The eye disorder glaucoma is the leading cause of irreversible blindness. Vision loss results from degeneration of the optic nerve and loss of retinal ganglion cells, the specialized retinal neurons that transmit the visual information from the eye to the brain. Current state-of-the-art treatments often fail to halt the disease. While the pathophysiology is not known in detail, glaucoma certainly is a heterogeneous disorder. Thus, it is required to characterize patients extensively and to diversify and personalize the treatment.
The postdoc will help to build a glaucoma research center which employs biochemical analysis of blood and aqueous humor samples, and in vitro assays on patient cells to assess patients’ individual glaucoma profile. An important task of the postdoc will be to establish in vitro glaucoma models using cells of patients, including retinal cells derived from iPSCs. These in vitro models will be used to develop and select appropriate treatment options. The postdoc will work in a team of glaucoma specialists, senior scientists, PhDs and technicians.