Thomas Van Sloten

Post doc

Dr Thomas van Sloten studied Medicine at Maastricht University and Clinical Epidemiology at VU University Amsterdam, both in the Netherlands. The focus of his research is the role of primordial prevention of cardiovascular and cerebrovascular diseases and the contribution of vascular dysfunction to brain diseases (stroke, dementia, depression).

He did his PhD research under supervision of Prof. Coen Stehouwer at the Department of Internal Medicine of Maastricht UMC+, within CARIM. During his PhD project, Thomas also worked at the National Institutes of Health, Bethesda, Maryland, under supervision of Dr Launer and Dr Mitchell. Recently, he did a post-doctoral research fellowship at INSERM U970, Cardiovascular Research Center, Paris, France, under supervision of Dr Empana, Prof. Boutouyrie and Prof. Laurent.

Currently, Thomas works as a resident internal medicine and post-doctoral researcher at Maastricht UMC+. In 2018, Thomas was awarded a Veni grant by the Dutch Research Council NWO talent scheme and Dr. Dekker clinical scientist grant by the Dutch Heart Foundation. Using this grants, Thomas investigates the role of microvascular dysfunction in the development of depression in individuals with and without cardiovascular disease.

Department of Internal Medicine
Randwycksingel 35, 6229 EG Maastrichtl
T: +31(0)621 214 590

  • 2020
    • Lisan, Q., van Sloten, T., Climie, R. E., Boutouyrie, P., Guibout, C., Thomas, F., Danchin, N., Jouven, X., & Empana, J-P. (2020). Sleep apnoea is associated with hearing impairment: The Paris prospective study 3. Clinical Otolaryngology, 45(5), 681-686. https://doi.org/10.1111/coa.13557
    • Geraets, A. F. J., van Agtmaal, M. J. M., Stehouwer, C. D. A., Sörensen, B. M., Berendschot, T. T. J. M., Webers, C. A. B., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Eussen, S. J. P. M., Koster, A., van Sloten, T. T., Köhler, S., Schram, M. T., & Houben, A. J. H. M. (2020). Association of Markers of Microvascular Dysfunction With Prevalent and Incident Depressive Symptoms: The Maastricht Study. Hypertension, 76(2), 342-349. https://doi.org/10.1161/HYPERTENSIONAHA.120.15260
    • Zhou, T. L., Rensma, S. P., van der Heide, F. C. T., Henry, R. M. A., Kroon, A. A., Houben, A. J. H. M., Jansen, J. F. A., Backes, W. H., Berendschot, T. T. J. M., Schouten, J. S. A. G., van Dongen, M. C. J. M., Eussen, S. J. P. M., Dagnelie, P. C., Webers, C. A. B., Schram, M. T., Schalkwijk, C. G., van Sloten, T. T., & Stehouwer, C. D. A. (2020). Blood pressure variability and microvascular dysfunction: the Maastricht Study. Journal of Hypertension, 38(8), 1541-1550. https://doi.org/10.1097/HJH.0000000000002444
    • Rensma, S. P., van Sloten, T. T., Ding, J., Sigurdsson, S., Stehouwer, C. D. A., Gudnason, V., & Launer, L. J. (2020). Type 2 Diabetes, Change in Depressive Symptoms Over Time, and Cerebral Small Vessel Disease: Longitudinal Data of the AGES-Reykjavik Study. Diabetes Care, 43(8), 1781-1787. https://doi.org/10.2337/dc19-2437
    • Rensma, S. P., Stehouwer, C. D. A., Van Boxtel, M. P. J., Houben, A. J. H. M., Berendschot, T. T. J. M., Jansen, J. F. A., Schalkwijk, C. G., Verhey, F. R. J., Kroon, A. A., Henry, R. M. A., Backes, W. H., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bosma, H., Köhler, S., Reesink, K. D., Schram, M. T., & van Sloten, T. T. (2020). Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction: The Maastricht Study. Hypertension, 75(6), 1607-1614. https://doi.org/10.1161/HYPERTENSIONAHA.119.14307
    • Vulser, H., Lemogne, C., Boutouyrie, P., Cote, F., Perier, M-C., Van Sloten, T., Hoertel, N., Danchin, N., Limosin, F., Jouven, X., & Empana, J-P. (2020). Depression, antidepressants and low hemoglobin level in the Paris Prospective Study III: A cross-sectional analysis. Preventive Medicine, 135, [106050]. https://doi.org/10.1016/j.ypmed.2020.106050
    • van Sloten, T. T., Sedaghat, S., Carnethon, M. R., Launer, L. J., & Stehouwer, C. D. A. (2020). Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression. The Lancet Diabetes & Endocrinology, 8(4), 325-336. https://doi.org/10.1016/S2213-8587(19)30405-X
    • Rensma, S. P., van Sloten, T. T., Houben, A. J. H. M., Koehler, S., van Boxtel, M. P. J., Berendschot, T. T. J. M., Jansen, J. F. A., Verhey, F. R. J., Kroon, A. A., Koster, A., Backes, W. H., Schaper, N., Dinant, G-J., Schalkwijk, C. G., Henry, R. M. A., Wolfs, E. M. L., van Heumen, M. J. A., Schram, M. T., & Stehouwer, C. D. A. (2020). Microvascular Dysfunction Is Associated With Worse Cognitive Performance The Maastricht Study. Hypertension, 75(1), 237-245. https://doi.org/10.1161/HYPERTENSIONAHA.119.13023
  • 2019
    • Climie, R. E., Boutouyrie, P., Perier, M-C., Chaussade, E., Plichart, M., Offredo, L., Guibout, C., van Sloten, T. T., Thomas, F., Pannier, B., Sharman, J. E., Laurent, S., Jouven, X., & Empana, J-P. (2019). Association Between Occupational, Sport, and Leisure Related Physical Activity and Baroreflex Sensitivity The Paris Prospective Study III. Hypertension, 74(6), 1476-1483. https://doi.org/10.1161/HYPERTENSIONAHA.119.13461
    • Lisan, Q., van Sloten, T. T., Lemogne, C., Offredo, L., Climie, R. E., Boutouyrie, P., Guibout, C., Thomas, F., Danchin, N., Jouven, X., & Empana, J-P. (2019). Association of Hearing Impairment with Incident Depressive Symptoms: A Community-Based Prospective Study. American Journal of Medicine, 132(12), 1441-1449.e4. https://doi.org/10.1016/j.amjmed.2019.05.039
    • Climie, R. E., Gallo, A., Picone, D. S., Di Lascio, N., van Sloten, T. T., Guala, A., Mayer, C. C., Hametner, B., & Bruno, R. M. (2019). Measuring the Interaction Between the Macro- and Micro-Vasculature. Frontiers in cardiovascular medicine, 6, 1-15. [169]. https://doi.org/10.3389/fcvm.2019.00169
    • Hausler, N., Lisan, Q., Van Sloten, T., Haba-Rubio, J., Perier, M-C., Thomas, F., Danchin, N., Guibout, C., Boutouyrie, P., Heinzer, R., Jouven, X., Marques-Vidal, P., & Empana, J-P. (2019). Cardiovascular health and sleep disturbances in two population-based cohort studies. Heart, 105(19), 1500-1506. https://doi.org/10.1136/heartjnl-2018-314485
    • Climie, R. E., van Sloten, T. T., Perier, M-C., Tafflet, M., Fayosse, A., Dugravot, A., Singh-Manoux, A., & Empana, J-P. (2019). Change in Cardiovascular Health and Incident Type 2 Diabetes and Impaired Fasting Glucose: The Whitehall II Study. Diabetes Care, 42(10), 1981-1987. https://doi.org/10.2337/dc19-0379
    • Lisan, Q., Van Sloten, T., Vidal, P. M., Rubio, J. H., Heinzer, R., & Empana, J. P. (2019). Association of Positive Airway Pressure Prescription With Mortality in Patients With Obesity and Severe Obstructive Sleep Apnea: The Sleep Heart Health Study. JAMA Otolaryngology - Head and Neck Surgery, 145(6), 509-514. https://doi.org/10.1001/jamaoto.2019.0281
    • Climie, R. E., Boutouyrie, P., Perier, M-C., Guibout, C., van Sloten, T. T., Thomas, F., Danchin, N., Sharman, J. E., Laurent, S., Jouven, X., & Empana, J-P. (2019). Individual and Neighborhood Deprivation and Carotid Stiffness: The Paris Prospective Study III. Hypertension, 73(6), 1185-1194. https://doi.org/10.1161/HYPERTENSIONAHA.118.12186
    • Climie, R. E., van Sloten, T. T., Bruno, R-M., Taddei, S., Empana, J-P., Stehouwer, C. D. A., Sharman, J. E., Boutouyrie, P., & Laurent, S. (2019). Macrovasculature and Microvasculature at the Crossroads Between Type 2 Diabetes Mellitus and Hypertension. Hypertension, 73(6), 1138-1149. https://doi.org/10.1161/HYPERTENSIONAHA.118.11769
    • Zhou, T. L., Kroon, A. A., Sloten, T. T. V., van Boxtel, M. P. J., Verhey, F. R. J., Schram, M. T., Köhler, S., Stehouwer, C. D. A., & Henry, R. M. A. (2019). Greater Blood Pressure Variability Is Associated With Lower Cognitive Performance: The Maastricht Study. Hypertension, 73(4), 803–811. https://doi.org/10.1161/HYPERTENSIONAHA.118.12305
    • van Sloten, T. T., Boutouyrie, P., Tafflet, M., Offredo, L., Thomas, F., Guibout, C., Climie, R. E., Lemogne, C., Pannier, B., Laurent, S., Jouven, X., & Empana, J-P. (2019). Carotid Artery Stiffness and Incident Depressive Symptoms: The Paris Prospective Study III. Biological Psychiatry, 85(6), 498-505. https://doi.org/10.1016/j.biopsych.2018.09.018
    • Lisan, Q., Tafflet, M., Thomas, F., Boutouyrie, P., Guibout, C., Haba-Rubio, J., Climie, R., Perier, M. C., Van Sloten, T., Pannier, B., Marques-Vidal, P., Jouven, X., & Empana, J. P. (2019). Body Silhouette Trajectories Over the Lifespan and Insomnia Symptoms: The Paris Prospective Study 3. Scientific Reports, 9, 1-9. [1581]. https://doi.org/10.1038/s41598-018-38145-7
    • Rensma, S., van Sloten, T. T., Houben, A. J. H. M., van Boxtel, M. P. J., Berendschot, T. T. J. M., Jansen, J. F. A., Kroon, A. A., Koster, A., Backes, W. H., Schaper, N., Dinant, G. J., Schalkwijk, C. G., Henry, R. M. A., Wolfs, E. M. L., van Heumen, M. J. A., Schram, M. T., & Stehouwer, C. D. A. (2019). Microvascular Dysfunction Is Associated with Worse Cognitive Performance: The Maastricht Study. Journal of Vascular Research, 56(S1), 94-94. https://doi.org/10.1159/000499516
  • 2018
    • van Sloten, T. T., Tafflet, M., Perier, M-C., Dugravot, A., Climie, R. E. D., Singh-Manoux, A., & Empana, J-P. (2018). Association of Change in Cardiovascular Risk Factors With Incident Cardiovascular Events. JAMA-Journal of the American Medical Association, 320(17), 1793-1804. https://doi.org/10.1001/jama.2018.16975
    • van Sloten, T. T., Boutouyrie, P., Lisan, Q., Tafflet, M., Thomas, F., Guibout, C., Climie, R. E., Pannier, B., Sharman, J. E., Laurent, S., Jouven, X., & Empana, J-P. (2018). Body Silhouette Trajectories Across the Lifespan and Vascular Aging: The Paris Prospective Study 3. Hypertension, 72(5), 1095-1102. https://doi.org/10.1161/HYPERTENSIONAHA.118.11442
    • Zhou, T. L., Henry, R. M. A., Stehouwer, C. D. A., van Sloten, T. T., Reesink, K. D., & Kroon, A. A. (2018). Blood Pressure Variability, Arterial Stiffness, and Arterial Remodeling: The Maastricht Study. Hypertension, 72(4), 1002-1010. https://doi.org/10.1161/HYPERTENSIONAHA.118.11325
    • Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., van Sloten, T. T., Roodt, J. O. H., Henry, R. M. A., Reesink, K. D., Schaper, N. C., Dagnelie, P. C., van der Kallen, C. J. H., Biessels, G. J., & Stehouwer, C. D. A. (2018). Carotid circumferential wall stress is not associated with cognitive performance among individuals in late middle age: The Maastricht Study. Atherosclerosis, 276, 15-22. https://doi.org/10.1016/j.atherosclerosis.2018.07.003
    • Rensma, S. P., van Sloten, T. T., Launer, L. J., & Stehouwer, C. D. A. (2018). Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 90, 164-173. https://doi.org/10.1016/j.neubiorev.2018.04.003
    • Sedaghat, S., van Sloten, T. T., Laurent, S., London, G. M., Pannier, B., Kavousi, M., Mattace-Raso, F., Franco, O. H., Boutouyrie, P., Ikram, M. A., & Stehouwer, C. D. A. (2018). Common Carotid Artery Diameter and Risk of Cardiovascular Events and Mortality: Pooled Analyses of Four Cohort Studies. Hypertension, 72(1), 85-92. https://doi.org/10.1161/HYPERTENSIONAHA.118.11253
  • 2017
    • Goeijenbier, M., van Sloten, T. T., Slobbe, L., Mathieu, C., van Genderen, P., Beyer, W. E. P., & Osterhaus, A. D. M. E. (2017). Benefits of flu vaccination for persons with diabetes mellitus: A review. Vaccine, 35(38), 5095-5101. https://doi.org/10.1016/j.vaccine.2017.07.095
    • van Sloten, T. T. (2017). Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms. Artery Research, 19, 18-23. https://doi.org/10.1016/j.artres.2017.05.002
    • Stehouwer, C. D. A., & van Sloten, T. T. (2017). Microvascular outcomes in type 2 diabetes. The Lancet Diabetes & Endocrinology, 5(8), 579-579. https://doi.org/10.1016/S2213-8587(17)30187-0
    • Veugen, M. G. J., Henry, R. M. A., van Sloten, T. T., Hermeling, E., Brunner-La Rocca, H-P., Schram, M. T., Dagnelie, P. C., Schalkwijk, C. G., Kroon, A. A., Stehouwer, C. D. A., & Reesink, K. D. (2017). The systolic-diastolic difference in carotid stiffness is increased in type 2 diabetes: The Maastricht Study. Journal of Hypertension, 35(5), 1052-1060. https://doi.org/10.1097/HJH.0000000000001298
  • 2016
    • Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., van Sloten, T. T., Henry, R. M. A., Reesink, K. D., Kroon, A. A., Koster, A., Schaper, N. C., Dagnelie, P. C., van der Kallen, C. J. H., Biessels, G. J., & Stehouwer, C. D. A. (2016). Carotid stiffness is associated with impairment of cognitive performance in individuals with and without type 2 diabetes. The Maastricht Study. Atherosclerosis, 253, 186-193. https://doi.org/10.1016/j.atherosclerosis.2016.07.912
    • van Eupen, M. G. A., Schram, M. T., van Sloten, T. T., Scheijen, J., Sep, S. J. S., van der Kallen, C. J., Dagnelie, P. C., Koster, A., Schaper, N., Henry, R. M. A., Kroon, A. A., Smit, A. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2016). Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening: The Maastricht Study. Hypertension, 68(4), 956-963. https://doi.org/10.1161/HYPERTENSIONAHA.116.07446
    • van Sloten, T. T., Mitchell, G. F., Sigurdsson, S., van Buchem, M. A., Jonsson, P. V., Garcia, M. E., Harris, T. B., Henry, R. M. A., Levey, A. S., Stehouwer, C. D. A., Gudnason, V., & Launer, L. J. (2016). Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study. Journal of Psychiatry & Neuroscience, 41(3), 162-168. https://doi.org/10.1503/jpn.140334
    • van Sloten, T. T., & Stehouwer, C. D. A. (2016). Carotid Stiffness: A Novel Cerebrovascular Disease Risk Factor. Pulse, 4(1), 24-27. https://doi.org/10.1159/000445354
  • 2015
    • van Sloten, T. T., Sedaghat, S., Laurent, S., London, G. M., Pannier, B., Ikram, M. A., Kavousi, M., Mattace-Raso, F., Franco, O. H., Boutouyrie, P., & Stehouwer, C. D. A. (2015). Carotid Stiffness Is Associated With Incident Stroke A Systematic Review and Individual Participant Data Meta-Analysis. Journal of the American College of Cardiology, 66(19), 2116-2125. https://doi.org/10.1016/j.jacc.2015.08.888
    • Wijnands, J. M. A., Boonen, A., van Sloten, T. T., Schram, M. T., Sep, S. J. S., Koster, A., van der Kallen, C. J. H., Henry, R. M. A., Dagnelie, P. C., Stehouwer, C. D. A., van der Linden, S., & Arts, I. C. W. (2015). Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40-75 years without and with type 2 diabetes mellitus: The Maastricht Study. Journal of Hypertension, 33(8), 1642-1650. https://doi.org/10.1097/HJH.0000000000000593
    • van Sloten, T. T., Czernichow, S., Houben, A. J., Protogerou, A. D., Henry, R. M., Muris, D. M., Schram, M. T., Sep, S. J., Dagnelie, P. C., van der Kallen, C. J., Schaper, N. C., Blacher, J., Hercberg, S., Levy, B. I., & Stehouwer, C. D. (2015). Association Between Arterial Stiffness and Skin Microvascular Function: The SUVIMAX2 Study and The Maastricht Study. American Journal of Hypertension, 28(7), 868-876. https://doi.org/10.1093/ajh/hpu246
    • van Sloten, T. T., Protogerou, A. D., Henry, R. M. A., Schram, M. T., Launer, L. J., & Stehouwer, C. D. A. (2015). Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 53, 121-130. https://doi.org/10.1016/j.neubiorev.2015.03.011
    • van Sloten, T. T., Sigurdsson, S., van Buchem, M. A., Phillips, C. L., Jonsson, P. V., Ding, J., Schram, M. T., Harris, T. B., Gudnason, V., & Launer, L. J. (2015). Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study. American Journal of Psychiatry, 172(6), 570-578. https://doi.org/10.1176/appi.ajp.2014.14050578
    • van Sloten, T. T., & Stehouwer, C. D. A. (2015). Effects of RAS inhibitors on diabetic retinopathy Reply. The Lancet Diabetes & Endocrinology, 3(5), 316-316. https://doi.org/10.1016/S2213-8587(15)00084-4
    • van Sloten, T. T., & Stehouwer, C. D. A. (2015). No need to change guidelines for diabetic retinopathy and renin-angiotensin system inhibitors. The Lancet Diabetes & Endocrinology, 3(4), 231-232. https://doi.org/10.1016/S2213-8587(15)70006-9
  • 2014
    • van Sloten, T. T., Henry, R. M. A., Dekker, J. M., Nijpels, G., Unger, T., Schram, M. T., & Stehouwer, C. D. A. (2014). Endothelial Dysfunction Plays a Key Role in Increasing Cardiovascular Risk in Type 2 Diabetes The Hoorn Study. Hypertension, 64(6), 1299-U293. https://doi.org/10.1161/HYPERTENSIONAHA.114.04221
    • van Sloten, T. T., Schram, M. T., van den Hurk, K., Dekker, J. M., Nijpels, G., Henry, R. M. A., & Stehouwer, C. D. A. (2014). Local Stiffness of the Carotid and Femoral Artery Is Associated With Incident Cardiovascular Events and All-Cause Mortality The Hoorn Study. Journal of the American College of Cardiology, 63(17), 1739-1747. https://doi.org/10.1016/j.jacc.2013.12.041
    • van Sloten, T. T., Schram, M. T., Adriaanse, M. C., Dekker, J. M., Nijpels, G., Teerlink, T., Scheffer, P. G., Pouwer, F., Schalkwijk, C. G., Stehouwer, C. D. A., & Henry, R. M. A. (2014). Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study. Psychological Medicine, 44(7), 1403-1416. https://doi.org/10.1017/S0033291713002043
  • 2012
    • van Sloten, T. T., Pijpers, E., Stehouwer, C. D. A., & Brouwers, M. C. (2012). Metformin-associated lactic acidosis in a patient with normal kidney function.Diabetes Research and Clinical Practice, 96(3), E57-E58. https://doi.org/10.1016/j.diabres.2011.07.021
  • 2011
    • van Sloten, T. T., Savelberg, H. H., Duimel-Peeters, I. G. M., Meijer, K., Henry, R. M., Stehouwer, C. D. A., & Schaper, N. C. (2011). Peripheral neuropathy, decreased muscle strength and obesity are strongly associated with walking in persons with type 2 diabetes without manifest mobility limitations.Diabetes Research and Clinical Practice, 91(1), 32-39. https://doi.org/10.1016/j.diabres.2010.09.030