Coen Stehouwer

Professor

Prof. Coen Stehouwer (born Rotterdam, 1960) obtained an MD at the Erasmus University in Rotterdam (1985; cum laude). He was registered as internist in 1990 and obtained a PhD in 1992 (Vrije Universiteit Medical Centre, Amsterdam). He received postgraduate training in epidemiology and molecular biology. He was appointed professor of medicine and vice-chair of the Department of Medicine in 2000 at the Vrije Universiteit in Amsterdam). In 2004, he accepted a position as professor of medicine and chair of the Department of Medicine at the University of Maastricht. Coen Stehouwer currently is Professor of Internal Medicine and Chair of the Department of Internal Medicine at Maastricht University in the Netherlands.

He is an internationally recognised clinician-scientist in the field of microcirculatory as well as large artery research, notably in the context of cardiovascular complications of diabetes and the metabolic syndrome. Since 1990, the work of Professor Stehouwer and his group has led to 77 completed PhD theses, and more than 800 peer-reviewed papers in international journals.

His work is well-recognised, as shown by a Hirsh index of 109 (Web of Science); >52,000 citations; several awards, such as the Dr F. Gerritzen Award for excellent diabetes research (Dutch Diabetes Research Foundation, 1993); the Castelli-Pedroli Award for excellent research into the complications of diabetes (European Association for the Study of Diabetes, 2005); the Dutch Society of Vascular Medicine Career Award (2007); the Ruitenga Van Swieten honorary professorship of the University of Amsterdam (2009); and the Donald McDonald Award of Artery Society (2017); as well as many invited lectures at (inter)national meetings, such as those of the European Society for Microcirculation, the World Congress for Microcirculation, the European Society for the Study of Diabetes, the American Diabetes Association, the European Society for Cardiology, and the American Heart Association.

His research programme focuses on the elucidation of how metabolic changes in (pre)diabetes and the metabolic syndrome cause micro- and macrovascular disease. A key element of the programme is to combine epidemiology, clinical physiology and experimental approaches, in the conviction that these approaches should complement and mutually inspire each other. He is one of the principal investigators of the well-known Hoorn Study (since 1992). He also obtained national and European funding (16 M€) for, and is the initiator and Scientific Director of the Maastricht Study (started 2010), which combines very detailed phenotyping (with a focus on microcirculatory, large artery and cardiac function and structure) with an ‘omics’ approach in 7000 individuals without and 2000 with type 2 diabetes to elucidate how diabetes leads not only to classic complications but also to so-called emerging complications such as cognitive dysfunction, mood disorders, liver disease, musculoskeletal disease, pulmonary disease, sleep-disordered breathing, and infectious diseases.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T:+31(0)43 387 70 06

  • 2020
    • de Ritter, R., de Jong, M., Vos, R. C., van der Kallen, C. J. H., Sep, S. J. S., Woodward, M., Stehouwer, C. D. A., Bots, M. L., & Peters, S. A. E. (2020). Sex differences in the risk of vascular disease associated with diabetes. Biology of Sex Differences, 11(1), [1]. https://doi.org/10.1186/s13293-019-0277-z
    • Nielen, J. T. H., Driessen, J. H. M., Dagnelie, P. C., Boonen, A., van den Bemt, B., van Onzenoort, H. A. W., Neef, C., Henry, R. M. A., Burden, A. M., Sep, S. J. S., van der Kallen, C. J., Schram, M. T., Schaper, N., Stehouwer, C. D. A., Smits, L., & de Vries, F. (2020). Drug utilization in the Maastricht Study: A comparison with nationwide data. Medicine, 99(1), [18524]. https://doi.org/10.1097/MD.0000000000018524
    • van Meijel, L. A., de Vegt, F., Abbink, E. J., Rutters, F., Schram, M. T., van der Klauw, M. M., Wolffenbuttel, B. H. R., Siegelaar, S., DeVries, J. H., Sijbrands, E. J. G., Ozcan, B., de Valk, H. W., Silvius, B., Schaper, N., Stehouwer, C. D. A., Elders, P. J. M., Tack, C. J., & de Galan, B. E. (2020). High prevalence of impaired awareness of hypoglycemia and severe hypoglycemia among people with insulin-treated type 2 diabetes: The Dutch Diabetes Pearl Cohort. BMJ Open Diabetes Research & Care, 8(1), [000935]. https://doi.org/10.1136/bmjdrc-2019-000935
    • Brouwers, M. C. G. J., de Graaf, J., Simons, N., Meex, S., ten Doeschate, S., van Heertum, S., Heidemann, B., Luijten, J., de Boer, D., Schaper, N., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2020). Incidence of type 2 diabetes in familial combined hyperlipidemia. BMJ Open Diabetes Research & Care, 8(1), [001107]. https://doi.org/10.1136/bmjdrc-2019-001107
    • Schalkwijk, C. G., & Stehouwer, C. D. A. (2020). METHYLGLYOXAL, A HIGHLY REACTIVE DICARBONYL COMPOUND, IN DIABETES, ITS VASCULAR COMPLICATIONS, AND OTHER AGE-RELATED DISEASES. Physiological Reviews, 100(1), 407-461. https://doi.org/10.1152/physrev.00001.2019
    • Rensma, S. P., van Sloten, T. T., Houben, A. J. H. M., Koehler, S., van Boxtel, M. P. J., Berendschot, T. T. J. M., Jansen, J. F. A., Verhey, F. R. J., Kroon, A. A., Koster, A., Backes, W. H., Schaper, N., Dinant, G-J., Schalkwijk, C. G., Henry, R. M. A., Wolfs, E. M. L., van Heumen, M. J. A., Schram, M. T., & Stehouwer, C. D. A. (2020). Microvascular Dysfunction Is Associated With Worse Cognitive Performance The Maastricht Study. Hypertension, 75(1), 237-245. https://doi.org/10.1161/HYPERTENSIONAHA.119.13023
    • Vergoossen, L. W., Schram, M. T., de Jong, J. J., Stehouwer, C. D., Schaper, N. C., Henry, R. M., van der Kallen, C. J., Dagnelie, P. C., van Boxtel, M. P., Eussen, S. J., Backes, W. H., & Jansen, J. F. (2020). White Matter Connectivity Abnormalities in Prediabetes and Type 2 Diabetes: The Maastricht Study. Diabetes Care, 43(1), 201-208. https://doi.org/10.2337/dc19-0762
    • Josefs, T., Wouters, K., Tietge, U. J. F., Annema, W., Dullaart, R. P. F., Vaisar, T., Arts, I. C. W., van der Kallen, C. J. H., Stehouwer, C. D. A., Schalkwijk, C. G., Goldberg, I. J., Fisher, E. A., & van Greevenbroek, M. M. J. (2020). High-density lipoprotein cholesterol efflux capacity is not associated with atherosclerosis and prevalence of cardiovascular outcome: The CODAM study. Journal of Clinical Lipidology, 14(1), 122-132.e4. https://doi.org/10.1016/j.jacl.2019.10.012
    • Tas, J., van Gassel, R. J. J., Heines, S. J. H., Mulder, M. M. G., Heijnen, N. F. L., Acampo-de Jong, M. J., Bels, J. L. M., Bennis, F. C., Koelmann, M., Groven, R. V. M., Donkers, M. A., van Rosmalen, F., Hermans, B. J. M., Meex, S. J. R., Mingels, A., Bekers, O., Savelkoul, P., Oude Lashof, A. M. L., Wildberger, J., ... van Bussel, B. C. T. (2020). Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht). BMJ Open, 10(9), [040175]. https://doi.org/10.1136/bmjopen-2020-040175
    • de Jong, M., Oskam, M. J., Sep, S. J. S., Ozcan, B., Rutters, F., Sijbrands, E. J. G., Elders, P. J. M., Siegelaar, S. E., DeVries, J. H., Tack, C. J., Schroijen, M., de Valk, H. W., Abbink, E. J., Stehouwer, C. D. A., Jazet, I., Wolffenbuttel, B. H. R., Peters, S. A. E., Schram, M. T., & Diabet Pearl Parelsnoer Initiative (2020). Sex differences in cardiometabolic risk factors, pharmacological treatment and risk factor control in type 2 diabetes: findings from the Dutch Diabetes Pearl cohort. BMJ Open Diabetes Research & Care, 8(1), [001365]. https://doi.org/10.1136/bmjdrc-2020-001365
  • 2019
    • van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T., & Blaak, E. E. (2019). Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans. Diabetes, 68(12), 2247-2258. https://doi.org/10.2337/db19-0560
    • Foreman, Y. D., Brouwers, M. C. G. J., Berendschot, T. T. J. M., van Dongen, M. C. J. M., Eussen, S. J. P. M., van Greevenbroek, M. M. J., Henry, R. M. A., Houben, A. J. H. M., van der Kallen, C. J. H., Kroon, A. A., Reesink, K. D., Schram, M. T., Schaper, N. C., & Stehouwer, C. D. A. (2019). The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study. Cardiovascular Diabetology, 18(1), [152]. https://doi.org/10.1186/s12933-019-0950-x
    • Ginsberg, C., Houben, A. J. H. M., Malhotra, R., Berendschot, T. T. J. M., Dagnelie, P. C., Kooman, J. P., Webers, C. A., Stehouwer, C. D. A., & Ix, J. H. (2019). Serum Phosphate and Microvascular Function in a Population-Based Cohort. Clinical journal of the American Society of Nephrology, 14(11), 1626-1633. https://doi.org/10.2215/CJN.02610319
    • Simons, N., Debray, F-G., Schaper, N. C., Kooi, M. E., Feskens, E. J. M., Hollak, C. E. M., Lindeboom, L., Koek, G. H., Bons, J. A. P., Lefeber, D. J., Hodson, L., Schalkwijk, C. G., Stehouwer, C. D. A., Cassiman, D., & Brouwers, M. C. G. J. (2019). Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content. Journal of Clinical Endocrinology & Metabolism, 104(11), 5053-5061. https://doi.org/10.1210/jc.2018-02795
    • Heintjes, E. M., Houben, E., Beekman-Hendriks, W. L., Lighaam, E., Cremers, S. M., Penning-van Beest, F. J. A., Stehouwer, C. D. A., & Herings, R. M. C. (2019). Trends in mortality, cardiovascular complications, and risk factors in type 2 diabetes. Netherlands Journal of Medicine, 77(9), 317-329. http://www.njmonline.nl/getpdf.php?id=2159
    • van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., Boomsma, D., Heijmans, B. T., t'Hoen, P. A. G., van Meurs, J., Isaacs, A., Jansen, R., Franke, L., ... BIOS Consortium (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biological Psychiatry, 86(8), 599-607. https://doi.org/10.1016/j.biopsych.2019.02.016
    • de Ritter, R., Sep, S. J. S., van der Kallen, C. J. H., Schram, M. T., Koster, A., Kroon, A. A., van Greevenbroek, M. M. J., Eussen, S. J. P. M., Dagnelie, P. C., de Jong, M., Vos, R. C., Woodward, M., Bots, M. L., Peters, S. A. E., & Stehouwer, C. D. A. (2019). Adverse differences in cardiometabolic risk factor levels between individuals with pre-diabetes and normal glucose metabolism are more pronounced in women than in men: the Maastricht Study. BMJ Open Diabetes Research & Care, 7(1), [000787]. https://doi.org/10.1136/bmjdrc-2019-000787
    • Denissen, K. F. M., Boonen, A., Nielen, J. T. H., Feitsma, A. L., van den Heuvel, E. G. H. M., Emans, P. J., Stehouwer, C. D. A., Sep, S. J. S., van Dongen, M. C. J. M., Dagnelie, P. C., & Eussen, S. J. P. M. (2019). Consumption of dairy products in relation to the presence of clinical knee osteoarthritis: The Maastricht Study. European Journal of Nutrition, 58(7), 2693-2704. https://doi.org/10.1007/s00394-018-1818-7
    • Ahluwalia, T. S., Tofte, N., Vogelzangs, N., Mook-Kanamori, D., Brahimaj, A., Frimodt-Moller, M., Arts, I., Beulens, J., van der Heijden, A., Stehouwer, C., Nijpels, G., van Greevenbroek, M., van der Kallen, C., Rossing, P., & 't Hart, L. M. (2019). Plasma metabolomics identifies markers of kidney function in 3,064 Europeans with type 2 diabetes. Diabetologia, 62, S456-S456.
    • van der Berg, J. D., Stehouwer, C. D. A., Bosma, H., Caserotti, P., Eiriksdottir, G., Arnardottir, N. Y., Van Domelen, D. R., Brychta, R. J., Chen, K. Y., Sveinsson, T., Johannsson, E., Launer, L. J., Gudnason, V., Jonsson, P. V., Harris, T. B., & Koster, A. (2019). Dynamic sitting: Measurement and associations with metabolic health. Journal of Sports Sciences, 37(15), 1746-1754. https://doi.org/10.1080/02640414.2019.1592800
    • van Der Plaat, D., Vonk, J. M., Terzikhan, N., de Jong, K., de Vries, M., La Bastide-van Gemert, S., van Diemen, C. C., Lahousse, L., Brusselle, G., Nedeljkovic, I., Amin, N., Kromhout, H., Vermeulen, R. C. H., Postma, D. S., van Duijn, C. M., Boezen, H. M., Heijmans, B. T., Hoen, P. A. C. T., van Meurs, J., ... BIOS Consortium (2019). Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression. Human Molecular Genetics, 28(15), 2477-2485. https://doi.org/10.1093/hmg/ddz067
    • Mandaviya, P. R., Joehanes, R., Brody, J., Castillo-Fernandez, J. E., Dekkers, K. F., Do, A. N., Graff, M., Hänninen, I. K., Tanaka, T., de Jonge, E. A. L., Kiefte-de Jong, J. C., Absher, D. M., Aslibekyan, S., de Rijke, Y. B., Fornage, M., Hernandez, D. G., Hurme, M. A., Ikram, M. A., Jacques, P. F., ... BIOS Consortium, CHARGE Consortium Epigenetics Working Group, CHARGE Consortium Nutrition Working Group (2019). Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals. American Journal of Clinical Nutrition, 110(2), 437-450. [15]. https://doi.org/10.1093/ajcn/nqz031
    • Maasen, K., van Greevenbroek, M. M. J., Scheijen, J. L. J. M., van der Kallen, C. J. H., Stehouwer, C. D. A., & Schalkwijk, C. G. (2019). High dietary glycemic load is associated with higher concentrations of urinary advanced glycation endproducts: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) Study. American Journal of Clinical Nutrition, 110(2), 358-366. https://doi.org/10.1093/ajcn/nqz119
    • Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M-J., Franke, L., ... Kutalik, Z. (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10, [3300]. https://doi.org/10.1038/s41467-019-10936-0
    • Telgenkamp, I., Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., Bons, J. A. P., Schaper, N. C., Joris, P. J., Plat, J., Mensink, R. P., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2019). Contribution of Liver Fat to Weight Loss-Induced Changes in Serum Hepatokines: A Randomized Controlled Trial. Journal of Clinical Endocrinology & Metabolism, 104(7), 2719-2727. https://doi.org/10.1210/jc.2018-02378
    • de Jong, M., Vos, R. C., de Ritter, R., van der Kallen, C. J., Sep, S. J., Woodward, M., Stehouwer, C. DA., Bots, M. L., & Peters, S. A. (2019). Sex differences in cardiovascular risk management for people with diabetes in primary care: a cross-sectional study. BJGP Open, 3(2), 1-11. [bjgpopen19X101645]. https://doi.org/10.3399/bjgpopen19X101645
    • O'Donovan, S. D., Lenz, M., Goossens, G. H., van der Kallen, C. J. H., Eussen, S. J. M. P., Stehouwer, C. D. A., van Greevenbroek, M. M., Schram, M. T., Sep, S. J., Peeters, R. L. M., Blaak, E. E., van Riel, N. A. W., de Kok, T. M. C. M., & Arts, I. C. W. (2019). Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator. Scientific Reports, 9, [9388]. https://doi.org/10.1038/s41598-019-45858-w
    • Climie, R. E., van Sloten, T. T., Bruno, R-M., Taddei, S., Empana, J-P., Stehouwer, C. D. A., Sharman, J. E., Boutouyrie, P., & Laurent, S. (2019). Macrovasculature and Microvasculature at the Crossroads Between Type 2 Diabetes Mellitus and Hypertension. Hypertension, 73(6), 1138-1149. https://doi.org/10.1161/HYPERTENSIONAHA.118.11769
    • van Dongen, M. C. J. M., Wijckmans-Duysens, N. E. G., den Biggelaar, L. J. C. J., Ocke, M. C., Meijboom, S., Brants, H. A. M., de Vries, J. H. M., Feskens, E. J. M., Bueno-de-Mesquita, H. B., Geelen, A., Stehouwer, C. D. A., Dagnelie, P. C., & Eussen, S. J. P. M. (2019). The Maastricht FFQ: Development and validation of a comprehensive food frequency questionnaire for the Maastricht study. Nutrition, 62, 39-46. https://doi.org/10.1016/j.nut.2018.10.015
    • Qi, Y., Koster, A., van Boxtel, M., Köhler, S., Schram, M., Schaper, N., Stehouwer, C., & Bosma, H. (2019). Adulthood Socioeconomic Position and Type 2 Diabetes Mellitus-A Comparison of Education, Occupation, Income, and Material Deprivation: The Maastricht Study. International Journal of Environmental Research and Public Health, 16(8), [1435]. https://doi.org/10.3390/ijerph16081435
    • Onderwater, G. L. J., Ligthart, L., Bot, M., Demirkan, A., Fu, J., van der Kallen, C. J. H., Vijfhuizen, L. S., Pool, R., Liu, J., Vanmolkot, F. H. M., Beekman, M., Wen, K., Amin, N., Thesing, C. S., Pijpers, J. A., Kies, D. A., Zielman, R., de Boer, I., van Greevenbroek, M. M. J., ... BBMRI Metabolomics Consortium (2019). Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine. Neurology, 92(16), E1899-E1911. https://doi.org/10.1212/WNL.0000000000007313
    • Zhou, T. L., Kroon, A. A., Sloten, T. T. V., van Boxtel, M. P. J., Verhey, F. R. J., Schram, M. T., Köhler, S., Stehouwer, C. D. A., & Henry, R. M. A. (2019). Greater Blood Pressure Variability Is Associated With Lower Cognitive Performance: The Maastricht Study. Hypertension, 73(4), 803–811. https://doi.org/10.1161/HYPERTENSIONAHA.118.12305
    • Brouwers, M. C. G. J., Simons, N., Stehouwer, C. D. A., Koek, G. H., Schaper, N. C., & Isaacs, A. (2019). Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease. Hepatology communications, 3(4), 587-596. https://doi.org/10.1002/hep4.1319
    • den Biggelaar, L. J. C. J., Eussen, S. J. P. M., Sep, S. J. S., Mari, A., Ferrannini, E., van Greevenbroek, M. M., van der Kallen, C. J., Schalkwijk, C. G., Arts, I. C. W., Stehouwer, C. D. A., & Dagnelie, P. C. (2019). Prospective associations of dietary carbohydrate, fat, and protein intake with -cell function in the CODAM study. European Journal of Nutrition, 58(2), 597-608. https://doi.org/10.1007/s00394-018-1644-y
    • Shvetsova, E., Sofronova, A., Monajemi, R., Gagalova, K., Draisma, H. H. M., White, S. J., Santen, G. W. E., Lopes, S. M. C. D. S., Heijmans, B. T., van Meurs, J., Jansen, R., Franke, L., Kielbasa, S. M., den Dunnen, J. T., 't Hoen, P. A. C., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., ... GoNL consortium (2019). Skewed X-inactivation is common in the general female population. European Journal of Human Genetics, 27(3), 455-465. https://doi.org/10.1038/s41431-018-0291-3
    • Driessen, J. H. M., de Vries, F., van Onzenoort, H. A. W., Schram, M. T., van der Kallen, C., Reesink, K. D., Sep, S., Stehouwer, C. D. A., Schaper, N., Kroon, A. A., Schalkwijk, C., van den Bergh, J. P. W., & Henry, R. M. A. (2019). Metformin use in type 2 diabetic patients is not associated with lower arterial stiffness: the Maastricht Study. Journal of Hypertension, 37(2), 365-371. https://doi.org/10.1097/HJH.0000000000001892
    • Tran-Duy, A., Connell, N. J., Vanmolkot, F. H., Souverein, P. C., de Wit, N. J., Stehouwer, C. D. A., Hoes, A. W., de Vries, F., & de Boer, A. (2019). Use of proton pump inhibitors and risk of iron deficiency: a population-based case-control study. Journal of Internal Medicine, 285(2), 205-214. https://doi.org/10.1111/joim.12826
    • Roebroek, Y. G. M., Paulus, G. F., van Mil, E. G. A. H., Vreugdenhil, A. C. E., Winkens, B., Nederkoorn, C., Stehouwer, C. D. A., Greve, J. W. M., Bouvy, N. D., & van Heurn, L. W. E. (2019). Bariatric surgery in adolescents: a prospective randomized controlled trial comparing laparoscopic gastric banding to combined lifestyle interventions in adolescents with severe obesity (BASIC trial). Bmc Pediatrics, 19(1), [34]. https://doi.org/10.1186/s12887-019-1395-9
    • Zhong, H., Penders, J., Shi, Z., Ren, H., Cai, K., Fang, C., Ding, Q., Thijs, C., Blaak, E. E., Stehouwer, C. D. A., Xu, X., Yang, H., Wang, J., Wang, J., Jonkers, D. M. A. E., Masclee, A. A. M., Brix, S., Li, J., Arts, I. C. W., & Kristiansen, K. (2019). Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children. Microbiome, 7, [2]. https://doi.org/10.1186/s40168-018-0608-z
    • Nielen, J. T. H., de Vries, F., van der Velde, J. H. P. M., Savelberg, H. H. C. M., Schaper, N. C., Dagnelie, P. C., Henry, R. M. A., Schram, M., Stehouwer, C. D. A., Boonen, A., Koster, A., & van den Bemt, B. J. F. (2019). The Association Between β-Blocker Use and Cardiorespiratory Fitness: The Maastricht Study. Journal of Cardiovascular Pharmacology and Therapeutics, 24(1), 37-45. https://doi.org/10.1177/1074248418778551
    • Luijten, J., van Greevenbroek, M. M. J., Schaper, N. C., Meex, S. J. R., van der Steen, C., Meijer, L. J., de Boer, D., de Graaf, J., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2019). Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study. Atherosclerosis, 280, 1-6. https://doi.org/10.1016/j.atherosclerosis.2018.11.013
    • Hanssen, N. M. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2019). Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease. Current Opinion in Nephrology and Hypertension, 28(1), 26-33. https://doi.org/10.1097/MNH.0000000000000465
    • Bijnen, M., van Greevenbroek, M. M. J., van Der Kallen, C. J. H., Scheijen, J. L., van de Waarenburg, M. P. H., Stehouwer, C. D. A., Wouters, K., & Schallcwijk, C. G. (2019). Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The CODAM Study. Journal of Diabetes Research, 2019, [6289831]. https://doi.org/10.1155/2019/6289831
    • Rensma, S., van Sloten, T. T., Houben, A. J. H. M., van Boxtel, M. P. J., Berendschot, T. T. J. M., Jansen, J. F. A., Kroon, A. A., Koster, A., Backes, W. H., Schaper, N., Dinant, G. J., Schalkwijk, C. G., Henry, R. M. A., Wolfs, E. M. L., van Heumen, M. J. A., Schram, M. T., & Stehouwer, C. D. A. (2019). Microvascular Dysfunction Is Associated with Worse Cognitive Performance: The Maastricht Study. Journal of Vascular Research, 56(S1), 94-94. https://doi.org/10.1159/000499516
  • 2018
    • van Agtmaal, M. J. M., Houben, A. J. H. M., de Wit, V., Henry, R. M. A., Schaper, N. C., Dagnelie, P. C., van der Kallen, C. J., Koster, A., Sep, S. J., Kroon, A. A., Jansen, J. F. A., Hofman, P. A., Backes, W. H., Schram, M. T., & Stehouwer, C. D. A. (2018). Prediabetes Is Associated With Structural Brain Abnormalities: The Maastricht Study. Diabetes Care, 41(12), 2535-2543. https://doi.org/10.2337/dc18-1132
    • Sharif, S., Bots, M. L., Schalkwijk, C., Stehouwer, C. D. A., Visseren, F. L. J., Westerink, J., & SMART Study Grp (2018). Association between bone metabolism regulators and arterial stiffness in type 2 diabetes patients. Nutrition Metabolism and Cardiovascular Diseases, 28(12), 1245-1252. https://doi.org/10.1016/j.numecd.2018.06.004
    • 't Hart, L. M., Vogelzangs, N., Mook-Kanamori, D. O., Brahimaj, A., Nano, J., van der Heijden, A. A. W. A., van Dijk, K. W., Slieker, R. C., Steyerberg, E. W., Ikram, M. A., Beekman, M., Boomsma, D. I., van Duijn, C. M., Slagboom, P. E., Stehouwer, C. D. A., Schalkwijk, C. G., Arts, I. C. W., Dekker, J. M., Dehghan, A., ... van Greevenbroek, M. M. J. (2018). Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes. Journal of Clinical Endocrinology & Metabolism, 103(12), 4569-4579. https://doi.org/10.1210/jc.2018-01165
    • Xin, Y., Hertle, E., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2018). Complement C3 and C4, but not their regulators or activated products, are associated with incident metabolic syndrome: the CODAM study. Endocrine, 62(3), 617-627. https://doi.org/10.1007/s12020-018-1712-3
    • Van den Eynde, M. D. G., Geleijnse, J. M., Scheijen, J. L. J. M., Hanssen, N. M. J., Dower, J. I., Afman, L. A., Stehouwer, C. D. A., Hollman, P. C. H., & Schalkwijk, C. G. (2018). Quercetin, but Not Epicatechin, Decreases Plasma Concentrations of Methylglyoxal in Adults in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial with Pure Flavonoids. Journal of Nutrition, 148(12), 1911-1916. https://doi.org/10.1093/jn/nxy236