theses 2022

Gennaro Martucci
Supervisors: Prof. R. Lorusso, Prof. J.G. Maessen | Co-supervisor: Dr G.M. Raffa (ISMETT, Palermo, Italy)
Title: Challenges in Extracorporeal Membrane Oxygenation: Precision Management to Improve Survival
17 January

Li Li
Supervisor: Prof. H. ten Cate | Co-supervisor: Dr D. Huskens, Dr M. Roest
Title: Platelets in thrombosis and haemostasis: synergy with thrombin generation
24 January

Frank van der Heide
Supervisor: Prof. C.D.A. Stehouwer | Co-supervisors: Dr R.M.A. Henry, Dr J.S.A.G. Schouten
Title: Neurodegeneration and microvascular dysfunction - causes and consequences
26 January

Maria Abbattista
Supervisor: Prof. H. ten Cate | Co-supervisors: Prof. P.M. Mannucci (University of Milan), Dr I. Martinelli (Fondazione IRCCS Ca' Grande, Milan)
Title: Venous thromboembolism in women - A focus on unusual sites, pregnancy and thrombophilia
11 February

Harilaos Bogassian
Supervisors: Prof. H.J.G.M. Crijns, Prof. M. Zarse (Luedenscheid, Germany) | Co-supervisors: Dr J. Heijman, Dr D. Linz
Title: New Insights into the Evaluation of Broad QRS Complexes: Relevance for Arrhythmia Management
15 February

Stan van der Beelen
Supervisor: Prof. T.M. Hackeng | Co-supervisors: Dr S.M. Agten, Dr B.M.E. Mees
Title: Catch FXIa
17 February

Ricardo Cerqueira de Abreu
Supervisors: Prof. P. da Costa Martins, Prof. L. da Silva Ferreira (University of Coimbra) | Co-supervisor: Dr H. Fernandes (University of Coimbra)
Title: Extracellular Vesicles as Platforms for Therapeutic microRNA delivery
21 February

Francesca Torresan
Supervisors: Prof. A. Kroon, Prof. GP Rossi (University of Padova, Italy)
Title: Excess aldosterone as a mechanism of resistant salt sensitive arterial hypertension
21 February

Mieke Karel
Supervisor: Prof. J.M.E.M. Cosemans | Co-supervisors: Dr M.E. Kuijpers, Dr R.R. Koenen
Title: Platelets at the intersection of thrombosis and inflammation: establishing innovative methodologies
22 February

Grzegorz Wasilewski
Supervisors: Prof. L.J. Schurgers, Prof. C. Reutelingsperger
Title: The calcium paradox  the role of vitamin K in the bone-vascular axis
22 February

Annemiek Dickhout
Supervisors: Prof. T.M. Hackeng, Dr R.R. Koenen | Co-supervisor: Dr I. Dijkgraaf
Title: Painting proteins to study cardiovascular pathology
24 February

Francesco Londero
Supervisors: Prof. S. Gelsomino, Prof. J.G. Maessen
Co-supervisors: Dr A. Morelli (AOUD Santa Maria della Misericordia, Italy)
Title: Lung oligometastatic disease: redefining cancer pathogenesis from a surgical perspective
8 March

Justine Ravaux
Supervisors: Prof. R. Lorusso,  Prof. J.G. Maessen | Co-supervisor: Dr S. Kats
Title: Pacemaker Dependency after Permanent Pacemaker Implantation Following Cardiac Surgery and Transcatheter Aortic Valve Implantation
10 March

Vincent Nijenhuis
Supervisors: Prof. J.M. ten Berg, Prof. A.W.J. van t Hof
Title: Transcatheter Aortic-Valve Implantation: Antithrombotic Therapy and Individualized
Treatment Strategies
11 March

Bibi Martens
Supervisor: Prof. J.E. Wildberger | Co-supervisors: Dr C. Mihl, Dr E.C. Nijssen
Title: Computed tomography of the abdomen: From one size fits all to custom-made
17 March

Valeria Bisogni
Supervisors: Prof. A.A. Kroon, Prof. G.P. Rossi (University of Padova, Italy) | Co-supervisor: Prof. C. Letizia, University of Rome, Italy)
Title: Studies on Blood Pressure Variability and Pathogenic Mechanisms of Cardiovascular Risk in Secondary Hypertension
21 March

Shruti Bhargava
Supervisors: Prof. L. Schurgers, Prof. J. Jankowski (RWTH Aachen University)
Title: Identification and characterization of the mediators of the calcification paradox
21 March

Lars Bolt
Supervisor: Prof. G.W.H. Schurink | Co-supervisor: Dr L.H. Bouwman (Zuyderland Medisch Centrum)
Title: Implications in the treatment of peripheral arterial disease - Focussing on endovascular and non-invasive strategies
31 March

Nick van Osta
Supervisors: Prof. J. Lumens, Prof. T. Delhaas
Title: Making it Personal - Model-based Cardiac Tissue Characterization in Arrhythmogenic Cardiomyopathy
31 March

Erik de Loos
Supervisor: Prof. J.G. Maessen | Co-supervisors: Dr Y. Vissers (Zuyderland), Dr K Hulsewé (Zuyderland)
Title: PECTUS EXCAVATUM improvements in surgical care
7 April

Lina Wübbeke,
Supervisor: Prof. G. Schurink | Co-supervisors: Dr B. Mees, Dr J. Daemen
Title: Current Challenges in the treatment of chronic limb threatening Ischaemia
8 April

Kim Maasen, 13 April
Supervisors: Prof. C. Schalkwijk, Prof. C. Stehouwer | Co-supervisors: Dr M. van Greevenbroek
Title: Dietary dicarbonyls: friends or foes of human health?
13 April

Cristina Altrocchi
Supervisor: Prof. P. Volders | Co-supervisors: Dr C. Moreno Vadillo (National Institute of Neurological disorders and Stroke, USA)
Title: Cellular models of cardiac channelopathies
14 April

Juliane Hermann
Supervisors: Prof. L. Schurgers, Prof. J. Jankowski , Prof  V. Jankowski (RWTH Aachen)
Title: MALDI mass spectrometric imaging methods for localization and identification of pathophysiological relevant regulators in tissue samples
25 April

Jens Posma
Supervisor: Prof. H. ten Cate | Co-supervisor: Dr H. Spronk
Title: Coagulation Factor Xa as Driver of Cardiovascular Diseases
9 May

Rob Holtackers
Supervisors: Prof. J.E. Wildberger, Dr M.E. Kooi | Co-supervisors: Prof. A. Chiribiri (Kings College, London) Prof. C van de Heyning (University Hospital Antwerp)
Title: VISUALISING THE INVISIBLE Dark-blood late gadolinium enhancement MRI for improved detection of subendocardial scar
13 May

Sjoerd Timmermans
Supervisors: Dr. P. van Paassen, Prof. C. Reutelingsperger | Co-supervisor: Dr J. Damoiseaux 
Title: The syndromes of thrombotic microangiopathy: towards a true etiology-based approach
13 May

Shailesh Samal
Supervisors: Prof. Chris Reutelingsperger, Prof. Leon Schurgers, Prof. Johan Frostegard (Karolinska Institutet Stockholm)
Title: Immune Mechanisms and Potential Immunological Treatment in Atherosclerosis
16 May

Sofia Beghi
Supervisors: Prof. L. Schurgers, Prof. A. Buschini (Parma University, Italy) | Co-supervisors: Dr. E. Bidar, Dr. E. Natour 
Title: Genetic variants in calcium calmodulin pathway in association with cardiovascular disease: Focus on the potential role of CaMKK1 in heart and vessels
23 May

Marieke Gimbel
Supervisors: Prof. J. ten Berg, Prof. A. van 't Hof
Title: Antiplatelet therapy in elderly patients with an acute coronary syndrome
23 May

Nikolaos Taxiarchis Skenteris
Supervisors: Prof. E. Biesen, Prof. C. Reutelingsperger | Co-supervisors: Dr Hildur Arnardottir, Dr Ljubica Perisic Matic (Karolinska Institutet Stockholm)
Title: Interplay between inflammation and calcification in cardiovascular diseases
31 May

Judith de Ruijter-van Dalem
Supervisors: Prof. M.C.G.J. Brouwers, Emeritus Prof. F. de Vries | Co-supervisors: Drs A.M. Burden (ETH Zurich), Dr. J. H.M. Driessen
Title: Tailored therapy in type 2 diabetes unintended effects of glucose lowering agents
2 June

Luise Klein
Supervisors: Prof. D. van den Hove, Prof. L. Schurgers, Prof. C.P.M. Reutelingsperger, Dr T.G.A.M. Wolfs
Title: Protection of the preterm brain against inflammatory stress A promising role for stem cell-based therapy and Annexin A1
2 June

Jaap Selig
Supervisor: Prof. H. ten Cate | Co-supervisors: Dr M.E.W. Hemels (Rijnstate ziekenhuis Arnhem), Dr R. Pisters (Rijnstate ziekenhuis Arhnem)
Title: Quality of contemporary anticoagulation management in atrial fibrillation
8 June 

Pauline C.S. van Paridon
Supervisors: Prof. H. ten Cate, Prof. P. Wild (Johannes Gutenberg Universität Mainz, Duitsland) | Co-supervisors: Dr H.M. H. Spronk, Dr M. Panova- Noeva (Johannes Gutenberg Universität Mainz, Duitsland)
Title: Markers of Hypercoagulation in Cardiovascular Disease in the General Population
9 June

Pomme I.H.G. Simons
Supervisors: Prof. M.C.G.J. Brouwers, Prof. C.D.A. Stehouwer | Co-supervisor: Dr O. Valkenburg 
Title: Unravelling the triangular relationship between polycystic ovary syndrome, cardiometabolic disease and de novo lipogenesis
15 June

Joseph E .I.G. Brouwers
Supervisor: Prof. H. ten Cate | Co-supervisors: Dr J. A. Remijn (Meander Medical Center Amersfoort), Dr B. de Laat (Synapse Research Institute Maastricht) 
Title: Platelet-rich fibrin interactions in oral implantology
23 June

Dennis Krist
Supervisor: Prof. U. Schotten | Co-supervisors: Dr D. Linz, Dr S. Zeemering
Title: Novel laser energy applications for the treatment of cardiac arrhythmias
5 July

Raquel Figuinha Videira
Supervisors: Prof. P. da Costa Martins, Prof. I.  Falcao-Pires (Porto University, Portugal)
Title: Transcription Factors, microRNAs and Extracellular Vesicles at the crossroad of right and left heart failure
11 July

Stephanie Mezger
Supervisors: Prof. R.M.A. Heeren, Prof. O. Bekers | Co-supervisors: Dr B. Cillero-Pastor, Dr A. Mingels
Title: Molecular signatures of myocardial infarction:a multidisciplinary analytical approach
12 July

France Pirson
Supervisor: Dr J. Staals | Co-supervisors: Prof. W. van Zwam, Dr. W. Schonewille (Sint Antonius ziekenhuis)
Title: Endovascular treatment for acute ischemic stroke patients. Exploring predisposing factors and expanding indications
14 July

Marina Heuschkel
Supervisors: Prof. L. Schurgers, Prof. C. Goettsch (UK Aachen)
Title: Multi-omics discovery of novel molecular pathways in cardiovascular calcification
7 September

Rianneke de Ritter
Supervisor: Prof. C.D.A. Stehouwer | Co-supervisors: Dr C.van der Kallen, Dr S.J.S Sep (UMC Utrecht), Dr S. Peters (THe George Institute for Global Health, London)
Title: Sex differences in causes and consequences of type 2 diabetes
8 September

Anouk Gulpen
Supervisor: Prof. H. ten Cate | Co-supervisors: Dr A.J. ten Cate-Hoek, Prof. Y.M.C. Henskens
Title: Direct oral anticoagulant care Focus on management and monitoring
9 September

Florit Marcuse
Supervisors: Prof. J.G. Maessen, Prof. M.H.V. De Baets | Co-supervisor: Dr M. M. H. Hochstenbag
Title: Clinical care optimization for patients with a thymic tumor With special interest in myasthenia gravis and thymic epithelial tumors
16 September

Spencer Keene
Supervisors: Prof. Frits Franssen, Prof. Peymane Abab (University of Birmingham) | Co-supervisors: Dr Johanna Driessen, Dr Rachel E. Jordan (University of Birmingham)
Title: BEYOND AIRFLOW OBSTRUCTION: multicomponent COPD prognostication in personalised care
20 September

Hongxing Luo
Supervisors: Prof. F.W. Prinzen, Prof. T. Delhaas | Co-supervisor: Dr R.C. Cornelussen
Title: Heart sounds: From animal to patient and Mhealth
22 September

Nikki Pluymaekers
Supervisor: Prof H.J.G.M. Crijns | Co-supervisors: Dr J. Luermans, Dr D. Linz
Title: Cardioversion of atrial fibrillation revisited
23 September

Justas Simonavičius
Supervisor: Prof. H.P. Brunner-La Rocca | Co-supervisors: Dr C. Knackstedt, Dr S. van Wijk
Title: The relationship between the use of loop diuretics, congestion and heart failure outcome: in search of novel tools of congestion detection and grading
30 September

Gina Perrela
Supervisors: Prof. J. Heemskerk, Prof. S. Watson (University of Birminghan) | Co-supervisors: Dr M Watson (University of Birmingham), Dr M. Nagdy 
Title: Platelet Glycoprotein VI in the Regulation of Thrombus Growth
4 October

Armand Linkens
Supervisors: Prof. C. Schalkwijk, Prof. C. Stehouwer | Co-supervisors: Dr A. Houben, Dr S. Eussen
Title: The impact of dietary advanced glycation endproducts - Relevance to glucose metabolism, vascular function, and gut microbiota
5 October

Andreia Pinheiro Vilaca
Supervisors: Prof. L. de Windt, Prof. L. da Silva Ferreira (University of Coimbra) | Co-supervisor: Dr H. Agostinho Machado Fernandes (University of Coimbra)
Title: Targeting the heart: Extracellular vesicles and beyond
18 October

Elisa D'Alessandro 
Supervisors: Prof. H. ten Cate, Prof. U. Schotten | Co-supervisor: Dr F. van Nieuwenhoven
Title: Atrial fibrillation and hypercoagulability: A two-way street with many side-roads
20 October

Billy Scaf
Supervisor: Prof. U. Schotten 
Co-supervisors: Dr H. Spronk, Dr S. Verheule 
Title: Atrial fibrillation and hypercoagulability: A two-way street with many side-roads
20 October

Michiel Henkens
Supervisor: Prof. S. Heymans
Co-supervisors: Dr J.A.J. Verdonschot, Dr M.P. Hazebroek, Dr V.P.M. van Empel
Title: IMPROVING DIAGNOSIS AND RISK STRATIFICATION OF CARDIOMYOPATHIES ACROSS THE EJECTION FRACTION SPECTRUM – The past, present and future
24 October

Laura Willemsen
Supervisor: Prof. J.M. ten Berg | Co-supervisor: Dr C.M. Hackeng
Title: Thrombosis and Hemostasis in Coronary Artery Bypass Grafting Surgery
10 November

Anne Tavenier
Supervisors: Prof. A.W.J. van 't Hof, Prof. J.M. ten Berg | Co-supervisors: Dr R.S. Hermanides (Isala Zwolle), Dr J.P. Ottervanger (Isala Zwolle)
Title: Towards optimal platelet inhibition and pain relief in STelevation myocardial infarction17 November

Chang Lu,
Supervisors: Prof. E.A.L. Biessen, Dr J.M.H. Karel | Co-supervisor: Dr P. Goossens
Title: Computational strategies in cardiometabolic diseases: a portal to deeper mechanistic understanding
24 November

Dawid Kaczor
Supervisors: Prof. T.M. Hackeng, Dr R.R. Koenen | Co-supervisor: Prof. R. Kramann
Title: Inflammatory actions of chemokines and extracellular vesicles in pathological tissue remodeling
28 November

Jorn Brouwer
Supervisors: Prof. J.M. ten Berg, Prof. A.W.J. van 't Hof | Co-supervisor: Dr M.J. Swaans (St. Antonius Ziekenhuis Nieuwegein)
Title: Reducing the risk of transcatheter aortic valve implantation
1 December

Cengiz Akbulut
Supervisor: Prof. L. Schurgers | Co-supervisors: Prof. R. Kramann (RWTH Aachen University), Prof. S. Sinha (University of Cambridge)
Title: Spatiotemporal developmental regulation of arteriosclerosis
2 December

Anne Raafs
Supervisor: Prof. S.R.B. Heymans | Co-supervisors: Dr C. Knackstedt, Dr M.R. Hazebroek, Dr J.A.J. Verdonschot
Title: Atrioventricular imaging to predict outcome in dilated cardiomyopathy: Towards a multimodality approach
6 December

Myrthe van der Bruggen
Supervisors: Prof. T. Delhaas, Prof. C.G. Schalkwijk | Co-supervisors: Dr K.D. Reesink, Dr B. Spronck
Title: Multi-model assessment of arterial stiffness: focus on methylglyoxal
8 December

Vincenza Gianfredi
Supervisor: Prof. N.C. Schaper | Co-supervisors: Dr A. Koster, Dr M.T. Schram, Prof. A. Odone (University of Pavia)
Title: An epidemiological approach to depression: social networks, physical activity and diet
19 December

Jingnan Huang
Supervisors: Prof. J.W.M. Heemskerk, Prof. A. Sickmann (Leibniz-
Institut für Analytische Wissenschaften-ISAS) | Co-supervisors: Prof. H. ten Cate, Dr A. García (Universidade Santiago de Compostela)
Title: Platelet proteomic progress and retraining mechanisms in glycoprotein VI-mediated thrombus formation
20 December

Paolo Meani, 22 December
Supervisors: Prof. R. Lorusso, Prof. J.G. Maessen | Co-supervisor: Prof. M. Ranucci (University of Milan)
Title: Left Ventricular Unloading in Extracorporeal Life Support
22 December