Joost Lumens


Professor Joost Lumens studied Biomedical Engineering at the Eindhoven University of Technology where he obtained his MSc degree in Medical Engineering in 2005. He obtained his PhD degree in 2010 at Maastricht University (Dept. of Biomedical Engineering and Dept. of Physiology). During his PhD, he developed and validated a computational model of left-right ventricular interaction dynamics and applied it to study right ventricular failure in patients with pulmonary arterial hypertension. He continued his academic career as a post-doctoral fellow at the LIRYC Electrophysiology and Heart Modelling Institute of CHU de Bordeaux (France), where he combined computational, experimental and clinical data to unravel the working mechanisms of cardiac pacing therapies in the dyssynchronous failing heart.

Since 2012, he is working again at CARIM, where he leads the CircAdapt Research and Education team ( In 2021, he was appointed Professor of Computational Cardiology. His research team typically combines advanced computational modelling/simulation techniques with experimental and/or clinical data to gain mechanistic insight in cardiac diseases and their treatments. Importantly, translation of novel mechanistic insights into diagnostic, therapeutic and educational improvement is always pursued. Prof Joost Lumens received prestigious personal (Dutch Heart Foundation & NWO Vidi) and EU consortium funding (H2020 ERA-NET EraCoSysMed Joint Transnational Call 2015; ERA-CVD Joint Transnational Call 2018, coordinator of EMPATHY project; Marie Curie Intelligent Ultrasound, MARCIUS) for projects focussed on computational cardiac electro-mechanics and hemodynamics. He was the chairperson of the European Society of Cardiology (ESC) working group on e-Cardiology (2018-2020) and serves as deputy editor of the European Heart Journal – Digital Health.

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H3.362
T: +31(0)43 388 16 66

  • 2023
    • Weerts, J., Amin, H., Barandiarán Aizpurua, A., Gevaert, A. B., Handoko, M. L., Dauw, J., Tun, H. N., Rommel, K-P., Verbrugge, F. H., Kresoja, K-P., Sanders-van Wijk, S., Brunner-La Rocca, H-P., Bayés-Genís, A., Lumens, J., Knackstedt, C., & van Empel, V. P. M. (2023). Webtool to enhance the accuracy of diagnostic algorithms for HFpEF: a prospective cross-over study. Esc heart failure.
    • Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2023). Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization. The Journal of Physiology. Advance online publication.
    • Kirkels, F. P., van Osta, N., Rootwelt-Norberg, C., Chivulescu, M., van Loon, T., Aabel, E. W., Castrini, A. I., Lie, Ø. H., Asselbergs, F. W., Delhaas, T., Cramer, M. J., Teske, A. J., Haugaa, K. H., & Lumens, J. (2023). Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum. Journal of the American College of Cardiology, 82(9), 785-797.
    • Beela, A. S., Manetti, C. A., Lyon, A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2023). Impact of Estimated Left Atrial Pressure on Cardiac Resynchronization Therapy Outcome. Journal of Clinical Medicine, 12(15), Article 4908.
    • Kirkels, F. P., Rootwelt-Norberg, C., Bosman, L. P., Aabel, E. W., Muller, S., Castrini, A. I., Taha, K., van Osta, N., Lie, Ø. H., Asselbergs, F. W., Lumens, J., Te Riele, A. S. J. M., Hasselberg, N. E., Cramer, M. J., Haugaa, K., & Teske, A. J. (2023). The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy. European heart journal. Cardiovascular Imaging, 1-9. Article jead174. Advance online publication.
    • van Mourik, M. J. W., Linz, D., Verwijs, H. J. A., Bekkers, S. C. A. M., Weerts, J., Schotten, U., Rocca, H. B-L., Lumens, J., Crijns, H. J. G. M., Weijs, B., & Knackstedt, C. (2023). Evaluating subclinical left ventricular and left atrial dysfunction in idiopathic atrial fibrillation: A speckle-tracking based strain-analysis. International Journal of Cardiology, 383, 159-165. Advance online publication.
    • Munneke, A. G., Lumens, J., Arts, T., Prinzen, F. W., & Delhaas, T. (2023). Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model. Journal of Applied Physiology, 135(3), 489-499.
    • Meiburg, R., Rijks, J. H. J., Beela, A. S., Bressi, E., Grieco, D., Delhaas, T., Luermans, J. G. L. M., Prinzen, F. W., Vernooy, K., & Lumens, J. (2023). Comparison of novel ventricular pacing strategies using an electro-mechanical simulation platform. EP Europace, 25(6), 1-11. Article euad144.
    • Knackstedt, C., Schummers, G., Schroder, J., Marx, N., Lumens, J., Sanders-van Wijk, S., Ramaekers, B., Becker, M., van Empel, V., Brunner-La Rocca, H. P., & PsychEcho study group (2023). A graphical analysis of aspects contributing to the spreading of measurements of left ventricular function. International Journal of Cardiovascular Imaging, 39(5), 915-927. Advance online publication.
    • Hermans, A. N. L., Isaksen, J. L., Gawalko, M., Pluymaekers, N. A. H. A., van der Velden, R. M. J., Snippe, H., Evens, S., De Witte, G., Luermans, J. G. L. M., Manninger, M., Lumens, J., Kanters, J. K., & Linz, D. (2023). Accuracy of continuous photoplethysmography-based 1 min mean heart rate assessment during atrial fibrillation. EP Europace, 25(3), 835-844. Advance online publication.
    • De Jaegere, P., Van Der Boon, R., Lumens, J., & Bruining, N. (2023). PubMed indexation for the European Heart Journal - Digital Health: a small step for the European Heart Journal family, a giant leap in the digital future of cardiovascular disease management. European Heart Journal - Digital Health, 4(2), 63-64. Article ztad013.
    • Prinzen, F. W., Lumens, J., Duchenne, J., & Vernooy, K. (2023). Electro-energetics of Biventricular, Septal and Conduction System Pacing (vol 10, pg 250, 2021). Arrhythmia & Electrophysiology Review, 12, Article e19.
    • HENKENS, MICHIEL. T. H. M., RAAFS, ANNE. G., VANLOON, T. I. M., VOS, JACQUELINE. L., VANDENWIJNGAARD, ARTHUR., BRUNNER, HAN. G., KRAPELS, INGRID. P. C., KNACKSTEDT, CHRISTIAN., GERRETSEN, SUZANNE., HAZEBROEK, MARK. R., VERNOOY, KEVIN., NIJVELDT, ROBIN., LUMENS, JOOST., & VERDONSCHOT, JOB. A. J. (2023). Left Atrial Function in Patients with Titin Cardiomyopathy. Journal of Cardiac Failure. Advance online publication.
    • Akdeniz, M., Manetti, C. A., Koopsen, T., Mirar, H. N., Snare, S. R., Aase, S. A., Lumens, J., Sprem, J., & McLeod, K. S. (2023). Deep Learning for Multi-Level Detection and Localization of Myocardial Scars Based on Regional Strain Validated on Virtual Patients. IEEE Access, 11, 15788-15798.
  • 2022
    • van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcão-Pires, I., Ferdinandy, P., ... Thum, T. (2022). Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research, 118(15), 3016-3051. Advance online publication.
    • Guasti, L., Dilaveris, P., Mamas, M. A., Richter, D., Christodorescu, R., Lumens, J., Schuuring, M. J., Carugo, S., Afilalo, J., Ferrini, M., Asteggiano, R., & Cowie, M. R. (2022). Digital health in older adults for the prevention and management of cardiovascular diseases and frailty. A clinical consensus statement from the ESC Council for Cardiology Practice/Taskforce on Geriatric Cardiology, the ESC Digital Health Committee and the ESC Working Group on e-Cardiology. Esc heart failure, 9(5), 2808-2822. Advance online publication.
    • Dilaveris, P. E., Antoniou, C. K., Caiani, E. G., Casado-Arroyo, R., Climent, A. Μ., Cluitmans, M., Cowie, M. R., Doehner, W., Guerra, F., Jensen, M. T., Kalarus, Z., Locati, E. T., Platonov, P., Simova, I., Schnabel, R. B., Schuuring, M., Tsivgoulis, G., & Lumens, J. (2022). ESC Working Group on e-Cardiology Position Paper: accuracy and reliability of electrocardiogram monitoring in the detection of atrial fibrillation in cryptogenic stroke patients : In collaboration with the Council on Stroke, the European Heart Rhythm Association, and the Digital Health Committee. European Heart Journal - Digital Health, 3(3), 341-358.
    • Van Mourik, M. J. W., Arita, V. A., Lyon, A., Lumens, J., De With, R. R., van Melle, J. P., Schotten, U., Bekkers, S. C. A. M., Crijns, H. J. G. M., Van Gelder, I. C., Rienstra, M., & Linz, D. K. (2022). Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK. International Journal of Cardiology, 360, 29-35. Advance online publication.
    • Bouwmeester, S., van Loon, T., Ploeg, M., Mast, T. P., Verzaal, N. J., van Middendorp, L. B., Strik, M., van Nieuwenhoven, F. A., Dekker, L. R., Prinzen, F. W., Lumens, J., & Houthuizen, P. (2022). Left atrial remodeling in mitral regurgitation: A combined experimental-computational study. PLOS ONE, 17(7), Article e0271588.
    • Rijks, J., Luermans, J., Heckman, L., van Stipdonk, A. M. W., Prinzen, F., Lumens, J., & Vernooy, K. (2022). Physiology of Left Ventricular Septal Pacing and Left Bundle Branch Pacing. Cardiac Electrophysiology Clinics, 14(2), 181-189.
    • Koopsen, T., Van Osta, N., Van Loon, T., Van Nieuwenhoven, F. A., Prinzen, F. W., Van Klarenbosch, B. R., Kirkels, F. P., Teske, A. J., Vernooy, K., Delhaas, T., & Lumens, J. (2022). A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease. Frontiers in physiology, 13, Article 782592.
    • Salden, F. C. W. M., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Atrioventricular dromotropathy: an important substrate for complete resynchronization therapy-Authors' reply. EP Europace, 24(5), 868-869. Advance online publication.
    • Salden, F. C. W. M., Huntjens, P. R., Schreurs, R., Willemen, E., Kuiper, M., Wouters, P., Maessen, J. G., Bordachar, P., Delhaas, T., Luermans, J., Meine, M., Allaart, C. P., van Stipdonk, A. M. W., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Pacing therapy for atrioventricular dromotropathy: a combined computational-experimental-clinical study. EP Europace, 24(5), 784-795. Advance online publication.
    • Ribeiro, J. M., Astudillo, P., de Backer, O., Budde, R., Nuis, R. J., Goudzwaard, J., Van Mieghem, N. M., Lumens, J., Mortier, P., Mattace-Raso, F., Boersma, E., Cummins, P., Bruining, N., & de Jaegere, P. P. (2022). Artificial Intelligence and Transcatheter Interventions for Structural Heart Disease: A glance at the (near) future. Trends in Cardiovascular Medicine, 32(3), 153-159. Advance online publication.
    • Munneke, A. G., Lumens, J., Arts, T., & Delhaas, T. (2022). A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling. Frontiers in physiology, 13, Article 830925.
    • de Groot, N. M. S., Shah, D., Boyle, P. M., Anter, E., Clifford, G. D., Deisenhofer, I., Deneke, T., van Dessel, P., Doessel, O., Dilaveris, P., Heinzel, F. R., Kapa, S., Lambiase, P. D., Lumens, J., Platonov, P. G., Ngarmukos, T., Martinez, J. P., Sanchez, A. O., Takahashi, Y., ... Linz, D. (2022). Critical appraisal of technologies to assess electrical activity during atrial fibrillation: a position paper from the European Heart Rhythm Association and European Society of Cardiology Working Group on eCardiology in collaboration with the Heart Rhythm Society, Asia Pacific Heart Rhythm Society, Latin American Heart Rhythm Society and Computing in Cardiology. EP Europace, 24(2), 313–330. Advance online publication.
    • Villalobos Lizardi, J. C., Baranger, J., Nguyen, M. B., Asnacios, A., Malik, A., Lumens, J., Mertens, L., Friedberg, M., Simmons, C. A., Pernot, M., & Villemain, O. (2022). A guide for assessment of myocardial stiffness in health and disease. Nature cardiovascular research, 1, 8-22.
    • Munneke, A. G., Lumens, J., & Delhaas, T. (2022). Cardiovascular fetal-to-neonatal transition: an in silico model. Pediatric Research, 91(1), 116-128. Advance online publication.
    • Weerts, J., Barandiarán Aizpurua, A., Henkens, M. T. H. M., Lyon, A., van Mourik, M. J. W., van Gemert, M. R. A. A., Raafs, A., Sanders-van Wijk, S., Bayés-Genís, A., Heymans, S. R. B., Crijns, H. J. G. M., Brunner-La Rocca, H-P., Lumens, J., van Empel, V. P. M., & Knackstedt, C. (2022). The prognostic impact of mechanical atrial dysfunction and atrial fibrillation in heart failure with preserved ejection fraction. European Heart Journal Cardiovascular Imaging, 23(1), 74-84. Advance online publication.
  • 2021
    • Augustin, C. M., Gsell, M. A. F., Karabelas, E., Willemen, E., Prinzen, F. W., Lumens, J., Vigmond, E. J., & Plank, G. (2021). A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation. Computer Methods in Applied Mechanics and Engineering, 386, Article 114092.
    • Prinzen, F. W., Lumens, J., Duchenn, J., & Vernooy, K. (2021). Electro-energetics of Biventricular, Septal and Conduction System Pacing. Arrhythmia & Electrophysiology Review, 10(4), 250-257.
    • de Jaegere, P., Lumens, J., & Bruining, N. (2021). The 1-year anniversary of the European Heart Journal – Digital Health. European Heart Journal - Digital Health, 2(4), 548–549.
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Understanding the effects of heart beat irregularity on ventricular function in human atrial fibrillation: simulation models may help to untie the knot-Authors' reply. EP Europace, 23(11), 1869-1869.
    • van Osta, N., Kirkels, F. P., van Loon, T., Koopsen, T., Lyon, A., Meiburg, R., Huberts, W., Cramer, M. J., Delhaas, T., Haugaa, K. H., Teske, A. J., & Lumens, J. (2021). Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling. Frontiers in physiology, 12, Article 738926.
    • Lumens, J., Koopsen, T., & Beela, A. S. (2021). What Do We Gain From Septal Strain?JACC-Cardiovascular Imaging, 14(9), 1703-1706.
    • de Jaegere, P., Lumens, J., & Bruining, N. (2021). The 12-lead surface electrocardiogram: a sheet of paper or a realm of concealed information asking for deep learning analysis. European Heart Journal - Digital Health, 2(3), 356–357.
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. EP Europace, 23, I21-I28.
    • van Osta, N., Kirkels, F., Lyon, A., Koopsen, T., van Loon, T., Cramer, M-J., Teske, A. J., Delhaas, T., & Lumens, J. (2021). Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations. EP Europace, 23, I153-I160.
    • Dilaveris, P., & Lumens, J. (2021). The ESC Working Group on e-Cardiology. European Heart Journal, 42(2), 143-144.
  • 2020
    • Sutanto, H., Lyon, A., Lumens, J., Schotten, U., Dobrev, D., & Heijman, J. (2020). Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies. Progress in Biophysics & Molecular Biology, 157, 54-75.
    • Prinzen, F. W., & Lumens, J. (2020). Investigating myocardial work as a CRT response predictor is not a waste of work. European Heart Journal, 41(39), 3824-3826.
    • Dilaveris, P., Casado-Arroyo, R., & Lumens, J. (2020). A roadmap to nationwide monitoring of Cardiovascular Implantable Electronic Devices in Greece: staying safe in the era of COVID-19 pandemic. Hellenic Journal of Cardiology, 61(6), 396-397.
    • Lyon, A., Dupuis, L. J., Arts, T., Crijns, H. J. G. M., Prinzen, F. W., Delhaas, T., Heijman, J., & Lumens, J. (2020). Differentiating the effects of β-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. American Journal of Physiology-heart and Circulatory Physiology, 319(3), H519-H530.
    • Lumens, J., Willemen, E., & Prinzen, F. W. (2020). Does the Right Go Wrong During Cardiac Resynchronization Therapy?JACC-Cardiovascular Imaging, 13(7), 1485-1488.
    • van Osta, N., Lyon, A., Kirkels, F., Koopsen, T., van Loon, T., Cramer, M. J., Teske, A. J., Delhaas, T., Huberts, W., & Lumens, J. (2020). Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173), Article 20190347.
    • Gauthey, A., Willemen, E., Lumens, J., Ploux, S., Bordachar, P., Ritter, P., Prinzen, F. W., Lejeune, S., Pouleur, A-C., Garnir, Q., Marchandise, S., Scavee, C., Wauters, A., & De Waroux, J-B. L. P. (2020). Impact of paced left ventricular dyssynchrony on left ventricular reverse remodeling after cardiac resynchronization therapy. Journal of Cardiovascular Electrophysiology, 31(2), 494-502.
    • Verdonschot, J. A. J., Merken, J. J., Brunner-La Rocca, H-P., Hazebroek, M. R., Eurlings, C. G. M. J., Thijssen, E., Wang, P., Weerts, J., van Empel, V., Schummers, G., Schreckenberg, M., van den Wijngaard, A., Lumens, J., Brunner, H. G., Heymans, S. R. B., Krapels, I. P. C., & Knackstedt, C. (2020). Value of Speckle Tracking-Based Deformation Analysis in Screening Relatives of Patients With Asymptomatic Dilated Cardiomyopathy. JACC-Cardiovascular Imaging, 13(2), 549-558.
    • van Loon, T., Knackstedt, C., Cornelussen, R., Reesink, K., Brunner-La Rocca, H., Delhaas, T., van Empel, V., & Lumens, J. (2020). Increased myocardial stiffness more than impaired relaxation function limits cardiac performance during exercise in heart failure with preserved ejection fraction: a virtual patient study. European Heart Journal - Digital Health, 1(1), 40-50.
  • 2019
    • Gorcsan, J., & Lumens, J. (2019). Opposing Wall Pushing and Stretching: Response to Cardiac Resynchronization Therapy Requires Electrical Delay and Viability. JACC-Cardiovascular Imaging, 12(12), 2414-2416.
    • Walmsley, J., Squara, P., Wolfhard, U., Cornelussen, R., & Lumens, J. (2019). Impact of abrupt versus gradual correction of mitral and tricuspid regurgitation: a modelling study. Eurointervention, 15(10), 902-911.