• 2022
    • Gianfredi, V., Schaper, N. C., Odone, A., Signorelli, C., Amerio, A., Eussen, S. J. P. M., Köhler, S., Savelberg, H. H. C. M., Stehouwer, C. D. A., Dagnelie, P. C., Henry, R. M. A., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Schram, M. T., & Koster, A. (2022). Daily patterns of physical activity, sedentary behavior, and prevalent and incident depression-The Maastricht Study. Scandinavian Journal of Medicine & Science in Sports, 32(12), 1768-1780. https://doi.org/10.1111/sms.14235
    • Empana, J-P., Lerner, I., Perier, M-C., Guibout, C., Jabre, P., Bailly, K., Andrieu, M., Climie, R., van Sloten, T., Vedie, B., Geromin, D., Marijon, E., Thomas, F., Danchin, N., Boutouyrie, P., & Jouven, X. (2022). Ultrasensitive Troponin I and Incident Cardiovascular Disease. Arteriosclerosis Thrombosis and Vascular Biology, 42(12), 1471-1481. https://doi.org/10.1161/ATVBAHA.122.317961
    • Ren, Z. W., Simons, P. I. H. G., Wesselius, A., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Untitled Reply. Hepatology, 76(6), E129-E130. https://doi.org/10.1002/hep.32611
    • De Hert, E., Verboven, K., Wouters, K., Jocken, J. W. E., & De Meester, I. (2022). Prolyl Carboxypeptidase Activity Is Present in Human Adipose Tissue and Is Elevated in Serum of Obese Men with Type 2 Diabetes. International journal of molecular sciences, 23(21), [13529]. https://doi.org/10.3390/ijms232113529
    • Jin, S., Reesink, K. D., Kroon, A. A., de Galan, B., van der Kallen, C. J. H., Wesselius, A., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2022). Complement factors D and C3 cross-sectionally associate with arterial stiffness, but not independently of metabolic risk factors: The Maastricht Study. Journal of Hypertension, 40(11), 2161-2170. https://doi.org/10.1097/HJH.0000000000003237
    • van der Heide, F. C. T., Foreman, Y. D., Franken, I. W. M., Henry, R. M. A., Kroon, A. A., Dagnelie, P. C., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Schaper, N. C., Brouwers, M. C. G. J., & Stehouwer, C. D. A. (2022). (Pre)diabetes, glycemia, and daily glucose variability are associated with retinal nerve fiber layer thickness in The Maastricht Study. Scientific Reports, 12(1), [17750]. https://doi.org/10.1038/s41598-022-22748-2
    • Konopka, M. J., Kohler, S., Stehouwer, C. D. A., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Savelberg, H. H. C. M., Eussen, S. J. P. M., Dagniele, P. C., van Dongen, M. C. J. M., Schram, M. T., & Koster, A. (2022). Accelerometer-derived sedentary time and physical activity and the incidence of depressive symptoms - The Maastricht Study. Psychological Medicine, 52(13), 2786-2793. https://doi.org/10.1017/S0033291720004924
    • Top, W. M. C., Lehert, P., Schalkwijk, C. G., Stehouwer, C. D. A., & Kooy, A. (2022). Effect of metformin on arginine and dimethylarginines in patients with advanced type 2 diabetes: A post hoc analysis of a randomized trial. Diabetes Obesity & Metabolism, 24(10), 1983-1988. https://doi.org/10.1111/dom.14784
    • Janssen, L. E. F., Simons, N., Simons, P. I. H. G., Schaper, N. C., Feskens, E. J. M., van der Ploeg, L. M. C., Van den Eynde, M. D. G., Schalkwijk, C. G., Houben, A. J. H. M., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Effects of fructose restriction on blood pressure: Secondary analysis of a double-blind randomized controlled trial. Clinical Nutrition ESPEN, 51, 97-103. https://doi.org/10.1016/j.clnesp.2022.07.009
    • Brouwers, M. C. G. J. (2022). Fructose 1-phosphate, an evolutionary signaling molecule of abundancy. Trends in Endocrinology and Metabolism, 33(10), 680-689. https://doi.org/10.1016/j.tem.2022.07.007
    • Pinxt, C. M. H., Bogie, R. M. M., Hanssen, N. M. J., & Spaetgens, B. (2022). COVID-19: a wake-up call for antibiotic overuse in older patients?QJM: An International Journal of Medicine, 115(9), 637-637. https://doi.org/10.1093/qjmed/hcab234
    • Geraets, A. F. J., Schram, M. T., Jansen, J. F. A., Backes, W. H., Schalkwijk, C. G., Stehouwer, C. D. A., van Boxtel, M. P. J., Eussen, S. J. P. M., Kooman, J. P., Verhey, F. R. J., & Köhler, S. (2022). The cardiometabolic depression subtype and its association with clinical characteristics: The Maastricht Study. Journal of Affective Disorders, 313, 110-117. https://doi.org/10.1016/j.jad.2022.06.045
    • Baylan, U., Korn, A., Emmens, R. W., Schalkwijk, C. G., Niessen, H. W. M., Krijnen, P. A. J., & Simsek, S. (2022). Liraglutide treatment attenuates inflammation markers in the cardiac, cerebral and renal microvasculature in streptozotocin-induced diabetic rats. European Journal of Clinical Investigation, 52(9), [13807]. https://doi.org/10.1111/eci.13807
    • van Vliet, K., van Ginkel, W. G., Jahja, R., Daly, A., MacDonald, A., Santra, S., De Laet, C., Goyens, P. J., Vara, R., Rahman, Y., Cassiman, D., Eyskens, F., Timmer, C., Mumford, N., Gissen, P., Bierau, J., van Hasselt, P. M., Wilcox, G., Morris, A. A. M., ... van Spronsen, F. J. (2022). Neurocognitive outcome and mental health in children with tyrosinemia type 1 and phenylketonuria: A comparison between two genetic disorders affecting the same metabolic pathway. Journal of Inherited Metabolic Disease, 45(5), 952-962. https://doi.org/10.1002/jimd.12528
    • Koene, E., Schrauwen-Hinderling, V. B., Schrauwen, P., & Brouwers, M. C. G. J. (2022). Novel insights in intestinal and hepatic fructose metabolism: from mice to men. Current Opinion in Clinical Nutrition and Metabolic Care, 25(5), 354-359. https://doi.org/10.1097/MCO.0000000000000853
    • Kloka, J., Friedrichson, B., Dauth, S., Foldenauer, A. C., Bulczak-Schadendorf, A., Vehreschild, M. J. G. T., Matos, F. M., Riera-Mestre, A., van Asselt, A. D. I., De Robertis, E., Juskeviciene, V. T., Meybohm, P., Tomescu, D., Lacombe, K., Stehouwer, C. D. A., Zacharowski, K., & IXION Collaboration Group (2022). Potential of FX06 to prevent disease progression in hospitalized non-intubated COVID-19 patients - the randomized, EU-wide, placebo-controlled, phase II study design of IXION. Trials, 23(1), [688]. https://doi.org/10.1186/s13063-022-06609-x
    • Goossens, P., Lu, C., Cao, J., Gijbels, M. J., Karel, J. M. H., Wijnands, E., Claes, B. S. R., Fazzi, G. E., Hendriks, T. F. E., Wouters, K., Smirnov, E., van Zandvoort, M. J. M., Balluff, B., Cuypers, E., Donners, M. M. P. C., Heeren, R. M. A., & Biessen, E. A. L. (2022). Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context. Cell Metabolism, 34(8), 1214-1225.e6. https://doi.org/10.1016/j.cmet.2022.06.012
    • Hengeveld, L. M., de Goede, J., Afman, L. A., Bakker, S. J. L., Beulens, J. W. J., Blaak, E. E., Boersma, E., Geleijnse, J. M., van Goudoever, J. H. B., Hopman, M. T. E., Iestra, J. A., Kremers, S. P. J., Mensink, R. P., de Roos, N. M., Stehouwer, C. D. A., Verkaik-Kloosterman, J., de Vet, E., & Visser, M. (2022). Health Effects of Increasing Protein Intake Above the Current Population Reference Intake in Older Adults: A Systematic Review of the Health Council of the Netherlands. Advances in Nutrition, 13(4), 1083-1117. [nmab140]. https://doi.org/10.1093/advances/nmab140
    • Zhang, X., Schalkwijk, C. G., & Wouters, K. (2022). Immunometabolism and the modulation of immune responses and host defense: A role for methylglyoxal?Biochimica et Biophysica Acta-Molecular Basis of Disease, 1868(8), [166425]. https://doi.org/10.1016/j.bbadis.2022.166425
    • Barutta, F., Bellini, S., Guarrera, S., Matullo, G., Schalkwijk, C., Stehouwer, C. D., Chaturvedi, N., Soedamah-Muthu, S. S., Durazzo, M., & Gruden, G. (2022). Association of Serum MicroRNA-145-5p Levels with Microvascular Complications of Type 1 Diabetes: the EURODIAB Prospective Complications Study. Diabetes Research and Clinical Practice, 190, [109987]. https://doi.org/10.1016/j.diabres.2022.109987
    • Haring, M. P. D., Peeks, F., Oosterveer, M. H., Brouwers, M. C. G. J., Hollak, C. E. M., Janssen, M. C. H., Langendonk, J. G., Rennings, A. J. M., Wagenmakers, M. A. E. M., Verkade, H. J., Derks, T. G. J., & de Meijer, V. E. (2022). High childhood serum triglyceride concentrations associate with hepatocellular adenoma development in patients with glycogen storage disease type Ia. JHEP Reports, 4(8), [100512]. https://doi.org/10.1016/j.jhepr.2022.100512
    • Brouwers, M. C. G. J., Simons, N., Kooi, M. E., de Ritter, R., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bekers, O., Kooman, J., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Schram, M. T., Schaper, N. C., Schalkwijk, C. G., & Stehouwer, C. D. A. (2022). Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study. Digestive and Liver Disease, 54(8), 1038-1043. https://doi.org/10.1016/j.dld.2022.01.130
    • Wauben, B., van Yperen, N. C., van der Poel, M. W., Köhler, S., van Greevenbroek, M. M., & Schouten, H. C. (2022). Long-term effects after stem cell transplantation identified: design of the MOSA study. Journal of Clinical Epidemiology, 148, 10-16. https://doi.org/10.1016/j.jclinepi.2022.03.012
    • van Dalem, J., Werkman, N. C. C., van den Bergh, J. P., Rossi, B., Viggers, R., Eastell, R., Burden, A. M., Stehouwer, C. D. A., Klungel, O. H., Brouwers, M. C. G. J., & Driessen, J. H. M. (2022). "Use of sodium-glucose co-transporter 2 inhibitors, changes in body mass index and risk of fracture: a population-based cohort study". Diabetes Research and Clinical Practice, 190, [109993]. https://doi.org/10.1016/j.diabres.2022.109993
    • Clemmensen, K. K. B., Koster, A., Nielen, J. T. H., Dagnelie, P. C., Stehouwer, C. D. A., Bosma, H., Wesselius, A., Færch, K., & Eussen, S. J. P. M. (2022). Role of weekday variation on glucose, insulin, and triglyceride: A cross-sectional analysis from The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 107(8), E3145-E3151. https://doi.org/10.1210/clinem/dgac286
    • Rebelos, E., Daniele, G., Campi, B., Saba, A., Koskensalo, K., Ihalainen, J., Saukko, E., Nuutila, P., Backes, W. H., Jansen, J. F. A., Dagnelie, P. C., Köhler, S., de Galan, B. E., van Sloten, T. T., Stehouwer, C. D. A., & Ferrannini, E. (2022). Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans. Scientific Reports, 12(1), 11530. [11530]. https://doi.org/10.1038/s41598-022-15670-0
    • Qiao, Y-S., Tang, X., Chai, Y-H., Gong, H-J., Zhang, X., Stehouwer, C. D. A., & Zhou, J-B. (2022). Association of Sarcopenia and A Body Shape Index With Overall and Cause-Specific Mortality. Frontiers in Endocrinology, 13, [839074]. https://doi.org/10.3389/fendo.2022.839074
    • Jin, S., Kusters, Y. H. A. M., Houben, A. J. H. M., Plat, J., Joris, P. J., Mensink, R. P., Schalkwijk, C. G., Stehouwer, C. D. A., & van Greevenbroek, M. M. J. (2022). A randomized diet-induced weight-loss intervention reduces plasma complement C3: Possible implication for endothelial dysfunction. Obesity, 30(7), 1401-1410. https://doi.org/10.1002/oby.23467
    • Chai, Y-H., Zhang, Y-P., Qiao, Y-S., Gong, H-J., Xu, H., She, H-C., Patel, I., Liu, W., Stehouwer, C. D. A., Zhou, J-B., & Simó, R. (2022). Association between diabetic retinopathy, brain structural abnormalities and cognitive impairment for accumulated evidence in observational studies. American Journal of Ophthalmology, 239, 37-53. https://doi.org/10.1016/j.ajo.2022.01.011
    • Ruiz, A., Sanchez, D., Lafuente, A., Ortega, G., Buendia, M., Papasey, J., Jimeno, S. Y., Badia, F. P., Palacio, M. E., Abdelnour, C., Ramirez-Torano, F., Maestu, F., Saez, M. E., Tarraga, L., Dagnelie, P. C., & Boada, M. (2022). Evaluation of the Feasibility, Safety and Efficacy of the Use of Intravenous Infusions of Adenosine Triphosphate (ATP) in People Affected by Moderate to Severe Alzheimer's Disease: A Double-Blind Masked Clinical Trial for Dose Finding. JPAD-Journal of prevention of alzheimers disease, 9(3), 425-434. https://doi.org/10.14283/jpad.2022.38
    • Sharma, S., Katz, R., Ginsberg, C., Bullen, A., Vallon, V., Thomson, S., Moe, O. W., Hoofnagle, A. N., de Leeuw, P. W., Kroon, A. A., Houben, A. J. H. M., & Ix, J. H. (2022). Renal Clearance of Fibroblast Growth Factor-23 (FGF23) and its Fragments in Humans. Journal of Bone and Mineral Research, 37(6), 1170-1178. https://doi.org/10.1002/jbmr.4553
    • Simons, P. I. H. G., Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Derks, T. G. J., Schalkwijk, C. G., Schrauwen-Hinderling, V. B., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Serum sex hormone-binding globulin levels are reduced and inversely associated with intrahepatic lipid content and saturated fatty acid fraction in adult patients with glycogen storage disease type 1a. Journal of Endocrinological Investigation, 45(6), 1227-1234. https://doi.org/10.1007/s40618-022-01753-2
    • Doola, R., Deane, A. M., Barrett, H. L., Okano, S., Tolcher, D. M., Gregory, K., Coombes, J. S., Schalkwijk, C., Todd, A. S., Forbes, J. M., & Sturgess, D. J. (2022). The impact of a modified carbohydrate formula, and its constituents, on glycaemic control and inflammatory markers: A nested mechanistic sub-study. Journal of Human Nutrition and Dietetics, 35(3), 455-465. https://doi.org/10.1111/jhn.12959
    • Linkens, A. M. A., van Best, N., Niessen, P. M., Wijckmans, N. E. G., de Goei, E. E. C., Scheijen, J. L. J. M., van Dongen, M. C. J. M., van Gool, C. C. J. A. W., de Vos, W. M., Houben, A. J. H. M., Stehouwer, C. D. A., Eussen, S. J. M. P., Penders, J., & Schalkwijk, C. G. (2022). A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial. International journal of molecular sciences, 23(10), [5328]. https://doi.org/10.3390/ijms23105328
    • Veugen, M. G. J., Onete, V. G., Henry, R. M. A., Brunner-La Rocca, H-P., Koster, A., Dagnelie, P. C., Schaper, N. C., Sep, S. J. S., van der Kallen, C. J. H., van Boxtel, M. P. J., Reesink, K. D., Schouten, J. S., Savelberg, H. H. C. M., Köhler, S., Verhey, F. R., van den Bergh, J. P. W., Schram, M. T., & Stehouwer, C. D. A. (2022). Health burden in type 2 diabetes and prediabetes in The Maastricht Study. Scientific Reports, 12(1), 1-11. [7337]. https://doi.org/10.1038/s41598-022-11136-5
    • van Sloten, T. T., Souverein, P. C., Stehouwer, C. DA., & Driessen, J. H. (2022). Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and risk of depression among older people with hypertension. Journal of Psychopharmacology, 36(5), 594-603. [02698811221082470]. https://doi.org/10.1177/02698811221082470
    • Buziau, A. M., Eussen, S. J. P. M., Kooi, M. E., van der Kallen, C. J. H., van Dongen, M. C. J. M., Schaper, N. C., Henry, R. M. A., Schram, M. T., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Bekers, O., Meex, S. J. R., Schalkwijk, C. G., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2022). Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study. Diabetes Care, 45(5), 1116-1123. https://doi.org/10.2337/dc21-2123
    • Deraz, O., Range, H., Boutouyrie, P., Chatzopoulou, E., Asselin, A., Guibout, C., Van Sloten, T., Bougouin, W., Andrieu, M., Vedie, B., Thomas, F., Danchin, N., Jouven, X., Bouchard, P., & Empana, J. P. (2022). Oral Condition and Incident Coronary Heart Disease: A Clustering Analysis. Journal of Dental Research, 101(5), 526-533. [00220345211052507]. https://doi.org/10.1177/00220345211052507
    • Vandercappellen, E. J., Koster, A., Savelberg, H. H. C. M., Eussen, S. J. P. M., Dagnelie, P. C., Schaper, N. C., Schram, M. T., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Kroon, A. A., Henry, R. M. A., & Stehouwer, C. D. A. (2022). Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation-relevance for (pre)diabetes: The Maastricht Study. Diabetologia, 65(5), 777-789. https://doi.org/10.1007/s00125-022-05651-3
    • Climie, R. E., Tafflet, M., van Sloten, T., de Lauzon-Guillain, B., Bernard, J. Y., Dargent-Molina, P., Plancoulaine, S., Lioret, S., Jouven, X., Charles, M-A., Heude, B., & Empana, J-P. (2022). Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment. Frontiers in pediatrics, 10, [827525]. https://doi.org/10.3389/fped.2022.827525
    • Stultiens, J. M. G., Top, W. M. C., Kimenai, D. M., Lehert, P., Bekers, O., Stehouwer, C. D. A., Kooy, A., & Meex, S. J. R. (2022). Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial. Cardiovascular Diabetology, 21(1), [49]. https://doi.org/10.1186/s12933-022-01482-z
    • Ottaviani, L., Pinto, V. S., Knoops, K., Wouters, K., Martins, P. A. D., & Abreu, R. (2022). Cre/Lox-Assisted Tracking Of Cardiac Intercellular Communication. Tissue Engineering, 28, S339-S340.
    • Mashnafi, S., Plat, J., Mensink, R. P., Joris, P. J., Kusters, Y. H. A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Baumgartner, S. (2022). Effects of Diet-Induced Weight Loss on Plasma Markers for Cholesterol Absorption and Synthesis: Secondary Analysis of a Randomized Trial in Abdominally Obese Men. Nutrients, 14(8), [1546]. https://doi.org/10.3390/nu14081546
    • Simons, P. I. H. G., Cornelissen, M. E. B., Valkenburg, O., Onland-Moret, N. C., van der Schouw, Y. T., Stehouwer, C. D. A., Burgess, S., & Brouwers, M. C. G. J. (2022). Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study. Clinical Endocrinology, 96(4), 599-604. https://doi.org/10.1111/cen.14593
    • Gennip, A. C. E., Sedaghat, S., Carnethon, M. R., Allen, N. B., Klein, B. E. K., Cotch, M. F., Chirinos, D. A., Stehouwer, C. D. A., & van Sloten, T. T. (2022). Retinal Microvascular Caliber and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology, 191(5), 843-855. https://doi.org/10.1093/aje/kwab255
    • Linkens, A. M. A., Houben, A. J., Niessen, P. M., Wijckmans, N., de Goei, E., Van den Eynde, M. D. G., Scheijen, J. L. J. M., Waarenburg, M., Mari, A., Berendschot, T. T. J. M., Streese, L., Hanssen, H., van Dongen, M. C. J. M., van Gool, C., Stehouwer, C. D. A., Eussen, S. J. P. M., & Schalkwijk, C. (2022). A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals. JCI INSIGHT, 7(6), [156950]. https://doi.org/10.1172/jci.insight.156950
    • Top, W. M. C., Kooy, A., & Stehouwer, C. D. A. (2022). Metformin: A Narrative Review of Its Potential Benefits for Cardiovascular Disease, Cancer and Dementia. Pharmaceuticals, 15(3), [312]. https://doi.org/10.3390/ph15030312
    • van Hulten, V., Sarodnik, C., Driessen, J. H. M., Schaper, N. C., Geusens, P. P. M. M., Webers, C. A. B., Dinant, G-J., Ottenheijm, R. P. G., Rasmussen, N. H., Viggers, R., Stehouwer, C. D. A., van der Kallen, C. J. H., Schram, M. T., Bours, S. P. G., Dagnelie, P. C., & van den Bergh, J. P. (2022). Prevalent Morphometrically Assessed Vertebral Fractures in Individuals With Type 2 Diabetes, Prediabetes and Normal Glucose Metabolism: The Maastricht Study. Frontiers in Endocrinology, 13, [832977]. https://doi.org/10.3389/fendo.2022.832977
    • Wu, L., Baylan, U., van der Leeden, B., Schurink, B., Roos, E., Schalkwijk, C. G., Bugiani, M., van der Valk, P., van Rossum, A. C., Zeerleder, S. S., Heunks, L. M. A., Boon, R. A., de Boer, O. J., van der Wal, A. C., Niessen, H. W. M., & Krijnen, P. A. J. (2022). Cardiac inflammation and microvascular procoagulant changes are decreased in second wave compared to first wave deceased COVID-19 patients. International Journal of Cardiology, 349, 157-165. https://doi.org/10.1016/j.ijcard.2021.11.079