Frans van Nieuwenhoven

Assistant Professor

Dr Frans van Nieuwenhoven received his PhD in 1996 at Maastricht University on a thesis about the biological significance of fatty acid-binding proteins (FABP) in cardiac fatty acid uptake and on the use of FABP as plasma marker for myocardial tissue damage. From 1996-2005, he was post-doc in Maastricht and Utrecht studying myocardial metabolism and the role of growth factors in long term renal and cardiac complications of diabetes mellitus. During this period he was trained in physiology, and he was registered as Medical Physiologist by the Dutch Committee for Medical-Biological Research Training (SMBWO) in 2001. In 2005, he was appointed as Assistant Professor at the Department of Physiology at Maastricht University, investigating cardiomyocyte-fibroblast interaction and the role of paracrine growth factor signalling in cardiac hypertrophy and heart failure.

An important focus of the research is the effect of electro-mechanical stimulation on the heart and on the isolated cardiac cell types: cardiomyocytes and fibroblasts. Aside from neurohumoral and local paracrine factors, it is becoming increasingly evident that electrical and mechanical signaling significantly determine cardiac structure and function both in health and in disease. Currently, the possible beneficial effect of electromechanical stimulation of the heart to improve myocardial infarct healing is studied. The effects of electromechanical stimulation are explored both in vivo and in vitro. Cardiomyocytes and fibroblasts are isolated from adult hearts and cultured separately and in co-culture, and the influence of electrical and mechanical stimulation is determined. Finally, 3D-cultures of cardiomyocytes and fibroblasts in engineered heart matrix are used to study the cellular function in a more physiological environment.

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2021
    • Wang, S. J., Schianchi, F., Neumann, D., Wong, L. Y., Sun, A. M., van Nieuwenhoven, F. A., Zeegers, M. P., Strzelecka, A., Col, U., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2021). Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis. Molecular Metabolism, 53, [101293].
    • Ploeg, M. C., Munts, C., Prinzen, F. W., Turner, N. A., van Bilsen, M., & van Nieuwenhoven, F. A. (2021). Piezo1 Mechanosensitive Ion Channel Mediates Stretch-Induced Nppb Expression in Adult Rat Cardiac Fibroblasts. Cells, 10(7), [1745].
  • 2019
    • Blythe, N. M., Muraki, K., Ludlow, M. J., Stylianidis, V., Gilbert, H. T. J., Evans, E. L., Cuthbertson, K., Foster, R., Swift, J., Li, J., Drinkhill, M. J., van Nieuwenhoven, F. A., Porter, K. E., Beech, D. J., & Turner, N. A. (2019). Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. Journal of Biological Chemistry, 294(46), 17395-17408.
  • 2018
    • Chau Nguyen, U., Verzaal, N. J., van Nieuwenhoven, F. A., Vernooy, K., & Prinzen, F. (2018). Pathobiology of cardiac dyssynchrony and resynchronization therapy. EP Europace, 20(12), 1898-1909.
    • Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A., & Schroen, B. (2018). MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure. Hypertension, 71(2), 280-288.
  • 2017
    • van Nieuwenhoven, F. A., Munts, C., op't Veld, R. C., Gonzalez, A., Diez, J., Heymans, S., Schroen, B., & van Bilsen, M. (2017). Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling. Scientific Reports, 7, [16042].
    • van Middendorp, L. B., Kuiper, M., Munts, C., Wouters, P., Maessen, J. G., van Nieuwenhoven, F. A., & Prinzen, F. W. (2017). Local microRNA-133a downregulation is associated with hypertrophy in the dyssynchronous heart. Esc heart failure, 4(3), 241-251.
  • 2014
    • van Bilsen, M., Daniels, A., Brouwers, O., Janssen, B. J. A., Derks, W. J. A., Brouns, A. E., Munts, C., Schalkwijk, C. G., van der Vusse, G. J., & van Nieuwenhoven, F. A. (2014). Hypertension Is a Conditional Factor for the Development of Cardiac Hypertrophy in Type 2 Diabetic Mice. PLOS ONE, 9(1), [e85078].
  • 2013
    • Van Neerven, S. G. A., Pannaye, P., Bozkurt, A., Van Nieuwenhoven, F., Joosten, E., Hermans, E., Taccola, G., & Deumens, R. (2013). SCHWANN CELL MIGRATION AND NEURITE OUTGROWTH ARE INFLUENCED BY MEDIA CONDITIONED BY EPINEURIAL FIBROBLASTS. Neuroscience, 252, 144-153.
    • Blaauw, E., Lorenzen-Schmidt, I., Babiker, F. A., Munts, C., Prinzen, F. W., Snoeckx, L. H., van Bilsen, M., van der Vusse, G. J., & van Nieuwenhoven, F. A. (2013). Stretch-Induced Upregulation of Connective Tissue Growth Factor in Rabbit Cardiomyocytes. Journal of Cardiovascular Translational Research, 6(5), 861-869.
    • Hall-Glenn, F., Aivazi, A., Akopyan, L., Ong, J. R., Baxter, R. R., Benya, P. D., Goldschmeding, R., van Nieuwenhoven, F. A., Hunziker, E. B., & Lyons, K. M. (2013). CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress. Journal of Cell Communication and Signaling, 7(3), 219-30.
    • Brouwers, O., de Vos-Houben, J. M., Niessen, P. M., Miyata, T., van Nieuwenhoven, F., Janssen, B. J., Hageman, G., Stehouwer, C. D., & Schalkwijk, C. G. (2013). Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression. International Journal of Molecular Sciences, 14(8), 15724-15739.
    • van Nieuwenhoven, F. A., & Turner, N. A. (2013). The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction. Vascular Pharmacology, 58(3), 182-188.
    • van Nieuwenhoven, F. A., Hemmings, K. E., Porter, K. E., & Turner, N. A. (2013). Combined effects of interleukin-1 alpha and transforming growth factor-beta 1 on modulation of human cardiac fibroblast function. Matrix Biology, 32(7-8), 399-406.
  • 2012
    • Daniels, A., Linz, D., van Bilsen, M., Ruetten, H., Sadowski, T., Ruf, S., Juretschke, H-P., Neumann-Haefelin, C., Munts, C., van der Vusse, G. J., & van Nieuwenhoven, F. A. (2012). Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats. European journal of heart failure, 14(2), 193-201.
  • 2010
    • van Bilsen, M., & van Nieuwenhoven, F. A. (2010). PPARs as therapeutic targets in cardiovascular disease. Expert Opinion on Therapeutic Targets, 14(10), 1029-1045.
    • Daniels, A., van Bilsen, M., Janssen, B. J. A., Brouns, A. E., Cleutjens, J. P. M., Roemen, T. H., Schaart, G., van der Velden, J., van der Vusse, G. J., & van Nieuwenhoven, F. A. (2010). Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling. Acta Physiologica, 200(1), 11-22.
    • Blaauw, E., van Nieuwenhoven, F. A., Willemsen, P., Delhaas, T., Prinzen, F. W., Snoeckx, L. H., van Bilsen, M., & van der Vusse, G. J. (2010). Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes. American Journal of Physiology-heart and Circulatory Physiology, 299(3), H780-H787.