Coen Stehouwer

Professor

Coen Stehouwer (Rotterdam, 1960) obtained an MD at the Erasmus University in Rotterdam (1985; cum laude); registered as internist in 1990; and obtained a PhD in 1992 (Vrije Universiteit, Amsterdam). He did postgraduate training in epidemiology and molecular biology.

In 2000, he was appointed Professor of Internal Medicine at the Vrije Universiteit in Amsterdam. In 2004, he accepted a position as Professor of Internal Medicine and Chair of the Department of Internal Medicine at the University of Maastricht in the Netherlands.

In 2019, 463 million people had diabetes worldwide, at stupendous personal, health-care and societal costs. In 2010, ~10% of global health-care expenditure was spent on treatment of diabetes. Prof. Stehouwer has devoted his career to systematically deciphering the pathophysiology of diabetes and its cardiovascular complications.

Since 1990, the work of Professor Stehouwer and his group has led to 87 completed PhD theses and more than 800 peer-reviewed papers in international journals.

Prof. Stehouwer’s work is well-recognized as shown by a Hirsh index of 121 (Web of Science); >72,000 citations; and several awards, notably the Dr. F. Gerritzen Award for excellent diabetes research (Dutch Diabetes Research Foundation, 1993); the Castelli-Pedroli Award for excellent research into the complications of diabetes (European Association for the Study of Diabetes, 2005); the Dutch Society of Vascular Medicine Career Award (2007); membership of the Faculty of 1000 (2009); Fellowship of the European Society of Cardiology (2009); the Ruitenga Van Swieten honorary professorship of the University of Amsterdam (2009); the Ruysch Lecture Award (Academic Medical Centre - University of Amsterdam (2010); the Donald McDonald Award of Artery Society (2017); and the Clarivate / Web of Science Highly Cited Researcher Award in recognition of exceptional research performance demonstrated by production of multiple highly cited papers that rank in the top 1% for field and year (2020).

He has given Invited Lectures at meetings of the European Association for the Study of Diabetes; European Society of Cardiology; European Council for Cardiovascular Research; European Society of Hypertension; European Association for the Study of Obesity; European Society for Microcirculation; European Association for Cardiovascular Prevention and Rehabilitation; European College of Sports Science; Euretina Congress; International Society of Nephrology; International Society of Atherosclerosis; Danish Academy of Science; Danish Diabetes Association; Swedish Diabetes Association; Karolinska Institute; Finnish Diabetes Association; Collège de France; INSERM at Paris Descartes University; Diabetes UK; American Diabetes Association; American Heart Association; German Center for Neurodegenerative Diseases in Bonn; and World Congress for Microcirculation.

Prof. Stehouwer is highly regarded by young researchers for his scientific originality, rigour and integrity; accessibility; coaching and mentoring skills; and rapidity and thoroughness of providing comments on draft papers. He has supervised four theses that have been awarded a ‘cum laude’ judgement. Five former PhD students have advanced to full professorships and eight to associate professorships. His interest in teaching is shown also by his serving as Editor-in-Chief of the Dutch Textbook of Internal Medicine (1996-current; 12th-15th edition).

His research programme focuses on the elucidation of how metabolic and microvascular changes in (pre)diabetes cause micro- and macrovascular disease. A key element of the programme is to combine epidemiology, clinical physiology and experimental approaches. He obtained national and European funding M€16) for, and is the initiator and Scientific Director of, the Maastricht Study (started 2011), which uses very detailed phenotyping (with a focus on microcirculatory, large artery and cardiac function and structure) in 7000 individuals without and 2000 with type 2 diabetes to elucidate how diabetes leads not only to classic complications but also to so-called emerging complications such as cognitive dysfunction, mood disorders, liver disease, musculoskeletal disease, pulmonary disease, sleep-disordered breathing, and infectious diseases. National and international grants (2007-current) awarded to Prof. Stehouwer amount to the sum of 30.2 M€.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T:+31(0)43 387 70 06

  • 2022
    • Gianfredi, V., Schaper, N. C., Odone, A., Signorelli, C., Amerio, A., Eussen, S. J. P. M., Köhler, S., Savelberg, H. H. C. M., Stehouwer, C. D. A., Dagnelie, P. C., Henry, R. M. A., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Schram, M. T., & Koster, A. (2022). Daily patterns of physical activity, sedentary behavior, and prevalent and incident depression-The Maastricht Study. Scandinavian Journal of Medicine & Science in Sports, 32(12), 1768-1780. https://doi.org/10.1111/sms.14235
    • Ren, Z. W., Simons, P. I. H. G., Wesselius, A., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Untitled Reply. Hepatology, 76(6), E129-E130. https://doi.org/10.1002/hep.32611
    • Jin, S., Reesink, K. D., Kroon, A. A., de Galan, B., van der Kallen, C. J. H., Wesselius, A., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2022). Complement factors D and C3 cross-sectionally associate with arterial stiffness, but not independently of metabolic risk factors: The Maastricht Study. Journal of Hypertension, 40(11), 2161-2170. https://doi.org/10.1097/HJH.0000000000003237
    • van der Heide, F. C. T., Foreman, Y. D., Franken, I. W. M., Henry, R. M. A., Kroon, A. A., Dagnelie, P. C., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Schaper, N. C., Brouwers, M. C. G. J., & Stehouwer, C. D. A. (2022). (Pre)diabetes, glycemia, and daily glucose variability are associated with retinal nerve fiber layer thickness in The Maastricht Study. Scientific Reports, 12(1), [17750]. https://doi.org/10.1038/s41598-022-22748-2
    • Konopka, M. J., Kohler, S., Stehouwer, C. D. A., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Savelberg, H. H. C. M., Eussen, S. J. P. M., Dagniele, P. C., van Dongen, M. C. J. M., Schram, M. T., & Koster, A. (2022). Accelerometer-derived sedentary time and physical activity and the incidence of depressive symptoms - The Maastricht Study. Psychological Medicine, 52(13), 2786-2793. https://doi.org/10.1017/S0033291720004924
    • Top, W. M. C., Lehert, P., Schalkwijk, C. G., Stehouwer, C. D. A., & Kooy, A. (2022). Effect of metformin on arginine and dimethylarginines in patients with advanced type 2 diabetes: A post hoc analysis of a randomized trial. Diabetes Obesity & Metabolism, 24(10), 1983-1988. https://doi.org/10.1111/dom.14784
    • Janssen, L. E. F., Simons, N., Simons, P. I. H. G., Schaper, N. C., Feskens, E. J. M., van der Ploeg, L. M. C., Van den Eynde, M. D. G., Schalkwijk, C. G., Houben, A. J. H. M., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Effects of fructose restriction on blood pressure: Secondary analysis of a double-blind randomized controlled trial. Clinical Nutrition ESPEN, 51, 97-103. https://doi.org/10.1016/j.clnesp.2022.07.009
    • Geraets, A. F. J., Schram, M. T., Jansen, J. F. A., Backes, W. H., Schalkwijk, C. G., Stehouwer, C. D. A., van Boxtel, M. P. J., Eussen, S. J. P. M., Kooman, J. P., Verhey, F. R. J., & Köhler, S. (2022). The cardiometabolic depression subtype and its association with clinical characteristics: The Maastricht Study. Journal of Affective Disorders, 313, 110-117. https://doi.org/10.1016/j.jad.2022.06.045
    • Kloka, J., Friedrichson, B., Dauth, S., Foldenauer, A. C., Bulczak-Schadendorf, A., Vehreschild, M. J. G. T., Matos, F. M., Riera-Mestre, A., van Asselt, A. D. I., De Robertis, E., Juskeviciene, V. T., Meybohm, P., Tomescu, D., Lacombe, K., Stehouwer, C. D. A., Zacharowski, K., & IXION Collaboration Group (2022). Potential of FX06 to prevent disease progression in hospitalized non-intubated COVID-19 patients - the randomized, EU-wide, placebo-controlled, phase II study design of IXION. Trials, 23(1), [688]. https://doi.org/10.1186/s13063-022-06609-x
    • Hengeveld, L. M., de Goede, J., Afman, L. A., Bakker, S. J. L., Beulens, J. W. J., Blaak, E. E., Boersma, E., Geleijnse, J. M., van Goudoever, J. H. B., Hopman, M. T. E., Iestra, J. A., Kremers, S. P. J., Mensink, R. P., de Roos, N. M., Stehouwer, C. D. A., Verkaik-Kloosterman, J., de Vet, E., & Visser, M. (2022). Health Effects of Increasing Protein Intake Above the Current Population Reference Intake in Older Adults: A Systematic Review of the Health Council of the Netherlands. Advances in Nutrition, 13(4), 1083-1117. [nmab140]. https://doi.org/10.1093/advances/nmab140
    • Barutta, F., Bellini, S., Guarrera, S., Matullo, G., Schalkwijk, C., Stehouwer, C. D., Chaturvedi, N., Soedamah-Muthu, S. S., Durazzo, M., & Gruden, G. (2022). Association of Serum MicroRNA-145-5p Levels with Microvascular Complications of Type 1 Diabetes: the EURODIAB Prospective Complications Study. Diabetes Research and Clinical Practice, 190, [109987]. https://doi.org/10.1016/j.diabres.2022.109987
    • Brouwers, M. C. G. J., Simons, N., Kooi, M. E., de Ritter, R., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bekers, O., Kooman, J., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Schram, M. T., Schaper, N. C., Schalkwijk, C. G., & Stehouwer, C. D. A. (2022). Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study. Digestive and Liver Disease, 54(8), 1038-1043. https://doi.org/10.1016/j.dld.2022.01.130
    • van Dalem, J., Werkman, N. C. C., van den Bergh, J. P., Rossi, B., Viggers, R., Eastell, R., Burden, A. M., Stehouwer, C. D. A., Klungel, O. H., Brouwers, M. C. G. J., & Driessen, J. H. M. (2022). "Use of sodium-glucose co-transporter 2 inhibitors, changes in body mass index and risk of fracture: a population-based cohort study". Diabetes Research and Clinical Practice, 190, [109993]. https://doi.org/10.1016/j.diabres.2022.109993
    • Clemmensen, K. K. B., Koster, A., Nielen, J. T. H., Dagnelie, P. C., Stehouwer, C. D. A., Bosma, H., Wesselius, A., Færch, K., & Eussen, S. J. P. M. (2022). Role of weekday variation on glucose, insulin, and triglyceride: A cross-sectional analysis from The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 107(8), E3145-E3151. https://doi.org/10.1210/clinem/dgac286
    • Rebelos, E., Daniele, G., Campi, B., Saba, A., Koskensalo, K., Ihalainen, J., Saukko, E., Nuutila, P., Backes, W. H., Jansen, J. F. A., Dagnelie, P. C., Köhler, S., de Galan, B. E., van Sloten, T. T., Stehouwer, C. D. A., & Ferrannini, E. (2022). Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans. Scientific Reports, 12(1), 11530. [11530]. https://doi.org/10.1038/s41598-022-15670-0
    • Qiao, Y-S., Tang, X., Chai, Y-H., Gong, H-J., Zhang, X., Stehouwer, C. D. A., & Zhou, J-B. (2022). Association of Sarcopenia and A Body Shape Index With Overall and Cause-Specific Mortality. Frontiers in Endocrinology, 13, [839074]. https://doi.org/10.3389/fendo.2022.839074
    • Jin, S., Kusters, Y. H. A. M., Houben, A. J. H. M., Plat, J., Joris, P. J., Mensink, R. P., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2022). A randomized diet-induced weight-loss intervention reduces plasma complement C3: Possible implication for endothelial dysfunction. Obesity, 30(7), 1401-1410. https://doi.org/10.1002/oby.23467
    • Chai, Y-H., Zhang, Y-P., Qiao, Y-S., Gong, H-J., Xu, H., She, H-C., Patel, I., Liu, W., Stehouwer, C. D. A., Zhou, J-B., & Simó, R. (2022). Association between diabetic retinopathy, brain structural abnormalities and cognitive impairment for accumulated evidence in observational studies. American Journal of Ophthalmology, 239, 37-53. https://doi.org/10.1016/j.ajo.2022.01.011
    • Simons, P. I. H. G., Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Derks, T. G. J., Schalkwijk, C. G., Schrauwen-Hinderling, V. B., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Serum sex hormone-binding globulin levels are reduced and inversely associated with intrahepatic lipid content and saturated fatty acid fraction in adult patients with glycogen storage disease type 1a. Journal of Endocrinological Investigation, 45(6), 1227-1234. https://doi.org/10.1007/s40618-022-01753-2
    • Linkens, A. M. A., van Best, N., Niessen, P. M., Wijckmans, N. E. G., de Goei, E. E. C., Scheijen, J. L. J. M., van Dongen, M. C. J. M., van Gool, C. C. J. A. W., de Vos, W. M., Houben, A. J. H. M., Stehouwer, C. D. A., Eussen, S. J. M. P., Penders, J., & Schalkwijk, C. G. (2022). A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial. International journal of molecular sciences, 23(10), [5328]. https://doi.org/10.3390/ijms23105328
    • Veugen, M. G. J., Onete, V. G., Henry, R. M. A., Brunner-La Rocca, H-P., Koster, A., Dagnelie, P. C., Schaper, N. C., Sep, S. J. S., van der Kallen, C. J. H., van Boxtel, M. P. J., Reesink, K. D., Schouten, J. S., Savelberg, H. H. C. M., Köhler, S., Verhey, F. R., van den Bergh, J. P. W., Schram, M. T., & Stehouwer, C. D. A. (2022). Health burden in type 2 diabetes and prediabetes in The Maastricht Study. Scientific Reports, 12(1), 1-11. [7337]. https://doi.org/10.1038/s41598-022-11136-5
    • van Sloten, T. T., Souverein, P. C., Stehouwer, C. DA., & Driessen, J. H. (2022). Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and risk of depression among older people with hypertension. Journal of Psychopharmacology, 36(5), 594-603. [02698811221082470]. https://doi.org/10.1177/02698811221082470
    • Buziau, A. M., Eussen, S. J. P. M., Kooi, M. E., van der Kallen, C. J. H., van Dongen, M. C. J. M., Schaper, N. C., Henry, R. M. A., Schram, M. T., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Bekers, O., Meex, S. J. R., Schalkwijk, C. G., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study. Diabetes Care, 45(5), 1116-1123. https://doi.org/10.2337/dc21-2123
    • Vandercappellen, E. J., Koster, A., Savelberg, H. H. C. M., Eussen, S. J. P. M., Dagnelie, P. C., Schaper, N. C., Schram, M. T., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Kroon, A. A., Henry, R. M. A., & Stehouwer, C. D. A. (2022). Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation-relevance for (pre)diabetes: The Maastricht Study. Diabetologia, 65(5), 777-789. https://doi.org/10.1007/s00125-022-05651-3
    • Stultiens, J. M. G., Top, W. M. C., Kimenai, D. M., Lehert, P., Bekers, O., Stehouwer, C. D. A., Kooy, A., & Meex, S. J. R. (2022). Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial. Cardiovascular Diabetology, 21(1), [49]. https://doi.org/10.1186/s12933-022-01482-z
    • Mashnafi, S., Plat, J., Mensink, R. P., Joris, P. J., Kusters, Y. H. A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Baumgartner, S. (2022). Effects of Diet-Induced Weight Loss on Plasma Markers for Cholesterol Absorption and Synthesis: Secondary Analysis of a Randomized Trial in Abdominally Obese Men. Nutrients, 14(8), [1546]. https://doi.org/10.3390/nu14081546
    • Simons, P. I. H. G., Cornelissen, M. E. B., Valkenburg, O., Onland-Moret, N. C., van der Schouw, Y. T., Stehouwer, C. D. A., Burgess, S., & Brouwers, M. C. G. J. (2022). Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study. Clinical Endocrinology, 96(4), 599-604. https://doi.org/10.1111/cen.14593
    • Gennip, A. C. E., Sedaghat, S., Carnethon, M. R., Allen, N. B., Klein, B. E. K., Cotch, M. F., Chirinos, D. A., Stehouwer, C. D. A., & van Sloten, T. T. (2022). Retinal Microvascular Caliber and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology, 191(5), 843-855. https://doi.org/10.1093/aje/kwab255
    • Linkens, A. M. A., Houben, A. J., Niessen, P. M., Wijckmans, N., de Goei, E., Van den Eynde, M. D. G., Scheijen, J. L. J. M., Waarenburg, M., Mari, A., Berendschot, T. T. J. M., Streese, L., Hanssen, H., van Dongen, M. C. J. M., van Gool, C., Stehouwer, C. D. A., Eussen, S. J. P. M., & Schalkwijk, C. (2022). A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals. JCI INSIGHT, 7(6), [156950]. https://doi.org/10.1172/jci.insight.156950
    • Top, W. M. C., Kooy, A., & Stehouwer, C. D. A. (2022). Metformin: A Narrative Review of Its Potential Benefits for Cardiovascular Disease, Cancer and Dementia. Pharmaceuticals, 15(3), [312]. https://doi.org/10.3390/ph15030312
    • van Hulten, V., Sarodnik, C., Driessen, J. H. M., Schaper, N. C., Geusens, P. P. M. M., Webers, C. A. B., Dinant, G-J., Ottenheijm, R. P. G., Rasmussen, N. H., Viggers, R., Stehouwer, C. D. A., van der Kallen, C. J. H., Schram, M. T., Bours, S. P. G., Dagnelie, P. C., & van den Bergh, J. P. (2022). Prevalent Morphometrically Assessed Vertebral Fractures in Individuals With Type 2 Diabetes, Prediabetes and Normal Glucose Metabolism: The Maastricht Study. Frontiers in Endocrinology, 13, [832977]. https://doi.org/10.3389/fendo.2022.832977
    • Linkens, A. M. A., Houben, A. J. H. M., Kroon, A. A., Schram, M. T., Berendschot, T. T. J. M., Webers, C. A. B., van Greevenbroek, M., Henry, R. M. A., de Galan, B., Stehouwer, C. D. A., Eussen, S. J. M. P., & Schalkwijk, C. G. (2022). Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function-the Maastricht Study. American Journal of Clinical Nutrition, 115(2), 444-455. https://doi.org/10.1093/ajcn/nqab302
    • van Dinther, M., Schram, M. T., Jansen, J. F. A., Backes, W. H., Houben, A. J. H. M., Berendschot, T. T. J. M., Schalkwijk, C. G., Stehouwer, C. D. A., van Oostenbrugge, R. J., & Staals, J. (2022). Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study. Geroscience, 44(1), 147-157. https://doi.org/10.1007/s11357-021-00493-0
    • Maasen, K., Eussen, S. J. P. M., Scheijen, J. L. J. M., van der Kallen, C. J. H., Dagnelie, P. C., Opperhuizen, A., Stehouwer, C. D. A., van Greevenbroek, M. M. J., & Schalkwijk, C. G. (2022). Higher habitual intake of dietary dicarbonyls is associated with higher corresponding plasma dicarbonyl concentrations and skin autofluorescence: the Maastricht Study. American Journal of Clinical Nutrition, 115(1), 34-44. https://doi.org/10.1093/ajcn/nqab329
  • 2021
    • Qiao, Y-S., Chai, Y-H., Gong, H-J., Zhuldyz, Z., Stehouwer, C. D. A., Zhou, J-B., & Simó, R. (2021). The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies. Frontiers in Endocrinology, 12, [782391]. https://doi.org/10.3389/fendo.2021.782391
    • Malik, A. E. F., Delhaas, T., Spronck, B., Henry, R. M. A., Joseph, J., Stehouwer, C. D. A., Mess, W. H., & Reesink, K. D. (2021). Single M-Line Is as Reliable as Multiple M-Line Ultrasound for Carotid Artery Screening. Frontiers in physiology, 12, [787083]. https://doi.org/10.3389/fphys.2021.787083
    • van Son, J., Oussaada, S. M., Sekercan, A., Beudel, M., Dongelmans, D. A., van Assen, S., Eland, I. A., Moeniralam, H. S., Dormans, T. P. J., van Kalkeren, C. A. J., Douma, R. A., Rusch, D., Simsek, S., Liu, L., Kootte, R. S., Wyers, C. E., IJzerman, R. G., van den Bergh, J. P., Stehouwer, C. D. A., ... Serlie, M. J. (2021). Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study. Frontiers in Endocrinology, 12, [747732]. https://doi.org/10.3389/fendo.2021.747732
    • Kalafati, M., Kutmon, M., Evelo, C. T., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Blaak, E. E., van Greevenbroek, M. M. J., Adriaens, M., & BIOS Consortium (2021). An interferon-related signature characterizes the whole blood transcriptome profile of insulin-resistant individuals-the CODAM study. Genes and nutrition, 16(1), [22]. https://doi.org/10.1186/s12263-021-00702-7
    • Barutta, F., Corbetta, B., Bellini, S., Guarrera, S., Matullo, G., Scandella, M., Schalkwijk, C., Stehouwer, C. D., Chaturvedi, N., Soedamah-Muthu, S. S., Durazzo, M., & Gruden, G. (2021). MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS. Journal of Translational Medicine, 19(1), [475]. https://doi.org/10.1186/s12967-021-03142-4
    • van der Heide, F. C. T., Steens, I. L. M., Geraets, A. F. J., Foreman, Y. D., Henry, R. M. A., Kroon, A. A., van der Kallen, C. J. H., van Sloten, T. T., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., van Greevenbroek, M. M. J., Wesselius, A., Koster, A., Schaper, N. C., Schram, M. T., ... Stehouwer, C. D. A. (2021). Association of Retinal Nerve Fiber Layer Thickness, an Index of Neurodegeneration, With Depressive Symptoms Over Time. Jama network open, 4(11), e2134753. [2134753]. https://doi.org/10.1001/jamanetworkopen.2021.34753
    • Tang, X. Y., Zhao, W., Lu, M., Zhang, X., Zhang, P., Xin, Z., Sun, R., Tian, W., Cardoso, M. A., Yang, J. K., Sim, R., Zhou, J. B., & Stehouwer, C. D. A. (2021). Relationship between Central Obesity and the incidence of Cognitive Impairment and Dementia from Cohort Studies Involving 5,060,687 Participants. Neuroscience and Biobehavioral Reviews, 130, 301-313. https://doi.org/10.1016/j.neubiorev.2021.08.028
    • van Gennip, A. C. E., Stehouwer, C. D. A., van Boxtel, M. P. J., Verhey, F. R. J., Koster, A., Kroon, A. A., Köhler, S., van Greevenbroek, M. M. J., Wesselius, A., Eussen, S. J. P. M., Backes, W. H., Jansen, J. F., Schram, M. T., Henry, R. M. A., Singh-Manoux, A., & van Sloten, T. T. (2021). Association of Type 2 Diabetes, According to the Number of Risk Factors Within Target Range, With Structural Brain Abnormalities, Cognitive Performance, and Risk of Dementia. Diabetes Care, 44(11), 2493-2502. https://doi.org/10.2337/dc21-0149
    • Bakker, L., Ramakers, I. H. G. B., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., van der Kallen, C. J. H., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Midttun, Ø., Ueland, P. M., Verhey, F. R. J., Eussen, S. J. P. M., & Köhler, S. (2021). Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. Diabetologia, 64(11), 2445-2457. https://doi.org/10.1007/s00125-021-05521-4
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