Yvonne Henskens

Associate professor

Dr Yvonne Henskens graduated with the specialisations in Biochemistry and Toxicology at Wageningen University. She worked on salivary cystatins in periodontal health and disease at the Department of Oral Biochemistry, Free University Amsterdam/Academic Centre for Dentistry (ACTA). After her PhD she started her specialisation for Clinical Chemistry at the Reinier de Graaf Gasthuis in Delft.

At this moment she is a clinical biochemist, working in laboratories for the past 15 years (Amsterdam Medical Centre and Maastricht UMC+). She has been responsible for the diagnostic tests concerning hematology, hemostasis and transfusion at Maastricht UMC+ since 2003.  She has special research interest in laboratory predictors of bleeding and in pre- and peri-operative management of coagulopathies: Active in the boards of the Dutch societies for hematologicallaboratories and clinical chemistry. Involved in training and education of medical and life sciences students, laboratory technicians and residents. Founder of a re-training programme on hemostasis and transfusion for technicians and clinical biochemists for the south-east part of the Netherlands.

Central Diagnostic Laboratory MUMC+
Department of Biochemistry
P. Debyelaan 25, 6229 HX Maastricht
Room number: 5.E2.001
T: +31(0)43 387 79 76

  • 2019
    • Jooss, N. J., De Simone, I., Provenzale, I., Fernández, D. I., Brouns, S. L. N., Farndale, R. W., Henskens, Y. M. C., Kuijpers, M. J. E., Ten Cate, H., van der Meijden, P. E. J., Cavill, R., & Heemskerk, J. W. M. (2019). Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces. International journal of molecular sciences, 20(11), Article 2788. https://doi.org/10.3390/ijms20112788
    • Henriquez, D. D. C. A., Bloemenkamp, K. W. M., Loeff, R. M., Zwart, J. J., van Roosmalen, J. J. M., Zwaginga, J. J., van der Bom, J. G., Adriaanse, H. J., van den Akker, E. S. A., Baas, M. I., Bank, C. M. C., van Beek, E., de Boer, B. A., de Boer, K., van der Borden, D. M. R., Bremer, H. A., Brons, J. T. J., Burggraaff, J. M., Ceelie, H., ... TeMpOH-1 study group (2019). Fluid resuscitation during persistent postpartum haemorrhage and maternal outcome: A nationwide cohort study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 235, 49-56. https://doi.org/10.1016/j.ejogrb.2019.01.027
    • Krekels, J. P. M., Verhezen, P. W. M., & Henskens, Y. M. C. (2019). Platelet Aggregation in Healthy Participants is Not Affected by Smoking, Drinking Coffee, Consuming a High-Fat Meal, or Performing Physical Exercise. Clinical and Applied Thrombosis-Hemostasis, 25, 1-9. Article 1076029618782445. https://doi.org/10.1177/1076029618782445
    • Vries, M. J. A., Macrae, F., Nelemans, P. J., Kuiper, G. J. A. J. M., Wetzels, R. J. H., Bowman, P., Verhezen, P. W. M., ten Cate, H., Ariens, R. A. S., & Henskens, Y. M. C. (2019). Assessment and determinants of whole blood and plasma fibrinolysis in patients with mild bleeding symptoms. Thrombosis Research, 174, 88-94. https://doi.org/10.1016/j.thromres.2018.12.004
    • Kuiper, G. J. A. J. M., van Egmond, L. T., Henskens, Y. M. C., Roekaerts, P. M., Maessen, J. G., ten Cate, H., Buhre, W. F., & Lance, M. D. (2019). Shifts of Transfusion Demand in Cardiac Surgery After Implementation of Rotational Thromboelastometry-Guided Transfusion Protocols: Analysis of the HEROES-CS (HEmostasis Registry of patiEntS in Cardiac Surgery) Observational, Prospective Open Cohort Database. Journal of Cardiothoracic and Vascular Anesthesia, 33(2), 307-317. https://doi.org/10.1053/j.jvca.2018.08.203
    • Moenen, F. C. J., Vries, M. J. A., Nelemans, P. J., van Rooy, K. J. M., Vranken, J. R. R. A., Verhezen, P. W. M., Wetzels, R. J. H., ten Cate, H., Schouten, H. C., Beckers, E. A. M., & Henskens, Y. M. C. (2019). Screening for platelet function disorders with Multiplate and platelet function analyzer. Platelets, 30(1), 81-87. https://doi.org/10.1080/09537104.2017.1371290
  • 2018
    • Oshagbemi, O. A., Franssen, F. M. E., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Maitland-van der Zee, A.-H., Burden, A. M., & de Vries, F. (2018). Blood eosinophilia, use of inhaled corticosteroids, and risk of COPD exacerbations and mortality. Pharmacoepidemiology and Drug Safety, 27(11), 1191-1199. https://doi.org/10.1002/pds.4655
    • Gillissen, A., van den Akker, T., Caram-Deelder, C., Henriquez, D. D. C. A., Bloemenkamp, K. W. M., van Roosmalen, J. J. M., Eikenboom, J., van der Bom, J. G., Henskens, Y., Scheepers, L., & TeMpOH-1 study group (2018). Association between fluid management and dilutional coagulopathy in severe postpartum haemorrhage: a nationwide retrospective cohort study. BMC Pregnancy and Childbirth, 18, Article 398. https://doi.org/10.1186/s12884-018-2021-9
    • Vries, M. J., van der Meijden, P. E., Kuiper, G. J., Nelemans, P. J., Wetzels, R. J., van Oerle, R. G., Lance, M. D., ten Cate, H., & Henskens, Y. M. (2018). Preoperative screening for bleeding disorders: A comprehensive laboratory assessment of clinical practice. Research and practice in thrombosis and haemostasis, 2(4), 767-777. https://doi.org/10.1002/rth2.12114
    • Henskens, Y., & NIHR BioResource - Rare Diseases (2018). Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Scientific Reports, 8(1), Article 13376. https://doi.org/10.1038/s41598-018-31524-0
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., ten Cate, H., Holloway, G. P., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica-the Hematology Journal, 103(9), 1557-1567. https://doi.org/10.3324/haematol.2017.185165
    • Whitworth, J., Smith, P. S., Martin, J.-E., West, H., Luchetti, A., Rodger, F., Clark, G., Carss, K., Stephens, J., Stirrups, K., Penkett, C., Mapeta, R., Ashford, S., Megy, K., Shakeel, H., Ahmed, M., Adlard, J., Barwell, J., Brewer, C., ... NIHR BioResource Rare Diseases Consortium (2018). Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. American Journal of Human Genetics, 103(1), 3-18. https://doi.org/10.1016/j.ajhg.2018.04.013
    • Ito, Y., Carss, K. J., Duarte, S. T., Hartley, T., Keren, B., Kurian, M. A., Marey, I., Charles, P., Mendonca, C., Nava, C., Pfundt, R., Sanchis-Juan, A., van Bokhoven, H., van Essen, A., van Ravenswaaij-Arts, C., Boycott, K. M., Kernohan, K. D., Dyack, S., Raymond, F. L., ... Care4Rare Canada Consortium (2018). De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures. American Journal of Human Genetics, 103(1), 144-153. https://doi.org/10.1016/j.ajhg.2018.06.001
    • Moenen, F. C. J. I., Nelemans, P. J., Schols, S. E. M., Schouten, H. C., Henskens, Y. M. C., & Beckers, E. A. M. (2018). The diagnostic accuracy of bleeding assessment tools for the identification of patients with mild bleeding disorders: A systematic review. Haemophilia, 24(4), 525-535. https://doi.org/10.1111/hae.13486
    • ten Cate, H., Olie, R. H., ten Cate-Hoek, A. J., & Henskens, Y. M. C. (2018). Direct oral anticoagulants: When to consider laboratory testing?International Journal of Laboratory Hematology, 40(S1), 30-33. https://doi.org/10.1111/ijlh.12816
    • de Lange, N., Schol, P., Lance, M., Woiski, M., Langenveld, J., Rijnders, R., Smits, L., Wassen, M., Henskens, Y., & Scheepers, H. (2018). Restrictive Versus Massive Fluid Resuscitation Strategy (REFILL study), influence on blood loss and hemostatic parameters in obstetric hemorrhage: study protocol for a randomized controlled trial. Trials, 19, Article 166. https://doi.org/10.1186/s13063-018-2512-z
    • Kuiper, G. J. A. J. M., Christiaans, M. H. L., Mullens, M. H. J. . M., ten Cate, H., Hamulyak, K., & Henskens, Y. M. C. (2018). Routine haemostasis testing before transplanted kidney biopsy: a cohort study. Transplant International, 31(3), 302-312. https://doi.org/10.1111/tri.13090
    • Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., ... ten Cate, H. (2018). Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 118(2), 229-250. https://doi.org/10.1160/TH17-07-0492
    • Henskens, Y. M. C., Gulpen, A. J. W., van Oerle, R., Wetzels, R., Verhezen, P., Spronk, H., Schalla, S., Crijns, H. J., ten Cate, H., & ten Cate-Hoek, A. (2018). Detecting clinically relevant rivaroxaban or dabigatran levels by routine coagulation tests or thromboelastography in a cohort of patients with atrial fibrillation. Thrombosis Journal, 16, Article 3. https://doi.org/10.1186/s12959-017-0160-2
    • Habets, T. H. P. M., Vanderlocht, J., Straat, R. J. M. H. E., van Smaalen, T. C., Bos, G. M. J., Beckers, E. A., Christiaans, M. H. L., & Henskens, Y. M. C. (2018). The development of D antibodies after D-mismatched kidney transplantation in a setting of reduced immunosuppression. Transfusion, 58(1), 100-104. https://doi.org/10.1111/trf.14405
  • 2017
    • ten Cate, H., Henskens, Y. M. C., & Lance, M. D. (2017). Practical guidance on the use of laboratory testing in the management of bleeding in patients receiving direct oral anticoagulants. Vascular health and risk management, 13, 457-467. https://doi.org/10.2147/VHRM.S126265
    • BioResource-Rare Dis Consortium, UK Natl Cohort Study Idiopathic He, BRIDGE-BPD Consortium, Henskens, Y., Heemskerk, J., & Vries, M. (2017). Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension. Circulation, 136(21), 2022-2033. https://doi.org/10.1161/CIRCULATIONAHA.117.028351
    • Olie, R. H., Meertens, N. E. L., Henskens, Y. M. C., & ten Cate, H. (2017). Empirically Reduced Dosages of Tinzaparin in Patients with Moderate-to-Severe Renal Insufficiency Lead to Inadequate Anti-Xa Levels. The Nephron Journals, 137(2), 113-123. https://doi.org/10.1159/000477474
    • Orsini, S., Noris, P., Bury, L., Heller, P. G., Santoro, C., Kadir, R. A., Butta, N. C., Falcinelli, E., Cid, A. R., Fabris, F., Fouassier, M., Miyazaki, K., Luisa Lozano, M., Zuniga, P., Flaujac, C., Podda, G. M., Bermejo, N., Favier, R., Henskens, Y., ... EHA-SWG Thrombocytopenias Platelet (2017). Bleeding risk of surgery and its prevention in patients with inherited platelet disorders. Haematologica-the Hematology Journal, 102(7), 1192-1203. https://doi.org/10.3324/haematol.2016.160754
    • Hilderink, J. M., Klinkenberg, L. J. J., Aakre, K. M., de Wit, N. C. J., Henskens, Y. M. C., van der Linden, N., Bekers, O., Rennenberg, R. J. M. W., Koopmans, R. P., & Meex, S. J. R. (2017). Within-day biological variation and hour-to-hour reference change values for hematological parameters. Clinical Chemistry and Laboratory Medicine, 55(7), 1013-1024. https://doi.org/10.1515/cclm-2016-0716
    • Vajen, T., Benedikter, B. J., Heinzmann, A. C. A., Vasina, E. M., Henskens, Y., Parsons, M., Maguire, P. B., Stassen, F. R., Heemskerk, J. W. M., Schurgers, L. J., & Koenen, R. R. (2017). Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype. Journal of Extracellular Vesicles, 6(1), Article 1322454. https://doi.org/10.1080/20013078.2017.1322454
    • Oshagbemi, O. A., Burden, A. M., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Driessen, J. H. M., Maitland-van der Zee, A. H., de Vries, F., & Franssen, F. M. E. (2017). Stability of Blood Eosinophils in Patients with Chronic Obstructive Pulmonary Disease and in Control Subjects, and the Impact of Sex, Age, Smoking, and Baseline Counts. American Journal of Respiratory and Critical Care Medicine, 195(10), 1402-1404. https://doi.org/10.1164/rccm.201701-0009LE
    • Kleinegris, M.-C. F., Konings, J., Daemen, J. W., Henskens, Y., de Laat, B., Spronk, H. M. H., ten Cate-Hoek, A. J., & ten Cate, H. (2017). Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study. Frontiers in Cardiovascular Medicine, 4, Article 23. https://doi.org/10.3389/fcvm.2017.00023
    • Kicken, C. H., Roest, M., Henskens, Y. M. C., de Laat, B., & Huskens, D. (2017). Application of an optimized flow cytometry-based quantification of Platelet Activation (PACT): Monitoring platelet activation in platelet concentrates. PLOS ONE, 12(2), Article e0172265. https://doi.org/10.1371/journal.pone.0172265
    • Arno, G., Carss, K. J., Hull, S., Zihni, C., Robson, A. G., Fiorentino, A., Hardcastle, A. J., Holder, G. E., Cheetham, M. E., Plagnol, V., Moore, A. T., Raymond, F. L., Matter, K., Balda, M. S., UK Inherited Retinal Dis, Henskens, Y., NIHR-BioResource Rare Dis, & Webster, A. R. (2017). Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. American Journal of Human Genetics, 100(2), 334-342. https://doi.org/10.1016/j.ajhg.2016.12.014
    • Carss, K. J., Arno, G., Erwood, M., Stephens, J., Sanchis-Juan, A., Hull, S., Megy, K., Grozeva, D., Dewhurst, E., Malka, S., Plagnol, V., Penkett, C., Stirrups, K., Rizzo, R., Wright, G., Josifova, D., Bitner-Glindzicz, M., Scott, R. H., Clement, E., ... Raymond, F. L. (2017). Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. American Journal of Human Genetics, 100(1), 75-90. https://doi.org/10.1016/j.ajhg.2016.12.003
    • Vries, M. J. A., Bouman, H. J., Olie, R. H., Veenstra, L. F., Zwaveling, S., Verhezen, P. W. M., ten Cate-Hoek, A. J., ten Cate, H., Henskens, Y. M. C., & van der Meijden, P. E. J. (2017). Determinants of agreement between proposed therapeutic windows of platelet function tests in vulnerable patients. European Heart Journal-Cardiovascular Pharmacotherapy, 3(1), 11-17. https://doi.org/10.1093/ehjcvp/pvw026
    • Kuiper, G. J. A. J. M., Houben, R., Wetzels, R. J. H., Verhezen, P. W. M., van Oerle, R., ten Cate, H., Henskens, Y. M. C., & Lance, M. D. (2017). The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function. Platelets, 28(7), 668-675. https://doi.org/10.1080/09537104.2016.1257782
  • 2016
    • van Beers, J. J. B. C., van Egmond, L. T., Wetzels, R. J. H., Verhezen, P. W. M., Beckers, E. A. M., van Oerle, R., Spronk, H. M. H., Straat, R. J. M. H. E., & Henskens, Y. M. C. (2016). Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma. Vox Sanguinis, 111(1), 33-42. https://doi.org/10.1111/vox.12395
    • Van Poucke, S., Zhang, Z., Roest, M., Vukicevic, M., Beran, M., Lauwereins, B., Zheng, M.-H., Henskens, Y., Lance, M., & Marcus, A. (2016). Normalization methods in time series of platelet function assays A SQUIRE compliant study. Medicine, 95(28). https://doi.org/10.1097/MD.0000000000004188
    • Simeoni, I., Stephens, J. C., Hu, F., Deevi, S. V. V., Megy, K., Bariana, T. K., Lentaigne, C., Schulman, S., Sivapalaratnam, S., Vries, M. J. A., Westbury, S. K., Greene, D., Papadia, S., Alessi, M.-C., Attwood, A. P., Ballmaier, M., Baynam, G., Bermejo, E., Bertoli, M., ... Turro, E. (2016). A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood, 127(23), 2791-2803. https://doi.org/10.1182/blood-2015-12-688267
    • Mattheij, N. J. A., Swieringa, F., Mastenbroek, T. G., Berny-Lang, M. A., May, F., Baaten, C. C. F. M. J., van der Meijden, P. E. J., Henskens, Y. M. C., Beckers, E. A. M., Suylen, D. P. L., Nolte, M. W., Hackeng, T. M., McCarty, O. J. T., Heemskerk, J. W. M., & Cosemans, J. M. E. M. (2016). Coated platelets function in platelet-dependent fibrin formation via integrin alpha(IIb)beta(3) and transglutaminase factor XIII. Haematologica-the Hematology Journal, 101(4), 427-436. https://doi.org/10.3324/haematol.2015.131441
    • Eijgenraam, P., ten Cate, H., Henskens, Y., van den Ham, R., & ten Cate - Hoek , A. (2016). Effects of peri-operative bridging with low molecular weight heparins on coagulation during interruption of vitamin K antagonists: A mechanistic study. Thrombosis Research, 140, 59-65. https://doi.org/10.1016/j.thromres.2016.02.019
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R., van Oerle, R., ten Cate, H., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2016). Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy. Thrombosis Research, 140S1, S171-S171. https://doi.org/10.1016/s0049-3848(16)30125-6
    • Swieringa, F., Baaten, C. C. F. M. J., Verdoold, R., Mastenbroek, T. G., Rijnveld, N., van der Laan, K. O., Breel, E. J., Collins, P. W., Lance, M. D., Henskens, Y. M. C., Cosemans, J. M. E. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2016). Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow. Arteriosclerosis Thrombosis and Vascular Biology, 36(4), 692-699. https://doi.org/10.1161/ATVBAHA.115.306537
    • BRIDGE-BPD Consortium, Collaborators, Heemskerk, J., Henskens, Y., & Ouwehand, W. H. (2016). A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Science Translational Medicine, 8(328), Article 328ra30. https://doi.org/10.1126/scitranslmed.aad7666
    • Kuiper, G.-J., Kleinegris, M.-C., van Oerle, R., Spronk, H., Lance, M., ten Cate, H., & Henskens, Y. (2016). Validation of a modified thromboelastometry approach to detect changes in fibrinolytic activity. Thrombosis Journal, 14, Article 1. https://doi.org/10.1186/s12959-016-0076-2
    • Vries, M. J. A., van der Meijden, P. E. J., Henskens, Y. M. C., Ten Cate - Hoek, A., & ten Cate, H. (2016). Assessment of bleeding risk in patients with coronary artery disease on dual antiplatelet therapy A systematic review. Thrombosis and Haemostasis, 115(1), 7-24. https://doi.org/10.1160/TH15-04-0355
    • Straat, R., Habets, T., Vanderlocht, J., Tilanus, M., Beckers, E., Christiaans, M., & Henskens, Y. (2016). Anti-D vorming bij patiënten met rhesus-D incompatibele niertransplantaties. Tijdschrift voor Bloedtransfusie, 1, 17.
    • van Poucke, S., Stevens, K., Wetzels, R., Kicken, C., Verhezen, P., Theunissen, M., Kuiper, G.-J., van Oerle, R., Henskens, Y., & Lance, M. (2016). Early platelet recovery following cardiac surgery with cardiopulmonary bypass. Platelets, 27(8), 751-757. https://doi.org/10.3109/09537104.2016.1173665
    • van Yperen, N., Geelen, I., Jöbses, C., Henskens, Y., Schouten, H., & Beckers, E. (2016). Invloed van ABO-mismatch op behandelingsuitkomsten en transfusiebehoefte na niet-myeloablatieve, allogene perifere bloedstamceltransplantaties. Tijdschrift voor Bloedtransfusie, 1, Article 28.
    • Slomp, J., Soons, J. W. P. H., Henskens, Y., de Rijke, Y. B., Vossen, R. C. R. M., & Kortlandt, W. (2016). Tarieven voor inboeken en uitgifte van transfusie-eenheden en hemovigilantiewerkzaamheden. Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde, 41, 54-55.
    • Moenen, F. C., Vries, M. C., Henskens, Y., ten Cate, H., Wetzels, R. J., Verhezen, P. W., van Oerle, R., & Beckers, E. (2016). Uitdagingen bij het screenen en diagnosticeren van milde bloedingsziekten. Nederlands Tijdschrift voor Hematologie, 13(5), 182-189. http://docplayer.nl/38565846-Uitdagingen-bij-het-screenen-en-diagnosticeren-van-milde-bloedingsziekten.html
    • Straat, R., Habets, T., Vanderlocht, J., Tilanus, M., Beckers, E., Christiaans, M., & Henskens, Y. (2016). Validatie ih-1000 voor geautomatiseerde antistof identificatie. Tijdschrift voor Bloedtransfusie, 1, 19-20.
  • 2015
    • Baaten, C. C. F. M. J., Veenstra, L. F., Wetzels, R., van Geffen, J. P., Swieringa, F., de Witt, S. M., Henskens, Y. M. C., Crijns, H., Nylander, S., van Giezen, J. J. J., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2015). Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication. Haematologica-the Hematology Journal, 100(9), 1131-1138. https://doi.org/10.3324/haematol.2014.122457