Koen Reesink

Assistant Professor

Dr Koen Reesink was originally trained in Electrical Engineering and has been active in biomedical research for over 20 years. His interests and specialties are vascular structure and function, ventricular-vascular hemodynamic interaction, system dynamics and signal processing. Dr Reesink’s group has made significant and awarded contributions to quantify and interpret arterial stiffness measurements, especially in clinical settings. Reesink leads his research line ‘Constitutive and system characteristics of large arteries’ within in the CARIM programme 'Complex Arrhythmias' (PI Prof. Tammo Delhaas).

Dr Reesink contributes actively to research organisational development, as initiator/chair of the Vascular Network Group, as steering group member of the CARIM Muroidean Facility, and as chair of the Operational Excellence project MF2BMC around the new Biomedical Center (BMC) for animal research in Maastricht.

Dr Reesink’s current research line ‘Constitutive and system characteristics of large arteries’ is focussed on unravelling the multi-scale structure-function relations that underlie the pathophysiology of accelerated arterial stiffening. Quantitative insights into these relations are of utmost importance to conceive, develop and validate therapeutic approaches for de-stiffening arteries, in order to combat the growing epidemic of ‘old-age’ systolic hypertension and its desastrous cardiovascular and societal sequelae.

Reesink is currently involved in the EU H2020 Demonstrator project CARDIS (as WP co-lead), and in the EU grant proposals MSCA-ITN-EJD2019 MINDSHIFT (as coordinator) and COST VascAge (as participant).

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H3.360
T: +31(0)43 388 16 59

  • 2021
    • Giudici, A., Khir, A. W., Reesink, K. D., Delhaas, T., & Spronck, B. (2021). Five years of cardio-ankle vascular index (CAVI) and CAVI0: how close are we to a pressure-independent index of arterial stiffness?Journal of Hypertension, 39(11), 2128-2138. https://doi.org/10.1097/HJH.0000000000002928
    • Beutel, F., Van Hoof, C., Rottenberg, X., Reesink, K., & Hermeling, E. (2021). Pulse Arrival Time Segmentation Into Cardiac and Vascular Intervals - Implications for Pulse Wave Velocity and Blood Pressure Estimation. Ieee Transactions on Biomedical Engineering, 68(9), 2810-2820. https://doi.org/10.1109/TBME.2021.3055154
    • De Clerck, E. E. B., Schouten, J. S. A. G., Berendschot, T. T. J. M., Goezinne, F., Liesenborghs, I., Dagnelie, P. C., Schaper, N. C., Kroon, A. A., Henry, R. M. A., Reesink, K. D., Schram, M. T., Stehouwer, C. D. A., & Webers, C. A. B. (2021). Vascular risk factors for optical coherence tomography-detected macular cysts: The Maastricht Study. Acta Ophthalmologica, 99(6), e860-e868. https://doi.org/10.1111/aos.14677
    • Lisan, Q., van Sloten, T., Boutouyrie, P., Laurent, S., Danchin, N., Thomas, F., Guibout, C., Perier, M-C., Dagnelie, P., Henry, R. M., Schram, M. T., Heinzer, R., Marques-Vidal, P., van der Kallen, C. J., Crijns, H. J., van Greevenbroek, M., Reesink, K., Kohler, S., Sastry, M., ... Empana, J-P. (2021). Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community-Based Cohort Studies. Journal of the American Heart Association, 10(15), [021318]. https://doi.org/10.1161/JAHA.120.021318
    • van der Heide, F. C. T., Zhou, T. L., Henry, R. M. A., Houben, A. J. H. M., Kroon, A. A., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Koster, A., Savelberg, H. H. C. M., Schaper, N. C., Reesink, K. D., & Stehouwer, C. D. A. (2021). Carotid stiffness is associated with retinal microvascular dysfunction- The Maastricht Study. Microcirculation, 28(6), [e12702]. https://doi.org/10.1111/micc.12702
    • Foreman, Y. D., van Doorn, W. P. T. M., Schaper, N. C., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Eussen, S. J. P. M., Wesselius, A., Reesink, K. D., Schram, M. T., Dagnelie, P. C., Kroon, A. A., Brouwers, M. C. G. J., & Stehouwer, C. D. A. (2021). Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study. Diabetologia, 64(8), 1880-1892. https://doi.org/10.1007/s00125-021-05474-8
    • Parikh, S., Ganizada, B., Debeij, G., Natour, E., Maessen, J., Spronck, B., Schurgers, L., Delhaas, T., Huberts, W., Bidar, E., & Reesink, K. (2021). Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta. Biomedicines, 9(6), [670]. https://doi.org/10.3390/biomedicines9060670
    • Tanghe, A., Celie, B., Shadid, S., Rietzschel, E., Op't Roodt, J., Reesink, K. D., Heyman, E., & Calders, P. (2021). Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension: A Protocol for an Acute, Randomized, Double-Blinded, Placebo-Controlled Cross-Over Trial. Frontiers in cardiovascular medicine, 8, [602086]. https://doi.org/10.3389/fcvm.2021.602086
    • Heusinkveld, M. H. G., Holtackers, R. J., Adriaans, B. P., Op't Roodt, J., Arts, T., Delhaas, T., Reesink, K. D., & Huberts, W. (2021). Complementing sparse vascular imaging data by physiological adaptation rules. Journal of Applied Physiology, 130(3), 571-588. https://doi.org/10.1152/japplphysiol.00250.2019
    • Zhou, T. L., Kroon, A. A., Henry, R. M. A., Koster, A., Dagnelie, P. C., Bosma, H., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Schalkwijk, C. G., Wesselius, A., Reesink, K. D., Kohler, S., Schram, M. T., Stehouwer, C. D. A., & van Sloten, T. T. (2021). Exercise SBP response and incident depressive symptoms: The Maastricht Study. Journal of Hypertension, 39(3), 494-502. https://doi.org/10.1097/HJH.0000000000002657
    • Hulman, A., Foreman, Y. D., Brouwers, M. C. G. J., Kroon, A. A., Reesink, K. D., Dagnelie, P. C., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Faerch, K., Vistisen, D., Jorgensen, M. E., Stehouwer, C. D. A., & Witte, D. R. (2021). Towards precision medicine in diabetes? A critical review of glucotypes. Plos Biology, 19(3), [3000890]. https://doi.org/10.1371/journal.pbio.3000890
    • van der Bruggen, M., Spronck, B., Bos, S., Heusinkveld, M. H. G., Taddei, S., Ghiadoni, L., Delhaas, T., Bruno, R. M., & Reesink, K. D. (2021). Pressure-corrected carotid stiffness and Young's modulus: evaluation in an outpatient clinic setting. American Journal of Hypertension, 34(7), 737-743. https://doi.org/10.1093/ajh/hpab028
    • Panteleev, M. A., Korin, N., Reesink, K. D., Bark, D. L., Cosemans, J. M. E. M., Gardiner, E. E., & Mangin, P. H. (2021). Wall shear rates in human and mouse arteries: Standardization of hemodynamics for in vitro blood flow assays: Communication from the ISTH SSC subcommittee on biorheology. Journal of Thrombosis and Haemostasis, 19(2), 588-595. https://doi.org/10.1111/jth.15174
    • Hanssen, N. M. J., Scheijen, J. L. J. M., Houben, A. J. H. M., van de Waarenburg, M., Berendschot, T. T. J. M., Webers, C. A. B., Reesink, K. D., van Greevenbroek, M. M. J., van der Kallen, C., Schaper, N. C., Schram, M. T., Henry, R. M. A., Stehouwer, C. D. A., & Schalkwijk, C. G. (2021). Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study. Diabetes & Metabolism, 47(1), [101148]. https://doi.org/10.1016/j.diabet.2020.02.002
    • van der Bruggen, M. M., Reesink, K. D., Spronck, P. J. M., Bitsch, N., Hameleers, J., Megens, R. T. A., Schalkwijk, C. G., Delhaas, T., & Spronck, B. (2021). An integrated set-up for ex vivo characterisation of biaxial murine artery biomechanics under pulsatile conditions. Scientific Reports, 11(1), [2671]. https://doi.org/10.1038/s41598-021-81151-5
    • Spronck, B., Tan, I., Reesink, K. D., Georgevsky, D., Delhaas, T., Avolio, A. P., & Butlin, M. (2021). Heart rate and blood pressure dependence of aortic distensibility in rats: comparison of measured and calculated pulse wave velocity. Journal of Hypertension, 39(1), 117-126. https://doi.org/10.1097/HJH.0000000000002608
  • 2020
    • Vandercappellen, E. J., Henry, R. M. A., Savelberg, H. H. C. M., van der Berg, J. D., Reesink, K. D., Schaper, N. C., Eussen, S. J. P. M., van Dongen, M. C. J. M., Dagnelie, P. C., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., van der Kallen, C. J. H., Kohler, S., Stehouwer, C. D. A., & Koster, A. (2020). Association of the Amount and Pattern of Physical Activity With Arterial Stiffness: The Maastricht Study. Journal of the American Heart Association, 9(20), [017502]. https://doi.org/10.1161/JAHA.120.017502
    • Rensma, S. P., Stehouwer, C. D. A., Van Boxtel, M. P. J., Houben, A. J. H. M., Berendschot, T. T. J. M., Jansen, J. F. A., Schalkwijk, C. G., Verhey, F. R. J., Kroon, A. A., Henry, R. M. A., Backes, W. H., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bosma, H., Köhler, S., Reesink, K. D., Schram, M. T., & van Sloten, T. T. (2020). Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction: The Maastricht Study. Hypertension, 75(6), 1607-1614. https://doi.org/10.1161/hypertensionaha.119.14307
    • van Loon, T., Knackstedt, C., Cornelussen, R., Reesink, K., Brunner-La Rocca, H., Delhaas, T., van Empel, V., & Lumens, J. (2020). Increased myocardial stiffness more than impaired relaxation function limits cardiac performance during exercise in heart failure with preserved ejection fraction: a virtual patient study. European Heart Journal - Digital Health, 1(1), 40-50. https://doi.org/10.1093/ehjdh/ztaa009
  • 2019
    • Foreman, Y. D., Brouwers, M. C. G. J., Berendschot, T. T. J. M., van Dongen, M. C. J. M., Eussen, S. J. P. M., van Greevenbroek, M. M. J., Henry, R. M. A., Houben, A. J. H. M., van der Kallen, C. J. H., Kroon, A. A., Reesink, K. D., Schram, M. T., Schaper, N. C., & Stehouwer, C. D. A. (2019). The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study. Cardiovascular Diabetology, 18(1), [152]. https://doi.org/10.1186/s12933-019-0950-x
    • Jaminon, A., Reesink, K., Kroon, A., & Schurgers, L. (2019). The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes. International journal of molecular sciences, 20(22), [5694]. https://doi.org/10.3390/ijms20225694
    • Heusinkveld, M. H. G., Delhaas, ET., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D., & Reesink, K. D. (2019). Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model. Journal of Applied Physiology, 127(2), 491-500. https://doi.org/10.1152/japplphysiol.00769.2018
    • Heusinkveld, M. H. G., Huberts, W., Lumens, J., Arts, T., Delhaas, T., & Reesink, K. D. (2019). Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction. PLoS Computational Biology, 15(7), [1007173]. https://doi.org/10.1371/journal.pcbi.1007173
    • Reesink, K. D., & Spronck, B. (2019). Constitutive interpretation of arterial stiffness in clinical studies: a methodological review. American Journal of Physiology-heart and Circulatory Physiology, 316(3), H693-H709. https://doi.org/10.1152/ajpheart.00388.2018
    • van der Waaij, K. M., Heusinkveld, M. H. G., Delhaas, T., Kroon, A. A., & Reesink, K. D. (2019). Do treatment-induced changes in arterial stiffness affect left ventricular structure? A meta-analysis. Journal of Hypertension, 37(2), 253-263. https://doi.org/10.1097/HJH.0000000000001918
    • Driessen, J. H. M., de Vries, F., van Onzenoort, H. A. W., Schram, M. T., van der Kallen, C., Reesink, K. D., Sep, S., Stehouwer, C. D. A., Schaper, N., Kroon, A. A., Schalkwijk, C., van den Bergh, J. P. W., & Henry, R. M. A. (2019). Metformin use in type 2 diabetic patients is not associated with lower arterial stiffness: the Maastricht Study. Journal of Hypertension, 37(2), 365-371. https://doi.org/10.1097/HJH.0000000000001892
  • 2018
    • Zhou, T. L., Henry, R. M. A., Stehouwer, C. D. A., van Sloten, T. T., Reesink, K. D., & Kroon, A. A. (2018). Blood Pressure Variability, Arterial Stiffness, and Arterial Remodeling: The Maastricht Study. Hypertension, 72(4), 1002-1010. https://doi.org/10.1161/HYPERTENSIONAHA.118.11325
    • Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., van Sloten, T. T., Roodt, J. O. H., Henry, R. M. A., Reesink, K. D., Schaper, N. C., Dagnelie, P. C., van der Kallen, C. J. H., Biessels, G. J., & Stehouwer, C. D. A. (2018). Carotid circumferential wall stress is not associated with cognitive performance among individuals in late middle age: The Maastricht Study. Atherosclerosis, 276, 15-22. https://doi.org/10.1016/j.atherosclerosis.2018.07.003
    • Steinbuch, J., Schreuder, F. H. B. M., Reesink, K. D., Hoeks, A. P. G., & Mess, W. H. (2018). ORTHOGONAL B-MODE EVALUATION OF COMMON CAROTID ARTERY PLAQUES REVEALS THE ABSENCE OF OUTWARD REMODELING. Ultrasound in Medicine and Biology, 44(5), 986-994. https://doi.org/10.1016/j.ultrasmedbio.2017.12.013
    • Spronck, B., Avolio, A. P., Tan, I., Butlin, M., Reesink, K. D., & Delhaas, T. (2018). Reply: Medical science is based on facts and evidence. Journal of Hypertension, 36(4), 960-962. https://doi.org/10.1097/HJH.0000000000001660
    • Reesink, K. D., Hendrikx, T., van Gorp, P. J., Hoeks, A. P., & Shiri-Sverdlov, R. (2018). Ultrasonic Perfluorohexane-Loaded Monocyte Imaging Toward a Minimally Invasive Technique for Selective Detection of Liver Inflammation in Fatty Liver Disease. Journal of Ultrasound in Medicine, 37(4), 921-933. https://doi.org/10.1002/jum.14432
    • Onete, V., Henry, R. M., Sep, S. J. S., Koster, A., van der Kallen, C. J., Dagnelie, P. C., Schaper, N., Kohler, S., Reesink, K., Stehouwer, C. D. A., & Schram, M. T. (2018). Arterial stiffness is associated with depression in middle-aged men - the Maastricht Study. Journal of Psychiatry & Neuroscience, 43(2), 111-119. https://doi.org/10.1503/jpn.160246
    • De Clerck, E. E. B., Schouten, J. S. A. G., Berendschot, T. T. J. M., Goezinne, F., Liesenborghs, I., Dagnelie, P. C., Schaper, N. C., Kroon, A. A., Henry, R. M. A., Reesink, K. D., Schram, M. T., Stehouwer, C. D. A., & Webers, C. A. B. (2018). Vascular risk factors for optical coherence tomography-detected cystoid macular edema: the Maastricht study. Acta Ophthalmologica, 96, 25-25.
    • Heusinkveld, M. H. G., Quicken, S., Holtackers, R. J., Huberts, W., Reesink, K. D., Delhaas, T., & Spronck, B. (2018). Uncertainty quantification and sensitivity analysis of an arterial wall mechanics model for evaluation of vascular drug therapies. Biomechanics and modeling in mechanobiology, 17(1), 55-69. https://doi.org/10.1007/s10237-017-0944-0
    • Zhou, T. L., Reesink, K., Schram, M., Koster, A., Schaper, N., Dagnelie, P., van der Kallen, C., Sep, S., Stehouwer, C., & Henry, R. (2018). Blood pressure variability in individuals with and without (pre)diabetes: the Maastricht Study. Journal of Hypertension, 36(2), 259-267. https://doi.org/10.1097/HJH.0000000000001543
  • 2017
    • Sörensen, B. M., Houben, A. J. H. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Reesink, K. D., Dagnelie, P. C., Schaper, N. C., Schalkwijk, C. G., Schram, M. T., & Stehouwer, C. D. A. (2017). Hyperglycemia Is the Main Mediator of Prediabetes- and Type 2 Diabetes-Associated Impairment of Microvascular Function: The Maastricht Study. Diabetes Care, 40(8), e103-e105. https://doi.org/10.2337/dc17-0574
    • de Lepper, A. G. W., Herold, I. H. F., Saporito, S., Bouwman, R. A., Mischi, M., Korsten, H. H. M., Reesink, K. D., & Houthuizen, P. (2017). Noninvasive pulmonary transit time: A new parameter for general cardiac performance. Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques, 34(8), 1138-1145. https://doi.org/10.1111/echo.13590
    • Spronck, B., Delhaas, T., De Lepper, A. G. W., Giroux, J., Goldwasser, F., Boutouyrie, P., Alivon, M., & Reesink, K. D. (2017). Patient-specific blood pressure correction technique for arterial stiffness: evaluation in a cohort on anti-angiogenic medication. Hypertension Research, 40(8), 752-757. https://doi.org/10.1038/hr.2017.32
    • Spronck, B., Avolio, A. P., Tan, I., Butlin, M., Reesink, K. D., & Delhaas, T. (2017). Reply: physics cannot be disputed. Journal of Hypertension, 35(7), 1523-1525. https://doi.org/10.1097/HJH.0000000000001350
    • Bloksgaard, M., Leurgans, T. M., Spronck, B., Heusinkveld, M. H. G., Thorsted, B., Rosenstand, K., Nissen, I., Hansen, U. M., Brewer, J. R., Bagatolli, L. A., Rasmussen, L. M., Irmukhamedov, A., Reesink, K. D., & De Mey, J. G. R. (2017). Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries. American Journal of Physiology-heart and Circulatory Physiology, 313(1), H164-H178. https://doi.org/10.1152/ajpheart.00110.2017
    • Segers, P., O'Rourke, M. F., Parker, K., Westerhof, N., Hughes, A., Participants 2016 Workshop, Spronck, B., & Reesink, K. (2017). Towards a consensus on the understanding and analysis of the pulse waveform: Results from the 2016 Workshop on Arterial Hemodynamics: Past, present and future. Artery Research, 18, 75-80. https://doi.org/10.1016/j.artres.2017.03.004
    • Veugen, M. G. J., Henry, R. M. A., van Sloten, T. T., Hermeling, E., Brunner-La Rocca, H-P., Schram, M. T., Dagnelie, P. C., Schalkwijk, C. G., Kroon, A. A., Stehouwer, C. D. A., & Reesink, K. D. (2017). The systolic-diastolic difference in carotid stiffness is increased in type 2 diabetes: The Maastricht Study. Journal of Hypertension, 35(5), 1052-1060. https://doi.org/10.1097/HJH.0000000000001298
    • Bruno, R. M., Reesink, K. D., & Ghiadoni, L. (2017). Advances in the non-invasive assessment of vascular dysfunction in metabolic syndrome and diabetes: Focus on endothelium, carotid mechanics and renal vessels. Nutrition Metabolism and Cardiovascular Diseases, 27(2), 121-128. https://doi.org/10.1016/j.numecd.2016.09.004
    • Spronck, B., Avolio, A. P., Tan, I., Butlin, M., Reesink, K. D., & Delhaas, T. (2017). Arterial stiffness index beta and cardio-ankle vascular index inherently depend on blood pressure but can be readily corrected. Journal of Hypertension, 35(1), 98-104. https://doi.org/10.1097/HJH.0000000000001132
    • Spronck, B., Delhaas, T., Butlin, M., Reesink, K., & Aviolo, A. P. (2017). Options for Dealing with Pressure Dependence of Pulse Wave Velocity as a Measure of Arterial Stiffness: An Update of Cardio-Ankle Vascular Index (CAVI) and CAVI0. Pulse, 5(1-4), 106-114. https://doi.org/10.1159/000479322
  • 2016
    • Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., van Sloten, T. T., Henry, R. M. A., Reesink, K. D., Kroon, A. A., Koster, A., Schaper, N. C., Dagnelie, P. C., van der Kallen, C. J. H., Biessels, G. J., & Stehouwer, C. D. A. (2016). Carotid stiffness is associated with impairment of cognitive performance in individuals with and without type 2 diabetes. The Maastricht Study. Atherosclerosis, 253, 186-193. https://doi.org/10.1016/j.atherosclerosis.2016.07.912
    • van Mil, A., Greyling, A., Zock, P. L., Geleijnse, J. M., Hopman, M. T., Mensink, R. P., Reesink, K. D., Green, D. J., Ghiadoni, L., & Thijssen, D. H. (2016). Impact of volunteer-related and methodology-related factors on the reproducibility of brachial artery flow-mediated vasodilation: analysis of 672 individual repeated measurements. Journal of Hypertension, 34(9), 1738-1745. https://doi.org/10.1097/HJH.0000000000001012
    • Holtackers, R. J., Spronck, B., Heusinkveld, M. H. G., Crombag, G., op het Roodt, J., Delhaas, T., Kooi, E., Reesink, K. D., & Hermeling, E. (2016). Head orientation should be considered in ultrasound studies on carotid artery distensibility. Journal of Hypertension, 34(8), 1551-1555. https://doi.org/10.1097/HJH.0000000000000985
    • Tan, I., Spronck, B., Kiat, H., Barin, E., Reesink, K. D., Delhaas, T., Avolio, A. P., & Butlin, M. (2016). Heart Rate Dependency of Large Artery Stiffness. Hypertension, 68(1), 236-242. https://doi.org/10.1161/HYPERTENSIONAHA.116.07462
    • Spronck, B., Megens, R. T. A., Reesink, K. D., & Delhaas, T. (2016). A method for three-dimensional quantification of vascular smooth muscle orientation: application in viable murine carotid arteries. Biomechanics and modeling in mechanobiology, 15(2), 419-432. https://doi.org/10.1007/s10237-015-0699-4