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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Longer and better lives for patients with atrial fibrillation

Longer and better lives for patients with atrial fibrillation

15 April 2024

An international panel of experts published recommendations to improve management of atrial fibrillation (AF).

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Carim Maastricht
Carim Maastricht

Guido Haenen

Assistant Professor

Prof/ Guido Haenen is currently Professor in 'Redox Modulation of Pharmacological and Toxicological Processes'. He was registered as Pharmacist in 1985 (with honours), and he obtained his PhD in Medicinal Chemistry in 1989. He was awarded the ‘Shell Prize’ for his thesis entitled ‘Thiols in Oxidative Stress’. Prof. Haenen is registered as Toxicologist and Clinical Pharmacologist. In 2015, he received the 'Grote Onderwijsprijs' (education prize) for being the best teacher in Biomedical Sciences at Maastricht University. He is Editor-in-Chief of the Molecular Toxicology section of the International Journal of Molecular Sciences.

Guido-haenen

Department of Pharmacology & Personalised Medicine
Universiteitsingel 40, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: C3.572
T: +31 (0)43 388 21 09

  • 2002
    • Stahl, W., van den Berg, H., Arthur, J., Bast, A., Dainty, J., Faulks, R. M., Gartner, C., Haenen, G. R. M. M., & et, A. (2002). Bioavailability and metabolism. Molecular Aspects of Medicine, 23(1-3), 39-100. https://doi.org/10.1016/S0098-2997(02)00016-X
    • Griffiths, H. R., Moller, L., Bartosz, G., Bast, A., Bertoni-Freddari, C., Collins, A., Cooke, M., Coolen, S., Haenen, G. R. M. M., Hoberg, A. M., Loft, S., Lun, J., Olinski, R., Parry, J., Pompella, A., Poulsen, H., & Verhagen, H. (2002). Biomarkers. Molecular Aspects of Medicine, 23(1-3), 101-108. https://doi.org/10.1016/S0098-2997(02)00017-1
    • Haenen, G. R. M. M., Borm, P. J. A., Knaapen, A. M., Albrecht, C., Becker, A., Hohr, D., Winzer, A., & Schins, R. P. F. (2002). DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation. Carcinogenesis, 23(7), 1111-1120. https://doi.org/10.1093/carcin/23.7.1111
    • van Schooten, F. J., Besarati Nia, A., de Flora, S., D'Agostini, F., Izzotti, A., Camoirano, A., Balm, A. J. M., Dallinga, J. W., Bast, A., Haenen, G. R. M. M., & et, A. (2002). Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiology Biomarkers & Prevention, 11(2), 167-175. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11867504&dopt=Abstract
    • den Hartog, G. J., Haenen, G. R. M. M., Vegt, E., van der Vijgh, W. J. F., & Bast, A. (2002). Efficacy of HOCI scavenging by sulfurcontaining compounds: antioxidant activity of glutathione disulfide?Biological Chemistry, 383, 709-713.
    • den Hartog, G. J. M., Haenen, G. R. M. M., Vegt, E., van der Vijgh, W. J. F., & Bast, A. (2002). Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide?Biological Chemistry, 383(3-4), 709-713. https://doi.org/10.1515/BC.2002.073
    • den Hartog, G. J. M., Vegt, E., van der Vijgh, W. J. F., Haenen, G. R. M. M., & Bast, A. (2002). Hypochlorous acid is a potent inhibitor of acetylcholinesterase. Toxicology and Applied Pharmacology, 181(3), 228-232. https://doi.org/10.1006/taap.2002.9419
    • Arts, M. J. T. J., Haenen, G. R. M. M., Wilms, L. C., Beetstra, S., Beerens - Heijnen, C. G. M., Voss, H. P., & Bast, A. (2002). Interactions between flavonoids and proteins: effect on the total antioxidant capacity. Journal of Agricultural and Food Chemistry, 50(5), 1184-1187. https://doi.org/10.1021/jf010855a
    • Boots, A. W., Haenen, G. R. M. M., den Hartog, G. J. M., & Bast, A. (2002). Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1583(3), 279-284. https://doi.org/10.1016/S1388-1981(02)00247-0
    • de Kort, J., Haenen, G. R. M. M., Bast, A., Koek, G. H., & Barnes , E. (2002). Oxidative stress in patients with active HCV infection. Hepatology, 36(4), 743. https://doi.org/10.1053/jhep.2002.35344
    • Beerens - Heijnen, C. G. M., Haenen, G. R. M. M., Oostveen, R. M., Stalpers, E. M., & Bast, A. (2002). Protection of flavonoids against lipid peroxidation: the structure activity relationship revisited. Free Radical Research, 36(5), 575-581. https://doi.org/10.1080/10715760290025951
    • Rezk, B. M., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2002). The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochemical and Biophysical Research Communications, 295(1), 9-13. https://doi.org/10.1016/S0006-291X(02)00618-6
    • Dallinga, J. W., Haenen, G. R. M. M., Bast, A., & van Schooten, F. J. (2002). The effect of the trolox equivalent antioxidant capacity (TEAC) in plasma on the formation of 4-aminobiphenylhaemoglobin adducts in smokers. Biomarkers, 7(4), 291-298. https://doi.org/10.1080/13547500210148306
    • Bast, A., & Haenen, G. R. M. M. (2002). The toxicity of antioxidants and their metabolites. Environmental Toxicology and Pharmacology, 11, 251-258. https://doi.org/10.1016/S1382-6689(01)00118-1
    • Haenen, G. R. M. M., & Bast, A. (2002). The use of vitamin supplements in self-medication. Therapie, 57(2), 119-122. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12185958&dopt=Abstract
    • van Haaften, R. I. M., Haenen, G. R. M. M., Evelo, C. T. A., & Bast, A. (2002). Tocotrienols inhibit human glutathione S-transferase P1-1. Iubmb Life, 54(2), 81-84. https://doi.org/10.1080/15216540214315
  • 2001
    • van Haaften, R. I. M., Evelo, C. T. A., Haenen, G. R. M. M., & Bast, A. (2001). alpha-Tocopherol inhibits human glutathione S-transferase pi.Biochemical and Biophysical Research Communications, 280, 631-633. https://doi.org/10.1006/bbrc.2000.4174
    • Nia, A. B., van Schooten, F. J., Schilderman-Houba, P. A. E. L., de Kok, T. M. C. M., Haenen, G. R. M. M., van Herwijnen, M. H. M., van Agen, E., Pachen, D. M. F. A., & Kleinjans, J. C. S. (2001). A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms.Carcinogenesis, 22, 395-401. https://doi.org/10.1093/carcin/22.3.395
    • van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H. (2001). A vegetable/fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers.Journal of Nutrition, 131, 1714-1722. https://doi.org/10.1093/jn/131.6.1714
    • Beerens - Heijnen, C. G. M., Haenen, G. R. M. M., van Acker, F. A. A., van der Vijgh, W. J. F., & Bast, A. (2001). Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups.Toxicology in Vitro, 15, 3-6. https://doi.org/10.1016/S0887-2333(00)00053-9
    • van Haaften, R. I. M., den Hartog, G. J. M., Evelo, C. T. A., Haenen, G. R. M. M., & Bast, A. (2001). Hypochlorous acid is a potent inhibitor of GST P1-1.Chemico-Biological Interactions, 138, 77-83. https://doi.org/10.1016/S0009-2797(01)00262-9
    • van Haaften, R. I. M., Evelo, C. T. A., Penders, J., Eijnwachter, M., Haenen, G. R. M. M., & Bast, A. (2001). Inhibition of human glutathione S-transferase P1-1 by tocopherols and alpha-tocopherol derivatives.Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1548, 23-28. https://doi.org/10.1016/S0167-4838(01)00211-4
    • Arts, M. J. T. J., Haenen, G. R. M. M., Voss, H. P., & Bast, A. (2001). Masking of antioxidant capacity by the interaction of flavonoids with protein.Food and Chemical Toxicology, 39, 787-791. https://doi.org/10.1016/S0278-6915(01)00020-5
    • van Acker, F. A. A., Hulshof, J., Haenen, G. R. M. M., Menge, W. M. P. B., van der Vijgh, W. J. F., & Bast, A. (2001). New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity.Free Radical Biology and Medicine, 31, 31-37. https://doi.org/10.1016/S0891-5849(01)00546-9
    • Drent, M., van den Berg, R., Haenen, G. R. M. M., van den Berg, H., Wouters, E. F. M., & Bast, A. (2001). NF-kappaB activation in sarcoidosis.Sarcoidosis Vasculitis and Diffuse Lung Diseases, 18(1), 50-56. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11354547&dopt=Abstract
    • van Haaften, R. I. M., Evelo, C. T. A., Haenen, G. R. M. M., & Bast, A. (2001). No reduction of alpha-tocopherol quinone by glutathione in rat liver microsomes. Biochemical Pharmacology, 61, 715-719. https://doi.org/10.1016/S0006-2952(01)00545-7
    • van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (2001). Nuclear factor-kappaB activation is higher in peripheral blood mononuclear cells of male smokers.Environmental Toxicology and Pharmacology, 9, 147-151. https://doi.org/10.1016/S1382-6689(00)00070-3
    • Beerens - Heijnen, C. G. M., Haenen, G. R. M. M., Vekemans, J., & Bast, A. (2001). Peroxynitrite scavenging of flavonoids: structure activity relationship. Environmental Toxicology and Pharmacology, 10, 199-206. https://doi.org/10.1016/S1382-6689(01)00083-7
    • Rhemrev, J. P. T., Vermeiden, J. P. W., Haenen, G. R. M. M., de Bruijne, J., Rekers-Mombarg, L., & Bast, A. (2001). Progressively motile human spermatozoa are well protected against in vitro lipid peroxidation imposed by induced oxidative stress.Andrologia, 33, 151-158. https://doi.org/10.1046/j.1439-0272.2001.00430.x
    • Ostby, O. B., Gundersen, L. L., Rise, F., Antonson, O., Fosnes, K., Larsen, V., Bast, A., Custers, I., & Haenen, G. R. M. M. (2001). Synthesis of 5-substituted pyrrolo[1,2-b]pyridazines with antioxidant properties. Archiv der Pharmazie, 334, 21-24. https://doi.org/10.1002/1521-4184(200101)334:1<21::AID-ARDP21>3.0.CO;2-W
    • van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (2001). Transcription factor NF-kappaB as a potential biomarker for oxidative stress.British Journal of Nutrition, 86 suppl 1, S121-S127. https://doi.org/10.1079/BJN2001340
  • 2000
    • van Acker, F. A. A., van Acker, S. A. B. E., Kramer, K., Haenen, G. R. M. M., Bast, A., & van der Vijgh, W. J. F. (2000). 7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week. Clinical Cancer Research, 6(4), 1337-1347. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10778960&dopt=Abstract
    • Heunks, L. M. A., Bast, A., van Herwaarden, C. L. A., Haenen, G. R. M. M., & Dekhuijzen, P. N. R. (2000). Effects of emphysema and training on glutathione oxidation in the hamster diaphragm. Journal of Applied Physiology, 88, 2054-2061. https://doi.org/10.1152/jappl.2000.88.6.2054
    • van Acker, F. A. A., Schouten, O., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2000). Flavonoids can replace alpha-tocopherol as an antioxidant. Febs Letters, 473, 145-148. https://doi.org/10.1016/S0014-5793(00)01517-9
    • van Acker, F. A. A., van Acker, S. A. B. E., Haenen, G. R. M. M., Bast, A., & van der Vijgh, W. J. F. (2000). In vitro screening of antitumour agents for cardiotoxicity by means of isolated mouse left atria. Anticancer Research, 20(6B), 4483-4487. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11205292&dopt=Abstract
    • Paquay, J. B. G., Haenen, G. R. M. M., Stender, G., Wiseman, S. A., Tijburg, L. B. M., & Bast, A. (2000). Protection against nitric oxide toxicity by tea. Journal of Agricultural and Food Chemistry, 48, 5768-5772. https://doi.org/10.1021/jf981316h
    • Rhemrev, J. P. T., van Overveld, F. W. P. C., Haenen, G. R. M. M., Teerlink, T., Bast, A., & Vermeiden, J. P. W. (2000). Quantification of the nonenzymatic fast and slow TRAP in a postaddition assay in human seminal plasma and the antioxidant contributions of various seminal compounds. Journal of Andrology, 21, 913-920. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11105918&dopt=Abstract
    • Vreman, H. J., Haenen, G. R. M. M., Stevenson, D. K., & Bast, A. (2000). Reduction of the NO-mediated response in the rat aorta by metalloporphyrins. Canadian Journal of Physiology and Pharmacology, 78, 457-461. https://doi.org/10.1139/y00-009
    • Ystby, O. B., Dalhus, B., Gundersen, L. L., Rise, F., Bast, A., & Haenen, G. R. M. M. (2000). Synthesis of 1-substituted 7-cyano-2,3-diphenylindolizines and evaluation of antioxidant properties. European Journal of Organic Chemistry, 3763-3770. https://doi.org/10.1002/1099-0690(200011)2000:22<3763::AID-EJOC3763>3.0.CO;2-S
    • van Acker, F. A. A., Hageman, G. J., Haenen, G. R. M. M., van der Vijgh, W. J. F., Bast, A., & Menge, W. M. P. B. (2000). Synthesis of novel 3,7-substituted-2-(3',4'-dihydroxyphenyl)flavones with improved antioxidant activity. Journal of Medicinal Chemistry, 43, 3752-3760. https://doi.org/10.1021/jm000951n
    • Beerens - Heijnen, C. G. M., Haenen, G. R. M. M., Wiseman, S. A., & Tijburg, L. B. M. (2000). The interaction of tea flavonoids with the NO-system: disrimination between good and bad NO. Food Chemistry, 70, 365-370. https://doi.org/10.1016/S0308-8146(00)00105-9
    • van den Berg, R., Haenen, G. R. M. M., van den Berg, H., van der Vijgh, W. J. F., & Bast, A. (2000). The predictive value of the antioxidant capacity of structurally related flavonoids using the Trolox equivalent antioxidant capacity TEAC assay. Food Chemistry, 70, 391-395. https://doi.org/10.1016/S0308-8146(00)00092-3
    • Vliet, L. A., Rodenhuis, N., Wikstrom, H., Pugsley, T. A., Serpa, K. A., Meltzer, L. T., Heffner, T. G., Wise, L. D., Laijness, M. E., Huff, R. M., Svensson, K., Haenen, G. R. M. M., & Bast, A. (2000). Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists. Journal of Medicinal Chemistry, 43, 3549-3557. https://doi.org/10.1021/jm000087z
    • van Overveld, F. W. P. C., Haenen, G. R. M. M., Rhemrev, J. P. T., Vermeiden, J. P. W., & Bast, A. (2000). Tyrosine as important contributor to the antioxidant capacity of seminal plasma. Chemico-Biological Interactions, 127, 151-161. https://doi.org/10.1016/S0009-2797(00)00179-4
  • 1999
    • van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (1999). Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures.Food Chemistry, 66(4), 511-518. https://doi.org/10.1016/S0308-8146(99)00089-8
    • Haenen, G. R. M. M., & Bast, A. (1999). Nitric Oxide Radical Scavenging of Flavonoids. Methods in Enzymology, 301, 490-503. https://doi.org/10.1016/S0076-6879(99)01112-X
    • Paquay, J. B. G., Hoen, P. A., Bast, A., Timmerman, H., & Haenen, G. R. M. M. (1999). Nitric oxide synthase inhibition by dimaprit and dimaprit analogues.British Journal of Pharmacology, 127(2), 331-334. https://doi.org/10.1038/sj.bjp.0702552
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