theses 2023

Rachel Schreurs
Supervisors: Dr A.J. ten Cate-Hoek, Dr M.A. Joore, Prof. H. ten Cate
Title: Towards improved organisation of care. Improving compression therapy for patients with DVT and CVD (CEAP3-5)
18 January

Sibel Altintas
Supervisors: Prof. H.J.G.M. Crijns, Prof. J.E. Wildberger | Co-supervisor: Dr B.L.J.H. Kietselaer
Title: Mechanisms of cardiovascular disease as defined by cardiac computed tomography
18 January

Mirko Belliato
Supervisors: Prof. R. Lorussa, Prof. J.G. Maessen
Title: The Use of Extracorporeal Life Support Systems in Patients with Acute Respiratory Insufficiency
19 January

William van Doorn
Supervisor: Prof. O. Bekers | Co-supervisor: Dr S.J.R. Meex
Title: Rethinking biomarkers. Innovations in laboratory medicine
20 January

Meike Ploeg
Supervisors: Prof. F.W. Prinzen, Dr F.A. van Nieuwenhoven
Title: Stretch, stiffness, sensing, signaling & speed. Mechanical activation of Cardiac Fibroblasts
24 January

Jana Hegenbarth
Supervisors: Prof. L. de Windt, Prof. M. Stoll 
Title: The transcriptomics of the ever-changing Heart: From Development to Senescence
1 February

Guiseppe Nasso
Supervisors: Prof. R. Lorusso, Prof. J. Maessen 
Title: Minimally Invasive Epicardial ablation for atrial fibrillation; From unipolar to hybrid bipolar treatment with a new treatment line
8 February

Anke Keijbeck
Supervisor: Prof. E. Biessen | Co-supervisors: Dr M. Christiaans, Dr C. Peutz Kootstra (Gelre Hospital, Apeldoorn)
Title: Protocol biopsies after kidney transplantation: emphasis on interstitial fibrosis/ tubular atrophy and peritubular capillary loss in relation to clinical parameters
14 February

Natalie Jooss
Supervisors: Prof. J. Heemskerk, Prof. Y. Henskens, Prof. S. Watson (University of Birmingham, UK) | Co-supervisor: Dr N. Poulter (University of Birmingham, UK)
Title: Targeting GPVI: impact of modulating platelet-collagen interactions on receptor signalling and thrombus formation
16 February

Marco Moscarelli
Supervisors: Prof. R. Lorusso, Prof. J. Maessen
Title: Advancements in Minimally Invasive Cardiac Surgery
18 February

Camilla Soragni
Supervisors: Prof. L.J. de Windt, Prof. P.A. da Costa Martins | Co-supervisor: Dr C. Ping Ng (MIMETAS BV Oestgeest)
Title: Next stop: screening-on-a-chip. Where biology meets scalability Development of assays for placenta-on-a-chip models
2 March
Alexandru Florea
Supervisors: Prof. F.M. Mottaghy, Prof. M.E. Kooi, Prof. L.J. Schurgers | Co-supervisor: Prof. J. Bucerius (RWTH Aachen University)
Title: Sodium [18F]Fluoride positron emission tomography for non-invasive identification of micro-calcifications as marker of atherosclerotic plaque vulnerability
8 March

Nicolò Mangraviti
Supervisors: Prof. L.J. de Windt, Prof. M. Stoll
Title: LncRNA Bigheart in cardiac disease and development
13 March

Renske Olie
Supervisors: Prof. H. ten Cate, Prof. J.M. ten Berg | Co-supervisor: Dr P.E.J. van der Meijden
Title: Personalized antithrombotic treatment in high-risk patients with coronary artery disease
20 March

Alexander Gombert
Supervisors: Prof. M.J. Jacobs, Dr B.M.E. Mees | Co-supervisor: Prof. G.W. Schurink
Title: Applications of new specific biomarkers for organ damage after open and endovascular thoracoabdominal aortic aneurysm surgery as model for more accurate perioperative patients’ surveillance
27 March

Isabella Provenzale
Supervisors: Prof. J.W.M. Heemskerk, Prof. J.M. Gibbins (University of Reading, UK) | Co-supervisors: Dr P.E.J. van der Meijden, Dr C.I. Jones (University of Reading, UK)
Title: The modulatory roles of collagen and endothelial cells on platelet function
28 March

Pieter Glerum
Supervisors: Prof. C. Neef, Prof. D.M. Burger (Radboud University) | Co-supervisor: Dr M. Maliepaard (College ter beoordeling van geneesmiddelen, Utrecht)
Title: Generic interchangeability: between science and regulation
29 March

Shunxin Jin
Supervisors: Dr M.M.J. van Greevenbroek, Prof. C.D.A. Stehouwer, Prof. C.G. Schalkwijk
Title: 'The alternative pathway of the complement system in vascular comorbidities of obesity and type 2 diabetes'
3 April

Renée Brüggemann
Supervisor: Prof. H. ten Cate | Co-supervisors: Dr A.J. ten Cate-Hoek, Dr B.P.A. Spaetgens
Title: Unraveling hypercoagulability in COVID-19 and optimizing VTE management in the frail nursing home population
4 April

Alicia Veninga
Supervisor: Dr J.W.M. Heemskerk | Co-supervisors: Dr P.E.J. van der Meijden, Dr C.C.F.M.J. Baaten
Title: Platelet heterogeneity: a colourful palette of populations
20 April

Tobias Meßmer
Supervisors: Prof. M.J. Post, Dr J.E. Flack
Title: Decoding cultured meat production. The transcriptomic landscape of bovine satellite cells in proliferation and differentiation
21 April

Stefano Navarro
Supervisors: Prof. J.W.M. Heemskerk, Prof. B. Nieswandt (University of Würzburg) | Co-supervisors: Dr M.J.E. Kuijpers, Dr H. Hermanns (University of Würzburg)
Title: Novel platelet glycoprotein VI and CLEC-2 targeting strategies: studies in humanized mouse models
25 April

Ilaria De Simone
Supervisors: Prof. H. ten Cate, Prof. J.M. Gibbins (University of Reading) | Co-supervisors: Dr P.E.J. van der Meijden, Dr C.I. Jones (University of Reading)
Title: Novel mechanisms of platelet activation and sustained signalling through GPVI and PAR1
26 April

Julia Wirth
Supervisors: Prof. E. Biessen, Prof. J. Jankowski (UM/University Hospital RWTH Aachen)
Co-supervisor: Dr H. Noels (UM/University Hospital RWTH Aachen)
Title: Uremia-induced effects on cardioregulatory mechanisms in the context of the cardiorenal syndrome
8 May

Yee Lai Lam, 9 May
Supervisor: Prof. C.H.A. Wittens, Prof. H. ten Cate
Title: Extending the frontiers beyond heat: Non-Thermal varicose vein treatments
9 May

Vishnu Suresh Babu
Supervisor: Prof. S.R.B. Heymans | Co-supervisor: Dr Arkasubhra Ghosh (Narayana Nethralaya Eye Hospital, Bangalore, India)
Title: Identification of metabolic dysregulation and transcriptional networks in retinoblastoma reveals novel therapeutic targets. Functional insights and novel therapeutic strategies using a correlative multi-omics approach
15 May

Nikolas Rapp
Supervisor: Prof. L. Schurgers | Co-supervisor: Dr A. Jaminon
Title: Chasing the perfect storm: Vascular calcification in chronic renocardiac syndrome
16 May

Anne Willers
Supervisors: Prof. R. Lorusso, Prof. J.G. Maessen | Co-supervisors: Dr J. Swol
Title: Bleeding-related conditions and complications in extracorporeal life support
25 May

Ard van Veelen
Supervisor: Prof. V.C.G. Tjan-Heijnen | Co-supervisors: Dr S. Croes, Dr P.C. Souverein (Utrecht University), Dr R.M.J.M. van Geel
Title: Treatment optimization in patients with non-small cell lung cancer
1 June

Alessandra Sala
Supervisors: Prof. R. Lorusso, Prof. J.G. Maessen | Co-supervisor: Prof. M. De Bonis (IRCCS, Vita-Salute San Raffaele University, Milan, Italy)
6 June

Delia Fernández de la Fuente
Supervisor: Prof. J.W.M. Heemskerk | Co-supervisors: Dr M. Kuijpers, Dr A. García (Universidade Santiago de Compostela)
Title: High throughput assessment of platelet signaling, function and inhibition
19 June