Otto Bekers


Prof. Otto Bekers studied Pharmacy at the University of Leiden and graduated in 1987 with honour. He recieved his PhD degree in 1991 at the Utrecht University, title of his dissertation was 'Inclusion comlexation of cyclodextrins with some cytostatic drugs'. After this he specialised in Clinical Chemistry at the Leyenburg Hospital (now Haga Hospital) in The Hague.

Since 1997 he is working as a Clinical Chemist at the Maastricht UMC+. First as head of the unit General Clinical Chemistry and from 2014 he is professor in Clinical Chemistry and head of the Central Diagnostic Laboratory (CDL).

He is heading the cardiac marker research at the CDL and also focussed on personalised medice.

Central Diagnostic Laboratory
P. Debyelaan 25, 6229 HX Maastricht
PO Box 5800, 6202 AZ Maastricht
Room number: 5.E2.004
T: +31 (0)43 387 646 94

  • 2015
    • Cardinaels, E. P., Cornelis, T., van der Sande, F. M., Leunissen, K. M., van Dieijen-Visser, M. P., Mingels, A. M., Kooman, J. P., & Bekers, O. (2015). Acute effects of conventional and extended hemodialysis and hemodiafiltration on high-sensitivity cardiac troponins. Clinical Chemistry and Laboratory Medicine, 53(11), e289-e292.
    • Knapen, M. H. J., Braam, L. A. J. L. M., Drummen, N. E., Bekers, O., Hoeks, A. P. G., & Vermeer, C. (2015). Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women A double-blind randomised clinical trial. Thrombosis and Haemostasis, 113(5), 1135-1144.
    • Cardinaels, E. P. M., Daamen, M. A. M. J., Bekers, O., ten Kate, J., Niens, M., van Suijlen, J. D. E., van Dieijen-Visser, M. P., Brunner-La Rocca, H. P., Schols, J. M. G. A., & Mingels, A. M. A. (2015). Clinical Interpretation of Elevated Concentrations of Cardiac Troponin T, but Not Troponin I, in Nursing Home Residents. Journal of the American Medical Directors Association, 16(10), 884-891.
    • de Raadt, W. M., Wijnen, P. A., Bast, A., Bekers, O., & Drent, M. (2015). Acute eosinophilic pneumonia associated with glyphosate-surfactant exposure. Sarcoidosis Vasculitis and Diffuse Lung Diseases, 32(2), 172-175.
  • 2014
    • Venema, L. H., Sharma, A. S., Simons, A. P., Bekers, O., & Weerwind, P. W. (2014). Contemporary Oxygenator Design Relative to Hemolysis. The Journal of extra-corporeal technology, 46(3), 212-6.
    • Vlassaks, E., Nikiforou, M., Strackx, E., Hutten, M., Bekers, O., Gazzolo, D., Li Volti, G., Martinez-Martinez, P., Kramer, B. W., & Gavilanes, A. W. (2014). Acute and chronic immunomodulatory changes in rat liver after fetal and perinatal asphyxia. Journal of developmental origins of health and disease, 5(2), 98-108.
    • Cornelis, T., van der Sande, F. M., Eloot, S., Cardinaels, E., Bekers, O., Damoiseaux, J., Leunissen, K. M., & Kooman, J. P. (2014). Acute Hemodynamic Response and Uremic Toxin Removal in Conventional and Extended Hemodialysis and Hemodiafiltration: A Randomized Crossover Study.American Journal of Kidney Diseases, 64(2), 247-265.
    • Wijnen, P. A., Cremers, J. P., Nelemans, P. J., Erckens, R. J., Hoitsma, E., Jansen, T. L., Bekers, O., & Drent, M. (2014). Association of the TNF-α G-308A polymorphism with TNF-inhibitor response in sarcoidosis. European Respiratory Journal, 43(6), 1730-1739.
  • 2013
    • Seehase, M., Houthuizen, P., Jellema, R. K., Collins, J. J., Bekers, O., Breuer, J., & Kramer, B. W. (2013). Propofol administration to the fetal-maternal unit reduces cardiac injury in late-preterm lambs subjected to severe prenatal asphyxia and cardiac arrest. Pediatric Research, 73(4), 427-434.
    • Wijnen, P. A. H. M., Verschakelen, J. A., Bast, A., Bekers, O., & Drent, M. (2013). Diffuse alveolar hemorrhage in coumarin users: a fibrosing interstitial pneumonia trigger?Lung, 191(1), 53-59.
    • Baumgartner, S., Mensink, R. P., den Hartog, G. J., Bast, A., Bekers, O., Husche, C., Lutjohann, D., & Plat, J. (2013). Oxyphytosterol formation in humans: Identification of high vs. low oxidizers.Biochemical Pharmacology, 86(1), 19-25.
  • 2012
    • van Gerven, P. W. M., van Boxtel, M. P. J., Ausems, E. E. B., Bekers, O., & Jolles, J. (2012). Do apolipoprotein E genotype and educational attainment predict the rate of cognitive decline in normal aging? A 12-year follow-up of the Maastricht Aging Study. Neuropsychology, 26(4), 459-472.
    • Hanssen, S. J. P., van de Poll, M. C. G., Houben, A. J., Vermeulen Windsant, I. C., Snoeijs, M. G., Bekers, O., Buurman, W. A., & Jacobs, M. J. H. M. (2012). Hemolysis compromises nitric oxide-dependent vasodilatory responses in patients undergoing major cardiovascular surgery.Thoracic and Cardiovascular Surgeon, 60(4), 255-261.
    • Cardinaels, E. P., Mingels, A. M., Jacobs, L. H., Meex, S. J., Bekers, O., & van Dieijen-Visser, M. P. (2012). A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: The challenges that lie ahead. Clinical Chemistry and Laboratory Medicine, 50(5), 791-806.
    • Knottnerus, I. L. H., Winckers, K., ten Cate, H., Hackeng, T. M., Lodder, J., Rouhl, R. P. W., Staals, J., Govers-Riemslag, J. W. P., Bekers, O., & van Oostenbrugge, R. J. (2012). Levels of heparin-releasable TFPI are increased in first-ever lacunar stroke patients. Neurology, 78(7), 493-498.
    • Vlassaks, E., Gavilanes, A. W. D., Bieghs, V., Reinartz, A., Gassler, N., van Gorp, P. J. J., Gijbels, M. J. J., Bekers, O., Zimmermann, L. J. I., Pillow, J. J., Polglase, G. R., Nitsos, I., Newnham, J. P., Kallapur, S. G., Jobe, A. H., Shiri-Sverdlov, R., & Kramer, B. W. (2012). Antenatal exposure to chorioamnionitis affects lipid metabolism in 7-week-old sheep. Journal of developmental origins of health and disease, 3(2), 103-110.
    • van Dieijen-Visser, M. P., Mingels, A. M., Jacobs, L. H., Cardinaels, E. P., Wodzig, K. W. H., Bekers, O., Klinkenberg, L. J., & Meex, S. J. R. (2012). Troponin, the best there is!Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde, 37, 15-18.
    • van Wijk, S., Jacobs, L., Eurlings, L. W., van Kimmenade, R., Lemmers, R., Broos, P., Bekers, O., Prins, M. H., Crijns, H. J., Pinto, Y. M., van Dieijen-Visser, M. P., & Brunner-La Rocca, H. P. (2012). Troponin T Measurements by High-Sensitivity vs Conventional Assays for Risk Stratification in Acute Dyspnea. Clinical Chemistry, 58(1), 284-292.
  • 2011
    • Schiepers, O. J. G., van Boxtel, M. P. J., de Groot, R. H. M., Jolles, J., Bekers, O., Kok, F. J., Verhoef, P., & Durga, J. (2011). Genetic variation in folate metabolism is not associated with cognitive functioning or mood in healthy adults. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(7), 1682-1688.
    • Debats, I. B., Koeneman, M. M., Booi, D. I., Bekers, O., & van der Hulst, R. R. W. J. (2011). Intravenous arginine and human skin graft donor site healing: A randomized controlled trial.Burns, 37(3), 420-426.
    • Wijnen, P. A. H. M., Voorter, C. E., Nelemans, P. J., Verschakelen, J. A., Bekers, O., & Drent, M. (2011). Butyrophilin-like 2 in pulmonary sarcoidosis: a factor for susceptibility and progression?Human Immunology, 72(4), 342-347.
    • Coolen, E. J., Arts, I. C., Bekers, O., Vervaet, C., Bast, A., & Dagnelie, P. C. (2011). Oral bioavailability of ATP after prolonged administration.British Journal of Nutrition, 105(3), 357-366.
    • Wijnen, P. A. H. M., Bekers, O., & Drent, M. (2011). Development of Cocaine-Induced Interstitial Lung Damage in Two CYP2C and VKORC1 Variant Allele Carriers. Molecular Diagnosis & Therapy, 15(3), 177-180.
    • Sep, S., Rijvers, C., Smits, L., van Bilsen, M., Bekers, O., & Peeters, L. (2011). Early-pregnancy changes in maternal lipid profile in women with recurrent preeclampsia and previously preeclamptic women with normal next pregnancy. Reproductive Sciences, 18(10), 998-1004.
  • 2010
    • Bieghs, V., Vlassaks, E., Custers, A., van Gorp, P. J. J., Gijbels, M. J. J., Bast, A., Bekers, O., Zimmermann, L. J. I., Lutjohann, D., Voncken, J. W., Gavilanes, A. W., Kramer, B. W., & Shiri-Sverdlov, R. (2010). Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep.Pediatric Research, 68(6), 466-472.
    • de Boer, D., Houben, C., Bekers, O., & Menheere, P. P. C. A. (2010). Gelofusine (R) affects the quality control performance of QuickVue (R) point-of-care human chorionic gonadotropin test devices. Clinical Biochemistry, 43(16-17), 1371-1372.
    • Cranenburg, E. C. M., Koos, R., Schurgers, L. J., Magdeleyns, E. J. P., Schoonbrood, T. H. M., Landewe, R. B., Brandenburg, V. M., Bekers, O., & Vermeer, C. (2010). Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thrombosis and Haemostasis, 104(4), 811-822.
    • Wijnen, P. A. H. M., Bekers, O., & Drent, M. (2010). Relationship between drug-induced interstitial lung diseases and cytochrome P450 polymorphisms.Current Opinion in Pulmonary Medicine, 16(5), 496-502.
    • Lind, J. S., Dingemans, A. M., Groen, H. J., Thunnissen, F. B., Bekers, O., Heideman, D. A., Honeywell, R. J., Giovannetti, E., Peters, G. J., Postmus, P. E., van Suylen, R. J., & Smit, E. F. (2010). A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer. Clinical Cancer Research, 16(11), 3078-3087.
    • Wijnen, P. A., Nelemans, P. J., Verschakelen, J. A., Bekers, O., Voorter, C. E., & Drent, M. (2010). The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis.Tissue Antigens, 75(3), 262-268.
    • Wijnen, P. A. H. M., Bekers, O., & Drent, M. (2010). 'Drug'-induced pneumonitis associated with CYP and VKORC1 variants.The Bulletin of contemporary clinical medicine, 3, 15-17.
    • Wijnen, P. A., Bekers, O., van Dieijen-Visser, M. P., & Drent, M. (2010). Pharmacogenetic testing after a simple DNA isolation method.The Bulletin of contemporary clinical medicine, 3, 9-14.
    • Wijnen, P. A., Linssen, C. F., Haenen, G. R., Bekers, O., & Drent, M. (2010). Variant VKORC1 and CYP2C9 Alleles in Patients with Diffuse Alveolar Hemorrhage Caused by Oral Anticoagulants. Molecular Diagnosis & Therapy, 14(1), 23-30.
  • 2009
    • Wijnen, P. A., Limantoro, I., Drent, M., Bekers, O., Kuijpers, P. M., & Koek, G. H. (2009). Depressive effect of an antidepressant: therapeutic failure of venlafaxine in a case lacking CYP2D6 activity. Annals of Clinical Biochemistry, 46(Pt 6), 527-30.
    • Wolfs, J. L., Comfurius, P., Bekers, O., Zwaal, R. F., Balasubramanian, K., Schroit, A. J., Lindhout, T., & Bevers, E. M. (2009). Direct inhibition of phospholipid scrambling activity in erythrocytes by potassium ions. Cellular and Molecular Life Sciences, 66(2), 314-23.
    • Lind, J. S., Postmus, P. E., Heideman, D. A., Thunnissen, E. B., Bekers, O., & Smit, E. F. (2009). Dramatic response to low-dose erlotinib of epidermal growth factor receptor mutation-positive recurrent non-small cell lung cancer after severe cutaneous toxicity. Journal of Thoracic Oncology, 4(12), 1585-6.
    • Wijnen, P. A. H. M., Drent, M., van Dieijen-Visser, M. P., & Bekers, O. (2009). Pharmacogenetic testing after a simple DNA isolation method on buccal swab samples. Pharmacogenomics, 10(6), 983-7.
  • 2008
    • Linssen, C. F. M., Bekers, O., Drent, M., & Jacobs, J. A. (2008). C-reactive protein and procalcitonin concentrations in bronchoalveolar lavage fluid as a predictor of ventilator-associated pneumonia. Annals of Clinical Biochemistry, 45(Pt 3), 293-8.
    • van Schaik, R. H. N., Grandia, L., de Goede, A., Bet, P. M., Bekers, O., Guchelaar, H. J., Goldschmidt, H. M. J., Meijer, M. M. C., Mulder, H., van der Weide, J., & Deneer, V. H. M. (2008). CYP2D6 genotype `1-0' ingedeeld als intermediaire metaboliseerder.Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde, 33(1), 52.
    • Wijnen, P. A. H. M., op den Buijsch, R. A., Cheung, S. C., van der Heijden, J., Hoogtanders, K., Stolk, L. M. L., van Dieijen-Visser, M., Neef, C. K., Drent, M., & Bekers, O. (2008). Genotyping with a dried blood spot method: a useful technique for application in pharmacogenetics. Clinica Chimica Acta, 388(1-2), 189-91.
    • Wijnen, P. A. H. M., Drent, M., Nelemans, P. J., Kuijpers, P. M., Koek, G. H., Neef, C. K., Haenen, G. R., & Bekers, O. (2008). Role of cytochrome p450 polymorphisms in the development of pulmonary drug toxicity: a case-control study in the Netherlands. Drug Safety, 31(12), 1125-34.
    • Ramakers, I. H. G. B., Visser, P. J., Aalten, P., Bekers, O., Sleegers, K., van Broeckhoven, C. L., Jolles, J., & Verhey, F. R. (2008). The association between APOE genotype and memory dysfunction in subjects with mild cognitive impairment is related to age and Alzheimer pathology. Dementia and Geriatric Cognitive Disorders, 26(2), 101-8.
  • 2007
    • op den Buijsch, R. A., van de Plas, A., Stolk, L. M. L., Christiaans, M. H., van Hooff, J. P., Undre, N. A., van Dieijen-Visser, M. P., & Bekers, O. (2007). Evaluation of limited sampling strategies for tacrolimus. European Journal of Clinical Pharmacology, 63(11), 1039-1044.
    • Veltkamp, M., Wijnen, P. A. H. M., Moorsel, C. H., Rijkers, G. T., Ruven, H. J., Heron, M., Bekers, O., Claessen, A. M., Drent, M., Van den Bosch, J. M. M., & Grutters, J. C. (2007). Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis.Clinical and Experimental Immunology, 149(3), 453-462.
    • Wijnen, P. A. H. M., Op den Buisch, R., Drent, M., Kuipers, P. M. J. C., Neefs, C., Bast, A., Bekers, O., & Koek, G. H. (2007). Review article: The prevalence and clinical relevance of cytochrome P450 polymorphisms.Alimentary Pharmacology & Therapeutics, 26(2), 211-219.
    • op den Buijsch, R. A., Christiaans, M. H., Stolk, L. M. L., de Vries, J. E., Cheung, C. Y., Undre, N. A., van Hooff, J. P., van Dieijen-Visser, M. P., & Bekers, O. (2007). Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms. Fundamental & Clinical Pharmacology, 21(4), 427-435.
    • Llerena, A., Michel, G., Jeannesson, E., Wong, S., Manolopoulos, V. G., Hockett, R. D., Boubekeur, K., Siest, G., Beaune, P., Haefliger, C., Arnold, H. P., Junien, C., Petrovic, N., Molloy, R., Bekers, O., Donnelly, C., Arens, H. J., Kaput, J., & McComb, J. (2007). Third Santorini conference pharmacogenomics workshop report: "Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?". Clinical Chemistry and Laboratory Medicine, 45(7), 843-850.
  • 2005
    • Fischer, M. A. J. G., Gransier, T. J., Beckers, L. M., Bekers, O., Bast, A., & Haenen, G. R. (2005). Determination of the antioxidant capacity in blood. Clinical Chemistry and Laboratory Medicine, 43(7), 735-740.
    • op den Buijsch, R. A., de Vries, J. E., Loots, W. J., Landt, O., Wijnen, P. A. H. M., van Dieijen-Visser, M. P., & Bekers, O. (2005). Genotyping of the PXR A11156C polymorphism with locked nucleic acid containing fluorogenic probes. Pharmacogenomics, 5(2), 72-74.