Joost Lumens

Professor

Professor Joost Lumens studied Biomedical Engineering at the Eindhoven University of Technology where he obtained his MSc degree in Medical Engineering in 2005. He obtained his PhD degree in 2010 at Maastricht University (Dept. of Biomedical Engineering and Dept. of Physiology). During his PhD, he developed and validated a computational model of left-right ventricular interaction dynamics and applied it to study right ventricular failure in patients with pulmonary arterial hypertension. He continued his academic career as a post-doctoral fellow at the LIRYC Electrophysiology and Heart Modelling Institute of CHU de Bordeaux (France), where he combined computational, experimental and clinical data to unravel the working mechanisms of cardiac pacing therapies in the dyssynchronous failing heart.

Since 2012, he is working again at CARIM, where he leads the CircAdapt Research and Education team (www.circadapt.org). In 2021, he was appointed Professor of Computational Cardiology. His research team typically combines advanced computational modelling/simulation techniques with experimental and/or clinical data to gain mechanistic insight in cardiac diseases and their treatments. Importantly, translation of novel mechanistic insights into diagnostic, therapeutic and educational improvement is always pursued. Prof Joost Lumens received prestigious personal (Dutch Heart Foundation & NWO Vidi) and EU consortium funding (H2020 ERA-NET EraCoSysMed Joint Transnational Call 2015; ERA-CVD Joint Transnational Call 2018, coordinator of EMPATHY project; Marie Curie Intelligent Ultrasound, MARCIUS) for projects focussed on computational cardiac electro-mechanics and hemodynamics. He was the chairperson of the European Society of Cardiology (ESC) working group on e-Cardiology (2018-2020) and serves as deputy editor of the European Heart Journal – Digital Health.

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H3.362
T: +31(0)43 388 16 66

  • 2024
    • Koopsen, T., van Osta, N., van Loon, T., Meiburg, R., Huberts, W., Beela, A. S., Kirkels, F. P., van Klarenbosch, B. R., Teske, A. J., Cramer, M. J., Bijvoet, G. P., van Stipdonk, A., Vernooy, K., Delhaas, T., & Lumens, J. (2024). Parameter subset reduction for imaging-based digital twin generation of patients with left ventricular mechanical discoordination. Biomedical Engineering Online, 23(1), Article 46. https://doi.org/10.1186/s12938-024-01232-0
    • Arts, T., Lyon, A., Delhaas, T., Kuster, D. W. D., van der Velden, J., & Lumens, J. (2024). Translating myosin-binding protein C and titin abnormalities to whole-heart function using a novel calcium-contraction coupling model. Journal of Molecular and Cellular Cardiology, 190, 13-23. https://doi.org/10.1016/j.yjmcc.2024.03.001
    • Dhont, S., van den Acker, G., van Loon, T., Verbrugge, F. H., Verwerft, J., Deferm, S., Churchill, T. W., Mullens, W., Lumens, J., & Bertrand, P. B. (2024). Mitral regurgitation in heart failure with preserved ejection fraction: The interplay of valve, ventricle, and atrium. European journal of heart failure, 26(4), 974-983. https://doi.org/10.1002/ejhf.3231
    • Ložek, M., Kovanda, J., Kubuš, P., Vrbík, M., Lhotská, L., Lumens, J., Delhaas, T., & Janoušek, J. (2024). How to assess and treat right ventricular electromechanical dyssynchrony in post-repair tetralogy of Fallot: insights from imaging, invasive studies and computational modelling. EP Europace, 26(2), Article euae024. https://doi.org/10.1093/europace/euae024
    • Koopsen, T., Gerrits, W., van Osta, N., van Loon, T., Wouters, P., Prinzen, F. W., Vernooy, K., Delhaas, T., Teske, A. J., Meine, M., Cramer, M. J., & Lumens, J. (2024). Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. EP Europace, 26(1), Article euae009. https://doi.org/10.1093/europace/euae009
    • Eerenberg, F., Luermans, J., Lumens, J., Nguyên, U. C., Vernooy, K., & van Stipdonk, A. (2024). Exploring QRS Area beyond Patient Selection in CRT-Can It Guide Left Ventricular Lead Placement?Journal of Cardiovascular Development and Disease, 11(1), Article 18. https://doi.org/10.3390/jcdd11010018
    • Stankovic, I., Voigt, J.-U., Burri, H., Muraru, D., Sade, L. E., Haugaa, K. H., Lumens, J., Biffi, M., Dacher, J.-N., Marsan, N. A., Bakelants, E., Manisty, C., Dweck, M. R., Smiseth, O. A., & Donal, E. (2024). Imaging in patients with cardiovascular implantable electronic devices: part 2-imaging after device implantation. A clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI) and the European Heart Rhythm Association (EHRA) of the ESC. European Heart Journal Cardiovascular Imaging, 25(1), E33-E54. Article jead273. https://doi.org/10.1093/ehjci/jead273
    • Stankovic, I., Voigt, J.-U., Burri, H., Muraru, D., Sade, L. E., Haugaa, K. H., Lumens, J., Biffi, M., Dacher, J.-N., Marsan, N. A., Bakelants, E., Manisty, C., Dweck, M. R., Smiseth, O. A., & Donal, E. (2024). Imaging in patients with cardiovascular implantable electronic devices: part 1-imaging before and during device implantation. A clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI) and the European Heart Rhythm Association (EHRA) of the ESC. European Heart Journal Cardiovascular Imaging, 25(1), e1–e32. https://doi.org/10.1093/ehjci/jead272
    • HENKENS, MICHIEL. T. H. M., RAAFS, ANNE. G., VANLOON, T. I. M., VOS, JACQUELINE. L., VANDENWIJNGAARD, ARTHUR., BRUNNER, HAN. G., KRAPELS, INGRID. P. C., KNACKSTEDT, CHRISTIAN., GERRETSEN, SUZANNE., HAZEBROEK, MARK. R., VERNOOY, KEVIN., NIJVELDT, ROBIN., LUMENS, JOOST., & VERDONSCHOT, JOB. A. J. (2024). Left Atrial Function in Patients with Titin Cardiomyopathy. Journal of Cardiac Failure, 30(1), 51-60. https://doi.org/10.1016/j.cardfail.2023.05.013
  • 2023
    • Tamargo, M., Martínez-Legazpi, P., Espinosa, M. Á., Lyon, A., Méndez, I., Gutiérrez-Ibañes, E., Fernández, A. I., Prieto-Arévalo, R., González-Mansilla, A., Arts, T., Delhaas, T., Mombiela, T., Sanz-Ruiz, R., Elízaga, J., Yotti, R., Tschöpe, C., Fernández-Avilés, F., Lumens, J., & Bermejo, J. (2023). Increased Chamber Resting Tone Is a Key Determinant of Left Ventricular Diastolic Dysfunction. Circulation-Heart Failure, 16(12), E010673. Article 010673. https://doi.org/10.1161/CIRCHEARTFAILURE.123.010673
    • Kirkels, F. P., Rootwelt-Norberg, C., Bosman, L. P., Aabel, E. W., Muller, S., Castrini, A. I., Taha, K., van Osta, N., Lie, Ø. H., Asselbergs, F. W., Lumens, J., Te Riele, A. S. J. M., Hasselberg, N. E., Cramer, M. J., Haugaa, K., & Teske, A. J. (2023). The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy. European heart journal. Cardiovascular Imaging, 24(12), 1710-1718. Article jead174. https://doi.org/10.1093/ehjci/jead174
    • Weerts, J., Amin, H., Barandiarán Aizpurua, A., Gevaert, A. B., Handoko, M. L., Dauw, J., Tun, H. N., Rommel, K.-P., Verbrugge, F. H., Kresoja, K.-P., Sanders-van Wijk, S., Brunner-La Rocca, H.-P., Bayés-Genís, A., Lumens, J., Knackstedt, C., & van Empel, V. P. M. (2023). Webtool to enhance the accuracy of diagnostic algorithms for HFpEF: a prospective cross-over study. Esc heart failure, 10(6), 3493 - 3503. https://doi.org/10.1002/ehf2.14525
    • Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2023). Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization. The Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP284439
    • Munneke, A. G., Lumens, J., Arts, T., Prinzen, F. W., & Delhaas, T. (2023). Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model. Journal of Applied Physiology, 135(3), 489-499. https://doi.org/10.1152/japplphysiol.00181.2023
    • Kirkels, F. P., van Osta, N., Rootwelt-Norberg, C., Chivulescu, M., van Loon, T., Aabel, E. W., Castrini, A. I., Lie, Ø. H., Asselbergs, F. W., Delhaas, T., Cramer, M. J., Teske, A. J., Haugaa, K. H., & Lumens, J. (2023). Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum. Journal of the American College of Cardiology, 82(9), 785-797. https://doi.org/10.1016/j.jacc.2023.05.065
    • Beela, A. S., Manetti, C. A., Lyon, A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2023). Impact of Estimated Left Atrial Pressure on Cardiac Resynchronization Therapy Outcome. Journal of Clinical Medicine, 12(15), Article 4908. https://doi.org/10.3390/jcm12154908
    • van Mourik, M. J. W., Linz, D., Verwijs, H. J. A., Bekkers, S. C. A. M., Weerts, J., Schotten, U., Rocca, H. B.-L., Lumens, J., Crijns, H. J. G. M., Weijs, B., & Knackstedt, C. (2023). Evaluating subclinical left ventricular and left atrial dysfunction in idiopathic atrial fibrillation: A speckle-tracking based strain-analysis. International Journal of Cardiology, 383(1), 159-165. https://doi.org/10.1016/j.ijcard.2023.04.024
    • Meiburg, R., Rijks, J. H. J., Beela, A. S., Bressi, E., Grieco, D., Delhaas, T., Luermans, J. G. L. M., Prinzen, F. W., Vernooy, K., & Lumens, J. (2023). Comparison of novel ventricular pacing strategies using an electro-mechanical simulation platform. EP Europace, 25(6), 1-11. Article euad144. https://doi.org/10.1093/europace/euad144
    • Knackstedt, C., Schummers, G., Schroder, J., Marx, N., Lumens, J., Sanders-van Wijk, S., Ramaekers, B., Becker, M., van Empel, V., Brunner-La Rocca, H. P., & PsychEcho study group (2023). A graphical analysis of aspects contributing to the spreading of measurements of left ventricular function. International Journal of Cardiovascular Imaging, 39(5), 915-927. https://doi.org/10.1007/s10554-023-02796-z
    • Hermans, A. N. L., Isaksen, J. L., Gawalko, M., Pluymaekers, N. A. H. A., van der Velden, R. M. J., Snippe, H., Evens, S., De Witte, G., Luermans, J. G. L. M., Manninger, M., Lumens, J., Kanters, J. K., & Linz, D. (2023). Accuracy of continuous photoplethysmography-based 1 min mean heart rate assessment during atrial fibrillation. EP Europace, 25(3), 835-844. https://doi.org/10.1093/europace/euad011
    • De Jaegere, P., Van Der Boon, R., Lumens, J., & Bruining, N. (2023). PubMed indexation for the European Heart Journal - Digital Health: a small step for the European Heart Journal family, a giant leap in the digital future of cardiovascular disease management. European Heart Journal - Digital Health, 4(2), 63-64. Article ztad013. https://doi.org/10.1093/ehjdh/ztad013
    • Prinzen, F. W., Lumens, J., Duchenne, J., & Vernooy, K. (2023). Erratum to: Electro-energetics of Biventricular, Septal and Conduction System Pacing. Arrhythmia & Electrophysiology Review, 12, Article e19. https://doi.org/10.15420/aer.2023.12.er1
    • Akdeniz, M., Manetti, C. A., Koopsen, T., Mirar, H. N., Snare, S. R., Aase, S. A., Lumens, J., Sprem, J., & McLeod, K. S. (2023). Deep Learning for Multi-Level Detection and Localization of Myocardial Scars Based on Regional Strain Validated on Virtual Patients. IEEE Access, 11(1), 15788-15798. https://doi.org/10.1109/ACCESS.2023.3243254
  • 2022
    • van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcão-Pires, I., Ferdinandy, P., ... Thum, T. (2022). Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research, 118(15), 3016-3051. https://doi.org/10.1093/cvr/cvab370
    • Guasti, L., Dilaveris, P., Mamas, M. A., Richter, D., Christodorescu, R., Lumens, J., Schuuring, M. J., Carugo, S., Afilalo, J., Ferrini, M., Asteggiano, R., & Cowie, M. R. (2022). Digital health in older adults for the prevention and management of cardiovascular diseases and frailty. A clinical consensus statement from the ESC Council for Cardiology Practice/Taskforce on Geriatric Cardiology, the ESC Digital Health Committee and the ESC Working Group on e-Cardiology. Esc heart failure, 9(5), 2808-2822. https://doi.org/10.1002/ehf2.14022
    • Dilaveris, P. E., Antoniou, C. K., Caiani, E. G., Casado-Arroyo, R., Climent, A. Μ., Cluitmans, M., Cowie, M. R., Doehner, W., Guerra, F., Jensen, M. T., Kalarus, Z., Locati, E. T., Platonov, P., Simova, I., Schnabel, R. B., Schuuring, M., Tsivgoulis, G., & Lumens, J. (2022). ESC Working Group on e-Cardiology Position Paper: accuracy and reliability of electrocardiogram monitoring in the detection of atrial fibrillation in cryptogenic stroke patients : In collaboration with the Council on Stroke, the European Heart Rhythm Association, and the Digital Health Committee. European Heart Journal - Digital Health, 3(3), 341-358. https://doi.org/10.1093/ehjdh/ztac026
    • Van Mourik, M. J. W., Arita, V. A., Lyon, A., Lumens, J., De With, R. R., van Melle, J. P., Schotten, U., Bekkers, S. C. A. M., Crijns, H. J. G. M., Van Gelder, I. C., Rienstra, M., & Linz, D. K. (2022). Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK. International Journal of Cardiology, 360, 29-35. https://doi.org/10.1016/j.ijcard.2022.05.044
    • Bouwmeester, S., van Loon, T., Ploeg, M., Mast, T. P., Verzaal, N. J., van Middendorp, L. B., Strik, M., van Nieuwenhoven, F. A., Dekker, L. R., Prinzen, F. W., Lumens, J., & Houthuizen, P. (2022). Left atrial remodeling in mitral regurgitation: A combined experimental-computational study. PLOS ONE, 17(7), Article e0271588. https://doi.org/10.1371/journal.pone.0271588
    • Rijks, J., Luermans, J., Heckman, L., van Stipdonk, A. M. W., Prinzen, F., Lumens, J., & Vernooy, K. (2022). Physiology of Left Ventricular Septal Pacing and Left Bundle Branch Pacing. Cardiac Electrophysiology Clinics, 14(2), 181-189. https://doi.org/10.1016/j.ccep.2021.12.010
    • Koopsen, T., Van Osta, N., Van Loon, T., Van Nieuwenhoven, F. A., Prinzen, F. W., Van Klarenbosch, B. R., Kirkels, F. P., Teske, A. J., Vernooy, K., Delhaas, T., & Lumens, J. (2022). A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease. Frontiers in physiology, 13, Article 782592. https://doi.org/10.3389/fphys.2022.782592
    • Salden, F. C. W. M., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Atrioventricular dromotropathy: an important substrate for complete resynchronization therapy-Authors' reply. EP Europace, 24(5), 868-869. https://doi.org/10.1093/europace/euac037
    • Salden, F. C. W. M., Huntjens, P. R., Schreurs, R., Willemen, E., Kuiper, M., Wouters, P., Maessen, J. G., Bordachar, P., Delhaas, T., Luermans, J., Meine, M., Allaart, C. P., van Stipdonk, A. M. W., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Pacing therapy for atrioventricular dromotropathy: a combined computational-experimental-clinical study. EP Europace, 24(5), 784-795. https://doi.org/10.1093/europace/euab248
    • Ribeiro, J. M., Astudillo, P., de Backer, O., Budde, R., Nuis, R. J., Goudzwaard, J., Van Mieghem, N. M., Lumens, J., Mortier, P., Mattace-Raso, F., Boersma, E., Cummins, P., Bruining, N., & de Jaegere, P. P. (2022). Artificial Intelligence and Transcatheter Interventions for Structural Heart Disease: A glance at the (near) future. Trends in Cardiovascular Medicine, 32(3), 153-159. https://doi.org/10.1016/j.tcm.2021.02.002
    • Munneke, A. G., Lumens, J., Arts, T., & Delhaas, T. (2022). A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling. Frontiers in physiology, 13, Article 830925. https://doi.org/10.3389/fphys.2022.830925
    • de Groot, N. M. S., Shah, D., Boyle, P. M., Anter, E., Clifford, G. D., Deisenhofer, I., Deneke, T., van Dessel, P., Doessel, O., Dilaveris, P., Heinzel, F. R., Kapa, S., Lambiase, P. D., Lumens, J., Platonov, P. G., Ngarmukos, T., Martinez, J. P., Sanchez, A. O., Takahashi, Y., ... Linz, D. (2022). Critical appraisal of technologies to assess electrical activity during atrial fibrillation: a position paper from the European Heart Rhythm Association and European Society of Cardiology Working Group on eCardiology in collaboration with the Heart Rhythm Society, Asia Pacific Heart Rhythm Society, Latin American Heart Rhythm Society and Computing in Cardiology. EP Europace, 24(2), 313–330. https://doi.org/10.1093/europace/euab254
    • Villalobos Lizardi, J. C., Baranger, J., Nguyen, M. B., Asnacios, A., Malik, A., Lumens, J., Mertens, L., Friedberg, M., Simmons, C. A., Pernot, M., & Villemain, O. (2022). A guide for assessment of myocardial stiffness in health and disease. Nature cardiovascular research, 1, 8-22. https://doi.org/10.1038/s44161-021-00007-3
    • Munneke, A. G., Lumens, J., & Delhaas, T. (2022). Cardiovascular fetal-to-neonatal transition: an in silico model. Pediatric Research, 91(1), 116-128. https://doi.org/10.1038/s41390-021-01401-0
    • Weerts, J., Barandiarán Aizpurua, A., Henkens, M. T. H. M., Lyon, A., van Mourik, M. J. W., van Gemert, M. R. A. A., Raafs, A., Sanders-van Wijk, S., Bayés-Genís, A., Heymans, S. R. B., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Lumens, J., van Empel, V. P. M., & Knackstedt, C. (2022). The prognostic impact of mechanical atrial dysfunction and atrial fibrillation in heart failure with preserved ejection fraction. European Heart Journal Cardiovascular Imaging, 23(1), 74-84. https://doi.org/10.1093/ehjci/jeab222
  • 2021
    • Augustin, C. M., Gsell, M. A. F., Karabelas, E., Willemen, E., Prinzen, F. W., Lumens, J., Vigmond, E. J., & Plank, G. (2021). A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation. Computer Methods in Applied Mechanics and Engineering, 386, Article 114092. https://doi.org/10.1016/j.cma.2021.114092
    • Prinzen, F. W., Lumens, J., Duchenn, J., & Vernooy, K. (2021). Electro-energetics of Biventricular, Septal and Conduction System Pacing. Arrhythmia & Electrophysiology Review, 10(4), 250-257. https://doi.org/10.15420/aer.2021.30
    • de Jaegere, P., Lumens, J., & Bruining, N. (2021). The 1-year anniversary of the European Heart Journal – Digital Health. European Heart Journal - Digital Health, 2(4), 548–549. https://doi.org/10.1093/ehjdh/ztab100
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Understanding the effects of heart beat irregularity on ventricular function in human atrial fibrillation: simulation models may help to untie the knot-Authors' reply. EP Europace, 23(11), 1869-1869. https://doi.org/10.1093/europace/euab144
    • van Osta, N., Kirkels, F. P., van Loon, T., Koopsen, T., Lyon, A., Meiburg, R., Huberts, W., Cramer, M. J., Delhaas, T., Haugaa, K. H., Teske, A. J., & Lumens, J. (2021). Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling. Frontiers in physiology, 12, Article 738926. https://doi.org/10.3389/fphys.2021.738926
    • Lumens, J., Koopsen, T., & Beela, A. S. (2021). What Do We Gain From Septal Strain?JACC-Cardiovascular Imaging, 14(9), 1703-1706. https://doi.org/10.1016/j.jcmg.2021.05.010
    • de Jaegere, P., Lumens, J., & Bruining, N. (2021). The 12-lead surface electrocardiogram: a sheet of paper or a realm of concealed information asking for deep learning analysis. European Heart Journal - Digital Health, 2(3), 356–357. https://doi.org/10.1093/ehjdh/ztab066
    • Jensen, M. T., Treskes, R. W., Caiani, E. G., Casado-Arroyo, R., Cowie, M. R., Dilaveris, P., Duncker, D., Di Rienzo, M., Frederix, I., De Groot, N., Kolh, P. H., Kemps, H., Mamas, M., McGreavy, P., Neubeck, L., Parati, G., Platonov, P. G., Schmidt-Trucksass, A., Schuuring, M. J., ... Lumens, J. (2021). ESC working group on e-cardiology position paper: Use of commercially available wearable technology for heart rate and activity tracking in primary and secondary cardiovascular prevention - In collaboration with the European Heart Rhythm Association, European Association of Preventive Cardiology, Association of Cardiovascular Nursing and Allied Professionals, Patient Forum, and the Digital Health Committee. European Heart Journal - Digital Health, 2(1), 49-59. https://doi.org/10.1093/ehjdh/ztab011
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. EP Europace, 23, I21-I28. https://doi.org/10.1093/europace/euaa387
    • van Osta, N., Kirkels, F., Lyon, A., Koopsen, T., van Loon, T., Cramer, M.-J., Teske, A. J., Delhaas, T., & Lumens, J. (2021). Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations. EP Europace, 23, I153-I160. https://doi.org/10.1093/europace/euaa407
    • Dilaveris, P., & Lumens, J. (2021). The ESC Working Group on e-Cardiology. European Heart Journal, 42(2), 143-144. https://doi.org/10.1093/eurheartj/ehaa401