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Professorship Julie Staals

Professorship Julie Staals

22 April 2024

Dr Julie Staals (Dept. of Neurology) has been appointed as professor 'Neurovascular disease' as of 1 April 2024.

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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Carim Maastricht
Carim Maastricht

Patricia Stassen

Associate professor

I completed my medical school in Maastricht in 1995. Then I was trained in internal medicine and specialized in nephrology in UMCG, where I also completed my PhD thesis on Wegener’s disease. Since 2008, I have worked at MUMC+, where I also started/designed a new internal medicine specialization: acute medicine. Since 2010, I have worked as chief of acute internal medicine in addition to practicing as an all-round clinician and engaging in student, nurse and resident education within the faculty of medicine and health. I was appointed as an associate professor (mixed profile) in 2022.

My area of interest is acute internal medicine. I concentrate on all kinds of diseases ranging from sepsis to cardiovascular diseases, and include not only the emergency department (ED) but also the trajectory before (general practitioner, EMS, acute internal medicine, emergency medicine) and after the ED (MCU/ICU).

The aim of my research is to improve acute care and to achieve a short laboratory-to-bed-time. In addition, my aim is to involve students and to improve their skills in both science and acute medicine. Currently, I am working on the prediction of poor outcomes in ED patients using ML technology, on an exploration of the acute care trajectory and on the added value of simulation techniques for residents in the acute care.

I am member of the national research consortium in acute medicine that organizes short but original studies called “flash mobs” across the country. I also coordinate studies in Limburg in collaboration with acute internists and emergency physicians. My goal is to work with all kinds of professionals interested in acute medicine at MUMC/FHML, including intensivists, general practitioners, education/simulation experts, clinical chemistry specialists and cardiologists.

Until now, I have been a co-promotor of 7 PhD students, and I currently supervise 4 PhD students.

Patricia stassen 2014

Dept of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 5C2025
T: +31(0)43 387 50 05

  • 2024
    • van Doorn, W. P. T. M., Helmich, F., van Dam, P. M. E. L., Jacobs, L. H. J., Stassen, P. M., Bekers, O., & Meex, S. J. R. (2024). Explainable Machine Learning Models for Rapid Risk Stratification in the Emergency Department: A Multicenter Study. Journal of Applied Laboratory Medicine, 9(2), 212-222. Article jfad094. https://doi.org/10.1093/jalm/jfad094
    • van Dam, P. M. E. L., van Doorn, W. P. T. M., van Gils, F., Sevenich, L., Lambriks, L., Meex, S. J. R., Cals, J. W. L., & Stassen, P. M. (2024). Machine learning for risk stratification in the emergency department (MARS-ED) study protocol for a randomized controlled pilot trial on the implementation of a prediction model based on machine learning technology predicting 31-day mortality in the emergency department. Scandinavian Journal of Trauma Resuscitation & Emergency Medicine, 32(1), Article 5. https://doi.org/10.1186/s13049-024-01177-2
  • 2023
    • van Dam, P. M. E. L., Lievens, S., Zelis, N., van Doorn, W. P. T. M., Meex, S. J. R., Cals, J. W. L., & Stassen, P. M. (2023). Head-to-head comparison of 19 prediction models for short-term outcome in medical patients in the emergency department: a retrospective study. Annals of Medicine, 55(2), Article 2290211. https://doi.org/10.1080/07853890.2023.2290211
    • Wanrooij, V. H. M., Cobussen, M., Stoffers, J., Buijs, J., Bergmans, D. C. J. J., Zelis, N., & Stassen, P. M. (2023). Sex differences in clinical presentation and mortality in emergency department patients with sepsis. Annals of Medicine, 55(2), Article 2244873. https://doi.org/10.1080/07853890.2023.2244873
    • van Bakel, S. I. J., Gietema, H. A., Stassen, P. M., Gosker, H. R., Gach, D., van den Bergh, J. P., van Osch, F. H. M., Schols, A. M. W. J., & Beijers, R. J. H. C. G. (2023). CT Scan-Derived Muscle, But Not Fat, Area Independently Predicts Mortality in COVID-19. Chest, 164(2), 314-322. https://doi.org/10.1016/j.chest.2023.02.048
    • Cobussen, M., Verhave, J. C., Buijs, J., & Stassen, P. M. (2023). The incidence and outcome of AKI in patients with sepsis in the emergency department applying different definitions of AKI and sepsis. International Urology and Nephrology, 55(1), 183-190. https://doi.org/10.1007/s11255-022-03267-5
  • 2022
    • Zelis, N., Roumans-van Oijen, A. M. M., Buijs, J., van Kraaij, D. J. W., van Kuijk, S. M. J., de Leeuw, P. W., & Stassen, P. M. (2022). Major adverse cardiovascular events in older emergency department patients presenting with non-cardiac medical complaints. Netherlands Heart Journal, 30(12), 559-566. https://doi.org/10.1007/s12471-022-01700-z
    • Latten, G., Claassen, L., Muris, J., Cals, J., & Stassen, P. (2022). Koorts op de HAP: vitals, beslisregels en niet-pluisgevoel. Huisarts en Wetenschap, 65(8), 21-25. https://doi.org/10.1007/s12445-022-1507-x
    • Stassen, P., & Westerman, D. (2022). Novice Doctors in the Emergency Department: A Scoping Review. Cureus Journal of Medical Science, 14(6), Article e26245. https://doi.org/10.7759/cureus.26245
    • van Geffen, M., van der Waaij, K. M., & Stassen, P. M. (2022). Number, nature & impact of incoming telephone calls on residents and their work during evening shifts. Acute Medicine, 21(1), 5-11. https://doi.org/10.52964/amja.0886
  • 2021
    • Latten, G. H. P., Polak, J., Merry, A. H. H., Muris, J. W. M., Ter Maaten, J. C., Olgers, T. J., Cals, J. W. L., & Stassen, P. M. (2021). Frequency of alterations in qSOFA, SIRS, MEWS and NEWS scores during the emergency department stay in infectious patients: a prospective study. International Journal of Emergency Medicine, 14(1), Article 69. https://doi.org/10.1186/s12245-021-00388-z
    • Bosveld, M. H., van Doorn, D. P. C., Stassen, P. M., Westerman, D., Bergmans, D. C. J. J., van der Horst, I. C. C., & van Mook, W. N. K. A. (2021). Lessons learned: Contribution to healthcare by medical students during COVID-19. Journal of Critical Care, 63, 113-116. https://doi.org/10.1016/j.jcrc.2020.09.015
    • Cobussen, M., Haeseker, M. B., Stoffers, J., Wanrooij, V. H. M., Savelkoul, P. H. M., & Stassen, P. M. (2021). Renal safety of a single dose of gentamicin in patients with sepsis in the emergency department. Clinical Microbiology and Infection, 27(5), 717-723. https://doi.org/10.1016/j.cmi.2020.06.030
    • Schalekamp, S., Bleeker-Rovers, C. P., Beenen, L. F. M., van Ufford, H. M. E. Q., Gietema, H. A., Stoger, J. L., Harris, V., Reijers, M. H. E., Rahamat-Langendoen, J., Korevaar, D. A., Smits, L. P., Korteweg, C., Vellinga, T. F. D. V., Vermaat, M., Stassen, P. M., Scheper, H., Wijnakker, R., Borm, F. J., Dofferhoff, A. S. M., & Prokop, M. M. (2021). Chest CT in the Emergency Department for Diagnosis of COVID-19 Pneumonia: Dutch Experience. Radiology, 298(2), E98-E106. https://doi.org/10.1148/radiol.2020203465
    • van Dam, P. M. E. L., Zelis, N., Stassen, P., van Twist, D. J. L., De Leeuw, P. W., van Kuijk, S., & Buijs, J. (2021). Validating the RISE UP score for predicting prognosis in patients with COVID-19 in the emergency department: a retrospective study. BMJ Open, 11(2), Article e045141. https://doi.org/10.1136/bmjopen-2020-045141
    • Ariës, M. J. H., van den Bergh, J. P., Beudel, M., Boersma, W., Dormans, T., Douma, R. A., Eerens, A., Elbers, P. W. G., Fleuren, L. M., Gritters van den Oever, N. C., de Haan, L., van der Horst, I. J. C. C., Hu, S., Hubers, D., Janssen, M. L. F., de Kruif, M., Kubben, P. L., van Kuijk, S. M. J., Noordzij, P. G., ... Wyers, C. E. (2021). Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf. Nederlands Tijdschrift voor Geneeskunde, 165(3), Article D5085. https://www.ntvg.nl/artikelen/klinisch-beloop-van-covid-19-nederland
    • van Dam, P. M. E. L., Zelis, N., van Kuijk, S. M. J., Linkens, A. E. M. J. H., Bruggemann, R. A. G., Spaetgens, B., van der Horst, I. C. C., & Stassen, P. M. (2021). Performance of prediction models for short-term outcome in COVID-19 patients in the emergency department: a retrospective study. Annals of Medicine, 53(1), 402-409. https://doi.org/10.1080/07853890.2021.1891453
    • Zelis, N., Hundscheid, R., Buijs, J., De Leeuw, P. W., Raijmakers, M. T. M., van Kuijk, S. M. J., & Stassen, P. M. (2021). Value of biomarkers in predicting mortality in older medical emergency department patients: a Dutch prospective study. BMJ Open, 11(1), Article 042989. https://doi.org/10.1136/bmjopen-2020-042989
    • Latten, G. H., Claassen, L., Coumans, L., Goedemondt, V., Brouwer, C., Muris, J. W., Cals, J. W., & Stassen, P. M. (2021). Vital signs, clinical rules, and gut feeling: an observational study among patients with fever. BJGP Open, 5(6). https://doi.org/10.3399/BJGPO.2021.0125
  • 2020
    • Bruggemann, R. A. G., Spaetgens, B., Gietema, H. A., Brouns, S. H. A., Stassen, P. M., Magdelijns, F. J., Rennenberg, R. J., Henry, R. M. A., Mulder, M. M. G., van Bussel, B. C. T., Schnabel, R. M., van der Horst, I. C. C., Wildberger, J. E., Stehouwer, C. D. A., & ten Cate, H. (2020). The prevalence of pulmonary embolism in patients with COVID-19 and respiratory decline: A three-setting comparison. Thrombosis Research, 196, 486-490. https://doi.org/10.1016/j.thromres.2020.10.012
    • Zelis, N., Buijs, J., de Leeuw, P. W., Stassen, P. M., van Kuijk, S. M. J., Hundscheid, R., Raijmakers, M. T. M., & RISE UP Investigator Group (2020). Do biomarkers add anything to clinical prediction of mortality in older medical emergency department patients?European journal of internal medicine, 81, 106-107. https://doi.org/10.1016/j.ejim.2020.07.016
    • Latten, G., Hensgens, K., de Bont, E. G. P. M., Muris, J. W. M., Cals, J. W. L., & Stassen, P. (2020). How well are sepsis and a sense of urgency documented throughout the acute care chain in the Netherlands? A prospective, observational study. BMJ Open, 10(7), e036276. Article 036276. https://doi.org/10.1136/bmjopen-2019-036276
    • Zelis, N., Huisman, S. E., Mauritz, A. N., Buijs, J., de Leeuw, P. W., & Stassen, P. M. (2020). Concerns of older patients and their caregivers in the emergency department. PLOS ONE, 15(7), Article 0235708. https://doi.org/10.1371/journal.pone.0235708
    • Gietema, H. A., Zelis, N., Nobel, J. M., Lambriks, L. J. G., van Alphen, L. B., Lashof, A. M. L. O., Wildberger, J. E., Nelissen, I. C., & Stassen, P. M. (2020). CT in relation to RT-PCR in diagnosing COVID-19 in The Netherlands: A prospective study. PLOS ONE, 15(7), Article e0235844. https://doi.org/10.1371/journal.pone.0235844
    • Zelis, N., Buijs, J., de Leeuw, P. W., van Kuijk, S. M. J., & Stassen, P. M. (2020). A new simplified model for predicting 30-day mortality in older medical emergency department patients: The rise up score. European journal of internal medicine, 77, 36-43. https://doi.org/10.1016/j.ejim.2020.02.021
    • Stassen, P. M., & Cals, J. W. L. (2020). Flashmobstudies: wetenschap in een flits. Nederlands Tijdschrift voor Geneeskunde, 164, Article D4736. https://www.ntvg.nl/artikelen/flashmobstudies-wetenschap-een-flits
  • 2019
    • Latten, G. H. P., Spek, M., Muris, J. W. M., Cals, J. W. L., & Stassen, P. M. (2019). Accuracy and interobserver-agreement of respiratory rate measurements by healthcare professionals, and its effect on the outcomes of clinical prediction/diagnostic rules. PLOS ONE, 14(10), e0223155. Article 0223155. https://doi.org/10.1371/journal.pone.0223155
    • Tuin, J., Stassen, P. M., Bogdan, D. I., Broekroelofs, J., van Paassen, P., Tervaert, J. W. C., Sanders, J.-S., & Stegeman, C. A. (2019). Mycophenolate Mofetil Versus Cyclophosphamide for the Induction of Remission in Nonlife-Threatening Relapses of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Randomized, Controlled Trial. Clinical journal of the American Society of Nephrology, 14(7), 1021-1028. https://doi.org/10.2215/CJN.11801018
    • Zelis, N., Buijs, J., de Leeuw, P. W., van Kuijk, S. M. J., & Stassen, P. M. (2019). Study protocol for a multicentre prospective cohort study to identify predictors of adverse outcome in older medical emergency department patients (the Risk Stratification in the Emergency Department in Acutely Ill Older Patients (RISE UP) study). BMC Geriatrics, 19, Article 65. https://doi.org/10.1186/s12877-019-1078-2
    • Latten, G. H. P., Claassen, L., Jonk, M., Cals, J. W. L., Muris, J. W. M., & Stassen, P. M. (2019). Characteristics of the prehospital phase of adult emergency department patients with an infection: A prospective pilot study. PLOS ONE, 14(2), Article 0212181. https://doi.org/10.1371/journal.pone.0212181
    • Cobussen, M., Stassen, P. M., Posthouwer, D., van Tiel, F. H., Savelkoul, P. H. M., Havenith, T., & Haeseker, M. B. (2019). Improving peak concentrations of a single dose regime of gentamicin in patients with sepsis in the emergency department. PLOS ONE, 14(1), Article 0210012. https://doi.org/10.1371/journal.pone.0210012
    • Zelis, N., Mauritz, A. N., Kuijpers, L. I. J., Buijs, J., de Leeuw, P. W., & Stassen, P. M. (2019). Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study. PLOS ONE, 14(1), Article 0208741. https://doi.org/10.1371/journal.pone.0208741
    • Schols, A. M. R., Willemsen, R. T. A., Bonten, T. N., Rutten, M. H., Stassen, P. M., Kietselaer, B. L. J. H., Dinant, G.-J., & Cals, J. W. L. (2019). A Nationwide Flash-Mob Study for Suspected Acute Coronary Syndrome. Annals of Family Medicine, 17(4), 296-303. https://doi.org/10.1370/afm.2401
    • Wachelder, J., Stassen, P. M., Fourmanov, R. S., Nickel, C. H., & Haak, H. R. (2019). Higher In-Hospital Mortality in Patients with Nonspecific Complaints Presenting to the Emergency Department. Acute Medicine, 18(4), 232-238. https://doi.org/10.52964/amja.0782
  • 2018
    • Wesselius, H. M., van den Ende, E. S., Alsma, J., ter Maaten, J. C., Schuit, S. C. E., Stassen, P. M., de Vries, O. J., Kaasjager, K. H. A. H., Haak, H. R., van Doormaal, F. F., Hoogerwerf, J. J., Terwee, C. B., van de Ven, P. M., Bosch, F. H., van Someren, E. J. W., Nanayakkara, P. W. B., & Onderzoeks Consortium Acute Genees (2018). Quality and Quantity of Sleep and Factors Associated With Sleep Disturbance in Hospitalized Patients. JAMA Internal Medicine, 178(9), 1201-1208. https://doi.org/10.1001/jamainternmed.2018.2669
    • Alam, N., Oskam, E., Stassen, P. M., van Exter, P., van de Ven, P. M., Haak, H. R., Holleman, F., van Zanten, A., van Leeuwen-Nguyen, H., Bon, V., Duineveld, B. A. M., Panday, R. S. N., Kramer, M. H. H., Nanayakkara, P. W. B., & PHANTASI Trial Investigators; ORCA Onderzoeks Consortium Acute (2018). Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. The Lancet Respiratory medicine, 6(1), 40-50. https://doi.org/10.1016/S2213-2600(17)30469-1
  • 2017
    • Wachelder, J. J. H., van Drunen, I., Stassen, P. M., Brouns, S. H. A., Lambooij, S. L. E., Aarts, M. J., & Haak, H. R. (2017). Association of socioeconomic status with outcomes in older adult community-dwelling patients after visiting the emergency department: a retrospective cohort study. BMJ Open, 7(12), Article e019318. https://doi.org/10.1136/bmjopen-2017-019318
    • Wachelder, J. J. H., Stassen, P. M., Hubens, L. P. A. M., Brouns, S. H. A., Lambooij, S. L. E., Dieleman, J. P., & Haak, H. R. (2017). Elderly emergency patients presenting with non-specific complaints: Characteristics and outcomes. PLOS ONE, 12(11), Article e0188954. https://doi.org/10.1371/journal.pone.0188954
    • Cobussen, M., Havenith, T., Posthouwer, D., van Tiel, F. H., Stassen, P. M., & Haeseker, M. B. (2017). Short Course of Empirical Gentamicin in Patients With Severe Sepsis and Septic Shock in the ICU: A Benefit or a Burden?Clinical Infectious Diseases, 65(5), 873-874. https://doi.org/10.1093/cid/cix447
    • Alsma, J., van Saase, J. L. C. M., Nanayakkara, P. W. B., Schouten, W. E. M. I., Baten, A., Bauer, M. P., Holleman, F., Ligtenberg, J. J. M., Stassen, P. M., Kaasjager, K. H. A. H., Haak, H. R., Bosch, F. H., Schuit, S. C. E., & Famous Study Grp (2017). The Power of Flash Mob Research Conducting a Nationwide Observational Clinical Study on Capillary Refill Time in a Single Day. Chest, 151(5), 1106-1113. https://doi.org/10.1016/j.chest.2016.11.035
    • Stassen, P. M. (2017). Acute medical units, providing continuity of care may be the next focus. European journal of internal medicine, 39, E12-E12. https://doi.org/10.1016/j.ejim.2017.01.005
    • Brouns, S. H. A., van der Schuit, K. C. H., Stassen, P. M., Lambooij, S. L. E., Dieleman, J., Vanderfeesten, I. T. P., & Haak, H. R. (2017). Applicability of the modified Emergency Department Work Index (mEDWIN) at a Dutch emergency department. PLOS ONE, 12(3), Article e0173387. https://doi.org/10.1371/journal.pone.0173387
    • Roest, A. A., Stoffers, J., Pijpers, E., Jansen, J., & Stassen, P. M. (2017). Ambulance patients with nondocumented sepsis have a high mortality risk: a retrospective study. European Journal of Emergency Medicine, 24(1), 36-43. https://doi.org/10.1097/MEJ.0000000000000302
    • van den Nouland, D. P. A., Brouwers, M. C. G. J., & Stassen, P. M. (2017). Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department. BMJ Open, 7(1), Article 011450. https://doi.org/10.1136/bmjopen-2016-011450
  • 2016
    • Magdelijns, F. J. H., van Avesaath, R. E. M., Pijpers, E., Stehouwer, C. D. A., & Stassen, P. M. (2016). Health-care-related adverse events leading to admission in older individuals: incidence, predictive factors and consequences. European Journal of Public Health, 26(5), 743-748. https://doi.org/10.1093/eurpub/ckw021
    • Magdelijns, F. J. H., Schepers, L., Pijpers, E., Stehouwer, C. D. A., & Stassen, P. M. (2016). Unplanned readmissions in younger and older adult patients: the role of healthcare-related adverse events. European Journal of Medical Research, 21, Article 35. https://doi.org/10.1186/s40001-016-0230-0
    • Cobussen, M., de Kort, J. M. L., Dennert, R. M., Lowe, S. H., & Stassen - Marx, P. (2016). No increased risk of acute kidney injury after a single dose of gentamicin in patients with sepsis. Infectious Diseases, 48(4), 274-280. https://doi.org/10.3109/23744235.2015.1109136
    • Alam, N., van de Ven, P. M., Oskam, E., Stassen, P., Kramer, M. H., Exter, P. V., & Nanayakkara, P. W. (2016). Study protocol for a Multi-centre, Investigator-initiated, Randomized Controlled Trial to Compare the Effects of Prehospital Antibiotic Treatment for Sepsis Patients with Usual Care after Training Emergency Medical Services (EMS) Personnel in Early Recognition (- The Prehospital ANTibiotics Against Sepsis (PHANTASi) trial. Acute Medicine, 15(4), 176-184. https://doi.org/10.52964/AMJA.0633
  • 2015
    • Magdelijns, F. J. H., Pijpers, E., Rouhl, R. P. W., Hannemann, P. F. W., ten Broeke, R. H. M., Dings, J. T. A., Stehouwer, C. D. A., & Stassen, P. M. (2015). Acute Hospital Admissions Because of Health Care-Related Adverse Events: A Retrospective Study of 5 Specialist Departments. Journal of the American Medical Directors Association, 16(12), 1055-1061. https://doi.org/10.1016/j.jamda.2015.06.019
    • Joosen, D. A. W. A., van de Laar, R. J. J. M., Koopmans, R. P., & Stassen, P. M. (2015). Acute Dyspnea Caused by Hypocalcemia-Related Laryngospasm. The Journal of Emergency Medicine, 48(1), 29-30. https://doi.org/10.1016/j.jemermed.2014.09.034
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