Frank de Vries

Professor

Prof. Frank de Vries started a PhD in pharmaco-epidemiology at Utrecht University in 2002 on side effects of use of inhaled corticosteroids. Since then, he has worked for the Medicine and Healthcare products Regulatory Agency. He has obtained several research grants and prizes, including the Swierenga award for respiratory disease, an NWO Veni grant and the Kohn prize from the UK National Osteoporosis Foundation. His work has been published in various journals including JAMA, the NEJM and BMJ. He is on secondment at the Utrecht Institute for Pharmaceutical Sciences, the Netherlands. He is a visiting scientist at the MRC Lifecourse Epidemiology Unit in Southampton, UK. Frank works as a hospital pharmacist in the Maastricht UMC+, apotheek.mumc.nl/en.

Frank’s current research activities mainly focus on effects of drugs in patients with diabetes mellitus and movement disorders. As the department’s head of research, he oversees other research lines on personalised medicine in the areas of lung oncology and psychiatric disorders.

Department of Clinical Pharmacy & Toxicology
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
T: +31(0)43 387 18 81

  • 2018
    • de Jong, H. J. I., Tervaert, J. W. C., Lalmohamed, A., de Vries, F., Vandebriel, R. J., van Loveren, H., Klungel, O. H., & van Staa, T. P. (2018). Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink. PLOS ONE, 13(2), [e0193297]. https://doi.org/10.1371/journal.pone.0193297
    • Knapen, L. M., de Beer, Y., Bruggemann, R. J. M., Stolk, L. M., de Vries, F., Tjan-Heijnen, V. C. G., van Erp, N. P., & Croes, S. (2018). Development and validation of an analytical method using UPLC-MS/MS to quantify everolimus in dried blood spots in the oncology setting. Journal of Pharmaceutical and Biomedical Analysis, 149, 106-113. https://doi.org/10.1016/j.jpba.2017.10.039
    • Nielen, J. T. H., Boonen, A., Dagnelie, P. C., van den Bemt, B. J. F., Emans, P. J., Lafeber, F. P. J. G., van Spil, W. E., de Vries, F., & Welsing, P. M. J. (2018). Disease burden of knee osteoarthritis patients with a joint replacement compared to matched controls: a population-based analysis of a Dutch medical claims database. Osteoarthritis and Cartilage, 26(2), 202-210. https://doi.org/10.1016/j.joca.2017.11.012
  • 2017
    • Williams, R., de Vries, F., Kothny, W., Serban, C., Lopez-Leon, S., Chu, C., & Schlienger, R. (2017). Cardiovascular safety of vildagliptin in patients with type 2 diabetes: A European multi-database, non-interventional post-authorization safety study. Diabetes Obesity & Metabolism, 19(10), 1473-1478. https://doi.org/10.1111/dom.12951
    • De Jong, H. J. I., van Staa, T. P., Lalmohamed, A., de Vries, F., Vandebriel, R. J., Van Loveren, H., Klungel, O. H., & Tervaert, J. W. C. (2017). Pattern of risks of systemic lupus erythematosus among statin users: a population-based cohort study. Annals of the Rheumatic Diseases, 76(10), 1723-1730. https://doi.org/10.1136/annrheumdis-2016-210936
    • Oshagbemi, O. A., Driessen, J. H. M., Pieffers, A., Wouters, E. F. M., Geusens, P., Vestergaard, P., van den Bergh, J., Franssen, F. M. E., & de Vries, F. (2017). Use of systemic glucocorticoids and the risk of major osteoporotic fractures in patients with sarcoidosis. Osteoporosis International, 28(10), 2859-2866. https://doi.org/10.1007/s00198-017-4115-z
    • But, A., De Bruin, M. L., Bazelier, M. T., Hjellvik, V., Andersen, M., Auvinen, A., Starup-Linde, J., Schmidt, M. K., Furu, K., de Vries, F., Karlstad, O., Ekstrom, N., & Haukka, J. (2017). Cancer risk among insulin users: comparing analogues with human insulin in the CARING five-country cohort study. Diabetologia, 60(9), 1691-1703. https://doi.org/10.1007/s00125-017-4312-5
    • Wang, S. V., Schneeweiss, S., Berger, M. L., Brown, J., de Vries, F., Douglas, I., Gagne, J. J., Gini, R., Klungel, O., Mullins, C. D., Nguyen, M. D., Rassen, J. A., Smeeth, L., Sturkenboom, M., & joint ISPE-ISPOR Special Task (2017). Reporting to Improve Reproducibility and Facilitate Validity Assessment for Healthcare Database Studies V1.0. Value in Health, 20(8), 1009-1022. https://doi.org/10.1016/j.jval.2017.08.3018
    • Wang, S. V., Schneeweiss, S., Berger, M. L., Brown, J., de Vries, F., Douglas, I., Gagne, J. J., Gini, R., Klungel, O., Mullins, C. D., Nguyen, M. D., Rassen, J. A., Smeeth, L., Sturkenboom, M., & joint ISPE-ISPOR Special Task (2017). Reporting to Improve Reproducibility and Facilitate Validity Assessment for Healthcare Database Studies V1.0. Pharmacoepidemiology and Drug Safety, 26(9), 1018-1032. https://doi.org/10.1002/pds.4295
    • Gieling, E. M., van den Ham, H. A., van Onzenoort, H., Bos, J., Kramers, C., de Boer, A., de Vries, F., & Burden, A. M. (2017). Risk of major bleeding and stroke associated with the use of vitamin K antagonists, nonvitamin K antagonist oral anticoagulants and aspirin in patients with atrial fibrillation: a cohort study. British Journal of Clinical Pharmacology, 83(8), 1844-1859. https://doi.org/10.1111/bcp.13265
    • Stolk, L. M., de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., ten Cate-Hoek, A., & Burden, A. M. (2017). Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants. British Journal of Clinical Pharmacology, 83(8), 1835-1843. https://doi.org/10.1111/bcp.13264
    • de Waard, E. A. C., Driessen, J. H. M., de Jong, J. J. A., van Geel, T. A. C. M., Henry, R. M. A., van Onzenoort, H. A. W., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Koster, A., Savelberg, H. H. C. M., Neef, C., Geusens, P. P. M. M., de Vries, F., & van den Bergh, J. P. W. (2017). The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes - The Maastricht study. Bone, 101, 156-161. https://doi.org/10.1016/j.bone.2017.05.004
    • de Jong, R. G. P. J., Burden, A. M., de Kort, S., van Herk-Sukel, M. P. P., Vissers, P. A. J., Janssen, P. K. C., Haak, H. R., Masclee, A. A. M., de Vries, F., & Janssen-Heijnen, M. L. G. (2017). Impact of detection bias on the risk of gastrointestinal cancer and its subsites in type 2 diabetes mellitus. European Journal of Cancer, 79, 61-71. https://doi.org/10.1016/j.ejca.2017.03.039
    • Oshagbemi, O. A., Burden, A. M., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Driessen, J. H. M., Maitland-van der Zee, A. H., de Vries, F., & Franssen, F. M. E. (2017). Stability of Blood Eosinophils in Patients with Chronic Obstructive Pulmonary Disease and in Control Subjects, and the Impact of Sex, Age, Smoking, and Baseline Counts. American Journal of Respiratory and Critical Care Medicine, 195(10), 1402-1404. https://doi.org/10.1164/rccm.201701-0009LE
    • Spaetgens, B., de Vries, F., Driessen, J. H. M., Leufkens, H. G., Souverein, P. C., Boonen, A., van der Meer, J. W. M., & Joosten, L. A. B. (2017). Risk of infections in patients with gout: a population-based cohort study. Scientific Reports, 7, [1429]. https://doi.org/10.1038/s41598-017-01588-5
    • de Jong, R. G., Burden, A. M., de Kort, S., van Herk-Sukel, M. P., Vissers, P. A., Janssen, P. K., Haak, H. R., Masclee, A. A., de Vries, F., & Janssen-Heijnen, M. L. (2017). No Decreased Risk of Gastrointestinal Cancers in Users of Metformin in The Netherlands; A Time-Varying Analysis of Metformin Exposure. Cancer prevention research, 10(5), 290-297. https://doi.org/10.1158/1940-6207.CAPR-16-0277
    • Hoenderboom, B. M., van Oeffelen, A. A. M., van Benthem, B. H. B., van Bergen, J. E. A. M., Dukers-Muijrers, N. H. T. M., Gotz, H. M., Hoebe, C. J. P. A., Hogewoning, A. A., van der Klis, F. R. M., van Baarle, D., Land, J. A., van der Sande, M. A. B., van Veen, M. G., de Vries, F., Morre, S. A., & van den Broek, I. V. F. (2017). The Netherlands Chlamydia cohort study (NECCST) protocol to assess the risk of late complications following Chlamydia trachomatis infection in women. BMC Infectious Diseases, 17, [264]. https://doi.org/10.1186/s12879-017-2376-y
    • Driessen, J. H. M., de Vries, F., van Onzenoort, H., Harvey, N. C., Neef, C., van den Bergh, J. P. W., Vestergaard, P., & Henry, R. M. A. (2017). The use of incretins and fractures - a meta-analysis on population-based real life data. British Journal of Clinical Pharmacology, 83(4), 923-926. https://doi.org/10.1111/bcp.13167
    • Driessen, J. H. M., van den Bergh, J. P. W., van Onzenoort, H. A. W., Henry, R. M. A., Leufkens, H. G. M., & de Vries, F. (2017). Long-term use of dipeptidyl peptidase-4 inhibitors and risk of fracture: A retrospective population-based cohort study. Diabetes Obesity & Metabolism, 19(3), 421-428. https://doi.org/10.1111/dom.12843
    • Knapen, L. M., de Jong, R. G. P. J., Driessen, J. H. M., Keulemans, Y. C., van Erp, N. P., De Bruin, M. L., Leufkens, H. G. M., Croes, S., & de Vries, F. (2017). Use of incretin agents and risk of acute and chronic pancreatitis: A population-based cohort study. Diabetes Obesity & Metabolism, 19(3), 401-411. https://doi.org/10.1111/dom.12833
    • Klop, C., van Staa, T. P., Cooper, C., Harvey, N. C., & de Vries, F. (2017). The epidemiology of mortality after fracture in England: variation by age, sex, time, geographic location, and ethnicity. Osteoporosis International, 28(1), 161-168. https://doi.org/10.1007/s00198-016-3787-0
    • van der Velde, R. Y., Wyers, C. E., Teesselink, E., Geusens, P. P. M. M., van den Bergh, J. P. W., de Vries, F., Cooper, C., Harvey, N. C., & van Staa, T. P. (2017). Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity. Bone, 94, 50-55. https://doi.org/10.1016/j.bone.2016.10.013
    • van de Plas, A., Slikkerveer, M., Hoen, S., Schrijnemakers, R., Driessen, J., de Vries, F., & van den Bemt, P. (2017). Experiences with Lean Six Sigma as improvement strategy to reduce parenteral medication administration errors and associated potential risk of harm. BMJ Open Quality, 6(1), [u215011.w5936]. https://doi.org/10.1136/bmjquality.u215011.w5936
    • Braeken, D. C. W., Rohde, G. G. U., Franssen, F. M. E., Driessen, J. H. M., van Staa, T. P., Souverein, P. C., Wouters, E. F. M., & de Vries, F. (2017). Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom. International journal of chronic obstructive pulmonary disease, 12, 2425-2432. https://doi.org/10.2147/COPD.S138435
    • de Vries, F., Rohde, G. G. U., Braeken, D. C. W., van Staa, T. P., Souverein, P. C., Wouters, E. F. M., & Franssen, F. M. E. (2017). Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia: Author's Reply. International journal of chronic obstructive pulmonary disease, 12, 3113-3113. https://doi.org/10.2147/COPD.S151142
    • Shudofsky, K. N., Burden, A., Vestergaard, P., & de Vries, F. (2017). Use of high-dose intermittent glucocorticoids and the risk of fracture in patients with COPD: Fractuurrisico bij patienten met COPD die intermitterend hooggedoseerde glucocorticoiden gebruiken. Pharmaceutisch Weekblad, 152, 7. [2017;2:a1639]. https://www.knmp.nl/professie/wetenschap/nederlands-platform-voor-farmaceutisch-onderzoek/fractuurrisico-bij-patienten-met-copd-die-intermitterend-hooggedoseerde-glucocorticoiden-gebruiken
  • 2016
    • de Jong, R. G. P. J., Gallagher, A. M., Herrett, E., Masclee, A. A. M., Janssen-Heijnen, M. L. G., & de Vries, F. (2016). Comparability of the age and sex distribution of the UK Clinical Practice Research Datalink and the total Dutch population. Pharmacoepidemiology and Drug Safety, 25(12), 1460-1464. https://doi.org/10.1002/pds.4074
    • Harvey, N. C., Curtis, E. M., van der Velde, R., Moon, R. J., van den Bergh, J. P. W., Geusens, P., de Vries, F., van Staa, T. P., & Cooper, C. (2016). On epidemiology of fractures and variation with age and ethnicity. Bone, 93, 230-231. https://doi.org/10.1016/j.bone.2016.07.011
    • Klop, C., de Vries, F., Bijlsma, J. W. J., Leufkens, H. G. M., & Welsing, P. M. J. (2016). Predicting the 10-year risk of hip and major osteoporotic fracture in rheumatoid arthritis and in the general population: an independent validation and update of UK FRAX without bone mineral density. Annals of the Rheumatic Diseases, 75(12), 2095-2100. https://doi.org/10.1136/annrheumdis-2015-208958
    • van der Velde, R. Y., Wyers, C. E., Curtis, E. M., Geusens, P. P. M. M., van den Bergh, J. P. W., de Vries, F., Cooper, C., van Staa, T. P., & Harvey, N. C. (2016). Secular trends in fracture incidence in the UK between 1990 and 2012. Osteoporosis International, 27(11), 3197-3206. https://doi.org/10.1007/s00198-016-3650-3
    • Nielen, J. T. H., Dagnelie, P. C., Emans, P., Veldhorst-Janssen, N., Lalmohamed, A., van Staa, T-P., Boonen, A., van den Bemt, B., & de Vries, F. (2016). Safety and efficacy of new oral anticoagulants and low-molecular-weight heparins compared with aspirin in patients undergoing total knee and hip replacements. Pharmacoepidemiology and Drug Safety, 25(11), 1245-1252. https://doi.org/10.1002/pds.4089
    • van Dalem, J., Brouwers, M. C. G. J., Stehouwer, C. D. A., Krings, A., Leufkens, H. G. M., Driessen, J. H. M., de Vries, F., & Burden, A. M. (2016). Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study. BMJ (e), 354, [i3625]. https://doi.org/10.1136/bmj.i3625
    • Lalmohamed, A., van Staa, T. P., Vestergaard, P., Leufkens, H. G. M., de Boer, A., Emans, P., Cooper, C., & de Vries, F. (2016). Statins and Risk of Lower Limb Revision Surgery: The Influence of Differences in Study Design Using Electronic Health Records From the United Kingdom and Denmark. American Journal of Epidemiology, 184(1), 58-66. https://doi.org/10.1093/aje/kwv311
    • de Jong, R. G. P. J., Nielen, Y., Masclee, A. A. M., Janssen-Heijnen, M. L. G., & de Vries, F. (2016). Comments on "Use of metformin and risk of kidney cancer in patients with type 2 diabetes", Chin-Hsiao Tseng, Eur J Cancer, 2016, No. 52, pp. 19-25. European Journal of Cancer, 61, 157-158. https://doi.org/10.1016/j.ejca.2016.03.065
    • Curtis, E. M., van der Velde, R., Moon, R. J., van den Bergh, J. P. W., Geusens, P., de Vries, F., van Staa, T. P., Cooper, C., & Harvey, N. C. (2016). Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status. Bone, 87, 19-26. https://doi.org/10.1016/j.bone.2016.03.006
    • Driessen, J. H. M., Hansen, L., Eriksen, S. A., van Onzenoort, H. A. W., Henry, R. M. A., van den Bergh, J., Abrahamsen, B., Vestergaard, P., & de Vries, F. (2016). The epidemiology of fractures in Denmark in 2011. Osteoporosis International, 27(6), 2017-2025. https://doi.org/10.1007/s00198-016-3488-8
    • Nielen, Y., Oshagbemi Ayodele, F., de Vries, F., & Burden, A. M. (2016). Effects of colchicine on risk of cardiovascular events and mortality among patients with gout: the effect of index date selection?Annals of the Rheumatic Diseases, 75(5), E26-E26. https://doi.org/10.1136/annrheumdis-2016-209224
    • Verhaegh, B. P. M., de Vries, F., Masclee, A. A. M., Keshavarzian, A., de Boer, A., Souverein, P. C., Pierik, M. J., & Jonkers, D. M. A. E. (2016). High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors. Alimentary Pharmacology & Therapeutics, 43(9), 1004-1013. https://doi.org/10.1111/apt.13583
    • Nielen, J. T. H., Emans, P. J., Dagnelie, P. C., Boonen, A., Lalmohamed, A., de Boer, A., van den Bemt, B. J. F., & de Vries, F. (2016). Severity of Diabetes Mellitus and Total Hip or Knee Replacement A Population-Based Case-Control Study. Medicine, 95(20), [e3739]. https://doi.org/10.1097/MD.0000000000003739
    • Moon, R. J., Harvey, N. C., Curtis, E. M., de Vries, F., van Staa, T., & Cooper, C. (2016). Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom. Bone, 85, 9-14. https://doi.org/10.1016/j.bone.2016.01.015
    • Bours, S., de Vries, F., van den Bergh, J. P., Lalmohamed, A., van Staa, T. P., Leufkens, H. G., Geusens, P. P., Drent, M., & Harvey, N. C. (2016). Risk of vertebral and non-vertebral fractures in patients with sarcoidosis: a population-based cohort. Osteoporosis International, 27(4), 1603-1610. https://doi.org/10.1007/s00198-015-3426-1
    • Lotters, F. J. B., van den Bergh, J. P., de Vries, F., & Rutten-van Molken, M. P. M. H. (2016). Current and Future Incidence and Costs of Osteoporosis-Related Fractures in The Netherlands: Combining Claims Data with BMD Measurements. Calcified Tissue International, 98(3), 235-243. https://doi.org/10.1007/s00223-015-0089-z
    • Huerta, C., Abbing-Karahagopian, V., Requena, G., Oliva, B., Alvarez, Y., Gardarsdottir, H., Miret, M., Schneider, C., Gil, M., Souverein, P. C., De Bruin, M. L., Slattery, J., De Groot, M. C. H., Hesse, U., Rottenkolber, M., Schmiedl, S., Montero, D., Bate, A., Ruigomez, A., ... Jose de Abajo, F. (2016). Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project. Pharmacoepidemiology and Drug Safety, 25(Suppl. 1), 56-65. https://doi.org/10.1002/pds.3825
    • Schuerch, M., Gasse, C., Robinson, N. J., Alvarez, Y., Walls, R., Mors, O., Christensen, J., Hesse, U., de Groot, M., Schlienger, R., Reynolds, R., Klungel, O., & de Vries, F. (2016). Impact of varying outcomes and definitions of suicidality on the associations of antiepileptic drugs and suicidality: comparisons from UK Clinical Practice Research Datalink (CPRD) and Danish national registries (DNR). Pharmacoepidemiology and Drug Safety, 25(Suppl 1), 142-155. https://doi.org/10.1002/pds.3928
    • Brauer, R., Ruigomez, A., Downey, G., Bate, A., Garcia Rodriguez, L. A., Huerta, C., Gil, M., de Abajo, F., Requena, G., Alvarez, Y., Slattery, J., de Groot, M., Souverein, P., Hesse, U., Rottenkolber, M., Schmiedl, S., de Vries, F., Tepie, M. F., Schlienger, R., ... Klungel, O. (2016). Prevalence of antibiotic use: a comparison across various European health care data sources. Pharmacoepidemiology and Drug Safety, 25, 11-20. https://doi.org/10.1002/pds.3831
    • PROTECT (2016). The IMI PROTECT project: purpose, organizational structure, and procedures. Pharmacoepidemiology and Drug Safety, 25(Suppl. 1), 5-10. https://doi.org/10.1002/pds.3933
    • Knapen, L., van Dalem, J., Keulemans, J., van Erp, N. P., Bazelier, M. T., de Bruin, M. L., Leufkens, H. G., Croes, S., Neef, C., de Vries, F., & Driessen, J. H. M. (2016). Use of incretin agents and risk of pancreatic cancer: a population-based cohort study. Diabetes Obesity & Metabolism, 18(3), 258-265. https://doi.org/10.1111/dom.12605
    • Gallagher, A. M., Williams, T., Leufkens, H. G. M., & de Vries, F. (2016). The Impact of the Choice of Data Source in Record Linkage Studies Estimating Mortality in Venous Thromboembolism. PLOS ONE, 11(2), [e0148349]. https://doi.org/10.1371/journal.pone.0148349
    • Nielen, J. T., de Vries, F., Dagnelie, P. C., van den Bemt, B. J., Emans, P. J., Lalmohamed, A., de Boer, A., & Boonen, A. E. (2016). Use of thiazolidinediones and the risk of elective hip or knee replacement: a population based case-control study. British Journal of Clinical Pharmacology, 81(2), 370-378. https://doi.org/10.1111/bcp.12786
    • Essers, I., Stolwijk, C., Boonen, A., de Bruin, M. L., Bazelier, M. T., de Vries, F., & van Tubergen, A. (2016). Ankylosing spondylitis and risk of ischaemic heart disease: a population-based cohort study. Annals of the Rheumatic Diseases, 75(1), 203-209. https://doi.org/10.1136/annrheumdis-2014-206147