Frank de Vries

Professor

Prof. Frank de Vries started a PhD in pharmaco-epidemiology at Utrecht University in 2002 on side effects of use of inhaled corticosteroids. Since then, he has worked for the Medicine and Healthcare products Regulatory Agency. He has obtained several research grants and prizes, including the Swierenga award for respiratory disease, an NWO Veni grant and the Kohn prize from the UK National Osteoporosis Foundation. His work has been published in various journals including JAMA, the NEJM and BMJ. He is on secondment at the Utrecht Institute for Pharmaceutical Sciences, the Netherlands. He is a visiting scientist at the MRC Lifecourse Epidemiology Unit in Southampton, UK. Frank works as a hospital pharmacist in the Maastricht UMC+, apotheek.mumc.nl/en.

Frank’s current research activities mainly focus on effects of drugs in patients with diabetes mellitus and movement disorders. As the department’s head of research, he oversees other research lines on personalised medicine in the areas of lung oncology and psychiatric disorders.

Department of Clinical Pharmacy & Toxicology
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
T: +31(0)43 387 18 81

  • 2021
    • Bultink, I. E. M., de Vries, F., van Vollenhoven, R. F., & Lalmohamed, A. (2021). Mortality, causes of death and influence of medication use in patients with systemic lupus erythematosus vs matched controls. Rheumatology, 60(1), 207-216. https://doi.org/10.1093/rheumatology/keaa267
  • 2020
    • Al-Mashhadi, Z., Viggers, R., Fuglsang-Nielsen, R., de Vries, F., van den Bergh, J. P., Harsløf, T., Langdahl, B., Gregersen, S., & Starup-Linde, J. (2020). Glucose-Lowering Drugs and Fracture Risk-a Systematic Review. Current Osteoporosis Reports, 18(6), 737-758. https://doi.org/10.1007/s11914-020-00638-8
    • Hoenderboom, B. M., van Bergen, J. E. A. M., Dukers-Muijrers, N. H. T. M., Götz, H. M., Hoebe, C. J. P. A., de Vries, H. J. C., van den Broek, I. V. F., de Vries, F., Land, J. A., van der Sande, M. A. B., Morré, S. A., & van Benthem, B. H. B. (2020). Pregnancies and time to pregnancy in women with and without a previous Chlamydia trachomatis infection. Sexually Transmitted Diseases, 47(11), 739-747. https://doi.org/10.1097/OLQ.0000000000001247
    • Werkman, N. C. C., Nielen, J. T. H., van den Bergh, J. P. W., Ejskjaer, N., Røikjer, J., Schaper, N. C., Rossi, B., Klungel, O., Vestergaard, P., de Vries, F., & Driessen, J. H. M. (2020). Use of Sodium-Glucose Co-Transporter-2-Inhibitors (SGLT2-Is) and Risk of Lower Limb Amputation. Current Drug Safety, 15(1). https://doi.org/10.2174/1574886315666200805103053
    • de Bruin, I. J. A., Wyers, C. E., Souverein, P. C., van Staa, T. P., Geusens, P. P. M. M., van den Bergh, J. P. W., de Vries, F., & Driessen, J. H. M. (2020). The risk of new fragility fractures in patients with chronic kidney disease and hip fracture-a population-based cohort study in the UK. Osteoporosis International, 31(8), 1487-1497. https://doi.org/10.1007/s00198-020-05351-x
    • Den Heijer, C. D. J., Hoebe, C. J. P. A., Driessen, J. H. M., Wolffs, P., Van Den Broek, I. V. F., Hoenderboom, B. M., Williams, R., De Vries, F., & Dukers-Muijrers, N. H. T. M. (2020). Erratum to: Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients. Clinical Infectious Diseases, 70(11), 2459. https://doi.org/10.1093/cid/ciz897
    • Abtahi, S., Burden, A. M., Geusens, P., van den Bergh, J. P., van Staa, T., & de Vries, F. (2020). The Association of Oral Bisphosphonate Use With Mortality Risk Following a Major Osteoporotic Fracture in the United Kingdom: Population-Based Cohort Study. Journal of the American Medical Directors Association, 21(6), 811-816. https://doi.org/10.1016/j.jamda.2019.11.003
    • Oortgiesen, B. E., Driessen, J. H. M., Hoogendoorn, M., Kibbelaar, R. E., Veeger, N. J. G. M., van den Bergh, J. P. W., Vestergaard, P., de Vries, F., & van Roon, E. N. (2020). No decrease in fracture risk despite 15 years of treatment evolution for multiple myeloma patients: A Danish nationwide case-control study. Bone, 134, [115299]. https://doi.org/10.1016/j.bone.2020.115299
    • van Durme, C., Spaetgens, B., Driessen, J., Nielen, J., Sastry, M., Boonen, A., & de Vries, F. (2020). Obstructive sleep apnea and the risk of gout: a population-based case-control study. Arthritis Research & Therapy, 22(1), [92]. https://doi.org/10.1186/s13075-020-02176-1
    • De Vries, F. (2020). Is there a need for review-a-thons?The Lancet Rheumatology, 2(4), e205. https://doi.org/10.1016/S2665-9913(20)30056-4
    • de Vries, F. (2020). Letter regarding "Cognitive outcomes in meningioma patients undergoing surgery: individual changes over time and predictors of late cognitive functioning". Neuro-oncology, 22(4), 580-581. https://doi.org/10.1093/neuonc/noz247
    • van Veelen, A., van Geel, R., de Beer, Y., Dingemans, A-M., Stolk, L., Ter Heine, R., de Vries, F., & Croes, S. (2020). Validation of an analytical method using HPLC-MS/MS to quantify osimertinib in human plasma and supplementary stability results. Biomedical Chromatography, 34(4), [e4771]. https://doi.org/10.1002/bmc.4771
    • Rasmussen, N. H., Dal, J., de Vries, F., van den Bergh, J. P., Jensen, M. H., & Vestergaard, P. (2020). Diabetes and fractures: new evidence of atypical femoral fractures?Osteoporosis International, 31(3), 447-455. https://doi.org/10.1007/s00198-019-05224-y
    • Oshagbemi, O. A., Franssen, F. M. E., Wouters, E. F. M., Maitland-van der Zee, A. H., Driessen, J. H. M., de Boer, A., & de Vries, F. (2020). C-reactive protein as a biomarker of response to inhaled corticosteroids among patients with COPD. Pulmonary Pharmacology & Therapeutics, 60, 101870. [101870]. https://doi.org/10.1016/j.pupt.2019.101870
    • Keene, S. J., Adab, P., de Vries, F., Franssen, F. M. E., Sitch, A., Martin, J., Marshall, T., & Jordan, R. (2020). The stability of the ADO score among UK COPD patients from The Health Improvement Network. ERJ Open Research, 6(1), [196]. https://doi.org/10.1183/23120541.00196-2019
    • Nielen, J. T. H., Driessen, J. H. M., Dagnelie, P. C., Boonen, A., van den Bemt, B., van Onzenoort, H. A. W., Neef, C., Henry, R. M. A., Burden, A. M., Sep, S. J. S., van der Kallen, C. J., Schram, M. T., Schaper, N., Stehouwer, C. D. A., Smits, L., & de Vries, F. (2020). Drug utilization in the Maastricht Study: A comparison with nationwide data. Medicine, 99(1), [18524]. https://doi.org/10.1097/MD.0000000000018524
    • Houghton, R., de Vries, F., & Loss, G. (2020). Psychostimulants/Atomoxetine and Serious Cardiovascular Events in Children with ADHD or Autism Spectrum Disorder. Cns Drugs, 34(1), 93-101. https://doi.org/10.1007/s40263-019-00686-4
  • 2019
    • van Herpen-Meeuwissen, L. J. M., van den Bemt, B. J. F., Derijks, H. J., van den Bemt, P. M. L. A., de Vries, F., Maat, B., & van Onzenoort, H. A. W. (2019). Economic impact of Patient's Own Medication use during hospitalisation: a multicentre pre-post implementation study. International Journal of Clinical Pharmacy, 41(6), 1658-1665. https://doi.org/10.1007/s11096-019-00932-1
    • Gieling, E., de Vries, F., Williams, R., van Onzenoort, H. A. W., de Boer, A., Ten Cate, V., Kramers, C., & Burden, A. (2019). Mortality risk in atrial fibrillation: the role of aspirin, vitamin K and non-vitamin K antagonists. International Journal of Clinical Pharmacy, 41(6), 1536-1544. https://doi.org/10.1007/s11096-019-00916-1
    • den Heijer, C. D. J., Hoebe, C. J. P. A., Driessen, J. H. M., Wolffs, P., van den Broek, I. V. F., Hoenderboom, B. M., Williams, R., de Vries, F., & Dukers-Muijrers, N. H. T. M. (2019). Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients. Clinical Infectious Diseases, 69(9), 1517-1525. https://doi.org/10.1093/cid/ciz429
    • Abtahi, S., Driessen, J. H. M., Vestergaard, P., van den Bergh, J., Boonen, A., de Vries, F., & Burden, A. M. (2019). Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010. Osteoporosis International, 30(11), 2217-2223. https://doi.org/10.1007/s00198-019-05109-0
    • van Maren, M. A., Wyers, C. E., Driessen, J. H. M., Visser, J. V., de Vries, F., van de Wijdeven, K., Gevers, S., Lems, W. F., Emmelot-Vonk, M. H., & van den Bergh, J. P. W. (2019). Two-year persistence with teriparatide improved significantly after introduction of an educational and motivational support program. Osteoporosis International, 30(9), 1837-1844. https://doi.org/10.1007/s00198-019-05052-0
    • Stolk, L. M., de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., Hoek - ten Cate, A., & Burden, A. (2019). Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants (vol 83, pg 1835, 2017). British Journal of Clinical Pharmacology, 85(8), 1864-1864. https://doi.org/10.1111/bcp.14001
    • Hjellvik, V., De Bruin, M. L., Samuelsen, S. O., Karlstad, Ø., Andersen, M., Haukka, J., Vestergaard, P., de Vries, F., & Furu, K. (2019). Adjusting for unmeasured confounding using validation data: Simplified two-stage calibration for survival and dichotomous outcomes. Statistics in Medicine, 38(15), 2719-2734. https://doi.org/10.1002/sim.8131
    • Abtahi, S., Driessen, J. H. M., Vestergaard, P., van den Bergh, J., Boonen, A., de Vries, F., & Burden, A. M. (2019). RETRACTION: Secular trends in major osteoporotic fractures among 50+adults in Denmark between 1995 and 2010 (Retraction of Vol 13, art no 91, 2018). Archives of Osteoporosis, 14(1), [77]. https://doi.org/10.1007/s11657-019-0614-1
    • Williams, R., Kothny, W., Serban, C., Lopez-Leon, S., de Vries, F., & Schlienger, R. (2019). Association between vildagliptin and risk of angioedema, foot ulcers, skin lesions, hepatic toxicity, and serious infections in patients with type 2 diabetes mellitus: A European multidatabase, noninterventional, postauthorization safety study. Endocrinology, Diabetes & Metabolism, 2(3), e00084. https://doi.org/10.1002/edm2.84
    • Houghton, R., Monz, B., Law, K., Loss, G., Le Scouiller, S., de Vries, F., & Willgoss, T. (2019). Correction to: Psychometric Validation of the Autism Impact Measure (AIM). Journal of Autism and Developmental Disorders, 49(6), 2571-2571. https://doi.org/10.1007/s10803-019-04076-z
    • Houghton, R., Monz, B., Law, K., Loss, G., Le Scouiller, S., de Vries, F., & Willgoss, T. (2019). Psychometric Validation of the Autism Impact Measure (AIM). Journal of Autism and Developmental Disorders, 49(6), 2559-2570. https://doi.org/10.1007/s10803-019-04011-2
    • Gallagher, A. M., Dedman, D., Padmanabhan, S., Leufkens, H. G. M., & de Vries, F. (2019). The accuracy of date of death recording in the Clinical Practice Research Datalink GOLD database in England compared with the Office for National Statistics death registrations. Pharmacoepidemiology and Drug Safety, 28(5), 563-569. https://doi.org/10.1002/pds.4747
    • de Bruin, I. J. A., Klop, C., Wyers, C. E., Overbeek, J. A., Geusens, P. P. M. M., van den Bergh, J. P. W., Driessen, J. H. M., & de Vries, F. (2019). All-cause mortality with current and past use of antidepressants or benzodiazepines after major osteoporotic and hip fracture. Osteoporosis International, 30(3), 573-581. https://doi.org/10.1007/s00198-019-04851-9
    • de Vries, F. (2019). Inconsistencies in Reporting Studies of Lactic Acidosis. JAMA Internal Medicine, 179(3), 455-456. https://doi.org/10.1001/jamainternmed.2018.8627
    • Nielen, J. T. H., Dagnelie, P. C., Boonen, A., Klungel, O., van den Bemt, B., & de Vries, F. (2019). Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink. Diabetes Research and Clinical Practice, 148, 240-248. https://doi.org/10.1016/j.diabres.2019.01.021
    • Driessen, J. H. M., de Vries, F., van Onzenoort, H. A. W., Schram, M. T., van der Kallen, C., Reesink, K. D., Sep, S., Stehouwer, C. D. A., Schaper, N., Kroon, A. A., Schalkwijk, C., van den Bergh, J. P. W., & Henry, R. M. A. (2019). Metformin use in type 2 diabetic patients is not associated with lower arterial stiffness: the Maastricht Study. Journal of Hypertension, 37(2), 365-371. https://doi.org/10.1097/HJH.0000000000001892
    • Tran-Duy, A., Connell, N. J., Vanmolkot, F. H., Souverein, P. C., de Wit, N. J., Stehouwer, C. D. A., Hoes, A. W., de Vries, F., & de Boer, A. (2019). Use of proton pump inhibitors and risk of iron deficiency: a population-based case-control study. Journal of Internal Medicine, 285(2), 205-214. https://doi.org/10.1111/joim.12826
    • Nielen, J. T. H., de Vries, F., van der Velde, J. H. P. M., Savelberg, H. H. C. M., Schaper, N. C., Dagnelie, P. C., Henry, R. M. A., Schram, M., Stehouwer, C. D. A., Boonen, A., Koster, A., & van den Bemt, B. J. F. (2019). The Association Between β-Blocker Use and Cardiorespiratory Fitness: The Maastricht Study. Journal of Cardiovascular Pharmacology and Therapeutics, 24(1), 37-45. https://doi.org/10.1177/1074248418778551
    • Oshagbemi, O. A., Franssen, F. M. E., van Kraaij, S., Braeken, D. C. W., Wouters, E. F. M., Maitland-van der Zee, A. H., Driessen, J. H. M., & de Vries, F. (2019). Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD). COPD, 16(2), 152-159. https://doi.org/10.1080/15412555.2019.1608172
    • Keene, S. J., Jordan, R. E., Franssen, F. M. E., de Vries, F., Martin, J., Sitch, A., Turner, A. M., Dickens, A. P., Fitzmaurice, D., & Adab, P. (2019). External Validation Of The Updated ADO Score In COPD Patients From The Birmingham COPD Cohort. International journal of chronic obstructive pulmonary disease, 14, 2395-2407. https://doi.org/10.2147/COPD.S212381
  • 2018
    • van de Ven, L. I., Klop, C., Overbeek, J. A., de Vries, F., Burden, A. M., & Janssen, P. K. (2018). Association between use of antidepressants or benzodiazepines and the risk of subsequent fracture among those aged 65+ in the Netherlands. Osteoporosis International, 29(11), 2477-2485. https://doi.org/10.1007/s00198-018-4632-4
    • Oshagbemi, O. A., Franssen, F. M. E., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Maitland-van der Zee, A-H., Burden, A. M., & de Vries, F. (2018). Blood eosinophilia, use of inhaled corticosteroids, and risk of COPD exacerbations and mortality. Pharmacoepidemiology and Drug Safety, 27(11), 1191-1199. https://doi.org/10.1002/pds.4655
    • van der Velde, R. Y., Wyers, C. E., Geusens, P. P. M. M., van den Bergh, J. P. W., de Vries, F., Cooper, C., van de Staa, T. P., & Harvey, N. C. (2018). Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50years or older. Osteoporosis International, 29(11), 2469-2475. https://doi.org/10.1007/s00198-018-4636-0
    • Simeonova, M., de Vries, F., Pouwels, S., Driessen, J. H. M., Leufkens, H. G. M., Cadarette, S. M., & Burden, A. M. (2018). Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK. British Journal of Clinical Pharmacology, 84(11), 2551-2561. https://doi.org/10.1111/bcp.13708
    • Oshagbemi, O. A., Keene, S. J., Driessen, J. H. M., Jordan, R., Wouters, E. F. M., de Boer, A., de Vries, F., & Franssen, F. M. E. (2018). Trends in moderate and severe exacerbations among COPD patients in the UK from 2005 to 2013. Respiratory Medicine, 144, 1-6. https://doi.org/10.1016/j.rmed.2018.09.010
    • Scheepers, L. E. J. M., Burden, A. M., Arts, I. C. W., Spaetgens, B., Souverein, P., de Vries, F., & Boonen, A. (2018). Medication adherence among gout patients initiated allopurinol: a retrospective cohort study in the Clinical Practice Research Datalink (CPRD). Rheumatology, 57(9), 1641-1650. https://doi.org/10.1093/rheumatology/key155
    • Abtahi, S., Driessen, J. H. M., Vestergaard, P., van den Bergh, J., Boonen, A., de Vries, F., & Burden, A. M. (2018). Secular trends in major osteoporotic fractures among 50+adults in Denmark between 1995 and 2010. Archives of Osteoporosis, 13(1), [91]. https://doi.org/10.1007/s11657-018-0503-z
    • Nielen, J. T. H., Emans, P. J., van den Bemt, B., Dagnelie, P. C., Schram, M. T., Stehouwer, C. D. A., Schaper, N. C., Denissen, K. F. M., de Vries, F., & Boonen, A. (2018). Association of type 2 diabetes mellitus with self-reported knee pain and clinical knee osteoarthritis: The Maastricht Study. Diabetes & Metabolism, 44(3), 296-299. https://doi.org/10.1016/j.diabet.2018.01.013
    • de Jong, R. G. P. J., Peeters, P. J. H. L., Burden, A. M., de Bruin, M. L., Haak, H. R., Masclee, A. A. M., de Vries, F., & Janssen-Heijnen, M. L. G. (2018). Gastrointestinal cancer incidence in type 2 diabetes mellitus; results from a large population-based cohort study in the UK. Cancer Epidemiology, 54, 104-111. https://doi.org/10.1016/j.canep.2018.04.008
    • Knapen, L. M., Koornstra, R. H. T., Driessen, J. H. M., van Vlijmen, B., Croes, S., Schalkwijk, S., Colbers, A., Gerritsen, W. R., Burger, D. M., de Vries, F., & van Erp, N. P. (2018). The Impact of Dose and Simultaneous Use of Acid-Reducing Agents on the Effectiveness of Vemurafenib in Metastatic BRAF V600 Mutated Melanoma: a Retrospective Cohort Study. Targeted Oncology, 13(3), 363-370. https://doi.org/10.1007/s11523-018-0564-3
    • Williams, R., van Staa, T-P., Gallagher, A. M., Hammad, T., Leufkens, H. G. M., & de Vries, F. (2018). Cancer recording in patients with and without type 2 diabetes in the Clinical Practice Research Datalink primary care data and linked hospital admission data: a cohort study. BMJ Open, 8(5), [020827]. https://doi.org/10.1136/bmjopen-2017-020827
    • Keyany, A., Nielen, J. T. H., Souverein, P. C., de Vries, F., & van den Bemt, B. (2018). Use of parenteral glucocorticoids and the risk of new onset type 2 diabetes mellitus: A case-control study. Diabetes Research and Clinical Practice, 139, 100-106. https://doi.org/10.1016/j.diabres.2018.02.010
    • Oshagbemi, O. A., Burden, A. M., Shudofsky, K. N., Driessen, J. H. M., Vestergaard, P., Krings, A., Franssen, F. M. E., van den Bergh, J., & de Vries, F. (2018). Use of high-dose intermittent systemic glucocorticoids and the risk of fracture in patients with chronic obstructive pulmonary disease. Bone, 110, 238-243. https://doi.org/10.1016/j.bone.2018.02.007