Coen Stehouwer

Professor

Prof. Coen Stehouwer (born Rotterdam, 1960) obtained an MD at the Erasmus University in Rotterdam (1985; cum laude). He was registered as internist in 1990 and obtained a PhD in 1992 (Vrije Universiteit Medical Centre, Amsterdam). He received postgraduate training in epidemiology and molecular biology. He was appointed professor of medicine and vice-chair of the Department of Medicine in 2000 at the Vrije Universiteit in Amsterdam). In 2004, he accepted a position as professor of medicine and chair of the Department of Medicine at the University of Maastricht. Coen Stehouwer currently is Professor of Internal Medicine and Chair of the Department of Internal Medicine at Maastricht University in the Netherlands.

He is an internationally recognised clinician-scientist in the field of microcirculatory as well as large artery research, notably in the context of cardiovascular complications of diabetes and the metabolic syndrome. Since 1990, the work of Professor Stehouwer and his group has led to 77 completed PhD theses, and more than 800 peer-reviewed papers in international journals.

His work is well-recognised, as shown by a Hirsh index of 109 (Web of Science); >52,000 citations; several awards, such as the Dr F. Gerritzen Award for excellent diabetes research (Dutch Diabetes Research Foundation, 1993); the Castelli-Pedroli Award for excellent research into the complications of diabetes (European Association for the Study of Diabetes, 2005); the Dutch Society of Vascular Medicine Career Award (2007); the Ruitenga Van Swieten honorary professorship of the University of Amsterdam (2009); and the Donald McDonald Award of Artery Society (2017); as well as many invited lectures at (inter)national meetings, such as those of the European Society for Microcirculation, the World Congress for Microcirculation, the European Society for the Study of Diabetes, the American Diabetes Association, the European Society for Cardiology, and the American Heart Association.

His research programme focuses on the elucidation of how metabolic changes in (pre)diabetes and the metabolic syndrome cause micro- and macrovascular disease. A key element of the programme is to combine epidemiology, clinical physiology and experimental approaches, in the conviction that these approaches should complement and mutually inspire each other. He is one of the principal investigators of the well-known Hoorn Study (since 1992). He also obtained national and European funding (16 M€) for, and is the initiator and Scientific Director of the Maastricht Study (started 2010), which combines very detailed phenotyping (with a focus on microcirculatory, large artery and cardiac function and structure) with an ‘omics’ approach in 7000 individuals without and 2000 with type 2 diabetes to elucidate how diabetes leads not only to classic complications but also to so-called emerging complications such as cognitive dysfunction, mood disorders, liver disease, musculoskeletal disease, pulmonary disease, sleep-disordered breathing, and infectious diseases.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T:+31(0)43 387 70 06

  • 2016
  • 2015
    • Magdelijns, F. J. H., Pijpers, E., Rouhl, R. P. W., Hannemann, P. F. W., ten Broeke, R. H. M., Dings, J. T. A., Stehouwer, C. D. A., & Stassen, P. M. (2015). Acute Hospital Admissions Because of Health Care-Related Adverse Events: A Retrospective Study of 5 Specialist Departments. Journal of the American Medical Directors Association, 16(12), 1055-1061. https://doi.org/10.1016/j.jamda.2015.06.019
    • Gaens, K. H. J., Ferreira, I., van de Waarenburg, M. P. H., van Greevenbroek, M. M., van der Kallen, C. J. H., Dekker, J. M., Nijpels, G., Rensen, S. S., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). Protein-Bound Plasma N-epsilon-(Carboxymethyl) lysine Is Inversely Associated With Central Obesity and Inflammation and Significantly Explain a Part of the Central Obesity-Related Increase in Inflammation The Hoorn and CODAM Studies. Arteriosclerosis Thrombosis and Vascular Biology, 35(12), 2707-2713. https://doi.org/10.1161/ATVBAHA.115.306106
    • van Sloten, T. T., Sedaghat, S., Laurent, S., London, G. M., Pannier, B., Ikram, M. A., Kavousi, M., Mattace-Raso, F., Franco, O. H., Boutouyrie, P., & Stehouwer, C. D. A. (2015). Carotid Stiffness Is Associated With Incident Stroke A Systematic Review and Individual Participant Data Meta-Analysis. Journal of the American College of Cardiology, 66(19), 2116-2125. https://doi.org/10.1016/j.jacc.2015.08.888
    • Herber-Gast, G-C. M., Hulsegge, G., Hartman, L., Verschuren, W. M. M., Stehouwer, C. D. A., Gansevoort, R. T., Bakker, S. J. L., & Spijkerman, A. M. W. (2015). Physical Activity Is not Associated with Estimated Glomerular Filtration Rate among Young and Middle-Aged Adults: Results from the Population-Based Longitudinal Doetinchem Study. PLOS ONE, 10(10), [e0133864]. https://doi.org/10.1371/journal.pone.0133864
    • Engelen, L., Bossuyt, J., Ferreira, I., van Bortel, L. M., Reesink, K. D., Segers, P., Stehouwer, C. D., Laurent, S., & Boutouyrie, P. (2015). Reference values for local arterial stiffness. Part A: carotid artery. Journal of Hypertension, 33(10), 1981-1996. https://doi.org/10.1097/HJH.0000000000000654
    • Bossuyt, J., Engelen, L., Ferreira, I., Stehouwer, C. D., Boutouyrie, P., Laurent, S., Segers, P., Reesink, K., Van Bortel, L. M., & Reference Values for Arterial Measurements Collaboration (2015). Reference values for local arterial stiffness. Part B: femoral artery. Journal of Hypertension, 33(10), 1997-2009. https://doi.org/10.1097/HJH.0000000000000655
    • Tran-Duy, A., Vanmolkot, F. H., Joore, M. A., Hoes, A. W., & Stehouwer, C. D. A. (2015). Should patients prescribed long-term low-dose aspirin receive proton pump inhibitors? A systematic review and meta-analysis. International Journal of Clinical Practice, 69(10), 1088-1111. https://doi.org/10.1111/ijcp.12634
    • Wijnands, J. M. A., Boonen, A., van Sloten, T. T., Schram, M. T., Sep, S. J. S., Koster, A., van der Kallen, C. J. H., Henry, R. M. A., Dagnelie, P. C., Stehouwer, C. D. A., van der Linden, S., & Arts, I. C. W. (2015). Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40-75 years without and with type 2 diabetes mellitus: The Maastricht Study. Journal of Hypertension, 33(8), 1642-1650. https://doi.org/10.1097/HJH.0000000000000593
    • Spauwen, P. J. J., van Boxtel, M. P. J., Verhey, F. R. J., Kohler, S., Sep, S. J. S., Koster, A., Dagnelie, P. C., Henry, R. M. A., Schaper, N. C., van der Kallen, C. J. H., Schram, M. T., Kroon, A. A., & Stehouwer, C. D. A. (2015). Both Low and High 24-Hour Diastolic Blood Pressure Are Associated With Worse Cognitive Performance in Type 2 Diabetes: The Maastricht Study. Diabetes Care, 38(8), 1473-1480. https://doi.org/10.2337/dc14-2502
    • Di Angelantonio, E., Kaptoge, S., Wormser, D., Willeit, P., Butterworth, A. S., Bansal, N., O'Keeffe, L. M., Gao, P., Wood, A. M., Burgess, S., Freitag, D. F., Pennells, L., Peters, S. A., Hart, C. L., Haheim, L. L., Gillum, R. F., Nordestgaard, B. G., Psaty, B. M., Yeap, B. B., ... Danesh, J. (2015). Association of Cardiometabolic Multimorbidity With Mortality The Emerging Risk Factors Collaboration. JAMA-Journal of the American Medical Association, 314(1), 52-60. https://doi.org/10.1001/jama.2015.7008
    • Gijsberts, C. M., Groenewegen, K. A., Hoefer, I. E., Eijkemans, M. J. C., Asselbergs, F. W., Anderson, T. J., Britton, A. R., Dekker, J. M., Engstrom, G., Evans, G. W., de Graaf, J., Grobbee, D. E., Hedblad, B., Holewijn, S., Ikeda, A., Kitagawa, K., Kitamura, A., de Kleijn, D. P. V., Lonn, E. M., ... den Ruijter, H. M. (2015). Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. PLOS ONE, 10(7), [e0132321]. https://doi.org/10.1371/journal.pone.0132321
    • van Sloten, T. T., Czernichow, S., Houben, A. J., Protogerou, A. D., Henry, R. M., Muris, D. M., Schram, M. T., Sep, S. J., Dagnelie, P. C., van der Kallen, C. J., Schaper, N. C., Blacher, J., Hercberg, S., Levy, B. I., & Stehouwer, C. D. (2015). Association Between Arterial Stiffness and Skin Microvascular Function: The SUVIMAX2 Study and The Maastricht Study. American Journal of Hypertension, 28(7), 868-876. https://doi.org/10.1093/ajh/hpu246
    • Emerging Risk Factors Collaboration, & Stehouwer, C. (2015). Covariate-adjusted measures of discrimination for survival data. Biometrical Journal, 57(4), 592-613. https://doi.org/10.1002/bimj.201400061
    • Soedamah-Muthu, S. S., Livingstone, S. J., Charlton-Menys, V., Betteridge, D. J., Hitman, G. A., Neil, H. A. W., Bao, W., DeMicco, D. A., Preston, G. M., Fuller, J. H., Stehouwer, C. D. A., Schalkwijk, C. G., Durrington, P. N., & Colhoun, H. M. (2015). Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial. Diabetologia, 58(7), 1494-1502. https://doi.org/10.1007/s00125-015-3586-8
    • van Sloten, T. T., Protogerou, A. D., Henry, R. M. A., Schram, M. T., Launer, L. J., & Stehouwer, C. D. A. (2015). Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 53, 121-130. https://doi.org/10.1016/j.neubiorev.2015.03.011
    • Recarti, C., Sep, S. J. S., Stehouwer, C. D. A., & Unger, T. (2015). Excess Cardiovascular Risk in Diabetic Women: A Case for Intensive Treatment. Current Hypertension Reports, 17(6), [45]. https://doi.org/10.1007/s11906-015-0554-0
    • Maessen, D. E. M., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases. Clinical Science, 128(12), 839-861. https://doi.org/10.1042/CS20140683
    • van Marwijk, H. W. J., van der Kooy, K. G., Stehouwer, C. D. A., Beekman, A. T. F., & van Hout, H. P. J. (2015). Depression increases the onset of cardiovascular disease over and above other determinants in older primary care patients, a cohort study. BMC Cardiovascular disorders, 15, [40]. https://doi.org/10.1186/s12872-015-0036-y
    • van Sloten, T. T., & Stehouwer, C. D. A. (2015). Effects of RAS inhibitors on diabetic retinopathy Reply. The Lancet Diabetes & Endocrinology, 3(5), 316-316. https://doi.org/10.1016/S2213-8587(15)00084-4
    • van Bussel, F. C., Backes, W. H., Hofman, P. A., van Oostenbrugge, R. J., Kessels, A. G., van Boxtel, M. P., Schram, M. T., Stehouwer, C. D., Wildberger, J. E., & Jansen, J. F. (2015). On the Interplay of Microvasculature, Parenchyma, and Memory in Type 2 Diabetes. Diabetes Care, 38(5), 876-882. https://doi.org/10.2337/dc14-2043
    • Maessen, D. E., Hanssen, N. M., Scheijen, J. L., van der Kallen, C. J., van Greevenbroek, M. M., Stehouwer, C. D., & Schalkwijk, C. G. (2015). Post-Glucose Load Plasma alpha-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study. Diabetes Care, 38(5), 913-920. https://doi.org/10.2337/dc14-2605
    • Eikendal, A. L. M., Groenewegen, K. A., Anderson, T. J., Britton, A. R., Engstrom, G., Evans, G. W., de Graaf, J., Grobbee, D. E., Hedblad, B., Holewijn, S., Ikeda, A., Kitagawa, K., Kitamura, A., Lonn, E. M., Lorenz, M. W., Mathiesen, E. B., Nijpels, G., Dekker, J. M., Okazaki, S., ... den Ruijter, H. M. (2015). Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged <45 Years. Hypertension, 65(4), 707-+. https://doi.org/10.1161/HYPERTENSIONAHA.114.04658
    • Wlazlo, N., van Greevenbroek, M. M. J., Ferreira, I., Jansen, E. H. J. M., Feskens, E. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., Bravenboer, B., & Stehouwer, C. D. A. (2015). Iron metabolism is prospectively associated with insulin resistance and glucose intolerance over a 7-year follow-up period: the CODAM study. Acta Diabetologica, 52(2), 337-348. https://doi.org/10.1007/s00592-014-0646-3
    • van Sloten, T. T., & Stehouwer, C. D. A. (2015). No need to change guidelines for diabetic retinopathy and renin-angiotensin system inhibitors. The Lancet Diabetes & Endocrinology, 3(4), 231-232. https://doi.org/10.1016/S2213-8587(15)70006-9
    • Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., & Stehouwer, C. D. (2015). Plasma levels of matrix metalloproteinase-2,-3,-10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study. Cardiovascular Diabetology, 14, [31]. https://doi.org/10.1186/s12933-015-0195-2
    • van Bussel, B. C. T., Henry, R. M. A., Ferreira, I., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Twisk, J. W. R., Feskens, E. J. M., Schalkwijk, C. G., & Stehouwer, C. D. A. (2015). A Healthy Diet is Associated with Less Endothelial Dysfunction and Less Low-Grade Inflammation over a 7-Year Period in Adults at Risk of Cardiovascular Disease. Journal of Nutrition, 145(3), 532-540. https://doi.org/10.3945/jn.114.201236
    • Spauwen, P. J. J., van Eupen, M. G. A., Köhler, S., Stehouwer, C. D. A., Verhey, F. R. J., van der Kallen, C. J. H., Sep, S. J. S., Koster, A., Schaper, N. C., Dagnelie, P. C., Schalkwijk, C. G., Schram, M. T., & van Boxtel, M. P. J. (2015). Associations of Advanced Glycation End-Products With Cognitive Functions in Individuals With and Without Type 2 Diabetes: The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 100(3), 951-960. https://doi.org/10.1210/jc.2014-2754
    • Song, X., Jousilahti, P., Stehouwer, C. D. A., Soederberg, S., Onat, A., Laatikainen, T., Yudkin, J. S., Dankner, R., Morris, R., Tuomilehto, J., & Qiao, Q. (2015). Cardiovascular and all-cause mortality in relation to various anthropometric measures of obesity in Europeans. Nutrition Metabolism and Cardiovascular Diseases, 25(3), 295-304. https://doi.org/10.1016/j.numecd.2014.09.004
    • Touwslager, R. N. H., Houben, A. J. H. M., Tan, F. E. S., Gielen, M., Zeegers, M. P., Stehouwer, C. D. A., Gerver, W. J. M., Westerterp, K. R., Wouters, L., Blanco, C. E., Zimmermann, L. J., & Mulder, A. L. M. (2015). Growth and Endothelial Function in the First 2 Years of Life. Journal of Pediatrics, 166(3), 666-671.e1. https://doi.org/10.1016/j.jpeds.2014.11.059
    • Montero, D., Pierce, G. L., Stehouwer, C. D. A., Padilla, J., & Thijssen, D. H. J. (2015). The impact of age on vascular smooth muscle function in humans. Journal of Hypertension, 33(3), 445-453. https://doi.org/10.1097/HJH.0000000000000446
    • van Bussel, F. C. G., van Bussel, B. C. T., Hoeks, A. P. G., op 't Roodt, J., Henry, R. M. A., Ferreira, I., Vanmolkot, F. H. M., Schalkwijk, C. G., Stehouwer, C. D. A., & Reesink, K. D. (2015). A Control Systems Approach to Quantify Wall Shear Stress Normalization by Flow-Mediated Dilation in the Brachial Artery. PLOS ONE, 10(2), [e0115977]. https://doi.org/10.1371/journal.pone.0115977
    • Pilz, S., Rutters, F., Nijpels, G., Stehouwer, C. D. A., Hojlund, K., Nolan, J. J., Balkau, B., & Dekker, J. M. (2015). Insulin Sensitivity and Albuminuria: The RISC Study. Diabetes Care 2014; 37: 1597-1603. Diabetes Care, 38(2), E31-E31. https://doi.org/10.2337/dc14-2671
    • van Moorsel, D., van Greevenbroek, M. M. J., Schaper, N. C., Henry, R. M. A., Geelen, C. C., van Rossum, E. F. C., Nijpels, G., 't Hart, L. M., Schalkwijk, C. G., van der Kallen, C. J. H., Sauerwein, H. P., Dekker, J. M., Stehouwer, C. D. A., & Havekes, B. (2015). BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies. European Journal of Endocrinology, 173(4), 455-464. https://doi.org/10.1530/EJE-15-0381
    • Wijnands, J. M. A., Viechtbauer, W., Thevissen, K., Arts, I. C. W., Dagnelie, P. C., Stehouwer, C. D. A., van der Linden, S., & Boonen, A. (2015). Determinants of the prevalence of gout in the general population: a systematic review and meta-regression. European Journal of Epidemiology, 30(1), 19-33. https://doi.org/10.1007/s10654-014-9927-y
    • Wijnands, J. M. A., van Durme, C. M. P. G., Driessen, J. H. M., Boonen, A., Klop, C., Leufkens, B., Cooper, C., Stehouwer, C. D. A., & de Vries, F. (2015). Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This is Not Due to Diabetes: A Population-Based Cohort Study. Medicine, 94(32), [e1358]. https://doi.org/10.1097/MD.0000000000001358
    • Engelen, L., Schalkwijk, C. G., Eussen, S. J. P. M., Scheijen, J. L. J. M., Soedamah-Muthu, S. S., Chaturvedi, N., Fuller, J. H., & Stehouwer, C. D. A. (2015). Low 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 levels are independently associated with macroalbuminuria, but not with retinopathy and macrovascular disease in type 1 diabetes: the EURODIAB prospective complications study. Cardiovascular Diabetology, 14, [67]. https://doi.org/10.1186/s12933-015-0231-2
    • Brouwers, M. C. G. J., Jacobs, C., Bast, A., Stehouwer, C. D. A., & Schaper, N. C. (2015). Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?Trends in Molecular Medicine, 21(10), 583-594. https://doi.org/10.1016/j.molmed.2015.08.004
    • de Clerck, E. E. B., Schouten, J. S. A. G., Berendschot, T. T. J. M., Kessels, A. G. H., Nuijts, R. M. M. A., Beckers, H. J. M., Schram, M. T., Stehouwer, C. D. A., & Webers, C. A. B. (2015). New ophthalmologic imaging techniques for detection and monitoring of neurodegenerative changes in diabetes: a systematic review. The Lancet Diabetes & Endocrinology, 3(8), 653-663. https://doi.org/10.1016/S2213-8587(15)00136-9
    • Hilderink, M. J. M., Roest, A. A., Hermans, M., Keulemans, Y. C., Stehouwer, C. D. A., & Stassen, P. M. (2015). Predictive accuracy and feasibility of risk stratification scores for 28-day mortality of patients with sepsis in an emergency department. European Journal of Emergency Medicine, 22(5), 331-337. https://doi.org/10.1097/mej.0000000000000185
    • Roest, A. A., Tegtmeier, J., Heyligen, J. J., Duijst, J., Peeters, A., Borggreve, H. F., Oude Lashof, A. M. L., Stehouwer, C. D. A., & Stassen, P. M. (2015). Risk stratification by abbMEDS and CURB-65 in relation to treatment and clinical disposition of the septic patient at the emergency department: a cohort study. BMC Emergency Medicine, 15, [29]. https://doi.org/10.1186/s12873-015-0056-z
    • Magdelijns, F. J. H., Schepers, L., Pijpers, E., Stehouwer, C. D. A., & Stassen, P. M. (2015). The survival of patients admitted because of health-care-related adverse events is similar to that after admission for other reasons. European journal of internal medicine, 26(2), 146-147. https://doi.org/10.1016/j.ejim.2015.01.003
    • Wijnands, J. M. A., Houben, A. J. H. M., Muris, D. M. J., Boonen, A., Schram, M. T., Sep, S. J. S., van der Kallen, C. J. H., Henry, R. M. A., Dagnelie, P. C., van der Linden, S., Schaper, N. C., Arts, I. C. W., & Stehouwer, C. D. A. (2015). Uric acid and skin microvascular function: the Maastricht study. Journal of Hypertension, 33(8), 1651-1657. https://doi.org/10.1097/HJH.0000000000000583
    • Geijselaers, S. L. C., Sep, S. J. S., Stehouwer, C. D. A., & Biessels, G. J. (2015). Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review. The Lancet Diabetes & Endocrinology, 3(1), 75-89. https://doi.org/10.1016/S2213-8587(14)70148-2
    • Hanssen, N. M. J., Beulens, J. W. J., van Dieren, S., Scheijen, J. L. J. M., van der A, D. L., Spijkerman, A. M. W., van der Schouw, Y. T., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL). Diabetes, 64(1), 257-265. https://doi.org/10.2337/db13-1864
    • Rutters, F., Pilz, S., Koopman, A. D. M., Rauh, S. P., Pouwer, F., Stehouwer, C. D. A., Elders, P. J., Nijpels, G., & Dekker, J. M. (2015). Stressful life events and incident metabolic syndrome: the Hoorn study. Stress-the International Journal on the Biology of Stress, 18(5), 507-13. https://doi.org/10.3109/10253890.2015.1064891
  • 2014
    • Muris, D. M. J., Houben, A. J. H. M., Kroon, A. A., Henry, R. M. A., van der Kallen, C. J. H., Sep, S. J. S., Koster, A., Dagnelie, P. C., Schram, M. T., & Stehouwer, C. D. A. (2014). Age, waist circumference, and blood pressure are associated with skin microvascular flow motion: The Maastricht Study. Journal of Hypertension, 32(12), 2439-2449. https://doi.org/10.1097/HJH.0000000000000348
    • Magdelijns, F. J. H., Stassen, P. M., Stehouwer, C. D. A., & Pijpers, E. (2014). Direct health care costs of hospital admissions due to adverse events in the Netherlands. European Journal of Public Health, 24(6), 1028-1033. https://doi.org/10.1093/eurpub/cku037