Kuta, P., Bajorat, T., Torge, A., ... Nowak-Goettl, U. (2021). Role of prothrombin 19911 A > G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study. Journal of Thrombosis and Thrombolysis, 51(2), 494-501.
  • 2020
    • Winters, J., von Braunmuhl, M. E., Zeemering, S., Gilbers, M., Ten Brink, T., Scaf, B., Guasch, E., Mont, L., Batlle, M., Sinner, M., Hatem, S., Mansour, M. K., Fabritz, L., Sommerfeld, L. C., Kirchhof, P., Isaacs, A., Stoll, M., Schotten, U., & Verheule, S. (2020). JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling. Scientific Reports, 10(1), Article 20074.
    • Balamurali, D., & Stoll, M. (2020). Non-Coding RNA Databases in Cardiovascular Research. Non-coding RNA, 6(3), Article 35.
    • Witten, A., Ruehle, F., de Witt, M., Barysenka, A., Stach, M., Junker, R., Nowak-Goettl, U., & Stoll, M. (2020). ADAMTS12, a new candidate gene for pediatric stroke. PLOS ONE, 15(8), Article 0237928.
    • Reyat, J. S., Chua, W., Cardoso, V. R., Witten, A., Kastner, P. M., Kabir, S. N., Sinner, M. F., Wesselink, R., Holmes, A. P., Pavlovic, D., Stoll, M., Kaeaeb, S., Gkoutos, G., de Groot, J. R., Kirchhof, P., & Fabritz, L. (2020). Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation. JCI INSIGHT, 5(16), Article 139179.
    • Robinson, E. L., Gomes, C. P. C., Potocnjak, I., Hellemans, J., Betsou, F., de Gonzalo-Calvo, D., Stoll, M., Yilmaz, M. B., Agg, B., Beis, D., Carmo-Fonseca, M., Enguita, F. J., Dogan, S., Tuna, B. G., Schroen, B., Ammerlaan, W., Kuster, G. M., Carpusca, I., Pedrazzini, T., ... EU-CardioRNA COST Action (2020). A Year in the Life of the EU-CardioRNA COST Action: CA17129 Catalysing Transcriptomics Research in Cardiovascular Disease. Non-coding RNA, 6(2), Article 17.
    • De Majo, F., Hegenbarth, J-C., Ruehle, F., Baer, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A-S., Stoll, M., & De Windt, L. J. (2020). Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts. Scientific Reports, 10(1), Article 8136.
  • 2019
    • Gomes, C. P. D. C., Agg, B., Andova, A., Arslan, S., Baker, A., Bartekova, M., Beis, D., Betsou, F., Wettinger, S. B., Bugarski, B., Condorelli, G., da Silva, G. J. J., Danilin, S., de Gonzalo-Calvo, D., Buil, A., Carmo-Fonseca, M., Enguita, F. J., Felekkis, K., Ferdinandy, P., ... Devaux, Y. (2019). Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129. Non-coding RNA research, 5(2), Article 31.
    • van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikainen, L-P., Mei, H., Mueller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., ... Isaacs, A. (2019). Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. European Journal of Human Genetics, 27(6), 952-962.
    • Klotz, L., Eschborn, M., Lindner, M., Liebmann, M., Herold, M., Janoschka, C., Garrido, B. T., Schulte-Mecklenbeck, A., Gross, C. C., Breuer, J., Hundehege, P., Posevitz, V., Pignolet, B., Nebel, G., Glander, S., Freise, N., Austermann, J., Wirth, T., Campbell, G. R., ... Wiendl, H. (2019). Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Science Translational Medicine, 11(490), Article 5563.
    • Schulz, A., Mueller, N. V., van de Lest, N. A., Eisenreich, A., Schmidbauer, M., Barysenka, A., Purfuerst, B., Sporbert, A., Lorenzen, T., Meyer, A. M., Herlan, L., Witten, A., Ruehle, F., Zhou, W., de Heer, E., Scharpfenecker, M., Panakova, D., Stoll, M., & Kreutz, R. (2019). Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. Elife, 8, Article 42068.
    • Gandhi, S., Ruehle, F., & Stoll, M. (2019). Evolutionary Patterns of Non-Coding RNA in Cardiovascular Biology. Non-coding RNA, 5(1), Article 15.
  • 2018
    • Witten, A., Bolbrinker, J., Barysenka, A., Huber, M., Ruhle, F., Nowak-Gottl, U., Garbe, E., Kreutz, R., & Stoll, M. (2018). Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study. Journal of Molecular Medicine, 96(8), 765-775.
    • Ruhle, F., & Stoll, M. (2018). Advances in predicting venous thromboembolism risk in children. British Journal of Haematology, 180(5), 654-665.
    • Quaranta, R., Fell, J., Ruhle, F., Rao, J., Piccini, I., Arauzo-Brave, M. J., Verkerk, A. O., Stoll, M., & Greber, B. (2018). Revised roles of ISL1 in a hES cell-based model of human heart chamber specification. Elife, 7, Article e31706.
  • 2017
    • ter Bekke, R. M. A., Isaacs, A., Barysenka, A., Hoos, M. B., Jongbloed, J. D. H., Hoorntje, J. C. A., Patelski, A. S. M., Helderman-van den Enden, A. T. J. M., van den Wijngaard, A., Stoll, M., & Volders, P. G. A. (2017). Heritability in a SCN5A-mutation founder population with increased female susceptibility to non-nocturnal ventricular tachyarrhythmia and sudden cardiac death. Heart Rhythm, 14(12), 1873-1881.
    • Heinig, M., Adriaens, M. E., Schafer, S., van Deutekom, H. W. M., Lodder, E. M., Ware, J. S., Schneider, V., Felkin, L. E., Creemers, E. E., Meder, B., Katus, H. A., Rühle, F., Stoll, M., Cambien, F., Villard, E., Charron, P., Varro, A., Bishopric, N. H., George, A. L., ... Hubner, N. (2017). Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. Genome Biology, 18(1), Article 170.
    • Ruehle, F., Witten, A., Barysenka, A., Huge, A., Arning, A., Heller, C., Kruempel, A., Mesters, R., Franke, A., Lieb, W., Riemenschneider, M., Hiersche, M., Limperger, V., Nowak-Goettl, U., & Stoll, M. (2017). Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to pediatric venous thromboembolism. Blood, 129(6), 783-790.
    • Elands, R. J. J., Simons, C. C. J. M., Riemenschneider, M., Isaacs, A., Schouten, L. J., Verhage, B. A., Van Steen, K., Godschalk, R. W. L., van den Brandt, P. A., Stoll, M., & Weijenberg, M. P. (2017). A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk. Scientific Reports, 7, Article 41034.
  • 2016
    • Arning, A., Jeibmann, A., Koehnemann, S., Brokinkel, B., Ewelt, C., Berger, K., Wellmann, J., Nowak-Goettl, U., Stummer, W., Stoll, M., & Holling, M. (2016). ADAMTS genes and the risk of cerebral aneurysm. Journal of Neurosurgery, 125(2), 269-274.
    • Rühle, F., & Stoll, M. (2016). Long non-coding RNA Databases in Cardiovascular Research. Genomics, Proteomics and Bioinformatics, 14(4), 191–199.
    • Fabritz, L., Guasch, E., Antoniades, C., Bardinet, I., Benninger, G., Betts, T. R., Brand, E., Breithardt, G., Bucklar-Suchankova, G., Camm, A. J., Cartlidge, D., Casadei, B., Chua, W. W., Crijns, H., Deeks, J., Hatem, S., Hidden-Lucet, F., Kääb, S., Maniadakis, N., ... Kirchhof, P. (2016). Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment. Nature Reviews Cardiology, 13(4), 230-237.