theses 2023

Rachel Schreurs
Supervisors: Dr A.J. ten Cate-Hoek, Dr M.A. Joore, Prof. H. ten Cate
Title: Towards improved organisation of care. Improving compression therapy for patients with DVT and CVD (CEAP3-5)
18 January

Sibel Altintas
Supervisors: Prof. H.J.G.M. Crijns, Prof. J.E. Wildberger | Co-supervisor: Dr B.L.J.H. Kietselaer
Title: Mechanisms of cardiovascular disease as defined by cardiac computed tomography
18 January

Mirko Belliato
Supervisors: Prof. R. Lorussa, Prof. J.G. Maessen
Title: The Use of Extracorporeal Life Support Systems in Patients with Acute Respiratory Insufficiency
19 January

William van Doorn
Supervisor: Prof. O. Bekers | Co-supervisor: Dr S.J.R. Meex
Title: Rethinking biomarkers. Innovations in laboratory medicine
20 January

Meike Ploeg
Supervisors: Prof. F.W. Prinzen, Dr F.A. van Nieuwenhoven
Title: Stretch, stiffness, sensing, signaling & speed. Mechanical activation of Cardiac Fibroblasts
24 January

Jana Hegenbarth
Supervisors: Prof. L. de Windt, Prof. M. Stoll 
Title: The transcriptomics of the ever-changing Heart: From Development to Senescence
1 February

Guiseppe Nasso
Supervisors: Prof. R. Lorusso, Prof. J. Maessen 
Title: Minimally Invasive Epicardial ablation for atrial fibrillation; From unipolar to hybrid bipolar treatment with a new treatment line
8 February

Anke Keijbeck
Supervisor: Prof. E. Biessen | Co-supervisors: Dr M. Christiaans, Dr C. Peutz Kootstra (Gelre Hospital, Apeldoorn)
Title: Protocol biopsies after kidney transplantation: emphasis on interstitial fibrosis/ tubular atrophy and peritubular capillary loss in relation to clinical parameters
14 February

Natalie Jooss
Supervisors: Prof. J. Heemskerk, Prof. Y. Henskens, Prof. S. Watson (University of Birmingham, UK) | Co-supervisor: Dr N. Poulter (University of Birmingham, UK)
Title: Targeting GPVI: impact of modulating platelet-collagen interactions on receptor signalling and thrombus formation
16 February

Marco Moscarelli
Supervisors: Prof. R. Lorusso, Prof. J. Maessen
Title: Advancements in Minimally Invasive Cardiac Surgery
18 February

Camilla Soragni
Supervisors: Prof. L.J. de Windt, Prof. P.A. da Costa Martins | Co-supervisor: Dr C. Ping Ng (MIMETAS BV Oestgeest)
Title: Next stop: screening-on-a-chip. Where biology meets scalability Development of assays for placenta-on-a-chip models
2 March
 
Alexandru Florea
Supervisors: Prof. F.M. Mottaghy, Prof. M.E. Kooi, Prof. L.J. Schurgers | Co-supervisor: Prof. J. Bucerius (RWTH Aachen University)
Title: Sodium [18F]Fluoride positron emission tomography for non-invasive identification of micro-calcifications as marker of atherosclerotic plaque vulnerability
8 March

Nicolò Mangraviti
Supervisors: Prof. L.J. de Windt, Prof. M. Stoll
Title: LncRNA Bigheart in cardiac disease and development
13 March

Renske Olie
Supervisors: Prof. H. ten Cate, Prof. J.M. ten Berg | Co-supervisor: Dr P.E.J. van der Meijden
Title: Personalized antithrombotic treatment in high-risk patients with coronary artery disease
20 March

Alexander Gombert
Supervisors: Prof. M.J. Jacobs, Dr B.M.E. Mees | Co-supervisor: Prof. G.W. Schurink
Title: Applications of new specific biomarkers for organ damage after open and endovascular thoracoabdominal aortic aneurysm surgery as model for more accurate perioperative patients’ surveillance
27 March

Isabella Provenzale
Supervisors: Prof. J.W.M. Heemskerk, Prof. J.M. Gibbins (University of Reading, UK) | Co-supervisors: Dr P.E.J. van der Meijden, Dr C.I. Jones (University of Reading, UK)
Title: The modulatory roles of collagen and endothelial cells on platelet function
28 March

Pieter Glerum
Supervisors: Prof. C. Neef, Prof. D.M. Burger (Radboud University) | Co-supervisor: Dr M. Maliepaard (College ter beoordeling van geneesmiddelen, Utrecht)
Title: Generic interchangeability: between science and regulation
29 March

Shunxin Jin
Supervisors: Dr M.M.J. van Greevenbroek, Prof. C.D.A. Stehouwer, Prof. C.G. Schalkwijk
Title: 'The alternative pathway of the complement system in vascular comorbidities of obesity and type 2 diabetes'
3 April

Renée Brüggemann
Supervisor: Prof. H. ten Cate | Co-supervisors: Dr A.J. ten Cate-Hoek, Dr B.P.A. Spaetgens
Title: Unraveling hypercoagulability in COVID-19 and optimizing VTE management in the frail nursing home population
4 April

Alicia Veninga
Supervisor: Dr J.W.M. Heemskerk | Co-supervisors: Dr P.E.J. van der Meijden, Dr C.C.F.M.J. Baaten
Title: Platelet heterogeneity: a colourful palette of populations
20 April

Tobias Meßmer
Supervisors: Prof. M.J. Post, Dr J.E. Flack
Title: Decoding cultured meat production. The transcriptomic landscape of bovine satellite cells in proliferation and differentiation
21 April

Stefano Navarro
Supervisors: Prof. J.W.M. Heemskerk, Prof. B. Nieswandt (University of Würzburg) | Co-supervisors: Dr M.J.E. Kuijpers, Dr H. Hermanns (University of Würzburg)
Title: Novel platelet glycoprotein VI and CLEC-2 targeting strategies: studies in humanized mouse models
25 April

Ilaria De Simone
Supervisors: Prof. H. ten Cate, Prof. J.M. Gibbins (University of Reading) | Co-supervisors: Dr P.E.J. van der Meijden, Dr C.I. Jones (University of Reading)
Title: Novel mechanisms of platelet activation and sustained signalling through GPVI and PAR1
26 April

Julia Wirth
Supervisors: Prof. E. Biessen, Prof. J. Jankowski (UM/University Hospital RWTH Aachen)
Co-supervisor: Dr H. Noels (UM/University Hospital RWTH Aachen)
Title: Uremia-induced effects on cardioregulatory mechanisms in the context of the cardiorenal syndrome
8 May

Yee Lai Lam, 9 May
Supervisor: Prof. C.H.A. Wittens, Prof. H. ten Cate
Title: Extending the frontiers beyond heat: Non-Thermal varicose vein treatments
9 May

Vishnu Suresh Babu
Supervisor: Prof. S.R.B. Heymans | Co-supervisor: Dr Arkasubhra Ghosh (Narayana Nethralaya Eye Hospital, Bangalore, India)
Title: Identification of metabolic dysregulation and transcriptional networks in retinoblastoma reveals novel therapeutic targets. Functional insights and novel therapeutic strategies using a correlative multi-omics approach
15 May

Nikolas Rapp
Supervisor: Prof. L. Schurgers | Co-supervisor: Dr A. Jaminon
Title: Chasing the perfect storm: Vascular calcification in chronic renocardiac syndrome
16 May

Anne Willers
Supervisors: Prof. R. Lorusso, Prof. J.G. Maessen | Co-supervisors: Dr J. Swol
Title: Bleeding-related conditions and complications in extracorporeal life support
25 May

Ard van Veelen
Supervisor: Prof. V.C.G. Tjan-Heijnen | Co-supervisors: Dr S. Croes, Dr P.C. Souverein (Utrecht University), Dr R.M.J.M. van Geel
Title: Treatment optimization in patients with non-small cell lung cancer
1 June

Alessandra Sala
Supervisors: Prof. R. Lorusso, Prof. J.G. Maessen | Co-supervisor: Prof. M. De Bonis (IRCCS, Vita-Salute San Raffaele University, Milan, Italy)
Title: ISOLATED TRICUSPID VALVE REGURGITATION: ASSESSMENT, TIMING AND SURGICAL TREATMENT
6 June

Delia Fernández de la Fuente
Supervisor: Prof. J.W.M. Heemskerk | Co-supervisors: Dr M. Kuijpers, Dr A. García (Universidade Santiago de Compostela)
Title: High throughput assessment of platelet signaling, function and inhibition
19 June

Evelien Vandercappellen
Supervisors: Prof. C. Stehouwer, Dr. A. Koster | Co-supervisor: Dr Ronald Henry
Title: Physicial activity, sedentary behaviour and markers of cardiovascular and brain diseases; Does one size fit all?
3 July

Maurice Halder
Supervisors: Prof. L.J. Schurgers, Prof. R. Kramann (RWTH Aachen University)
Title: 'Dissecting mechanisms of heart failure and in-stent restenosis using fate tracing and scRNA-seq'
5 September

Mohamed Rahouma Ahmed
Supervisors: Prof. R. Lorusso, Prof. J.G. Maessen | Co-supervisor: Prof. M. Goudino (Weill Cornell Medicine, USA)
Title: 'In-depth clinical investigations over cardiac tumors in adult patients'
5 September

Robin Colpaert
Supervisor: Prof. L.J. de Windt | Co-supervisor: Dr M. Calore
Title: 'OF MICE AND MEN IN ACM Novel Models and Biomarkers for Arrhythmogenic Cardiomyopathy'
7 September

Robert Dzhanaev
Supervisors: Prof. L.J. Schurgers, Prof. W. Jahnen Dechent (RWTH Aachen University)
Title: 'FETUIN-A-BASED THERANOSTICS IN ECTOPIC CALCIFICATION'
12 September

Matteo Nardin
Supervisors: Prof. A.W.J. van 't Hof, Prof. J.M. ten Berg | Co-supervisor: Prof. G. De Luca (University of Messina, Italy)
Title: 'Implications of genetics and major risk factors  on platelet morphology, platelet aggregation and   their relationship with coronary atherosclerosis'
15 September

Hilaire Cheung
Supervisors: Prof. J.W.M. Heemskerk, Prof. S.P. Watson (University of Birmingham) | Co-supervisor: Dr N.S. Poulter (University of Birmingham)
Title: 'Deciphering glycoprotein VI signalling in platelet activation: integration of functional and computational modelling data'
27 September

Christophe Kuppe
Supervisors: Prof. L.J. Schurgers, Prof. R. Kramann (RWTH Aachen University)
Title: 'Unlocking the Complexities of Human Kidney and Heart Disease: An Integrative Single Cell and Spatial Analysis'
4 October

Joana Alves da Silva
Supervisors: Prof. P.A. da Costa Martins, Prof. L.J. de Windt
Title: 'MiR-199b and the hypertrophic heart: a journey across species'
4 October

Samantha Pasca
Supervisors: Prof. H. ten Cate, Prof. P. Mannuccio Mannucci (University of Milan) | Co-supervisor: Dr E. Zanon (University of Padua Medical School)
Title: 'AN OVERVIEW IN ACQUIRED HEMOPHILIA A: A RARE BUT COMPLICATED  DISEASE'
9 October

Abdulrahman Mohamed
Supervisors: Prof. H. ten Cate, Prof. B. de Laat | Co-supervisor: Dr M. Ninivaggi
Title: 'Contribution of genetic and environmental factors to a prothrombotic phenotype in native Saudi population with a focus on thrombin generation'
11 October

Cecilia Tetta
Supervisors: Prof. S. Gelsomino, Prof. J.G. Maessen | Co-supervisor: Dr M. Rocca
Title: 'Lung metastases from soft tissue sarcoma'
16 October

Luuk Heckman
Supervisors: Prof. F.W. Prinzen, Prof. K. Vernooy | Co-supervisor: Dr. J.G.L.M. Luermans
Title: 'Pacing the heart: one site fits all?'
26 October

Bart van Sloun
Supervisors: Prof.ir. I.C.W. Arts, Prof.ir. N.A.W. van Riel (Eindhoven University of Technology) | Co-supervisor: Dr G.H. Goossens
Title: 'Modelling of postprandial glucose and insulin dynamics: the role of amino acids'
27 October

Jules Olsthoorn
Supervisor: Prof. J.G. Maessen | Co-supervisor: Dr P. Sardari Nia
Title: 'Personalized Treatment in Mitral Valve Surgery'
27 October

Adele Ruder
Supervisors: Prof. E.A.L. Biessen, Prof. J.C. Sluimer | Co-supervisor: Dr L. Temmerman
Title: 'Origin versus Context Defining Key Determinants of Human Macrophage Function in Health and Disease'
31 October

Amée Buziau
Supervisors: Prof. M.C.G.J. Brouwers, Prof. C.D.A. Stehouwer Prof. C.G. Schalkwijk
Title: 'Combatting the Fructose Epidemic Fruitful or Fruitless?'
13 November

Sofia de la Puente Secades
Supervisors: Prof. L. Schurgers, Prof. J. Jankowski (RWTH Aachen University), Prof. Floege (RWTH Aachen University)
Title: 'Vascular calcification in chronic kidney disease: vitamin K deficiency and new mediators'
14 November

Dominique Verhaert
Supervisors: Prof. K. Vernooy, Prof. U. Schotten | Co-supervisors: Dr D.L. Linz, Dr R.J. Beukema (Radboud University)
Title: 'Integrating novel care approaches for atrial fibrillation patients undergoing ablation'
16 November

Uyen Chau Nguyen
Supervisors: Prof. F.W. Prinzen, Prof. K. Vernooy, Prof. A. Auricchio (Università della Svizzera Italiana), Prof. R. Krause (Università della Svizzera Italiana)
Title: 'Multi-modality imaging in Cardiac Resynchronization Therapy: In silico and in vivo analyses'
22 November

Bram Kremers
Supervisor: Dr H. Spronk | Co-supervisor: Dr A.J. ten Cate-Hoek, Dr B.M.E. Mees
Title: 'Defining atherothrombotic risk in peripheral artery disease'
24 November

Elena Caporali
Supervisors: Prof. Roberto Lorusso, Prof. Jos Maessen
Title: 'Assessment of different interventional treatments of aortic valve diseases'
6 December

Eva Harlacher
Supervisors: Prof. Erik Biessen, Prof. Joachim Jankowski, Prof. Lars Blank (RWTH Aachen University | Co-supervisor: Dr Heidi Noels
Title: 'Increased cardiovascular risk  in patients with chronic kidney disease:  Insight into mechanisms and mediators of kidney-heart crosstalk'
12 December

Mohamed Kassem
Supervisors: Prof. Eline Kooi, Prof. Robert van Oostenbrugge
Title: Intraplaque Hemorrhage on carotid MRI in stroke patients: on the road towards clinical application
13 December

Xiaodi Zhang
Supervisor: Prof. Casper Schalkwijk | Co-supervisor: Dr Kristiaan Wouters
TItle: 'Interplay of methylglyoxal and immune cells: implications for type 2 diabetes?'
13 December

Anne-Marije Hulshof
Supervisors: Prof. Yvonne Henskens, Prof. Hugo ten Cate | Co-supervisor: Dr Bas van Bussel
Title: 'Innovative applications of global assays of hemostasis'
15 December

Jennifer Monereo-Sánchez
Supervisors: Dr Miranda Schram, Prof. David Linden, Dr Jacobus Jansen
Title: 'Segmenting the human brain in population bases studies: Methodological considerations and clinical applications in diabetes, depression, and dementia'
18 December

Nikki Werkman
Supervisor: Prof. Coen Stehouwer | Co-supervisors: Dr Johanna Driessen, Dr Johannes Nielen
Title: 'Type 2 diabetes beyond glycaemic control: the impact of disease severity and therapy'
21 December

Ozan Yazar
Supervisor: Prof. Geert Willem Schurink | Co-supervisor: Dr Barend Mees
Title: 'Fenestrated and Branched Stent-grafts for Treatment of Complex Aortoiliac Aneurysms'
22 December