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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Nick van Osta

Post doc

Nick van Osta graduated from the Technical University Eindhoven in 2017 with a master in Biomedical Engineering. He obtained his PhD at the Department of Biomedical Engineering (Maastricht University) under the supervision of Prof. Joost Lumens and Prof. Tammo Delhaas. During his PhD, he worked on important aspects of patient-specific modelling. He developed a modelling framework which can estimate tissue properties based on clinical deformation measurements in patients with arrhythmogenic cardiomyopathy using the CircAdapt model – a model of the cardiovascular system.

As of November 2021, he continued his career as a platform scientist at the Department of Biomedical Engineering (Maastricht University) to further explore the applicability of the Digital Twin approach.

Nick van osta carimdsf0534
Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
  • 2025
    • van Osta, N., van Loon, T., & Lumens, J. (2025). Individual hearts: computational models for improved management of cardiovascular disease. Heart. Advance online publication. https://doi.org/10.1136/heartjnl-2024-324177
    • van Willigen, B. G., van Osta, N., van der Hout-van der Jagt, M. B., van de Vosse, F. N., & Huberts, W. (2025). A virtual population cohort approach for fetal cardiac valve modeling. Journal of Computational Science, 88, Article 102606. https://doi.org/10.1016/j.jocs.2025.102606
    • Manetti, C. A., van Osta, N., Beela, A. S., Herbots, L., Prinzen, F. W., Delhaas, T., & Lumens, J. (2025). Impact of myocardial phenotype on optimal atrioventricular delay settings during biventricular and left bundle-branch pacing at rest and during exercise: insights from a virtual patient study. EP Europace, 27(4), Article euaf082. https://doi.org/10.1093/europace/euaf082
    • Van Osta, N., Van Den Acker, G., Van Loon, T., Arts, T., Delhaas, T., & Lumens, J. (2025). Numerical accuracy of closed-loop steady state in a zero-dimensional cardiovascular model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 383(2293), Article 20240208. https://doi.org/10.1098/rsta.2024.0208
  • 2024
    • van Loon, T., Rijks, J., van Koll, J., Wolffs, J., Cornelussen, R., van Osta, N., Luermans, J., Prinzen, F., Linz, D., van Empel, V., Delhaas, T., Vernooy, K., & Lumens, J. (2024). Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study. European Heart Journal, 45(46), 4953-4964. https://doi.org/10.1093/eurheartj/ehae718
    • Koopsen, T., van Osta, N., van Loon, T., Meiburg, R., Huberts, W., Beela, A. S., Kirkels, F. P., van Klarenbosch, B. R., Teske, A. J., Cramer, M. J., Bijvoet, G. P., van Stipdonk, A., Vernooy, K., Delhaas, T., & Lumens, J. (2024). Parameter subset reduction for imaging-based digital twin generation of patients with left ventricular mechanical discoordination. Biomedical Engineering Online, 23(1), Article 46. https://doi.org/10.1186/s12938-024-01232-0
    • Koopsen, T., Gerrits, W., van Osta, N., van Loon, T., Wouters, P., Prinzen, F. W., Vernooy, K., Delhaas, T., Teske, A. J., Meine, M., Cramer, M. J., & Lumens, J. (2024). Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. EP Europace, 26(1), Article euae009. https://doi.org/10.1093/europace/euae009
  • 2023
    • Kirkels, F. P., Rootwelt-Norberg, C., Bosman, L. P., Aabel, E. W., Muller, S., Castrini, A. I., Taha, K., van Osta, N., Lie, Ø. H., Asselbergs, F. W., Lumens, J., Te Riele, A. S. J. M., Hasselberg, N. E., Cramer, M. J., Haugaa, K., & Teske, A. J. (2023). The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy. European heart journal. Cardiovascular Imaging, 24(12), 1710-1718. Article jead174. https://doi.org/10.1093/ehjci/jead174
    • Kirkels, F. P., van Osta, N., Rootwelt-Norberg, C., Chivulescu, M., van Loon, T., Aabel, E. W., Castrini, A. I., Lie, Ø. H., Asselbergs, F. W., Delhaas, T., Cramer, M. J., Teske, A. J., Haugaa, K. H., & Lumens, J. (2023). Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum. Journal of the American College of Cardiology, 82(9), 785-797. https://doi.org/10.1016/j.jacc.2023.05.065
  • 2022
    • Koopsen, T., Van Osta, N., Van Loon, T., Van Nieuwenhoven, F. A., Prinzen, F. W., Van Klarenbosch, B. R., Kirkels, F. P., Teske, A. J., Vernooy, K., Delhaas, T., & Lumens, J. (2022). A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease. Frontiers in physiology, 13, Article 782592. https://doi.org/10.3389/fphys.2022.782592
  • 2021
    • van Osta, N., Kirkels, F. P., van Loon, T., Koopsen, T., Lyon, A., Meiburg, R., Huberts, W., Cramer, M. J., Delhaas, T., Haugaa, K. H., Teske, A. J., & Lumens, J. (2021). Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling. Frontiers in physiology, 12, Article 738926. https://doi.org/10.3389/fphys.2021.738926
    • van Osta, N., Kirkels, F., Lyon, A., Koopsen, T., van Loon, T., Cramer, M.-J., Teske, A. J., Delhaas, T., & Lumens, J. (2021). Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations. EP Europace, 23, I153-I160. https://doi.org/10.1093/europace/euaa407
  • 2020
    • van Osta, N., Lyon, A., Kirkels, F., Koopsen, T., van Loon, T., Cramer, M. J., Teske, A. J., Delhaas, T., Huberts, W., & Lumens, J. (2020). Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173), Article 20190347. https://doi.org/10.1098/rsta.2019.0347
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