Coen Stehouwer

Professor

Prof. Coen Stehouwer (born Rotterdam, 1960) obtained an MD at the Erasmus University in Rotterdam (1985; cum laude). He was registered as internist in 1990 and obtained a PhD in 1992 (Vrije Universiteit Medical Centre, Amsterdam). He received postgraduate training in epidemiology and molecular biology. He was appointed professor of medicine and vice-chair of the Department of Medicine in 2000 at the Vrije Universiteit in Amsterdam). In 2004, he accepted a position as professor of medicine and chair of the Department of Medicine at the University of Maastricht. Coen Stehouwer currently is Professor of Internal Medicine and Chair of the Department of Internal Medicine at Maastricht University in the Netherlands.

He is an internationally recognised clinician-scientist in the field of microcirculatory as well as large artery research, notably in the context of cardiovascular complications of diabetes and the metabolic syndrome. Since 1990, the work of Professor Stehouwer and his group has led to 77 completed PhD theses, and more than 800 peer-reviewed papers in international journals.

His work is well-recognised, as shown by a Hirsh index of 109 (Web of Science); >52,000 citations; several awards, such as the Dr F. Gerritzen Award for excellent diabetes research (Dutch Diabetes Research Foundation, 1993); the Castelli-Pedroli Award for excellent research into the complications of diabetes (European Association for the Study of Diabetes, 2005); the Dutch Society of Vascular Medicine Career Award (2007); the Ruitenga Van Swieten honorary professorship of the University of Amsterdam (2009); and the Donald McDonald Award of Artery Society (2017); as well as many invited lectures at (inter)national meetings, such as those of the European Society for Microcirculation, the World Congress for Microcirculation, the European Society for the Study of Diabetes, the American Diabetes Association, the European Society for Cardiology, and the American Heart Association.

His research programme focuses on the elucidation of how metabolic changes in (pre)diabetes and the metabolic syndrome cause micro- and macrovascular disease. A key element of the programme is to combine epidemiology, clinical physiology and experimental approaches, in the conviction that these approaches should complement and mutually inspire each other. He is one of the principal investigators of the well-known Hoorn Study (since 1992). He also obtained national and European funding (16 M€) for, and is the initiator and Scientific Director of the Maastricht Study (started 2010), which combines very detailed phenotyping (with a focus on microcirculatory, large artery and cardiac function and structure) with an ‘omics’ approach in 7000 individuals without and 2000 with type 2 diabetes to elucidate how diabetes leads not only to classic complications but also to so-called emerging complications such as cognitive dysfunction, mood disorders, liver disease, musculoskeletal disease, pulmonary disease, sleep-disordered breathing, and infectious diseases.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T:+31(0)43 387 70 06

  • 2011
    • Jacobs, M., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Ferreira, I., Feskens, E. J., Jansen, E. H., Schalkwijk, C. G., & Stehouwer, C. D. (2011). The association between the metabolic syndrome and alanine amino transferase is mediated by insulin resistance via related metabolic intermediates (the Cohort on Diabetes and Atherosclerosis Maastricht [CODAM] study).Metabolism-Clinical and Experimental, 60(7), 969-975. https://doi.org/10.1016/j.metabol.2010.09.006
    • Jonk, A. M., Houben, A. J., Schaper, N. C., de Leeuw, P., Serne, E. H., Smulders, Y. M., & Stehouwer, C. D. A. (2011). Meal-related increases in microvascular vasomotion are impaired in obese individuals: a potential mechanism in the pathogenesis of obesity-related insulin resistance. Diabetes Care, 34 Suppl 2, S342-S348. https://doi.org/10.2337/dc11-s240
    • Alssema, M., Vistisen, D., Heymans, M. W., Nijpels, G., Glumer, C., Zimmet, P. Z., Shaw, J. E., Eliasson, M., Stehouwer, C. D. A., Tabak, A. G., Colagiuri, S., Borch-Johnsen, K., & Dekker, J. M. (2011). The evaluation of screening and early detection strategies for type 2 diabetes and impaired glucose tolerance (DETECT-2) update of the finnish diabetes risk score for prediction of incident type 2 diabetes. Diabetologia, 54(5), 1004-1012. https://doi.org/10.1007/s00125-010-1990-7
    • Beijers, H. J. B. H., Henry, R. M., Bravenboer, B., Ferreira, I., Dekker, J. M., Nijpels, G., & Stehouwer, C. D. A. (2011). Metabolic syndrome in nondiabetic individuals associated with maladaptive carotid remodeling: the Hoorn study. American Journal of Hypertension, 24(4), 429-436. https://doi.org/10.1038/ajh.2010.256
    • van Greevenbroek, M. M. J., Jacobs, M., van der Kallen, C. J. H., Vermeulen, V. M., Jansen, E. H., Schalkwijk, C. G., Ferreira, I., Feskens, E. J., & Stehouwer, C. D. A. (2011). The cross-sectional association between insulin resistance and circulating complement C3 is partly explained by plasma alanine aminotransferase, independent of central obesity and general inflammation (the CODAM study).European Journal of Clinical Investigation, 41(4), 372-379. https://doi.org/10.1111/j.1365-2362.2010.02418.x
    • Emerging Risk Factors Collaboration, & Stehouwer, C. (2011). Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death. New England Journal of Medicine, 364(9), 829-841. https://doi.org/10.1056/NEJMoa1008862
    • Engelen, L., Lund, S. S., Ferreira, I., Tarnow, L., Parving, H-H., Gram, J., Winther, K., Pedersen, O., Teerlink, T., Barto, R., Stehouwer, C. D. A., Vaag, A. A., & Schalkwijk, C. G. (2011). Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes. European Journal of Endocrinology, 164(3), 371-379. https://doi.org/10.1530/EJE-10-0851
    • Thewissen, M. M. G. L., Damoiseaux, J. G. M. C., Duijvestijn, A. M., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Feskens, E. J., Blaak, E. E., Schalkwijk, C. G., Stehouwer, C. D. A., Tervaert, J. W., & Ferreira, I. (2011). Abdominal Fat Mass Is Associated With Adaptive Immune Activation: The CODAM Study. Obesity, 19(8), 1690-1698. https://doi.org/10.1038/oby.2010.337
    • Jonk, A. M., Houben, A. J., Schaper, N. C., de Leeuw, P. W., Serne, E. H., Smulders, Y. M., & Stehouwer, C. D. A. (2011). Acute angiotensin II receptor blockade improves insulin-induced microvascular function in hypertensive individuals. Microvascular Research, 82(1), 77-83. https://doi.org/10.1016/j.mvr.2011.04.002
    • Heringa, S. M., van den Berg, E., Dekker, J. M., Nijpels, G., Kessels, R. P., Kappelle, L. J., Stehouwer, C. D. A., & Biessels, G. J. (2011). Albuminuria and cognitive functioning in an older population: The Hoorn study. Dementia and Geriatric Cognitive Disorders, 32(3), 182-187. https://doi.org/10.1159/000333076
    • Reijmer, Y. D., van den Berg, E., van Sonsbeek, S., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Kappelle, J. L., & Biessels, G. J. (2011). Dementia risk score predicts cognitive impairment after a period of 15 years in a nondemented population. Dementia and Geriatric Cognitive Disorders, 31(2), 152-157. https://doi.org/10.1159/000324437
    • Touwslager, R. N., Gielen, M. J. F., Derom, C., Mulder, A. L. M., Gerver, W. J. M., Zimmermann, L. J. I., Houben, A. J., Stehouwer, C. D. A., Vlietinck, R., Loos, R. J., & Zeegers, M. P. A. (2011). Determinants of infant growth in four age windows: a twin study. Journal of Pediatrics, 158(4), 566-572.e2. https://doi.org/10.1016/j.jpeds.2010.10.005
    • Wlazlo, N., Sauerwein, H. P., Schoon, E. J., Stehouwer, C. D. A., & Bravenboer, B. (2011). Diabetes mellitus en levercirrose: prognostisch ongunstige combinatie. Nederlands Tijdschrift voor Geneeskunde, 155(5), A2213. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21329534
    • van Bussel, B. C. T., Schouten, F., Henry, R. M., Schalkwijk, C. G., de Boer, M. R., Ferreira, I., Smulders, Y. M., Twisk, J. W., & Stehouwer, C. D. A. (2011). Endothelial Dysfunction and Low-Grade Inflammation Are Associated With Greater Arterial Stiffness Over a 6-Year Period. Hypertension, 58(4), 588-595. https://doi.org/10.1161/HYPERTENSIONAHA.111.174557
    • van Bussel, B. C. T., Henry, R. M., Schalkwijk, C. G., Ferreira, I., Feskens, E. J., Streppel, M. T., Smulders, Y. M., Twisk, J. W., & Stehouwer, C. D. A. (2011). Fish consumption in healthy adults is associated with decreased circulating biomarkers of endothelial dysfunction and inflammation during a 6-year follow-up. Journal of Nutrition, 141(9), 1719-1725. https://doi.org/10.3945/jn.111.139733
    • van de Laar, R. J., Ferreira, I., van Mechelen, W., Prins, M. H., Twisk, J. W., & Stehouwer, C. D. A. (2011). Habitual physical activity and peripheral arterial compliance in young adults: the amsterdam growth and health longitudinal study.American Journal of Hypertension, 24(2), 200-208. https://doi.org/10.1038/ajh.2010.201
    • Nin, J. W., Jorsal, A., Ferreira, I., Schalkwijk, C. G., Prins, M. H., Parving, H. H., Tarnow, L., Rossing, P., & Stehouwer, C. D. A. (2011). Higher Plasma Levels of Advanced Glycation End Products Are Associated With Incident Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes: A 12-year follow-up study. Diabetes Care, 34(2), 442-447. https://doi.org/10.2337/dc10-1087
    • Sipkens, J. A., Hahn, N. E., van Nieuw-Amerongen, G. P., Stehouwer, C. D. A., Rauwerda, J. A., van Hinsbergh, V. W. M., Niessen, H. W., & Krijnen, P. A. (2011). Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of rho kinase and flippase activity. Cellular Physiology and Biochemistry, 28(1), 53-62. https://doi.org/10.1159/000331713
    • Engelen, L., Persson, F., Ferreira, I., Rossing, P., Hovind, P., Teerlink, T., Stehouwer, C. D. A., Parving, H. H., & Schalkwijk, C. G. (2011). Irbesartan treatment does not influence plasma levels of the advanced glycation end products N(epsilon)(1-carboxymethyl)lysine and N(epsilon)(1-carboxyethyl)lysine in patients with type 2 diabetes and microalbuminuria. A randomized controlled trial.Nephrology Dialysis Transplantation, 26(11), 3573-3577. https://doi.org/10.1093/ndt/gfr102
    • Wijnands, J. M. A., Boonen, A., Arts, I. C., Dagnelie, P. C., Stehouwer, C. D. A., & van der Linden, S. (2011). Large epidemiologic studies of gout: challenges in diagnosis and diagnostic criteria. Current Rheumatology Reports, 13(2), 167-174. https://doi.org/10.1007/s11926-010-0157-3
    • Brouwers, O., Niessen, P. M., Ferreira, I., Miyata, T., Scheffer, P. G., Teerlink, T., Schrauwen, P., Brownlee, M., Stehouwer, C. D. A., & Schalkwijk, C. G. (2011). Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats.Journal of Biological Chemistry, 286(2), 1374-1380. https://doi.org/10.1074/jbc.M110.144097
    • Mulders, T. A., Meyer, Z., van der Donk, C. F. M., Kroon, A. A., Ferreira, I., Stehouwer, C. D. A., & Pinto-Sietsma, S. J. (2011). Patients with premature cardiovascular disease and a positive family history for cardiovascular disease are prone to recurrent events.International Journal of Cardiology, 153(1), 64-67. https://doi.org/10.1016/j.ijcard.2010.08.040
    • van Sloten, T. T., Savelberg, H. H., Duimel-Peeters, I. G. M., Meijer, K., Henry, R. M., Stehouwer, C. D. A., & Schaper, N. C. (2011). Peripheral neuropathy, decreased muscle strength and obesity are strongly associated with walking in persons with type 2 diabetes without manifest mobility limitations.Diabetes Research and Clinical Practice, 91(1), 32-39. https://doi.org/10.1016/j.diabres.2010.09.030
    • Brouwers, M. C., van Greevenbroek, M. M. J., Troutt, J., Bonner Freeman, A., Lu, A., Schaper, N. C., Konrad, R. J., & Stehouwer, C. D. A. (2011). Plasma proprotein convertase subtilisin kexin type 9 is a heritable trait of familial combined hyperlipidemia. Clinical Science, 121, 397-403. https://doi.org/10.1042/CS20110129
    • Brouwers, M. C., Troutt, J. S., van Greevenbroek, M. M. J., Ferreira, I., Feskens, E. J., van der Kallen, C. J. H., Schaper, N. C., Schalkwijk, C. G., Konrad, R. J., & Stehouwer, C. D. A. (2011). Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study. Atherosclerosis, 217(1), 263-267. https://doi.org/10.1016/j.atherosclerosis.2011.03.023
    • van Dijk, J. W. M., Manders, R. J. F., Hartgens, F., Stehouwer, C. D. A., Praet, S. F., & van Loon, L. J. C. (2011). Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Research and Clinical Practice, 93(1), 31-37. https://doi.org/10.1016/j.diabres.2011.03.021
    • Jacobs, M., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Ferreira, I., Blaak, E. E., Feskens, E. J., Jansen, E. H., Schalkwijk, C. G., & Stehouwer, C. D. A. (2011). The association between the metabolic syndrome and peripheral, but not coronary, artery disease is partly mediated by endothelial dysfunction: the CODAM study.European Journal of Clinical Investigation, 41(2), 167-175. https://doi.org/10.1111/j.1365-2362.2010.02392.x
    • Emerging Risk Factors Collaboration, & Stehouwer, C. (2011). Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet, 377(9771), 1085-1095. https://doi.org/10.1016/S0140-6736(11)60105-0
  • 2010
    • Beijers, H. J. B. H., Ferreira, I., Spronk, H. M. H., Bravenboer, B., Dekker, J. M., Nijpels, G., ten Cate, H., & Stehouwer, C. D. A. (2010). Body composition as determinant of thrombin generation in plasma: the Hoorn study.Arteriosclerosis Thrombosis and Vascular Biology, 30(12), 2639-2647. https://doi.org/10.1161/ATVBAHA.110.211946
    • Van der Zwan, L. P., Teerlink, T., Dekker, J. M., Henry, R. M., Stehouwer, C. D. A., Jakobs, C., Heine, R. J., & Scheffer, P. G. (2010). Plasma myeloperoxidase is inversely associated with endothelium-dependent vasodilation in elderly subjects with abnormal glucose metabolism.Metabolism-Clinical and Experimental, 59(12), 1723-1729. https://doi.org/10.1016/j.metabol.2010.04.012
    • Krijnen, P. A., Sipkens, J. A., Molling, J. W., Rauwerda, J. A., Stehouwer, C. D. A., Muller, A., Paulus, W. J., van Nieuw Amerongen, G. P., Hack, C. E., Verhoeven, A. J., van Hinsbergh, V. W. M., & Niessen, H. W. (2010). Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase.Journal of Molecular and Cellular Cardiology, 49(5), 781-790. https://doi.org/10.1016/j.yjmcc.2010.07.017
    • Mattace-Raso, F. U. S., Hofman, A., Verwoert, G. C., Witteman, J. C. M., Wilkinson, I., Cockcroft, J., McEniery, C., Yasmin, Laurent, S., Boutouyrie, P., Bozec, E., Hansen, T. W., Torp-Pedersen, C., Ibsen, H., Jeppesen, J., Vermeersch, S. J., Rietzschel, E. R., De Buyzere, M., Gillebert, T. C., ... Dolejsova, M. (2010). Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'. European Heart Journal, 31(19), 2338-2350. https://doi.org/10.1093/eurheartj/ehq165
    • Ketel, I. J., Stehouwer, C. D. A., Henry, R. M., Serne, E. H., Hompes, P., Homburg, R., Smulders, Y. M., & Lambalk, C. B. (2010). Greater arterial stiffness in polycystic ovary syndrome (PCOS) is an obesity--but not a PCOS-associated phenomenon.Journal of Clinical Endocrinology & Metabolism, 95(10), 4566-4575. https://doi.org/10.1210/jc.2010-0868
    • Emerging Risk Factors Collaboration, & Stehouwer, C. (2010). Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. International Journal of Epidemiology, 39(5), 1345-1359. https://doi.org/10.1093/ije/dyq063
    • Ruiter, M. S., van Golde, J. M., Schaper, N. C., Stehouwer, C. D. A., & Huijberts, M. S. P. (2010). Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms. Clinical Science, 119(5-6), 225-238. https://doi.org/10.1042/CS20100082
    • Zhou, X. H., Qiao, Q., Zethelius, B., Pyorala, K., Soderberg, S., Pajak, A., Stehouwer, C. D., Heine, R. J., Jousilahti, P., Ruotolo, G., Nilsson, P. M., Calori, G., & Tuomilehto, J. (2010). Diabetes, prediabetes and cancer mortality.Diabetologia, 53(9), 1867-1876. https://doi.org/10.1007/s00125-010-1796-7
    • Anderwald, C., Ankersmit, H. J., Badaoui, A., Beneduce, L., Buko, V. U., Calo, L. A., Carrero, J. J., Chang, C-Y., Chang, K-C., Chen, Y-J., Cnotliwy, M., Costelli, P., Crujeiras, A. B., Cuocolo, A., Davis, P. A., de Boer, O. J., Ebenbichler, C. F., Erridge, C., Fassina, G., ... Zhu, Y. (2010). Research update for articles published in EJCI in 2008. European Journal of Clinical Investigation, 40(9), 770-789. https://doi.org/10.1111/j.1365-2362.2010.02351.x
    • Van den Hurk, K., Alssema, M., Kamp, O., Henry, R. M., Stehouwer, C. D. A., Diamant, M., Boomsma, F., Heine, R. J., Nijpels, G., Paulus, W. J., & Dekker, J. M. (2010). Slightly elevated B-type natriuretic peptide levels in a non-heart failure range indicate a worse left ventricular diastolic function in individuals with, as compared with individuals without, type 2 diabetes: the Hoorn Study.European journal of heart failure, 12(9), 958-965. https://doi.org/10.1093/eurjhf/hfq119
    • Jonk, A. M., Houben, A. J., Schaper, N. C., de Leeuw, P., Serne, E. H., Smulders, Y. M., & Stehouwer, C. D. (2010). Angiotensin II Enhances Insulin-Stimulated Whole-Body Glucose Disposal but Impairs Insulin-Induced Capillary Recruitment in Healthy Volunteers. Journal of Clinical Endocrinology & Metabolism, 95(8), 3901-3908. https://doi.org/10.1210/jc.2009-2587
    • Nin, J. W., Jorsal, A., Ferreira, I., Schalkwijk, C. G., Prins, M. H., Parving, H. H., Tarnow, L., Rossing, P., & Stehouwer, C. D. (2010). Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study. incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-yr follow-up study. Diabetes, 59(8), 2027-2032. https://doi.org/10.2337/db09-1509
    • Bradley, E. A., Eringa, E. C., Stehouwer, C. D. A., Korstjens, I., van Nieuw Amerongen, G. P., Musters, R., Sipkema, P., Clark, M. G., & Rattigan, S. (2010). Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion.Arteriosclerosis Thrombosis and Vascular Biology, 30(6), 1137-1142. https://doi.org/10.1161/ATVBAHA.110.204404
    • Van der Zwan, L. P., Scheffer, P. G., Dekker, J. M., Stehouwer, C. D. A., Heine, R. J., & Teerlink, T. (2010). Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure.Hypertension, 55(6), 1366-1372. https://doi.org/10.1161/HYPERTENSIONAHA.109.147231
    • de Jager, J., Kooy, A., Lehert, P., Wulffele, M. G., van der Kolk, J., Bets, D., Verburg, J., Donker, A. J., & Stehouwer, C. D. (2010). Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ, 340, c2181. [2181]. https://doi.org/10.1136/bmj.c2181
    • Sarwar, N., Sandhu, M. S., Ricketts, S. L., Butterworth, A. S., Di Angelantonio, E., Ouwehand, W. H., Watkins, H., Samani, N. J., Saleheen, D., Reilly, M. P., Hingorani, A. D., Talmud, P. J., Danesh, J., Braund, P. S., Hall, A. S., Thompson, J., Marz, W., Sivapalaratnam, S., Soranzo, N., ... Wood, A. M. (2010). Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet, 375(9726), 1634-1639. https://doi.org/10.1016/S0140-6736(10)60545-4
    • Brouwers, O., Niessen, P. M., Haenen, G. R. M. M., Miyata, T., Brownlee, M., Stehouwer, C. D. A., de Mey, J. G. R., & Schalkwijk, C. G. (2010). Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.Diabetologia, 53(5), 989-1000. https://doi.org/10.1007/s00125-010-1677-0
    • Zhang, L., Qiao, Q., Tuomilehto, J., Janus, E. D., Lam, T. H., Ramachandran, A., Mohan, V., Stehouwer, C. D., Dong, Y., Nakagami, T., Onat, A., & Soderberg, S. (2010). Distinct Ethnic Differences in Lipid Profiles across Glucose Categories. Journal of Clinical Endocrinology & Metabolism, 95(4), 1793-1801. https://doi.org/10.1210/jc.2009-2348
    • Brouwers, M. C. G. J., van der Kallen, C. J. H., Schaper, N. C., van Greevenbroek, M. M. J., & Stehouwer, C. D. A. (2010). Five-year incidence of type 2 diabetes mellitus in patients with familial combined hyperlipidaemia. Netherlands Journal of Medicine, 68(4), 163-167. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20421657
    • van den Berg, E., Biessels, G. J., Stehouwer, C. D. A., Kappelle, L. J., Heine, R. J., Nijpels, G., & Dekker, J. M. (2010). Ten-year time course of risk factors for increased carotid intima-media thickness: the Hoorn Study. European Journal of Cardiovascular Prevention & Rehabilitation, 17(2), 168-174. https://doi.org/10.1097/HJR.0b013e3283319094
    • Engelen, L., Ferreira, I., Gaens, K. H. J., Henry, R. M. A., Dekker, J. M., Nijpels, G., Heine, R. J., 't Hart, L. M., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Blaak, E. E., Feskens, E. J. M., ten Cate, H., Stehouwer, C. D. A., & Schalkwijk, C. G. (2010). The association between the-374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies. Journal of Hypertension, 28(2), 285-293. https://doi.org/10.1097/HJH.0b013e3283330931
    • Kaptoge, S., Di Angelantonio, E., Lowe, G., Pepys, M. B., Thompson, S. G., Collins, R., Danesh, J., Tipping, R. W., Ford, C. E., Pressel, S. L., Walldius, G., Jungner, I., Folsom, A. R., Chambless, L. E., Ballantyne, C. M., Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Stefanadis, C., ... Danesh, J. (2010). C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet, 375(9709), 132-140. https://doi.org/10.1016/S0140-6736(09)61717-7