Rory Koenen

Associate professor

Dr Rory  Koenen studied biochemistry in Sittard (BSc) and at the Radboud University in Nijmegen (MSc), the Netherlands from 1993-1999. He completed his PhD in cardiovascular sciences at CARIM Maastricht University in 2005. He then worked in Germany at IMCAR, RWTH Aachen University until 2010 and then moved to IPEK at the LMU in Munich chaired by Christian Weber. In 2012, he returned to CARIM as the recipient of a Vidi grant.

Dr Koenen is currently investigating the functions of platelets beyond hemostasis, platelet microvesicles and the role of particular inflammatory molecules in vascular disease e.g. thrombosis and atherosclerosis. For example, he aims to characterise the molecular aspects of chemokine RANTES and platelet factor 4 secretion from platelets and its importance in the development of cardiovascular diseases. In addition, Dr Koenen is interested in the role of cell adhesion molecules in platelet function and in how platelets maintain interactions with other cell types (leukocytes, endothelial and smooth muscle cells). Finally, Dr Koenen investigates how platelets and their microvesicles can influence the behavior and phenotype of these cells.

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.366a
T: +31(0)43 388 33 90

  • 2011
    • Koenen, R. R., & Weber, C. (2011). Chemokines: established and novel targets in atherosclerosis. EMBO Molecular Medicine, 3(12), 713-725.
    • Butoi, E. D., Gan, A. M., Manduteanu, I., Stan, D., Calin, M., Pirvulescu, M., Koenen, R. R., Weber, C., & Simionescu, M. (2011). Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules. Biochimica et Biophysica Acta-Molecular Cell Research, 1813(12), 2026-2035.
    • Liehn, E. A., Tuchscheerer, N., Kanzler, I., Drechsler, M., Fraemohs, L., Schuh, A., Koenen, R. R., Zander, S., Soehnlein, O., Hristov, M., Grigorescu, G., Urs, A. O., Leabu, M., Bucur, I., Merx, M. W., Zernecke, A., Ehling, J., Gremse, F., Lammers, T., ... Weber, C. (2011). Double-Edged Role of the CXCL12/CXCR4 Axis in Experimental Myocardial Infarction. Journal of the American College of Cardiology, 58(23), 2415-2423.
    • Vasina, E. M., Cauwenberghs, S., Feijge, M. A. H., Heemskerk, J. W. M., Weber, C., & Koenen, R. R. (2011). Microparticles from apoptotic platelets promote resident macrophage differentiation. Cell Death & Disease, 2, 10.
    • Kramp, B. K., Sarabi, A., Koenen, R. R., & Weber, C. (2011). Heterophilic chemokine receptor interactions in chemokine signaling and biology. Experimental Cell Research, 317(5), 655-663.
    • de Jager, S. C. A., Bermudez, B., Bot, I., Koenen, R. R., Bot, M., Kavelaars, A., de Waard, V., Heijnen, C. J., Muriana, F. J. G., Weber, C., van Berkel, T. J. C., Kuiper, J., Lee, S-J., Abia, R., & Biessen, E. A. L. (2011). Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis. Journal of Experimental Medicine, 208(2), 217-225.
    • Sarabi, A., Kramp, B. K., Drechsler, M., Hackeng, T. M., Soehnlein, O., Weber, C., Koenen, R. R., & von Hundelshausen, P. (2011). CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. Journal of Thrombosis and Haemostasis, 9(1), 209-219.
  • 2010
    • Ren, M., Guo, Q., Guo, L., Lenz, M., Qian, F., Koenen, R. R., Xu, H., Schilling, A. B., Weber, C., Ye, R. D., Dinner, A. R., & Tang, W-J. (2010). Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. The Embo Journal, 29(23), 3952-3966.
    • Liehn, E. A., Piccinini, A-M., Koenen, R. R., Soehnlein, O., Adage, T., Fatu, R., Curaj, A., Popescu, A., Zernecke, A., Kungl, A. J., & Weber, C. (2010). A New Monocyte Chemotactic Protein-1/Chemokine CC Motif Ligand-2 Competitor Limiting Neointima Formation and Myocardial Ischemia/Reperfusion Injury in Mice. Journal of the American College of Cardiology, 56(22), 1847-1857.
    • Berres, M-L., Koenen, R. R., Rueland, A., Zaldivar, M. M., Heinrichs, D., Sahin, H., Schmitz, P., Streetz, K. L., Berg, T., Gassler, N., Weiskirchen, R., Proudfoot, A., Weber, C., Trautwein, C., & Wasmuth, H. E. (2010). Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. Journal of Clinical Investigation, 120(11), 4129-4140.
    • Rana, O. R., Schauerte, P., Kluttig, R., Schroeder, J. W., Koenen, R. R., Weber, C., Nolte, K. W., Weis, J., Hoffmann, R., Marx, N., & Saygili, E. (2010). Acetylcholine as an age-dependent non-neuronal source in the heart. Autonomic Neuroscience-basic & Clinical, 156(1-2), 82-89.
    • Koenen, R. R., & Weber, C. (2010). Manipulating the chemokine system: Therapeutic perspectives for atherosclerosis. Current Opinion in Investigational Drugs, 11(3), 265-272.
    • Koenen, R. R., & Weber, C. (2010). Platelet-Derived Chemokines in Vascular Remodeling and Atherosclerosis. Seminars in Thrombosis and Hemostasis, 36(2), 163-169.
    • Koenen, R. R., & Weber, C. (2010). Therapeutic targeting of chemokine interactions in atherosclerosis. Nature Reviews Drug Discovery, 9(2), 141-153.