Prof. Paul Volders, CARIM Principal Investigator and Cardiologist, coordinates the cardiogenetic care of patients with inherited cardiomyopathies, including those with inherited arrhythmias, at Maastricht UMC+. Within this clinical-experimental environment, the active research projects of his PI team focus on novel pathogenetic insights and improved management of ventricular arrhythmias and sudden cardiac arrest.
Paul Volders defended his PhD thesis 'Cellular Mechanisms of Acquired Torsades de Pointes in the Hypertrophied Canine Heart: The Substrate and the Trigger' in Maastricht in 1999 (cum laude). Since 2015 he is Professor of Genetic Cardiology.
Traditionally, the Volders team has focussed on the electrophysiological characterisation of arrhythmia substrates in inherited cardiomyopathies and in acquired cardiac overload, compensated hypertrophy and failure. While these studies continue at the cellular, intact-animal and patient level, increasing research activities are directed to:
(1) intracellular signaling pathways determining ion-channel function;
(2) the genetic and genomic basis of cardiac arrhythmias; and
(3) systems biology to integrate the basic molecular and functional determinants of arrhythmia syndromes with the clinical characteristics of individual patients, to provide better risk management and treatment.
The group has active research connections with other CARIM PI groups and many international colleagues.
Prof. Paul Volders is a past ZonMw Veni and Vidi laureate, and a Dutch Heart Foundation Junior-Staff member. Currently, he participates as work-package leader in the CVON Consortium Project PREDICT, on predicting sudden cardiac arrest, and he is the research leader of the CVON Consortium Project VIGILANCE, on idiopathic ventricular fibrillation. Several of his team members achieved personal grants (ZonMw Veni, Dutch Heart Foundation junior postdoc). Besides, he ran multiple investigator-initiated studies that were funded by industry. He is a past-chairman of the ESC Working Group on Cardiac Cellular Electrophysiology (2012-2014), and a past Working-Group Representative at the Board of the European Heart Rhythm Association (2011-2018).
He is (co-)author on 90 scientific articles, with 5673citations and H-index of 39.