Monika Stoll

Professor

Prof. Monika Stoll graduated from University of Giessen, Germany, where she received her Diploma in Biology in 1991, before finishing a PhD in Pharmacology in 1995 at University of Heidelberg, Germany. She then assumed a post-doctoral fellowship at the Medical College of Wisconsin, USA, where she discovered her interest in complex genetics and genomics. In 2003, she became Professor and Director of the Division Genetic Epidemiology at the Leibniz-Institute for Arteriosclerosis Research, and starting 2014, at the Institute of Human Genetics of the University of Muenster, Germany. In October 2013 she assumed a part-time position as Visiting Professor in Cardiovascular Genetics at Maastricht University. In 2015, she was appointed as Extraordinary Professor of Genetic Epidemiology and Statistical Genetics. In October 2016, she was appointed as Vice-Rector for Research of the University of Muenster.

Prof. Stoll is engaged in research in complex genetics and genetic epidemiology particularly relating to cardiovascular diseases and inflammation. Current research projects address the genetic and genomic basis of arrhythmogenic diseases and heart failure. She is involved in a number of large research networks, such as the EU-funded Horizon2020 consortium CATCH-ME, CVON RACE-V, CVON-PREDICT2 and the ITN TRAIN-HEART, and is responsible for all aspects of next generation sequencing approaches and the analysis thereof in the context of the pathogenesis of cardiovascular diseases. In addition, her group is running a core facility for genomics which supports high-density arrays and next generation sequencing applications and a (bio)informatics infrastructure for management and analysis of such large data sets.

Department of Biochemistry
Department of Genetic Epidemiology and Statistical Genetics
Universiteitssingel 60, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2020
    • Winters, J., von Braunmuhl, M. E., Zeemering, S., Gilbers, M., Ten Brink, T., Scaf, B., Guasch, E., Mont, L., Batlle, M., Sinner, M., Hatem, S., Mansour, M. K., Fabritz, L., Sommerfeld, L. C., Kirchhof, P., Isaacs, A., Stoll, M., Schotten, U., & Verheule, S. (2020). JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling. Scientific Reports, 10(1), [20074]. https://doi.org/10.1038/s41598-020-76932-3
    • Balamurali, D., & Stoll, M. (2020). Non-Coding RNA Databases in Cardiovascular Research. Non-coding RNA, 6(3), [35]. https://doi.org/10.3390/ncrna6030035
    • Witten, A., Ruehle, F., de Witt, M., Barysenka, A., Stach, M., Junker, R., Nowak-Goettl, U., & Stoll, M. (2020). ADAMTS12, a new candidate gene for pediatric stroke. PLOS ONE, 15(8), [0237928]. https://doi.org/10.1371/journal.pone.0237928
    • Reyat, J. S., Chua, W., Cardoso, V. R., Witten, A., Kastner, P. M., Kabir, S. N., Sinner, M. F., Wesselink, R., Holmes, A. P., Pavlovic, D., Stoll, M., Kaeaeb, S., Gkoutos, G., de Groot, J. R., Kirchhof, P., & Fabritz, L. (2020). Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation. JCI INSIGHT, 5(16), [139179]. https://doi.org/10.1172/jci.insight.139179
    • Robinson, E. L., Gomes, C. P. C., Potocnjak, I., Hellemans, J., Betsou, F., de Gonzalo-Calvo, D., Stoll, M., Yilmaz, M. B., Agg, B., Beis, D., Carmo-Fonseca, M., Enguita, F. J., Dogan, S., Tuna, B. G., Schroen, B., Ammerlaan, W., Kuster, G. M., Carpusca, I., Pedrazzini, T., ... EU-CardioRNA COST Action (2020). A Year in the Life of the EU-CardioRNA COST Action: CA17129 Catalysing Transcriptomics Research in Cardiovascular Disease. Non-coding RNA, 6(2), [17]. https://doi.org/10.3390/ncrna6020017
    • De Majo, F., Hegenbarth, J-C., Ruehle, F., Baer, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A-S., Stoll, M., & De Windt, L. J. (2020). Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts. Scientific Reports, 10(1), [8136]. https://doi.org/10.1038/s41598-020-65115-9
  • 2019
    • Gomes, C. P. D. C., Agg, B., Andova, A., Arslan, S., Baker, A., Bartekova, M., Beis, D., Betsou, F., Wettinger, S. B., Bugarski, B., Condorelli, G., da Silva, G. J. J., Danilin, S., de Gonzalo-Calvo, D., Buil, A., Carmo-Fonseca, M., Enguita, F. J., Felekkis, K., Ferdinandy, P., ... Devaux, Y. (2019). Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129. Non-coding RNA research, 5(2), [31]. https://doi.org/10.3390/ncrna5020031
    • van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikainen, L-P., Mei, H., Mueller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., ... Isaacs, A. (2019). Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. European Journal of Human Genetics, 27(6), 952-962. https://doi.org/10.1038/s41431-018-0295-z
    • Klotz, L., Eschborn, M., Lindner, M., Liebmann, M., Herold, M., Janoschka, C., Garrido, B. T., Schulte-Mecklenbeck, A., Gross, C. C., Breuer, J., Hundehege, P., Posevitz, V., Pignolet, B., Nebel, G., Glander, S., Freise, N., Austermann, J., Wirth, T., Campbell, G. R., ... Wiendl, H. (2019). Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Science Translational Medicine, 11(490), [5563]. https://doi.org/10.1126/scitranslmed.aao5563
    • Schulz, A., Mueller, N. V., van de Lest, N. A., Eisenreich, A., Schmidbauer, M., Barysenka, A., Purfuerst, B., Sporbert, A., Lorenzen, T., Meyer, A. M., Herlan, L., Witten, A., Ruehle, F., Zhou, W., de Heer, E., Scharpfenecker, M., Panakova, D., Stoll, M., & Kreutz, R. (2019). Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. Elife, 8, [42068]. https://doi.org/10.7554/eLife.42068
    • Gandhi, S., Ruehle, F., & Stoll, M. (2019). Evolutionary Patterns of Non-Coding RNA in Cardiovascular Biology. Non-coding RNA, 5(1), [15]. https://doi.org/10.3390/ncrna5010015
  • 2018
    • Witten, A., Bolbrinker, J., Barysenka, A., Huber, M., Ruhle, F., Nowak-Gottl, U., Garbe, E., Kreutz, R., & Stoll, M. (2018). Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study. Journal of Molecular Medicine, 96(8), 765-775. https://doi.org/10.1007/s00109-018-1661-6
    • Ruhle, F., & Stoll, M. (2018). Advances in predicting venous thromboembolism risk in children. British Journal of Haematology, 180(5), 654-665. https://doi.org/10.1111/bjh.15060
    • Quaranta, R., Fell, J., Ruhle, F., Rao, J., Piccini, I., Arauzo-Brave, M. J., Verkerk, A. O., Stoll, M., & Greber, B. (2018). Revised roles of ISL1 in a hES cell-based model of human heart chamber specification. Elife, 7, [e31706]. https://doi.org/10.7554/eLife.31706
  • 2017
    • ter Bekke, R. M. A., Isaacs, A., Barysenka, A., Hoos, M. B., Jongbloed, J. D. H., Hoorntje, J. C. A., Patelski, A. S. M., Helderman-van den Enden, A. T. J. M., van den Wijngaard, A., Stoll, M., & Volders, P. G. A. (2017). Heritability in a SCN5A-mutation founder population with increased female susceptibility to non-nocturnal ventricular tachyarrhythmia and sudden cardiac death. Heart Rhythm, 14(12), 1873-1881. https://doi.org/10.1016/j.hrthm.2017.07.036
    • Heinig, M., Adriaens, M. E., Schafer, S., van Deutekom, H. W. M., Lodder, E. M., Ware, J. S., Schneider, V., Felkin, L. E., Creemers, E. E., Meder, B., Katus, H. A., Rühle, F., Stoll, M., Cambien, F., Villard, E., Charron, P., Varro, A., Bishopric, N. H., George, A. L., ... Hubner, N. (2017). Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. Genome Biology, 18(1), 170. [170]. https://doi.org/10.1186/s13059-017-1286-z
    • Ruehle, F., Witten, A., Barysenka, A., Huge, A., Arning, A., Heller, C., Kruempel, A., Mesters, R., Franke, A., Lieb, W., Riemenschneider, M., Hiersche, M., Limperger, V., Nowak-Goettl, U., & Stoll, M. (2017). Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to pediatric venous thromboembolism. Blood, 129(6), 783-790. https://doi.org/10.1182/blood-2016-07-728840
    • Elands, R. J. J., Simons, C. C. J. M., Riemenschneider, M., Isaacs, A., Schouten, L. J., Verhage, B. A., Van Steen, K., Godschalk, R. W. L., van den Brandt, P. A., Stoll, M., & Weijenberg, M. P. (2017). A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk. Scientific Reports, 7, [41034]. https://doi.org/10.1038/srep41034
  • 2016
    • Arning, A., Jeibmann, A., Koehnemann, S., Brokinkel, B., Ewelt, C., Berger, K., Wellmann, J., Nowak-Goettl, U., Stummer, W., Stoll, M., & Holling, M. (2016). ADAMTS genes and the risk of cerebral aneurysm. Journal of Neurosurgery, 125(2), 269-274. https://doi.org/10.3171/2015.7.JNS154
    • Rühle, F., & Stoll, M. (2016). Long non-coding RNA Databases in Cardiovascular Research. Genomics, Proteomics and Bioinformatics, 14(4), 191–199. https://doi.org/10.1016/j.gpb.2016.03.001
    • Fabritz, L., Guasch, E., Antoniades, C., Bardinet, I., Benninger, G., Betts, T. R., Brand, E., Breithardt, G., Bucklar-Suchankova, G., Camm, A. J., Cartlidge, D., Casadei, B., Chua, W. W., Crijns, H., Deeks, J., Hatem, S., Hidden-Lucet, F., Kääb, S., Maniadakis, N., ... Kirchhof, P. (2016). Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment. Nature Reviews Cardiology, 13(4), 230-237. https://doi.org/10.1038/nrcardio.2015.194
    • Kirchhof, P., Breithardt, G., Bax, J., Benninger, G., Blomstrom-Lundqvist, C., Boriani, G., Brandes, A., Brown, H., Brueckmann, M., Calkins, H., Calvert, M., Christoffels, V., Crijns, H., Dobrev, D., Ellinor, P., Fabritz, L., Fetsch, T., Freedman, S. B., Gerth, A., ... Camm, A. J. (2016). A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference. EP Europace, 18(1), 37-50. https://doi.org/10.1093/europace/euv304
    • Stenzig, J., Hirt, M. N., Loeser, A., Bartholdt, L. M., Hensel, J-T., Werner, T. R., Riemenschneider, M., Indenbirken, D., Guenther, T., Mueller, C. P., Huebner, N., Stoll, M., & Eschenhagen, T. (2016). DNA methylation in an engineered heart tissue model of cardiac hypertrophy: common signatures and effects of DNA methylation inhibitors. Basic Research in Cardiology, 111(1), [9]. https://doi.org/10.1007/s00395-015-0528-z
    • Backes, C., Meder, B., Lai, A., Stoll, M., Ruehle, F., Katus, H. A., & Keller, A. (2016). Pathway-based variant enrichment analysis on the example of dilated cardiomyopathy. Human Genetics, 135(1), 31-40. https://doi.org/10.1007/s00439-015-1609-7