Paul Volders


Prof. Paul Volders, CARIM Principal Investigator and Cardiologist, coordinates the cardiogenetic care of patients with inherited cardiomyopathies, including those with inherited arrhythmias, at Maastricht UMC+. Within this clinical-experimental environment, the active research projects of his PI team focus on novel pathogenetic insights and improved management of ventricular arrhythmias and sudden cardiac arrest.

Paul Volders defended his PhD thesis 'Cellular Mechanisms of Acquired Torsades de Pointes in the Hypertrophied Canine Heart: The Substrate and the Trigger' in Maastricht in 1999 (cum laude). Since 2015 he is Professor of Genetic Cardiology.

Traditionally, the Volders team has focussed on the electrophysiological characterisation of arrhythmia substrates in inherited cardiomyopathies and in acquired cardiac overload, compensated hypertrophy and failure. While these studies continue at the cellular, intact-animal and patient level, increasing research activities are directed to:

(1) intracellular signaling pathways determining ion-channel function;
(2) the genetic and genomic basis of cardiac arrhythmias; and
(3) systems biology to integrate the basic molecular and functional determinants of arrhythmia syndromes with the clinical characteristics of individual patients, to provide better risk management and treatment.

The group has active research connections with other CARIM PI groups and many international colleagues.

Prof. Paul Volders is a past ZonMw Veni and Vidi laureate, and a Dutch Heart Foundation Junior-Staff member. Currently, he participates as work-package leader in the CVON Consortium Project PREDICT, on predicting sudden cardiac arrest, and he is the research leader of the CVON Consortium Project VIGILANCE, on idiopathic ventricular fibrillation. Several of his team members achieved personal grants (ZonMw Veni, Dutch Heart Foundation junior postdoc). Besides, he ran multiple investigator-initiated studies that were funded by industry. He is a past-chairman of the ESC Working Group on Cardiac Cellular Electrophysiology (2012-2014), and a past Working-Group Representative at the Board of the European Heart Rhythm Association (2011-2018).

He is (co-)author on 90 scientific articles, with 5673citations and H-index of 39.

Department of Cardiology
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
Room number: 3.C2.025
T: +31(0)43 387 51 06

  • 2020
    • Stoks, J., Chau Nguyen, U., Peeters, R., Volders, P., & Cluitmans, M. (2020). An Open-Source Algorithm for Standardized Bullseye Visualization of High-Resolution Cardiac Ventricular Data: UNISYS. Computing in Cardiology, 47, 1-4. [160].
    • Stoks, J., Van Rees, B., Groeneveld, S., Schipaanboord, D., Blom, L., Hassink, R., Cluitmans, M., Peeters, R., & Volders, P. (2020). Variability of Electrocardiographic Imaging Within and Between Leadsets. Computing in Cardiology, 47, 1-4. [097].
    • Stoks, J., Van Rees, B. D., Nguyen, U. C., Peeters, R. L. M., Dendale, P., Cluitmans, M. J. M., & Volders, P. G. A. (2020). Noninvasive assessment of dynamic cardiac electrophysiology in normal human subjects. European Heart Journal, 41(S2), [3596].
    • Sutanto, H., Cluitmans, M. J. M., Dobrev, D., Volders, P. G. A., Bébarová, M., & Heijman, J. (2020). Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses. Journal of Molecular and Cellular Cardiology, 146, 69-83.
    • Guns, P-J. D., Guth, B. D., Braam, S., Kosmidis, G., Matsa, E., Delaunois, A., Gryshkova, V., Bernasconi, S., Knot, H. J., Shemesh, Y., Chen, A., Markert, M., Fernandez, M. A., Lombardi, D., Grandmont, C., Cillero-Pastor, B., Heeren, R. M. A., Martinet, W., Woolard, J., ... Valentin, J-P. (2020). INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology. Journal of Pharmacological and Toxicological Methods, 105, [106889].
    • Altrocchi, C., de Korte, T., Bernardi, J., Spatjens, R. L. H. M. G., Braam, S. R., Heijman, J., Zaza, A., & Volders, P. G. A. (2020). Repolarization instability and arrhythmia by I-Kr block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D monolayers. EP Europace, 22(9), 1431-1441.
    • ter Bekke, R. M. A., & Volders, P. G. A. (2020). Haloperidol and sudden death in first acute myocardial infarction. IJC Heart & Vasculature, 26, [100482].
    • Blom, L. J., Groeneveld, S. A., Wulterkens, B. M., van Rees, B., Nguyen, U. C., Roudijk, R. W., Cluitmans, M., Volders, P. G. A., & Hassink, R. J. (2020). Novel use of repolarization parameters in electrocardiographic imaging to uncover arrhythmogenic substrate. Journal of Electrocardiology, 59, 116-121.
  • 2019
    • Blom, L. J., Visser, M., Christiaans, I., Scholten, M. F., Bootsma, M., van den Berg, M. P., Yap, S-C., van der Heijden, J. F., Doevendans, P. A., Loh, P., Postema, P. G., Barge-Schaapsveld, D. Q., Hofman, N., Volders, P. G. A., Wilde, A. A., & Hassink, R. J. (2019). Incidence and predictors of implantable cardioverter-defibrillator therapy and its complications in idiopathic ventricular fibrillation patients. EP Europace, 21(10), 1519-1526.
    • Bosman, L. P., Verstraelen, T. E., van Lint, F. H. M., Cox, M. G. P. J., Groeneweg, J. A., Mast, T. P., van der Zwaag, P. A., Volders, P. G. A., Evertz, R., Wong, L., de Groot, N. M. S., Zeppenfeld, K., van der Heijden, J. F., van den Berg, M. P., Wilde, A. A. M., Asselbergs, F. W., Hauer, R. N. W., te Riele, A. S. J. M., van Tintelen, J. P., ... Netherlands ACM Registry (2019). The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update. Netherlands Heart Journal, 27(10), 480-486.
    • ter Bekke, R. M. A., Moers, A. M. E., de Jong, M. M. J., Johnson, D. M., Schwartz, P. J., Vanoli, E., & Volders, P. G. A. (2019). Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1. International Journal of Cardiology, 286, 66-72.
    • Cluitmans, M. J. M., Stoks, J., & Volders, P. G. A. (2019). To the Editor-Interpretation of electrograms is key to understand the clinical potential of ECGI. Heart Rhythm, 16(6), E51-E52.
    • Nguyen, U. C., Cluitmans, M. J. M., Strik, M., Luermans, J. G., Gommers, S., Wildberger, J. E., Bekkers, S. C. A. M., Volders, P. G. A., Mihl, C., Prinzen, F. W., & Vernooy, K. (2019). Integration of cardiac magnetic resonance imaging, electrocardiographic imaging, and coronary venous computed tomography angiography for guidance of left ventricular lead positioning. EP Europace, 21(4), 626-635.
  • 2018
    • Cluitmans, M., Karel, J., Bonizzi, P., Volders, P., Westra, R., & Peeters, R. (2018). Wavelet-promoted sparsity for non-invasive reconstruction of electrical activity of the heart. Medical & Biological Engineering & Computing, 56(11), 2039-2050.
    • Ter Bekke, R. M. A., David, M., Krapels, I. P. C., Crijns, H. J. G. M., & Volders, P. G. A. (2018). Beauty and the beat: A complicated case of multifocal ectopic Purkinje-related premature contractions. HeartRhythm Case Reports, 4(9), 429-433.
    • Clerx, M., Heijman, J., Collins, P., & Volders, P. G. A. (2018). Predicting changes to I-Na from missense mutations in human SCN5A. Scientific Reports, 8(1), [12797].
    • Blom, L. J., Volders, P. G. A., Wilde, A. A., & Hassink, R. J. (2018). Life-long tailoring of diagnosis and management of patients with idiopathic ventricular fibrillation-future perspectives in research. Netherlands Heart Journal, 26(7-8), 367-374.
    • Conte, G., Caputo, M. L., Volders, P. G. A., Luca, A., Mainardi, L., Schotten, U., Corino, V. D. A., Regoli, F., Zeemering, S., Zink, M., Yazdani, S., Kappenberger, L., Moccetti, T., Vesin, J-M., & Auricchio, A. (2018). Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation. International Journal of Cardiology, 253, 66-70.
    • Nguyen, U., Weijs, B., Luyten, P., Blokzijl, C., Witsenburg, M., Volders, P., & Bekkers, B. (2018). Late complications of an atrial septal occluder provoked by anticoagulant therapy. Journal of Cardiology Cases, 17(2), 68-71.
  • 2017
    • ter Bekke, R. M. A., Isaacs, A., Barysenka, A., Hoos, M. B., Jongbloed, J. D. H., Hoorntje, J. C. A., Patelski, A. S. M., Helderman-van den Enden, A. T. J. M., van den Wijngaard, A., Stoll, M., & Volders, P. G. A. (2017). Heritability in a SCN5A-mutation founder population with increased female susceptibility to non-nocturnal ventricular tachyarrhythmia and sudden cardiac death. Heart Rhythm, 14(12), 1873-1881.
    • Hoorntje, E. T., Bollen, I. A., Barge-Schaapveld, D. Q., van Tienen, F. H., te Meerman, G. J., Jansweijer, J. A., van Essen, A. J., Volders, P. G., Constantinescu, A. A., van den Akker, P. C., van Spaendonck-Zwarts, K. Y., Oldenburg, R. A., Marcelis, C. L., van der Smagt, J. J., Hennekam, E. A., Vink, A., Bootsma, M., Aten, E., Wilde, A. A., ... van Tintelen, J. P. (2017). Lamin A/C-Related Cardiac Disease Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation. Circulation : Cardiovascular Genetics, 10(4), [001631].
    • Cluitmans, M. J. M., Clerx, M., Vandersickel, N., Peeters, R. L. M., Volders, P. G. A., & Westra, R. L. (2017). Physiology-based regularization of the electrocardiographic inverse problem. Medical & Biological Engineering & Computing, 55(8), 1353-1365.
    • Cluitmans, M. J. M., Bonizzi, P., Karel, J. M. H., Das, M., Kietselaer, B. L. J. H., Jong, M. M. J. D., Prinzen, F. W., Peeters, R. L. M., Westra, R. L., & Volders, P. G. A. (2017). In Vivo Validation of Electrocardiographic Imaging. JACC: Clinical Electrophysiology, 3(3), 232 - 242.
  • 2016
    • Claes, G. R. F., van Tienen, F. H. J., Lindsey, P., Krapels, I. P. C., van den Enden, A., Hoos, M., Barrois, Y. E. G., Janssen, J., Paulussen, A. D. C., Sels, J-W. E. M., Kuijpers, S. H. H., van Tintelen, J. P., van den Berg, M. P., Heesen, W. F., Garcia-Pavia, P., Perrot, A., Christiaans, I., Salemink, S., Marcelis, C. L. M., ... van den Wijngaard, A. (2016). Hypertrophic remodelling in cardiac regulatory myosin light chain (MYL2) founder mutation carriers. European Heart Journal, 37(23), 1815-1822.
    • Baumert, M., Porta, A., Vos, M. A., Malik, M., Couderc, J-P., Laguna, P., Piccirillo, G., Smith, G. L., Tereshchenko, L. G., & Volders, P. G. A. (2016). QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology. EP Europace, 18(6), 925-944.
    • Wellens, H., Lindemans, F. W., Houben, R. P., Gorgels, A., Volders, P. G., ter Bekke, R. M. A., & Crijns, H. J. (2016). Improving survival after out-of-hospital cardiac arrest requires new tools. European Heart Journal, 37(19), 1499-1503.
    • ten Sande, J. N., Postema, P. G., Boekholdt, S. M., Tan, H. L., van der Heijden, J. F., de Groot, N. M. S., Volders, P. G. A., Zeppenfeld, K., Boersma, L. V. A., Nannenberg, E. A., Christiaans, I., & Wilde, A. A. M. (2016). Detailed characterization of familial idiopathic ventricular fibrillation linked to the DPP6 locus. Heart Rhythm, 13(4), 905-912.
    • Clerx, M., Collins, P., de lange, E., & Volders, P. G. A. (2016). Myokit: A simple interface to cardiac cellular electrophysiology. Progress in Biophysics & Molecular Biology, 120(1-3), 100-114.
  • 2015
    • Verstraelen, T. E., Ter Bekke, R. M., Volders, P. G., Masclee, A. A. M., & Kruimel, J. W. (2015). The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders. Neurogastroenterology and Motility, 27(7), 906-913.
    • Groeneweg, J. A., Bhonsale, A., James, C. A., te Riele, A. S., Dooijes, D., Tichnell, C., Murray, B., Wiesfeld, A. C. P., Sawant, A. C., Kassamali, B., Atsma, D. E., Volders, P. G., de Groot, N. M., de Boer, K., Zimmerman, S. L., Kamel, I. R., van der Heijden, J. F., Russell, S. D., Cramer, M. J., ... Calkins, H. (2015). Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family Members. Circulation : Cardiovascular Genetics, 8(3), 437-446.
    • Cluitmans, M. J. M., Peeters, R. L. M., Westra, R. L., & Volders, P. G. A. (2015). Noninvasive reconstruction of cardiac electrical activity: update on current methods, applications and challenges. Netherlands Heart Journal, 23(6), 301-311.
    • Lau, D. H., Volders, P. G. A., Kohl, P., Prinzen, F. W., Zaza, A., Kaeaeb, S., Oto, A., & Schotten, U. (2015). Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula. EP Europace, 17(5), 825-833.
    • ter Bekke, R. M. A., Haugaa, K. H., van den Wijngaard, A., Bos, J. M., Ackerman, M. J., Edvardsen, T., & Volders, P. G. A. (2015). Electromechanical window negativity in genotyped long-QT syndrome patients: relation to arrhythmia risk. European Heart Journal, 36(3), 179-186.
  • 2014
    • Spätjens, R., Bebarova, M., Seyen, S. R. M., Lentink, V., Jongbloed, R. J., Arens, Y. H. J. M., Heijman, J., & Volders, P. G. A. (2014). Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation. Cardiovascular Research, 104(1), 216-225.
    • Molina, C. E., Johnson, D. M., Mehel, H., Spätjens, R., Mika, D., Algalarrondo, V., Slimane, Z. H., Lechene, P., Abi-Gerges, N., van der Linde, H. J., Leroy, J., Volders, P. G. A., Fischmeister, R., & Vandecasteele, G. (2014). Interventricular Differences in beta-Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases. Journal of the American Heart Association, 3(3), [e000858].
    • van den Berg, M. P., van den Heuvel, F., van Tintelen, J. P., Volders, P. G. A., & van Gelder, I. C. (2014). Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker. International Journal of Cardiology, 171(1), 90-92.
  • 2013
    • Dirkx, E., Gladka, M. M., Philippen, L. E., Armand, A-S., Kinet, V., Leptidis, S., el Azzouzi, H., Salic, K., Bourajjaj, M., da Silva, G. J. J., Olieslagers, S., van der Nagel, R., de Weger, R., Bitsch, N., Kisters, N., Seyen, S., Morikawa, Y., Chanoine, C., Heymans, S., ... De Windt, L. J. (2013). Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nature Cell Biology, 15(11), 1282-1293.
    • Zusterzeel, R., ter Bekke, R. M. A., Volders, P. G. A., Leijten, F. M. M., van den Wijngaard, A., Serroyen, J., & Gorgels, A. P. M. (2013). Right-Ventricular Enlargement in Arrhythmogenic Right-Ventricular Cardiomyopathy Is Associated with Decreased QRS Amplitudes and T-Wave Negativity. Annals of Noninvasive Electrocardiology, 18(6), 555-563.
    • Heijman, J., Zaza, A., Johnson, D. M., Rudy, Y., Peeters, R. L. M., Volders, P. G. A., & Westra, R. L. (2013). Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis. PLoS Computational Biology, 9(8), [e1003202].
    • Johnson, D. M., Heijman, J., Bode, E. F., Greensmith, D. J., van der Linde, H., Abi-Gerges, N., Eisner, D. A., Trafford, A. W., & Volders, P. G. A. (2013). Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After beta-Adrenergic Stimulation. Circulation Research, 112(2), 246-+.
  • 2012
    • Johnson, D. M., de Jong, M. M. J., Crijns, H. J. G. M., Carlsson, L. G., & Volders, P. G. A. (2012). Reduced Ventricular Proarrhythmic Potential of the Novel Combined Ion-Channel Blocker AZD1305 Versus Dofetilide in Dogs With Remodeled Hearts. Circulation-Arrhythmia and Electrophysiology, 5(1), 201-U328.