Coen Stehouwer

Professor

Prof. Coen Stehouwer (born Rotterdam, 1960) obtained an MD at the Erasmus University in Rotterdam (1985; cum laude). He was registered as internist in 1990 and obtained a PhD in 1992 (Vrije Universiteit Medical Centre, Amsterdam). He received postgraduate training in epidemiology and molecular biology. He was appointed professor of medicine and vice-chair of the Department of Medicine in 2000 at the Vrije Universiteit in Amsterdam). In 2004, he accepted a position as professor of medicine and chair of the Department of Medicine at the University of Maastricht. Coen Stehouwer currently is Professor of Internal Medicine and Chair of the Department of Internal Medicine at Maastricht University in the Netherlands.

He is an internationally recognised clinician-scientist in the field of microcirculatory as well as large artery research, notably in the context of cardiovascular complications of diabetes and the metabolic syndrome. Since 1990, the work of Professor Stehouwer and his group has led to 77 completed PhD theses, and more than 800 peer-reviewed papers in international journals.

His work is well-recognised, as shown by a Hirsh index of 109 (Web of Science); >52,000 citations; several awards, such as the Dr F. Gerritzen Award for excellent diabetes research (Dutch Diabetes Research Foundation, 1993); the Castelli-Pedroli Award for excellent research into the complications of diabetes (European Association for the Study of Diabetes, 2005); the Dutch Society of Vascular Medicine Career Award (2007); the Ruitenga Van Swieten honorary professorship of the University of Amsterdam (2009); and the Donald McDonald Award of Artery Society (2017); as well as many invited lectures at (inter)national meetings, such as those of the European Society for Microcirculation, the World Congress for Microcirculation, the European Society for the Study of Diabetes, the American Diabetes Association, the European Society for Cardiology, and the American Heart Association.

His research programme focuses on the elucidation of how metabolic changes in (pre)diabetes and the metabolic syndrome cause micro- and macrovascular disease. A key element of the programme is to combine epidemiology, clinical physiology and experimental approaches, in the conviction that these approaches should complement and mutually inspire each other. He is one of the principal investigators of the well-known Hoorn Study (since 1992). He also obtained national and European funding (16 M€) for, and is the initiator and Scientific Director of the Maastricht Study (started 2010), which combines very detailed phenotyping (with a focus on microcirculatory, large artery and cardiac function and structure) with an ‘omics’ approach in 7000 individuals without and 2000 with type 2 diabetes to elucidate how diabetes leads not only to classic complications but also to so-called emerging complications such as cognitive dysfunction, mood disorders, liver disease, musculoskeletal disease, pulmonary disease, sleep-disordered breathing, and infectious diseases.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T:+31(0)43 387 70 06

  • 2012
    • Nin, J. W. M., Ferreira, I., Schalkwijk, C. G., Jorsal, A., Prins, M. H., Parving, H. -H., Tarnow, L., Rossing, P., & Stehouwer, C. D. A. (2012). Higher plasma high-mobility group box 1 levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12 year follow-up study. Diabetologia, 55(9), 2489-2493. https://doi.org/10.1007/s00125-012-2622-1
    • Gruden, G., Barutta, F., Chaturvedi, N., Schalkwijk, C., Stehouwer, C. D., Pinach, S., Manzo, M., Loiacono, M., Tricarico, M., Mengozzi, G., Witte, D. R., Fuller, J. H., Perin, P. C., & Bruno, G. (2012). NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications Study. Diabetes Care, 35(9), 1931-1936. https://doi.org/10.2337/dc12-0089
    • Den Ruijter, H. M., Peters, S. A. E., Anderson, T. J., Britton, A. R., Dekker, J. M., Eijkemans, M. J., Engstrom, G., Evans, G. W., de Graaf, J., Grobbee, D. E., Hedblad, B., Hofman, A., Holewijn, S., Ikeda, A., Kavousi, M., Kitagawa, K., Kitamura, A., Koffijberg, H., Lonn, E. M., ... Bots, M. L. (2012). Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction A Meta-analysis. JAMA-Journal of the American Medical Association, 308(8), 796-803. https://doi.org/10.1001/jama.2012.9630
    • Hanssen, N. M. J., Huijberts, M. S., Schalkwijk, C. G., Nijpels, G., Dekker, J. M., & Stehouwer, C. D. A. (2012). Associations Between the Ankle-Brachial Index and Cardiovascular and All-Cause Mortality Are Similar in Individuals Without and With Type 2 Diabetes Nineteen-year follow-up of a population-based cohort study. Diabetes Care, 35(8), 1731-1735. https://doi.org/10.2337/dc12-0178
    • Ferreira, I., Beijers, H. J., Schouten, F., Smulders, Y. M., Twisk, J. W., & Stehouwer, C. D. (2012). Clustering of Metabolic Syndrome Traits Is Associated With Maladaptive Carotid Remodeling and Stiffening A 6-Year Longitudinal Study. Hypertension, 60(2), 542-549. https://doi.org/10.1161/HYPERTENSIONAHA.112.194738
    • Reijmer, Y. D., van den Berg, E., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Kappelle, L. J., & Biessels, G. J. (2012). Development of Vascular Risk Factors over 15 Years in Relation to Cognition: The Hoorn Study. Journal of the American Geriatrics Society, 60(8), 1426-1433. https://doi.org/10.1111/j.1532-5415.2012.04081.x
    • van de Laar, R. J. J., Stehouwer, C. D. A., van Bussel, B. C. T., te Velde, S. J., Prins, M. H., Twisk, J. W., & Ferreira, I. (2012). Lower lifetime dietary fiber intake is associated with carotid artery stiffness: the Amsterdam Growth and Health Longitudinal Study. American Journal of Clinical Nutrition, 96(1), 14-23. https://doi.org/10.3945/ajcn.111.024703
    • Ronden, R. A., Houben, A. J. H. M., Teerlink, T., Bakker, J. A., Bierau, J., Stehouwer, C. D. A., De Leeuw, P. W., & Kroon, A. A. (2012). Reduced renal plasma clearance does not explain increased plasma asymmetric dimethylarginine in hypertensive subjects with mild to moderate renal insufficiency. American Journal of Physiology-Renal Physiology, 303(1), F149-F156. https://doi.org/10.1152/ajprenal.00045.2012
    • Gruden, G., Barutta, F., Chaturvedi, N., Schalkwijk, C., Stehouwer, C. D., Witte, D. R., Fuller, J. H., Perin, P. C., & Bruno, G. (2012). Severe Hypoglycemia and Cardiovascular Disease Incidence in Type 1 Diabetes The EURODIAB Prospective Complications Study. Diabetes Care, 35(7), 1598-1604. https://doi.org/10.2337/dc11-1531
    • Ning, F., Zhang, L., Dekker, J. M., Onat, A., Stehouwer, C. D. A., Yudkin, J. S., Laatikainen, T., Tuomilehto, J., Pyorala, K., & Qiao, Q. (2012). Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range. Cardiovascular Diabetology, 11, 76. https://doi.org/10.1186/1475-2840-11-76
    • CONTRAST Investigators, & Stehouwer, C. (2012). Effect of Online Hemodiafiltration on All-Cause Mortality and Cardiovascular Outcomes. Journal of the American Society of Nephrology, 23(6), 1087-1096. https://doi.org/10.1681/ASN.2011121140
    • van den Hurk, K., Alssema, M., Kamp, O., Henry, R. M., Stehouwer, C. D., Smulders, Y. M., Nijpels, G., Paulus, W. J., & Dekker, J. M. (2012). Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction An 8-year follow-up of the Hoorn Study. Diabetes Care, 35(6), 1258-1264. https://doi.org/10.2337/dc11-1336
    • van Sloten, T. T., Pijpers, E., Stehouwer, C. D. A., & Brouwers, M. C. (2012). Metformin-associated lactic acidosis in a patient with normal kidney function.Diabetes Research and Clinical Practice, 96(3), E57-E58. https://doi.org/10.1016/j.diabres.2011.07.021
    • WC elderly collaborators, & Stehouwer, C. (2012). The association between waist circumference and risk of mortality considering body mass index in 65-to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons. International Journal of Epidemiology, 41(3), 805-817. https://doi.org/10.1093/ije/dys008
    • Brouwers, M. C. G. J., van Greevenbroek, M. M. J., Stehouwer, C. D. A., de Graaf, J., & Stalenhoef, A. F. H. (2012). The genetics of familial combined hyperlipidaemia. Nature Reviews Endocrinology, 8(6), 352-362. https://doi.org/10.1038/nrendo.2012.15
    • van Dijk, J. W., Manders, R. J. F., Tummers, K., Bonomi, A. G., Stehouwer, C. D. A., Hartgens, F., & van Loon, L. J. C. (2012). Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients. Diabetologia, 55(5), 1273-1282. https://doi.org/10.1007/s00125-011-2380-5
    • van Dijk, J. W., Tummers, K., Stehouwer, C. D. A., Hartgens, F., & van Loon, L. J. C. (2012). Exercise Therapy in Type 2 Diabetes: Is daily exercise required to optimize glycemic control?Diabetes Care, 35(5), 948-954. https://doi.org/10.2337/dc11-2112
    • Beijers, H. J. B. H., Ferreira, I., Spronk, H. M. H., Bravenboer, B., Dekker, J. M., Nijpels, G., ten Cate, H., & Stehouwer, C. D. A. (2012). Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: potential role of central adiposity and low-grade inflammation - The Hoorn Study. Thrombosis Research, 129(5), 557-562. https://doi.org/10.1016/j.thromres.2011.07.033
    • Pijpers, E., Ferreira, I., de Jongh, R. T., Deeg, D. J., Lips, P., Stehouwer, C. D. A., & Kruseman, A. C. N. (2012). Older individuals with diabetes have an increased risk of recurrent falls: analysis of potential mediating factors: the Longitudinal Ageing Study Amsterdam. Age and Ageing, 41(3), 358-365. https://doi.org/10.1093/ageing/afr145
    • Hertle, E., van Greevenbroek, M. M. J., & Stehouwer, C. D. A. (2012). Complement C3: an emerging risk factor in cardiometabolic disease. Diabetologia, 55(4), 881-884. https://doi.org/10.1007/s00125-012-2462-z
    • Alssema, M., Newson, R. S., Bakker, S. J. L., Stehouwer, C. D. A., Heymans, M. W., Nijpels, G., Hillege, H. L., Hofman, A., Witteman, J. C. M., Gansevoort, R. T., & Dekker, J. M. (2012). One Risk Assessment Tool for Cardiovascular Disease, Type 2 Diabetes, and Chronic Kidney Disease. Diabetes Care, 35(4), 741-748. https://doi.org/10.2337/dc11-1417
    • Gaens, K. H. J., Niessen, P. M. G., Rensen, S. S., Buurman, W. A., Greve, J. W. M., Driessen, A., Wolfs, M. G. M., Hofker, M. H., Bloemen, J. G., Dejong, C. H., Stehouwer, C. D. A., & Schalkwijk, C. G. (2012). Endogenous formation of Nε(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis. Journal of Hepatology, 56(3), 647-655. https://doi.org/10.1016/j.jhep.2011.07.028
    • Meta-Analysis for Eye Diseaes (META-EYE) Study Group, & Stehouwer, C. (2012). Global Prevalence and Major Risk Factors of Diabetic Retinopathy. Diabetes Care, 35(3), 556-564. https://doi.org/10.2337/dc11-1909
    • Sipkens, J. A., Hahn, N. E., Blom, H. J., Lougheed, S. M., Stehouwer, C. D. A., Rauwerda, J. A., Krijnen, P. A. J., van Hinsbergh, V. W. M., & Niessen, H. W. M. (2012). S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine. Atherosclerosis, 221(1), 48-54. https://doi.org/10.1016/j.atherosclerosis.2011.11.032
    • Pijpers, E., Ferreira, I., Stehouwer, C. D. A., & Kruseman, A. C. N. (2012). The frailty dilemma. Review of the predictive accuracy of major frailty scores. European journal of internal medicine, 23(2), 118-123. https://doi.org/10.1016/j.ejim.2011.09.003
    • Van Woudenbergh, G. J., Kuijsten, A., Van der Kallen, C. J., Van Greevenbroek, M. M., Stehouwer, C. D., Blaak, E. E., & Feskens, E. J. M. (2012). Comparison of fatty acid proportions in serum cholesteryl esters among people with different glucose tolerance status: The CoDAM study. Nutrition Metabolism and Cardiovascular Diseases, 22(2), 133-140. https://doi.org/10.1016/j.numecd.2010.05.008
    • Song, X., Pitkaniemi, J., Gao, W., Heine, R. J., Pyorala, K., Soderberg, S., Stehouwer, C. D. A., Zethelius, B., Tuomilehto, J., Laatikainen, T., Tabak, A. G., & Qiao, Q. (2012). Relationship between body mass index and mortality among Europeans. European Journal of Clinical Nutrition, 66(2), 156-165. https://doi.org/10.1038/ejcn.2011.145
    • Nin, J. W. M., Ferreira, I., Schalkwijk, C. G., Prins, M. H., Chaturvedi, N., Fuller, J. H., & Stehouwer, C. D. A. (2012). Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study. European Journal of Endocrinology, 166(2), 325-332. https://doi.org/10.1530/EJE-11-0662
    • Emerging Risk Factors Collaboration, & Stehouwer, C. (2012). A framework for quantifying net benefits of alternative prognostic models. Statistics in Medicine, 31(2), 114-130. https://doi.org/10.1002/sim.4362
    • Touwslager, R. N., Houben, A. J., Gielen, M. J. F., Zeegers, M. P. A., Stehouwer, C. D. A., Zimmermann, L. J. I., Kessels, A. G., Gerver, W. J. M., Blanco, C. E., & Mulder, A. L. M. (2012). Endothelial vasodilatation in newborns is related to body size and maternal hypertension.Journal of Hypertension, 30(1), 124-131. https://doi.org/10.1097/HJH.0b013e32834d75c6
    • van Greevenbroek, M. M. J., Jacobs, M., van der Kallen, C. J. H., Blaak, E. E., Jansen, E., Schalkwijk, C. G., Feskens, E. J. M., & Stehouwer, C. D. A. (2012). Human plasma complement C3 is independently associated with coronary heart disease, but only in heavy smokers (the CODAM study). International Journal of Cardiology, 154(2), 158-162. https://doi.org/10.1016/j.ijcard.2010.09.017
    • Touwslager, R. N. H., Gerver, W. J. M., Tan, F. E. S., Gielen, M., Zeegers, M. P., Zimmermann, L. J., Houben, A. J. H. M., Blanco, C. E., Stehouwer, C. D. A., & Mulder, A. L. M. (2012). Influence of Growth During Infancy on Endothelium-Dependent Vasodilatation at the Age of 6 Months. Hypertension, 60(5), 1294-1300. https://doi.org/10.1161/HYPERTENSIONAHA.112.199125
    • Scheijen, J. L. J. M., Hanssen, N. M., van de Waarenburg, M. P., Jonkers, D. M. A. E., Stehouwer, C. D. A., & Schalkwijk, C. G. (2012). L(+) and d(-) lactate are increased in plasma and urine samples of type 2 diabetes as measured by a simultaneous quantification of l(+) and d(-) lactate by reversed-phase liquid chromatography tandem mass spectrometry. Experimental Diabetes Research, 2012, 234812. [234812]. https://doi.org/10.1155/2012/234812
    • van Bussel, B. C. T., Henry, R. M., Schalkwijk, C. G., Dekker, J. M., Nijpels, G., & Stehouwer, C. D. A. (2012). Low-grade inflammation, but not endothelial dysfunction, is associated with greater carotid stiffness in the elderly: the Hoorn Study. Journal of Hypertension, 30(4), 744-752. https://doi.org/10.1097/HJH.0b013e328350a487
    • Ferreira, I., van de Laar, R. J., Prins, M. H., Twisk, J. W., & Stehouwer, C. D. (2012). Carotid Stiffness in Young Adults: A Life-Course Analysis of its Early Determinants The Amsterdam Growth and Health Longitudinal Study. Hypertension, 59(1), 54-U146. https://doi.org/10.1161/HYPERTENSIONAHA.110.156109
    • de Boer, M. P., Meijer, R. I., Wijnstok, N. J., Jonk, A. M., Houben, A. J. H. M., Stehouwer, C. D., Smulders, Y. M., Eringa, E. C., & Serne, E. H. (2012). Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity-associated Insulin Resistance and Hypertension. Microcirculation, 19(1), 5-18. https://doi.org/10.1111/j.1549-8719.2011.00130.x
    • Wlazlo, N., van Greevenbroek, M. M. J., Ferreira, I., Bravenboer, B., & Stehouwer, C. D. A. (2012). The diagnosis of non-alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics, 35(1), 204-205. https://doi.org/10.1111/j.1365-2036.2011.04909.x
    • van Ballegooijen, A. J., Snijder, M. B., Visser, M., van den Hurk, K., Kamp, O., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Henry, R. M. A., Paulus, W. J., & Brouwer, I. A. (2012). Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study. Annals of Nutrition and Metabolism, 60(1), 69-77. https://doi.org/10.1159/000336173
  • 2011
    • Touwslager, R. N., Gielen, M. J. F., Mulder, A. L. M., Gerver, W. J. M., Zimmermann, L. J. I., Fowler, T., Houben, A. J., Stehouwer, C. D. A., Derom, C., Vlietinck, R., Loos, R. J., & Zeegers, M. P. A. (2011). Changes in genetic and environmental effects on growth during infancy. American Journal of Clinical Nutrition, 94(6), 1568-1574. https://doi.org/10.3945/ajcn.111.012757
    • Van den Hurk, K., Reijmer, Y. D., van den Berg, E., Alssema, M., Nijpels, G., Kostense, P. J., Stehouwer, C. D. A., Paulus, W. J., Kamp, O., Dekker, J. M., & Biessels, G. J. (2011). Heart failure and cognitive function in the general population: The hoorn study. European journal of heart failure, 13(12), 1362-1369. https://doi.org/10.1093/eurjhf/hfr138
    • Sipkens, J. A., Krijnen, P. A., Hahn, N. E., Wassink, M., Meischl, C., Smith, D. E., Musters, R. J., Stehouwer, C. D. A., Rauwerda, J. A., van Hinsbergh, V. W. M., & Niessen, H. W. (2011). Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox). Molecular and Cellular Biochemistry, 358(1-2), 229-239. https://doi.org/10.1007/s11010-011-0973-4
    • Reijmer, Y. D., van den Berg, E., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Kappelle, L. J., & Biessels, G. J. (2011). The metabolic syndrome, atherosclerosis and cognitive functioning in a non-demented population: The Hoorn Study. Atherosclerosis, 219(2), 839-845. https://doi.org/10.1016/j.atherosclerosis.2011.08.032
    • van de Laar, R. J. J., Stehouwer, C. D. A., Boreham, C. A., Murray, L. M., Schalkwijk, C. G., Prins, M. H., Twisk, J. W. R., & Ferreira, I. (2011). Continuing smoking between adolescence and young adulthood is associated with higher arterial stiffness in young adults: the Northern Ireland Young Hearts Project. Journal of Hypertension, 29(11), 2201-2209. https://doi.org/10.1097/HJH.0b013e32834b0ecf
    • Ketel, I. J. G., Serne, E. H., Ijzerman, R. G., Korsen, T. J. M., Twisk, J. W., Hompes, P. G. A., Smulders, Y. M., Homburg, R., Vorstermans, L., Stehouwer, C. D. A., & Lambalk, C. B. (2011). Insulin-induced capillary recruitment is impaired in both lean and obese women with PCOS. Human Reproduction, 26(11), 3130-3137. https://doi.org/10.1093/humrep/der296
    • Jonk, A. M., Houben, A. J., Schaper, N. C., de Leeuw, P. W., Serne, E. H., Smulders, Y. M., & Stehouwer, C. D. A. (2011). Obesity is associated with impaired endothelial function in the postprandial state.Microvascular Research, 82(3), 423-429. https://doi.org/10.1016/j.mvr.2011.08.006
    • Dijkema, M. B. A., Mallant, S. F., Gehring, U., van den Hurk, K., Alssema, M., van Strien, R. T., Fischer, P. H., Nijpels, G., Stehouwer, C. D. A., Hoek, G., Dekker, J. M., & Brunekreef, B. (2011). Long-term Exposure to Traffic-related Air Pollution and Type 2 Diabetes Prevalence in a Cross-sectional Screening-study in the Netherlands. Environmental Health, 10, 9. https://doi.org/10.1186/1476-069X-10-76
    • Alssema, M., Vistisen, D., Heymans, M. W., Nijpels, G., Glumer, C., Zimmet, P. Z., Shaw, J. E., Eliasson, M., Stehouwer, C. D. A., Tabak, A. G., Colagiuri, S., Borch-Johnsen, K., & Dekker, J. M. (2011). Risk scores for predicting type 2 diabetes: using the optimal tool. Diabetologia, 54(9), 2468-2470. https://doi.org/10.1007/s00125-011-2214-5
    • Schouten, F., Twisk, J. W., de Boer, M. R., Stehouwer, C. D. A., Serne, E. H., Smulders, Y. M., & Ferreira, I. (2011). Increases in central fat mass and decreases in peripheral fat mass are associated with accelerated arterial stiffening in healthy adults: the Amsterdam Growth and Health Longitudinal Study.American Journal of Clinical Nutrition, 94(1), 40-48. https://doi.org/10.3945/ajcn.111.013532
    • Van der Zwan, L. P., Scheffer, P. G., Dekker, J. M., Stehouwer, C. D. A., Heine, R., & Teerlink, T. (2011). Systemic inflammation is linked to low arginine and high ADMA plasma levels resulting in an unfavourable NOS substrate-to-inhibitor ratio: the Hoorn Study. Clinical Science, 121(2), 71-78. https://doi.org/10.1042/CS20100595