Paola van der Meijden

Assistant Professor

Initially trained in Biological Health Sciences at Maastricht University, Dr Paola van der Meijden has obtained a PhD in Biochemistry on the interaction mechanisms of platelets and coagulation; focus on P2Y12receptor and factor XII.

In 2010, she acquired a unique bridging position, encapsulated within the Maastricht Thrombosis Expertise Center (TEC), aiming to link basic research on thrombosis and hemostasis with clinical research and applications. In 2014, she received the ISTH-EHA Fellowship to gain new insights into the determinants of bleeding in patients with thrombocytopenia due to hematological malignancies and chemotherapy. The focus of her current work is on the interactions between platelets and coagulation in acquired hemostatic dysfunction as a consequence of disease and treatment. She has a special interest in the negative and positive priming of platelets and the functional specialisation of platelet populations. Overall, knowledge on the factors contributing to hemostasis and thrombosis enables the development of predictive and diagnostic tests, resulting in improved disease management.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room: 4.322
T: +31(0)43 388 16 84

  • 2015
    • Swieringa, F., Lance, M. D., Fuchs, B., Feijge, M. A. H., Solecka, B. A., Verheijen, L. P. J., Hughes, K. R., Van Oerle, R., Deckmyn, H., Kannicht, C., Heemskerk, J. W. M., & Van der Meijden, P. E. J. (2015). Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding. Journal of Thrombosis and Haemostasis, 13(8), 1503-1513. https://doi.org/10.1111/jth.13007
    • Swieringa, F., Kuijpers, M. J. E., Lamers, M. M. E., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2015). Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow. Haematologica-the Hematology Journal, 100(6), 748-756. https://doi.org/10.3324/haematol.2014.116863
    • Posthuma, J. J., van der Meijden, P. E. J., ten Cate, H., & Spronk, H. M. H. (2015). Short- and Long-term exercise induced alterations in haemostasis: a review of the literature. Blood Reviews, 29(3), 171-178. https://doi.org/10.1016/j.blre.2014.10.005
    • Whyte, C. S., Swieringa, F., Mastenbroek, T. G., Lionikiene, A. S., Lance, M. D., van der Meijden, P. E. J., Heemskerk, J. W. M., & Mutch, N. J. (2015). Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow. Blood, 125(16), 2568-2578. https://doi.org/10.1182/blood-2014-09-599480
  • 2014
    • Kuijpers, M. J. E., van der Meijden, P. E. J., Feijge, M. A. H., Mattheij, N. J. A., May, F., Govers-Riemslag, J., Meijers, J. C. M., Heemskerk, J. W. M., Renne, T., & Cosemans, J. M. E. M. (2014). Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques. Arteriosclerosis Thrombosis and Vascular Biology, 34(8), 1674–1680. https://doi.org/10.1161/ATVBAHA.114.303315
    • Posthuma, J. J., Loeffen, R., van Oerle, R., Henskens, Y. M. C., ten Cate, H., Spronk, H. M. H., & van der Meijden, P. E. J. (2014). Long-term strenuous exercise induces a hypercoagulable state through contact activation. Thrombosis and Haemostasis, 111(6), 1197-1199. https://doi.org/10.1160/TH13-11-0963
    • Spronk, H. M. H., ten Cate, H., & van der Meijden, P. E. J. (2014). Differential roles of Tissue Factor and Phosphatidylserine in activation of coagulation. Thrombosis Research, 133, S54-S56. https://doi.org/10.1016/j.thromres.2014.03.022
    • Ninivaggi, M., Feijge, M. A. H., Baaten, C. C. F. M. J., Kuiper, G. J. A. J. M., Marcus, M. A. E., ten Cate, H., Lance, M. D., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2014). Additive roles of platelets and fibrinogen in whole-blood fibrin clot formation upon dilution as assessed by thromboelastometry. Thrombosis and Haemostasis, 111(3), 447-457. https://doi.org/10.1160/TH13-06-0493
    • Swieringa, F., Kuijpers, M. J. E., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2014). Targeting platelet receptor function in thrombus formation: The risk of bleeding. Blood Reviews, 28(1), 9-21. https://doi.org/10.1016/j.blre.2013.12.001
  • 2013
    • van der Meijden, P. E. J., Bouman, A. C., Feijge, M. A. H., van Oerle, R., Spronk, H. M. H., Hamulyak, K., ten Cate-Hoek, A. J., ten Cate, H., & Heemskerk, J. W. M. (2013). Platelet Dysfunction in Thrombosis Patients Treated with Vitamin K Antagonists and Recurrent Bleeding. PLOS ONE, 8(5). https://doi.org/10.1371/journal.pone.0064112
  • 2012
    • van der Meijden, P. E. J., Feijge, M. A. H., Swieringa, F., Gilio, K., Nergiz-Unal, R., Hamulyak, K., & Heemskerk, J. W. M. (2012). Key role of integrin alpha(IIb)beta(3) signaling to Syk kinase in tissue factor-induced thrombin generation. Cellular and Molecular Life Sciences, 69(20), 3481-3492. https://doi.org/10.1007/s00018-012-1033-2
    • van der Meijden, P. E. J., van Schilfgaarde, M., van Oerle, R., Renne, T., ten Cate, H., & Spronk, H. M. H. (2012). Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa. Journal of Thrombosis and Haemostasis, 10(7), 1355-1362. https://doi.org/10.1111/j.1538-7836.2012.04758.x
  • 2010
    • Gilio, K., van Kruchten, R., Braun, A., Berna-Erro, A., Feijge, M. A. H., Stegner, D., van der Meijden, P. E. J., Kuijpers, M. J. E., Varga-Szabo, D., Heemskerk, J. W. M., & Nieswandt, B. (2010). Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation. Journal of Biological Chemistry, 285(31), 23629-23638. https://doi.org/10.1074/jbc.M110.108696
    • Nergiz-Unal, R., Cosemans, J. M. E. M., Feijge, M. A. H., van der Meijden, P. E. J., Storey, R. F., van Giezen, J. J. J., Egbrink, M. G. A. O., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2010). Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques. PLOS ONE, 5(4), 13. https://doi.org/10.1371/journal.pone.0010130
  • 2008
    • Vanschoonbeek, K., Wouters, K., van der Meijden, P. E., van Gorp, P. J. J., Feijge, M. A., Herfs, M., Schurgers, L. J., Hofker, M. H., de Maat, M. P., & Heemskerk, J. W. (2008). Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.Arteriosclerosis Thrombosis and Vascular Biology, 28(11), 2023-2029. https://doi.org/10.1161/ATVBAHA.107.156992
  • 2005
    • van der Meijden, P. E. J., Feijge, M. A. H., Giesen, P. L. A., Huijberts, M. S. P., van Raak, L. P., & Heemskerk, J. W. (2005). Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk. Thrombosis and Haemostasis, 93(6), 1128-1136. https://doi.org/10.1160/TH04-09-0597