Frank de Vries

Professor

Prof. Frank de Vries started a PhD in pharmaco-epidemiology at Utrecht University in 2002 on side effects of use of inhaled corticosteroids. Since then, he has worked for the Medicine and Healthcare products Regulatory Agency. He has obtained several research grants and prizes, including the Swierenga award for respiratory disease, an NWO Veni grant and the Kohn prize from the UK National Osteoporosis Foundation. His work has been published in various journals including JAMA, the NEJM and BMJ. He is on secondment at the Utrecht Institute for Pharmaceutical Sciences, the Netherlands. He is a visiting scientist at the MRC Lifecourse Epidemiology Unit in Southampton, UK. Frank works as a hospital pharmacist in the Maastricht UMC+, apotheek.mumc.nl/en.

Frank’s current research activities mainly focus on effects of drugs in patients with diabetes mellitus and movement disorders. As the department’s head of research, he oversees other research lines on personalised medicine in the areas of lung oncology and psychiatric disorders.

Department of Clinical Pharmacy & Toxicology
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
T: +31(0)43 387 18 81

  • 2016
  • 2015
    • Klop, C., Welsing, P. M. J., Leufkens, H. G. M., Elders, P. J. M., Overbeek, J. A., van den Bergh, J. P., Bijlsma, J. W. J., & de Vries, F. (2015). The Epidemiology of Hip and Major Osteoporotic Fractures in a Dutch Population of Community-Dwelling Elderly: Implications for the Dutch FRAX(R) Algorithm. PLOS ONE, 10(12), [e0143800]. https://doi.org/10.1371/journal.pone.0143800
    • Driessen, J. H. M., van Onzenoort, H. A. W., Starup-Linde, J., Henry, R., Burden, A. M., Neef, C., van den Bergh, J. P., Vestergaard, P., & de Vries, F. (2015). Use of Glucagon-Like-Peptide 1 Receptor Agonists and Risk of Fracture as Compared to Use of Other Anti-hyperglycemic Drugs. Calcified Tissue International, 97(5), 506-515. https://doi.org/10.1007/s00223-015-0037-y
    • Bazelier, M. T., Eriksson, I., de Vries, F., Schmidt, M. K., Raitanen, J., Haukka, J., Starup-Linde, J., de Bruin, M. L., & Andersen, M. (2015). Data management and data analysis techniques in pharmacoepidemiological studies using a pre-planned multi-database approach: a systematic literature review. Pharmacoepidemiology and Drug Safety, 24(9), 897-905. https://doi.org/10.1002/pds.3828
    • Driessen, J. H. M., Henry, R. M. A., van Onzenoort, H. A. W., Lalmohamed, A., Burden, A. M., Prieto-Alhambra, D., Neef, C., Leufkens, H. G. M., & de Vries, F. (2015). Bone Fracture Risk is Not Associated with the Use of Glucagon-Like Peptide-1 Receptor Agonists: A Population-Based Cohort Analysis. Calcified Tissue International, 97(2), 104-112. https://doi.org/10.1007/s00223-015-9993-5
    • Klop, C., Gibson-Smith, D., Elders, P. J. M., Welsing, P. M. J., Leufkens, H. G. M., Harvey, N. C., Bijlsma, J. W. J., van Staa, T. P., & de Vries, F. (2015). Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000-2010. Osteoporosis International, 26(7), 1919-1928. https://doi.org/10.1007/s00198-015-3098-x
    • Stolwijk, C., Essers, I., van Tubergen, A., Boonen, A., Bazelier, M. T., de Bruin, M. L., & de Vries, F. (2015). The epidemiology of extra-articular manifestations in ankylosing spondylitis: a population-based matched cohort study. Annals of the Rheumatic Diseases, 74(7), 1373-1378. https://doi.org/10.1136/annrheumdis-2014-205253
    • Klop, C., Welsing, P. M. J., Elders, P. J. M., Overbeek, J. A., Souverein, P. C., Burden, A. M., van Onzenoort, H. A. W., Leufkens, H. G. M., Bijlsma, J. W. J., & de Vries, F. (2015). Long-term persistence with anti-osteoporosis drugs after fracture. Osteoporosis International, 26(6), 1831-1840. https://doi.org/10.1007/s00198-015-3084-3
    • Peeters, P. J. H. L., Bazelier, M. T., Leufkens, H. G. M., de Vries, F., & de Bruin, M. L. (2015). The Risk of Colorectal Cancer in Patients With Type 2 Diabetes: Associations With Treatment Stage and Obesity. Diabetes Care, 38(3), 495-502. https://doi.org/10.2337/dc14-1175
    • Prieto-Alhambra, D., Munoz-Ortego, J., de Vries, F., Vosse, D., Arden, N. K., Bowness, P., Cooper, C., Diez-Perez, A., & Vestergaard, P. (2015). Ankylosing spondylitis confers substantially increased risk of clinical spine fractures: a nationwide case-control study. Osteoporosis International, 26(1), 85-91. https://doi.org/10.1007/s00198-014-2939-3
    • Nielen, J. T. H., van den Bemt, B. J. F., Boonen, A., Dagnelie, P. C., Emans, P. J., Veldhorst, N., Lalmohamed, A., van Staa, T. P., & de Vries, F. (2015). Identification of antithrombotic drugs related to total joint replacement using anonymised free-text notes: a search strategy in the Clinical Practice Research Datalink. BMJ Open, 5(11), [e009017]. https://doi.org/10.1136/bmjopen-2015-009017
    • Wijnands, J. M. A., van Durme, C. M. P. G., Driessen, J. H. M., Boonen, A., Klop, C., Leufkens, B., Cooper, C., Stehouwer, C. D. A., & de Vries, F. (2015). Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This is Not Due to Diabetes: A Population-Based Cohort Study. Medicine, 94(32), [e1358]. https://doi.org/10.1097/MD.0000000000001358
    • Goossens, M. E., Buntinx, F., Zeegers, M. P., Driessen, J. H. M., de Bruin, M. L., & de Vries, F. (2015). Influence of metformin intake on the risk of bladder cancer in type 2 diabetes patients. British Journal of Clinical Pharmacology, 80(6), 1464-1472. https://doi.org/10.1111/bcp.12740
    • Yska, J. P., van Roon, E. N., de Boer, A., Leufkens, H. G. M., Wilffert, B., de Heide, L. J. M., de Vries, F., & Lalmohamed, A. (2015). Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery: A Population-Based Cohort Study in the United Kingdom. JAMA Surgery, 150(12), 1126-1133. https://doi.org/10.1001/jamasurg.2015.2398
    • Goossens, M. E., Zeegers, M. P., Bazelier, M. T., de Bruin, M. L., Buntinx, F., & de Vries, F. (2015). Risk of bladder cancer in patients with diabetes: a retrospective cohort study. BMJ Open, 5(6), [e007470]. https://doi.org/10.1136/bmjopen-2014-007470
    • van Durme, C. M., Spaetgens, B., Boonen, A., & de Vries, F. (2015). Risk of vascular disease with gout: overadjustment of the statistical analyses?Annals of the Rheumatic Diseases, 74(1), [e9]. https://doi.org/10.1136/annrheumdis-2014-206697
    • Been, J. V., Szatkowski, L., van Staa, T. P., Leufkens, H. G., van Schayck, O. C., Sheikh, A., de Vries, F., & Souverein, P. (2015). Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations. Scientific Reports, 5, [15246]. https://doi.org/10.1038/srep15246
    • Driessen, J. H. M., van Onzenoort, H. A. W., Starup-Linde, J., Henry, R., Neef, C., van den Bergh, J., Vestergaard, P., de Vries, F., & Burden, A. M. (2015). Use of dipeptidyl peptidase 4 inhibitors and fracture risk compared to use of other anti-hyperglycemic drugs. Pharmacoepidemiology and Drug Safety, 24(10), 1017-1025. https://doi.org/10.1002/pds.3837
    • van der Zanden, R. W., de Vries, F., Lalmohamed, A., Driessen, J. H. M., de Boer, A., Rohde, G., Neef, C., & den Heijer, C. (2015). Use of Dipeptidyl-Peptidase-4 Inhibitors and the Risk of Pneumonia: A Population-Based Cohort Study. PLOS ONE, 10(10), [e0139367]. https://doi.org/10.1371/journal.pone.0139367
  • 2014
    • Gibson-Smith, D., Klop, C., Elders, P. J. M., Welsing, P. M. J., van Schoor, N., Leufkens, H. G. M., Harvey, N. C., van Staa, T. P., & de Vries, F. (2014). The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000-2010. Osteoporosis International, 25(11), 2555-2563. https://doi.org/10.1007/s00198-014-2799-x
    • Klop, C., Welsing, P. M. J., Cooper, C., Harvey, N. C., Elders, P. J. M., Bijlsma, J. W. J., Leufkens, H. G. M., & de Vries, F. (2014). Mortality in British hip fracture patients, 2000-2010: A population-based retrospective cohort study. Bone, 66, 171-177. https://doi.org/10.1016/j.bone.2014.06.011
    • Eppenga, W. L., Lalmohamed, A., Geerts, A. F., Derijks, H. J., Wensing, M., Egberts, A., de Smet, P. A. G. M., & de Vries, F. (2014). Risk of Lactic Acidosis or Elevated Lactate Concentrations in Metformin Users With Renal Impairment: A Population-Based Cohort Study. Diabetes Care, 37(8), 2218-2224. https://doi.org/10.2337/dc13-3023
    • Abbing-Karahagopian, V., Huerta, C., Souverein, P. C., de Abajo, F., Leufkens, H. G., Slattery, J., Alvarez, Y., Miret, M., Gil, M., Oliva, B., Hesse, U., Requena, G., de Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlienger, R. G., de Groot, M. C. H., Klungel, O. H., ... de Bruin, M. L. (2014). Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications. European Journal of Clinical Pharmacology, 70(7), 849-857. https://doi.org/10.1007/s00228-014-1676-z
    • Wallace, G., Judge, A., Prieto-Alhambra, D., de Vries, F., Arden, N. K., & Cooper, C. (2014). The effect of body mass index on the risk of post-operative complications during the 6 months following total hip replacement or total knee replacement surgery. Osteoarthritis and Cartilage, 22(7), 918-927. https://doi.org/10.1016/j.joca.2014.04.013
    • Requena, G., Abbing-Karahagopian, V., Huerta, C., de Bruin, M. L., Alvarez, Y., Miret, M., Hesse, U., Gardarsdottir, H., Souverein, P. C., Slattery, J., Schneider, C., Rottenkolber, M., Schmiedl, S., Gil, M., de Groot, M. C. H., Bate, A., Ruigómez, A., García Rodríguez, L. A., Johansson, S., ... de Abajo, F. J. (2014). Incidence Rates and Trends of Hip/Femur Fractures in Five European Countries: Comparison Using E-Healthcare Records Databases. Calcified Tissue International, 94(6), 580-589. https://doi.org/10.1007/s00223-014-9850-y
    • Prieto-Alhambra, D., Güerri-Fernández, R., de Vries, F., Lalmohamed, A., Bazelier, M., Starup-Linde, J., Diez-Perez, A., Cooper, C., & Vestergaard, P. (2014). HIV Infection and Its Association With an Excess Risk of Clinical Fractures: A Nationwide Case-Control Study. Jaids-journal of Acquired Immune Deficiency Syndromes, 66(1), 90-95. https://doi.org/10.1097/QAI.0000000000000112
    • de Groot, M. C. H., Schuerch, M., de Vries, F., Hesse, U., Oliva, B., Gil, M., Huerta, C., Requena, G., de Abajo, F., Afonso, A. S., Souverein, P. C., Alvarez, Y., Slattery, J., Rottenkolber, M., Schmiedl, S., van Dijk, L., Schlienger, R. G., Reynolds, R., & Klungel, O. H. (2014). Antiepileptic drug use in seven electronic health record databases in Europe: A methodologic comparison. Epilepsia, 55(5), 666-673. https://doi.org/10.1111/epi.12557
    • Prieto-Alhambra, D., Petri, H., Goldenberg, J. S. B., Khong, T. P., Klungel, O. H., Robinson, N. J., & de Vries, F. (2014). Excess risk of hip fractures attributable to the use of antidepressants in five European countries and the USA. Osteoporosis International, 25(3), 847-855. https://doi.org/10.1007/s00198-013-2612-2
    • Lalmohamed, A., Vestergaard, P., de Boer, A., Leufkens, H. G. M., van Staa, T. P., & de Vries, F. (2014). Changes in Mortality Patterns Following Total Hip or Knee Arthroplasty Over the Past Two Decades: A Nationwide Cohort Study. Arthritis & Rheumatology, 66(2), 311-318. https://doi.org/10.1002/art.38232
    • Croes, S., & de Vries, F. (2014). Drug-drug interactions with tyrosine-kinase inhibitors. Lancet oncology, 15(10), e315-e326. https://doi.org/10.1016/S1470-2045(14)70187-1
    • de Vries, F. (2014). Effective writing and dealing with reviewers. Journal of Clinical Epidemiology, 67(7), 830. https://doi.org/10.1016/j.jclinepi.2014.02.013
    • Bultink, I. E. M., Harvey, N. C., Lalmohamed, A., Cooper, C., Lems, W. F., van Staa, T. P., & de Vries, F. (2014). Elevated risk of clinical fractures and associated risk factors in patients with systemic lupus erythematosus versus matched controls: a population-based study in the United Kingdom. Osteoporosis International, 25(4), 1275-1283. https://doi.org/10.1007/s00198-013-2587-z
    • Klop, C., de Vries, F., Vinks, T., Kooij, M. J., van Staa, T. P., Bijlsma, J. W. J., Egberts, A. C. G., & Bouvy, M. L. (2014). Increase in prophylaxis of glucocorticoid-induced osteoporosis by pharmacist feedback: a randomised controlled trial. Osteoporosis International, 25(1), 385-392. https://doi.org/10.1007/s00198-013-2562-8
    • Prieto-Alhambra, D., Lalmohamed, A., Abrahamsen, B., Arden, N. K., de Boer, A., Vestergaard, P., & de Vries, F. (2014). Oral Bisphosphonate Use and Total Knee/Hip Implant Survival: Validation of Results in an External Population-Based Cohort. Arthritis & Rheumatology, 66(11), 3233-3240. https://doi.org/10.1002/art.38789
    • Pouwels, S., de Boer, A., Leufkens, H. G., Weber, W. E. J., Cooper, C., & de Vries, F. (2014). RISK OF FRACTURE IN PATIENTS WITH CHARCOT-MARIE-TOOTH DISEASE. Muscle & Nerve, 50(6), 919-924. https://doi.org/10.1002/mus.24240
    • Pouwels, S., de Boer, A., Leufkens, H. G. M., Weber, W. E. J., Cooper, C., van Staa, T. P., & de Vries, F. (2014). Risk of fracture in patients with Guillain-Barré syndrome. Osteoporosis International, 25(7), 1845-1851. https://doi.org/10.1007/s00198-014-2705-6
    • Pouwels, S., de Boer, A., Leufkens, H. G. M., Weber, W. E. J., Cooper, C., van Onzenoort, H. A. W., & de Vries, F. (2014). Risk of fracture in patients with muscular dystrophies. Osteoporosis International, 25(2), 509-518. https://doi.org/10.1007/s00198-013-2442-2
    • Peeters, P. J. H. L., Bazelier, M. T., Uitdehaag, B. M., Leufkens, H. G. M., de Bruin, M. L., & de Vries, F. (2014). The risk of venous thromboembolism in patients with multiple sclerosis: the Clinical Practice Research Datalink. Journal of Thrombosis and Haemostasis, 12(4), 444-451. https://doi.org/10.1111/jth.12523
    • Driessen, J. H. M., van Onzenoort, H. A. W., Henry, R. M. A., Lalmohamed, A., van den Bergh, J. P., Neef, C. K., Leufkens, H. G. M., & de Vries, F. (2014). Use of dipeptidyl peptidase-4 inhibitors for type 2 diabetes mellitus and risk of fracture. Bone, 68, 124-130. https://doi.org/10.1016/j.bone.2014.07.030
  • 2013
    • Pouwels, S., Bazelier, M. T., de Boer, A., Weber, W. E., Neef, C. K., Cooper, C., & de Vries, F. (2013). Five-year fracture risk estimation in patients with Parkinson's disease. Bone, 56(2), 266-270. https://doi.org/10.1016/j.bone.2013.06.018
    • de Vries, F., Zeegers, M. P., Knapen, L. M., & Goossens, M. E. (2013). Thiazolodinediones and Cancer: Duplicate Publication Bias?Oncologist, 18(10), [1147]. https://doi.org/10.1634/theoncologist.2013-0087
    • Lalmohamed, A., Vestergaard, P., Javaid, M. K., de Boer, A., Leufkens, H. G. M., van Staa, T. P., & de Vries, F. (2013). Risk of Gastrointestinal Bleeding in Patients Undergoing Total Hip or Knee Replacement Compared With Matched Controls: A Nationwide Cohort Study. American Journal of Gastroenterology, 108(8), 1277-1285. https://doi.org/10.1038/ajg.2013.108
    • Lalmohamed, A., MacGregor, A. J., de Vries, F., Leufkens, H. G. M., & van Staa, T. P. (2013). Patterns of Risk of Cancer in Patients with Metal-on-Metal Hip Replacements versus Other Bearing Surface Types: A Record Linkage Study between a Prospective Joint Registry and General Practice Electronic Health Records in England. PLOS ONE, 8(7), [e65891]. https://doi.org/10.1371/journal.pone.0065891
    • Lalmohamed, A., Vestergaard, P., Jansen, P. A. F., Grove, E. L., de Boer, A., Leufkens, H. G. M., van Staa, T. P., & de Vries, F. (2013). Prolonged outpatient vitamin K antagonist use and risk of venous thromboembolism in patients undergoing total hip or knee replacement. Journal of Thrombosis and Haemostasis, 11(4), 642-650. https://doi.org/10.1111/jth.12158
    • PROTECT WP2, collaborator: de Vries F., & de Vries, F. (2013). Adjustment for continuous confounders: an example of how to prevent residual confounding. CMAJ, 185(5), 401-406. https://doi.org/10.1503/cmaj.120592
    • Klop, C., Driessen, J. H. M., & de Vries, F. (2013). Statin use and reduced cancer-related mortality...N Engl J Med. 2012 Nov 8;367(19): 1792-802. New England Journal of Medicine, 368(6), 574. https://doi.org/10.1056/NEJMc1214827
    • Pouwels, S., de Boer, A., Javaid, M. K., Hilton-Jones, D., Verschuuren, J., Cooper, C., Leufkens, H. G., & de Vries, F. (2013). Fracture rate in patients with myasthenia gravis: the general practice research database. Osteoporosis International, 24(2), 467-476. https://doi.org/10.1007/s00198-012-1970-5
    • de Vries, F., Zeegers, M. P. A., & Goossens, M. E. (2013). Pioglitazone and bladder cancer: two studies, same database, two answers. British Journal of Clinical Pharmacology, 76(3), 484-485. https://doi.org/10.1111/bcp.12145