Coen Stehouwer


Prof. Coen Stehouwer (born Rotterdam, 1960) obtained an MD at the Erasmus University in Rotterdam (1985; cum laude). He was registered as internist in 1990 and obtained a PhD in 1992 (Vrije Universiteit Medical Centre, Amsterdam). He received postgraduate training in epidemiology and molecular biology. He was appointed professor of medicine and vice-chair of the Department of Medicine in 2000 at the Vrije Universiteit in Amsterdam). In 2004, he accepted a position as professor of medicine and chair of the Department of Medicine at the University of Maastricht. Coen Stehouwer currently is Professor of Internal Medicine and Chair of the Department of Internal Medicine at Maastricht University in the Netherlands.

He is an internationally recognised clinician-scientist in the field of microcirculatory as well as large artery research, notably in the context of cardiovascular complications of diabetes and the metabolic syndrome. Since 1990, the work of Professor Stehouwer and his group has led to 77 completed PhD theses, and more than 800 peer-reviewed papers in international journals.

His work is well-recognised, as shown by a Hirsh index of 109 (Web of Science); >52,000 citations; several awards, such as the Dr F. Gerritzen Award for excellent diabetes research (Dutch Diabetes Research Foundation, 1993); the Castelli-Pedroli Award for excellent research into the complications of diabetes (European Association for the Study of Diabetes, 2005); the Dutch Society of Vascular Medicine Career Award (2007); the Ruitenga Van Swieten honorary professorship of the University of Amsterdam (2009); and the Donald McDonald Award of Artery Society (2017); as well as many invited lectures at (inter)national meetings, such as those of the European Society for Microcirculation, the World Congress for Microcirculation, the European Society for the Study of Diabetes, the American Diabetes Association, the European Society for Cardiology, and the American Heart Association.

His research programme focuses on the elucidation of how metabolic changes in (pre)diabetes and the metabolic syndrome cause micro- and macrovascular disease. A key element of the programme is to combine epidemiology, clinical physiology and experimental approaches, in the conviction that these approaches should complement and mutually inspire each other. He is one of the principal investigators of the well-known Hoorn Study (since 1992). He also obtained national and European funding (16 M€) for, and is the initiator and Scientific Director of the Maastricht Study (started 2010), which combines very detailed phenotyping (with a focus on microcirculatory, large artery and cardiac function and structure) with an ‘omics’ approach in 7000 individuals without and 2000 with type 2 diabetes to elucidate how diabetes leads not only to classic complications but also to so-called emerging complications such as cognitive dysfunction, mood disorders, liver disease, musculoskeletal disease, pulmonary disease, sleep-disordered breathing, and infectious diseases.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T:+31(0)43 387 70 06

  • 2004
    • van Dam, R. M., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Bouter, L. M., & Heine, R. J. (2004). Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study. Diabetologia, 47(12), 2152-2159.
    • Ferreira, I., Twisk, J. W., van Mechelen, W., Kemper, H. C. G., Seidell, J. C., & Stehouwer, C. D. A. (2004). Current and adolescent body fatness and fat distribution: relationships with carotid intima-media thickness and large artery stiffness at the age of 36 years. Journal of Hypertension, 22(1), 145-155.
    • Stehouwer, C. D. A., & Hu, G. (2004). Decode Insulin Study Group: Plasma insulin and cardiovascular mortality in non-diabetic European men and women: a meta-analysis of data from eleven prospective studies. Diabetologia, 47, 1245-1256.
    • Daelmans, H. E. M., Stokroos-van der Hem, H. H., Hoogenboom, R. J. I., Scherpbier, A. J. J. A., Stehouwer, C. D. A., & van der Vleuten, C. P. M. (2004). Feasibility and reliability of an in-training assessment programme in an undergraduate clerkship. Medical Education, 38, 1270-1277.
    • de Jongh, R. T., Serné, E. H., Ijzerman, R. G., de Vries, G., & Stehouwer, C. D. A. (2004). Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes, 53(11), 2873-2882.
    • Stam, F., van Guldener, C., ter Wee, P. M., Kulik, W., Smith, D. E. C., Jakobs, C., Stehouwer, C. D. A., & de Meer, K. (2004). Homocysteine clearance and methylation flux rates in health and end-stage renal disease: association with S-adenosylhomocysteine. American Journal of Physiology-Renal Physiology, 287(2), F215-F223.
    • de Jongh, R. T., Serné, E. H., Ijzerman, R. G., de Vries, G., & Stehouwer, C. D. A. (2004). Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation, 109(21), 2529-2535.
    • Scheffer, P. G., Henry, R. M. A., Wever, E. J. M., van Rooij, G. J., Bos, G. M. J., Heine, R. J., Dekker, J. M., Diamant, M., Stehouwer, C. D. A., Nijpels, G., Blankenstein, M. A., & Teerlink, T. (2004). LDL oxidative modifications in well- or moderately controlled type 2 diabetes. Diabetes-metabolism Research and Reviews, 20(4), 298-304.
    • de Jongh, R. T., Clark, A. D. H., Ijzerman, R. G., Serné, E. H., de Vries, G., & Stehouwer, C. D. A. (2004). Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers. Diabetologia, 47(6), 978-986.
    • Spijkerman, A. M., Henry, R. M. A., Dekker, J. M., Nijpels, G., Kostense, P. J., Kors, J. A., Ruwaard, D., Stehouwer, C. D. A., Bouter, L. M., & Heine, R. J. (2004). Prevalence of macrovascular disease amongst type 2 diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn Screening Study. Journal of Internal Medicine, 256(5), 429-436.
    • Snijder, M. B., Henry, R. M. A., Visser, M., Dekker, J. M., Seidell, J. C., Ferreira, I., Bouter, L. M., Yudkin, J. S., Westerhof, N., & Stehouwer, C. D. A. (2004). Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn Study. Journal of Hypertension, 22(12), 2339-2347.
    • Wulffele, M. G., Kooy, A., de Zeeuw, D., Stehouwer, C. D. A., & Gansevoort, R. T. (2004). The effect of metformin on blood pressure plasma cholesterol and triglycerides in type 2 diabetes mellitus; a systematic review. Journal of Internal Medicine, 256, 1-14.
    • Bos, G. M. J., Scheffer, P. G., Vieira, D., Dekker, J. M., Nijpels, G., Diamant, M., Teerlink, T., Stehouwer, C. D. A., Bouter, L. M., Heine, R. J., & Jansen, H. (2004). The relationship of lipoprotein lipase activity and LDL size is dependent on glucose metabolism in an elderly population: the Hoorn Study. Diabetes Care, 27(3), 796-798.
    • Snijder, M. B., Dekker, J. M., Visser, M., Bouter, L. M., Stehouwer, C. D. A., Yudkin, J. S., Heine, R. J., Nijpels, G., & Seidell, J. C. (2004). Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study. Diabetes Care, 27(2), 372-377.
    • Qiao, Q., Dekker, J. M., de Vegt, F., Nijpels, G., Nissinen, A., Stehouwer, C. D. A., Bouter, L. M., Heine, R. J., & Tuomilehto, J. (2004). Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c. Journal of Clinical Epidemiology, 57(6), 590-596.
  • 1998
    • Stehouwer, C. D. A., Weijenberg, M. P., Berg, M., Jacobs, C., Feskens, E., & Kromhout, D. (1998). Serum homocysteine and risk of coronary heart disease and cerebrovascular disease in elderly men: a 10-year follow-up.Arteriosclerosis Thrombosis and Vascular Biology, 18(12), 1895-1901.