Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2024
    • de Kok, J. W. T. M., van Bussel, B. C. T., Schnabel, R., van Herpt, T. T. W., Driessen, R. G. H., Meijs, D. A. M., Goossens, J. A., Mertens, H. J. M. M., van Kuijk, S. M. J., Wynants, L., van der Horst, I. C. C., & van Rosmalen, F. (2024). Table 0; documenting the steps to go from clinical database to research dataset. Journal of Clinical Epidemiology. Advance online publication. https://doi.org/10.1016/j.jclinepi.2024.111342
    • Aydeniz, E., van Bussel, B. C. T., de Jongh, S., Schellens, J., Heines, S. J. H., van Kuijk, S. M. J., Tas, J., van Rosmalen, F., van der Horst, I. C. C., Bergmans, D. C. J. J., & MaastrICCht Collaborators (2024). Serial electrical impedance tomography course in different treatment groups; The MaastrICCht cohort. Journal of Critical Care, 80, Article 154506. https://doi.org/10.1016/j.jcrc.2023.154506
    • Aydeniz, E., van Rosmalen, F., de Kok, J., Martens, B., Mingels, A. M. A., Canakci, M. E., Mihl, C., Vernooy, K., Prinzen, F. W., Wildberger, J. E., van der Horst, I. C. C., van Bussel, B. C. T., & Driessen, R. G. H. (2024). The association between coronary artery calcification and vectorcardiography in mechanically ventilated COVID-19 patients: the Maastricht Intensive Care COVID cohort. Intensive Care Medicine Experimental, 12(1), 26. https://doi.org/10.1186/s40635-024-00611-0
    • van der Knaap, N., Ariës, M. J. H., van der Horst, I. C. C., & Jansen, J. F. A. (2024). On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review. NeuroImage: Clinical, 42, Article 103589. https://doi.org/10.1016/j.nicl.2024.103589
    • van 't Hof, A. W. J., Delnoij, T. S. R., & van der Horst, I. C. C. (2024). Decision making in out-of-hospital cardiac arrest: what should come first?Netherlands Heart Journal, 32(3), 116-117. https://doi.org/10.1007/s12471-024-01856-w
    • Hesselink, G., Verhage, R., van der Horst, I. C. C., van der Hoeven, H., & Zegers, M. (2024). Consensus-based indicators for evaluating and improving the quality of regional collaborative networks of intensive care units: Results of a nationwide Delphi study. Journal of Critical Care, 79(1), Article 154440. https://doi.org/10.1016/j.jcrc.2023.154440
    • Heuts, S., van de Koolwijk, A. F., Gabrio, A., Ubben, J. F. H., van der Horst, I. C. C., Delnoij, T. S. R., Suverein, M. M., Maessen, J. G., Lorusso, R., & van de Poll, M. C. G. (2024). Extracorporeal life support in cardiac arrest: a post hoc Bayesian re-analysis of the INCEPTION trial. European Heart Journal: Acute Cardiovascular Care, 13(2), 191-200. Article zuad130. https://doi.org/10.1093/ehjacc/zuad130
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., ... van Royen, N. (2024). The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: A COACT Substudy. Journal of the Society for Cardiovascular Angiography and Interventions, 3(2), Article 101191. https://doi.org/10.1016/j.jscai.2023.101191
    • de Kok, J. W. T. M., van Rosmalen, F., Koeze, J., Keus, F., van Kuijk, S. M. J., Castela Forte, J., Schnabel, R. M., Driessen, R. G. H., van Herpt, T. T. W., Sels, J.-W. E. M., Bergmans, D. C. J. J., Lexis, C. P. H., van Doorn, W. P. T. M., Meex, S. J. R., Xu, M., Borrat, X., Cavill, R., van der Horst, I. C. C., & van Bussel, B. C. T. (2024). Deep embedded clustering generalisability and adaptation for integrating mixed datatypes: two critical care cohorts. Scientific Reports, 14(1), Article 1045. https://doi.org/10.1038/s41598-024-51699-z
    • Domensino, A.-F., Tas, J., Donners, B., Kooyman, J., van der Horst, I., Haeren, R., Aries, M., & Heugten, C. (2024). Long-Term Follow-Up of Critically Ill Patients With Traumatic Brain Injury: from intensive care parameters to patient and caregiver-reported outcome. Journal of Neurotrauma, 41(1-2), 123-134. https://doi.org/10.1089/neu.2022.0474
    • Simons, J., Di Mauro, M., Mariani, S., Ravaux, J., van der Horst, I. C. C., Driessen, R. G. H., Sels, J. W., Delnoij, T., Brodie, D., Abrams, D., Mueller, T., Taccone, F. S., Belliato, M., Broman, M. L., Malfertheiner, M. V., Boeken, U., Fraser, J., Wiedemann, D., Belohlavek, J., ... Lorusso, R. (2024). Bilateral Femoral Cannulation Is Associated With Reduced Severe Limb Ischemia-Related Complications Compared With Unilateral Femoral Cannulation in Adult Peripheral Venoarterial Extracorporeal Membrane Oxygenation: Results From the Extracorporeal Life Support Registry. Critical Care Medicine, 52(1), 80-91. https://doi.org/10.1097/CCM.0000000000006040
    • Ubben, J. F. H., Suverein, M. M., Delnoij, T. S. R., Heuts, S., Winkens, B., Gabrio, A., van der Horst, I. C. C., Maessen, J. G., Lorusso, R., van de Poll, M. C. G., & INCEPTION-investigators (2024). Early extracorporeal CPR for refractory out-of-hospital cardiac arrest - A pre-planned per-protocol analysis of the INCEPTION-trial. Resuscitation, 194, Article 110033. https://doi.org/10.1016/j.resuscitation.2023.110033
  • 2023
    • Mulder, M. M. G., Schellens, J., Sels, J.-W. E. M., van Rosmalen, F., Hulshof, A.-M., de Vries, F., Segers, R., Mihl, C., van Mook, W. N. K. A., Bast, A., Spronk, H. M. H., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Schurgers, L. J., Drent, M., & van Bussel, B. C. T. (2023). Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort. Journal of Intensive Care, 11(1), Article 63. https://doi.org/10.1186/s40560-023-00712-0
    • van Herpt, T. T. W., van Rosmalen, F., Hulsewé, H. P. M. G., van der Horst-Schrivers, A. N. A., Driessen, M., Jetten, R., Zelis, N., de Galan, B. E., van Kuijk, S. M. J., van der Horst, I. C. C., & van Bussel, B. C. T. (2023). Hyperglycemia and glucose variability are associated with worse survival in mechanically ventilated COVID-19 patients: the prospective Maastricht Intensive Care Covid Cohort. Diabetology & Metabolic Syndrome, 15(1), Article 253. https://doi.org/10.1186/s13098-023-01228-1
    • Wintjens, M. S. J. N., van Rosmalen, F., Hemmelder, M. H., Hulsewe-Evers, H. P. M. G., Kusters, Y. H. A. M., Ubben, J. F. H., van Renswouw, D. A. M., Gilissen, K. M. H., van der Horst, I. C. C., van Mook, W. N. K. A., & van Bussel, B. C. T. (2023). Prone positioning is followed by a transient decrease in glomerular filtration rate: the prospective Maastricht Intensive Care COVID cohort. Journal of Nephrology, 36(9), 2669-2671. https://doi.org/10.1007/s40620-023-01767-w
    • Mariani, S., Wang, I. W., van Bussel, B. C. T., Heuts, S., Wiedemann, D., Saeed, D., van der Horst, I. C. C., Pozzi, M., Loforte, A., Boeken, U., Samalavicius, R., Bounader, K., Hou, X., Bunge, J. J. H., Buscher, H., Salazar, L., Meyns, B., Herr, D., Matteucci, S., ... PELS-1 (PELS-1, Post-Cardiotomy Extracorporeal Life Support Study) Investigators (2023). The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation: A descriptive multicenter observational study. Journal of Thoracic and Cardiovascular Surgery, 166(6), 1670-1682.e33. Article 1670-1682.e33. https://doi.org/10.1016/j.jtcvs.2023.04.042
    • Mariani, S., Schaefer, A.-K., van Bussel, B. C. T., Di Mauro, M., Conci, L., Szalkiewicz, P., De Piero, M. E., Heuts, S., Ravaux, J., van der Horst, I. C. C., Saeed, D., Pozzi, M., Loforte, A., Boeken, U., Samalavicius, R., Bounader, K., Hou, X., Bunge, J. J. H., Buscher, H., ... PELS Investigators (2023). On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation. The Annals of thoracic surgery, 116(5), 1079-1089. https://doi.org/10.1016/j.athoracsur.2023.05.045
    • Heines, S. J. H., Becher, T. H., van der Horst, I. C. C., & Bergmans, D. C. J. J. (2023). Clinical Applicability of Electrical Impedance Tomography in Patient-Tailored Ventilation: A Narrative Review. TOMOGRAPHY, 9(5), 1903-1932. https://doi.org/10.3390/tomography9050150
    • Domensino, F., Tas, J., Donners, B., Kooyman, J., van der Horst, I., Haeren, R., Aries, M., & van Heugten, C. (2023). Long-term follow-up of critically ill traumatic brain injury patients: from intensive care parameters to patient and caregiver reported outcome. Brain Injury, 37, 148-148.
    • Stolk, R., Ellenbroek, D., Eijkenboom , J., Bergmans, D., & van der Horst, I. C. C. (2023). Na de opleiding aan het werk?De Intensivist, 190-194. https://de-intensivist.nl/na-de-opleiding-aan-het-werk/
    • Aydeniz, E., Weberndorfer, V., Brandts, L., Smulders, M. W., van Herpt, T. T. W., Martens, B., Vernooy, K., Linz, D., van der Horst, I. C. C., Wildberger, J. E., van Bussel, B. C. T., Driessen, R. G. H., & Mihl, C. (2023). Pericardial Fat Is Associated With Less Severe Multiorgan Failure Over Time in Patients With Coronavirus Disease-19: The Maastricht Intensive Care COVID Cohort. Journal of Thoracic Imaging. Advance online publication. https://doi.org/10.1097/RTI.0000000000000732
    • Schultinge, L., Hulshof, A. M., van Neerven, D., Mulder, M. M. G., Sels, J. W. E. M., Hulsewe, H. P. M. G., Kuiper, G. J. A. J. M., Olie, R. H., ten Cate, H., van der Horst, I. C. C., van Bussel, B. C. T., & Henskens, Y. M. C. (2023). Applications of rotational thromboelastometry in heparin monitoring in critical COVID-19 disease: Observations in the Maastricht Intensive Care COVID cohort. Thrombosis Update, 12(1), Article 100140. https://doi.org/10.1016/j.tru.2023.100140
    • Ubben, J. F. H., Heuts, S., Delnoij, T. S. R., Suverein, M. M., van de Koolwijk, A. F., van der Horst, I. C. C., Maessen, J. G., Bartos, J., Kavalkova, P., Rob, D., Yannopoulos, D., Belohlávek, J., Lorusso, R., & van de Poll, M. C. G. (2023). ECPR for refractory OHCA - lessons from 3 randomized controlled trials. The trialists´view. European Heart Journal: Acute Cardiovascular Care, 12(8), 540-547. Article zuad071. https://doi.org/10.1093/ehjacc/zuad071
    • de Kok, J. W. T. M., de la Hoz, M. Á. A., de Jong, Y., Brokke, V., Elbers, P. W. G., Thoral, P., Castillejo, A., Trenor, T., Castellano, J. M., Bronchalo, A. E., Merz, T. M., Faltys, M., Collaborator group, van der Horst, I. C. C., Xu, M., Celi, L. A., van Bussel, B. C. T., & Borrat, X. (2023). A guide to sharing open healthcare data under the General Data Protection Regulation. Scientific data, 10(1), Article 404. https://doi.org/10.1038/s41597-023-02256-2
    • Wilmes, N., Hendriks, C. W. E., Viets, C. T. A., Cornelissen, S. J. W. M., van Mook, W. N. K. A., Cox-Brinkman, J., Celi, L. A., Martinez-Martin, N., Gichoya, J. W., Watkins, C., Bakhshi-Raiez, F., Wynants, L., van der Horst, I. C. C., & van Bussel, B. C. T. (2023). Structural under-reporting of informed consent, data handling and sharing, ethical approval, and application of Open Science principles as proxies for study quality conduct in COVID-19 research: a systematic scoping review. BMJ Global Health, 8(5), Article e012007. https://doi.org/10.1136/bmjgh-2023-012007
    • Busch, M. H., Timmermans, S. A. M. E. G., Van Kuijk, S. M. J., Aendekerk, J. P., Ysermans, R., Van Doorn, D. P. C., Potjewijd, J., Van de Poll, M. C. G., Van der Horst, I. C. C., Damoiseaux, J. G. M. C., Spronk, H. M. H., Cate, H. T., Reutelingsperger, C. P., Nagy, M., & Van Paassen, P. (2023). Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19. Haematologica-the Hematology Journal, 108(5), 1417-1422. https://doi.org/10.3324/haematol.2022.281693
    • Klein, D. O., Moelans, B., Savelberg, W., van der Horst, I. C. C., Van Mook, W. N. K. A., & Rennenberg, R. J. M. W. (2023). COVID-19 pandemic: a qualitative study with an opportunity-centric approach from an ICU perspective in a teaching hospital. Upsides worth to secure?BMJ Open, 13(4), Article e065931. https://doi.org/10.1136/bmjopen-2022-065931
    • Hesselink, G., Verhage, R., Hoiting, O., Verweij, E., Janssen, I., Westerhof, B., Ambaum, G., van der Horst, I. C. C., de Jong, P., Postma, N., van der Hoeven, J. G., & Zegers, M. (2023). Time spent on documenting quality indicator data and associations between the perceived burden of documenting these data and joy in work among professionals in intensive care units in the Netherlands: a multicentre cross-sectional survey. BMJ Open, 13(3), Article e062939. https://doi.org/10.1136/bmjopen-2022-062939
    • Mariani, S., van Bussel, B. C. T., Ravaux, J. M., Roefs, M. M., De Piero, M. E., Di Mauro, M., Willers, A., Segers, P., Delnoij, T., van der Horst, I. C. C., Maessen, J., Lorusso, R., & Netherlands Heart Registration Cardiothoracic Surgery Registration Committee (2023). Variables associated with in-hospital and postdischarge outcomes after postcardiotomy extracorporeal membrane oxygenation: Netherlands Heart Registration Cohort. Journal of Thoracic and Cardiovascular Surgery, 165(3), 1127-1137.e14. https://doi.org/10.1016/j.jtcvs.2022.08.024
    • Kendall, H. J., van Kuijk, S. M., van der Horst, I. C., Dings, J. T., Aries, M. J., & Haeren, R. H. (2023). Difference between brain temperature and core temperature in severe traumatic brain injury: a systematic review. Journal of Neurosurgical Sciences, 67(1), 46-54. https://doi.org/10.23736/S0390-5616.21.05519-3
    • Al Ali, L., Groot, H. E., Assa, S., Lipsic, E., Hummel, Y. M., van Veldhuisen, D. J., Voors, A. A., van der Horst, I. C. C., Lam, C. S., & van der Harst, P. (2023). Predictors of adverse diastolic remodeling in non-diabetic patients presenting with ST-elevation myocardial infarction. BMC Cardiovascular disorders, 23(1), Article 44. https://doi.org/10.1186/s12872-023-03064-7
    • Heuts, S., Gollmann-Tepeköylü, C., Denessen, E. J. S., Olsthoorn, J. R., Romeo, J. L. R., Maessen, J. G., van 't Hof, A. W. J., Bekers, O., Hammarsten, O., Pölzl, L., Holfeld, J., Bonaros, N., van der Horst, I. C. C., Davidson, S. M., Thielmann, M., & Mingels, A. M. A. (2023). Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications. European Heart Journal, 44(2), 100-112. https://doi.org/10.1093/eurheartj/ehac604
    • de Jongh, S. A. M., Heines, S. J. H., de Jongh, F. H. C., Segers, R. P. J., van der Horst, I. C. C., van Bussel, B. C. T., & Bergmans, D. C. J. J. (2023). Regional peak flow as a novel approach to assess regional pulmonary mechanics by electrical impedance tomography: an observational validation study. Annals of translational medicine. Advance online publication. https://doi.org/10.21037/atm-22-3420
    • Volbeda, M., Oord, M., Koeze, J., Keus, E., van der Horst, I. C. C., & Franssen, C. F. M. (2023). Criteria for Continuous Kidney Replacement Therapy Cessation in ICU Patients. Blood Purification, 52(1), 32-40. https://doi.org/10.1159/000524180
    • Cox, E. G. M., Wiersema, R., Eck, R. J., Kaufmann, T., Granholm, A., Vaara, S. T., Møller, M. H., van Bussel, B. C. T., Snieder, H., Pleijhuis, R. G., van der Horst, I. C. C., & Keus, F. (2023). External Validation of Mortality Prediction Models for Critical Illness Reveals Preserved Discrimination but Poor Calibration. Critical Care Medicine, 51(1), 80-90. https://doi.org/10.1097/CCM.0000000000005712
  • 2022
    • Denessen, E. J., Heuts, S., Daemen, J. H., van Doorn, W. P., Vroemen, W. H., Sels, J.-W., Segers, P., Van't Hof, A. W., Maessen, J. G., Bekers, O., Van Der Horst, I. C., & Mingels, A. M. (2022). High-Sensitivity Cardiac Troponin I and T Kinetics Differ following Coronary Bypass Surgery: A Systematic Review and Meta-Analysis. Clinical Chemistry, 68(12), 1564-1575. Article hvac152. https://doi.org/10.1093/clinchem/hvac152
    • Tas, J., Czosnyka, M., van der Horst, I. C. C., Park, S., van Heugten, C., Sekhon, M., Robba, C., Menon, D. K., Zeiler, F. A., & Aries, M. J. H. (2022). Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury: A narrative review. Frontiers in physiology, 13, Article 1071161. https://doi.org/10.3389/fphys.2022.1071161
    • Meijs, D. A. M., van Kuijk, S. M. J., Wynants, L., Stessel, B., Mehagnoul-Schipper, J., Hana, A., Scheeren, C. I. E., Bergmans, D. C. J. J., Bickenbach, J., Vander Laenen, M., Smits, L. J. M., van der Horst, I. C. C., Marx, G., Mesotten, D., van Bussel, B. C. T., CoDaP Investigators, Mulder, M., Bels, J., Wilmes, N., ... Ghossein, C. (2022). Predicting COVID-19 prognosis in the ICU remained challenging: external validation in a multinational regional cohort. Journal of Clinical Epidemiology, 152, 257-268. https://doi.org/10.1016/j.jclinepi.2022.10.015
    • Ghossein-Doha, C., Wintjens, M. S. J. N., Janssen, E. B. N. J., Klein, D., Heemskerk, S. C. M., Asselbergs, F. W., Birnie, E., Bonsel, G. J., van Bussel, B. C. T., Cals, J. W. L., Ten Cate, H., Haagsma, J., Hemmen, B., van der Horst, I. C. C., Kietselaer, B. L. J. H., Klok, F. A., de Kruif, M. D., Linschoten, M., van Santen, S., ... van Kuijk, S. M. J. (2022). Prevalence, pathophysiology, prediction and health-related quality of life of long COVID: study protocol of the longitudinal multiple cohort CORona Follow Up (CORFU) study. BMJ Open, 12(11), Article e065142. https://doi.org/10.1136/bmjopen-2022-065142
    • Eck, R. J., van de Leur, J. J. C. M., Wiersema, R., Cox, E. G. M., Bult, W., Spanjersberg, A. J., van der Horst, I. C. C., Lukens, M. V., Gans, R. O. B., Meijer, K., & Keus, F. (2022). Trough anti-Xa activity after intermediate dose nadroparin for thrombosis prophylaxis in critically ill patients with COVID-19 and acute kidney injury. Scientific Reports, 12(1), Article 17408. https://doi.org/10.1038/s41598-022-21560-2
    • van de Berg, T. W., Mulder, M. M. G., Alnima, T., Nagy, M., van Oerle, R., Beckers, E. A. M., Hackeng, T. M., Hulshof, A. M., Sels, J. W. E. M., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Dutch COVID & Thrombosis Coalition (2022). Serial thrombin generation and exploration of alternative anticoagulants in critically ill COVID-19 patients: Observations from Maastricht Intensive Care COVID Cohort. Frontiers in Cardiovascular Medicine, 9, Article 929284. https://doi.org/10.3389/fcvm.2022.929284
    • Vos, M. E., Cox, E. G. M., Schagen, M. R., Hiemstra, B., Wong, A., Koeze, J., van der Horst, I. C. C., Wiersema, R., & SICS Study Group (2022). Right ventricular strain measurements in critically ill patients: an observational SICS sub-study. Annals of Intensive Care, 12(1), Article 92. https://doi.org/10.1186/s13613-022-01064-y
    • Ganushchak, Y. M., Kurniawati, E. R., van der Horst, I. C. C., van Kuijk, S. M. J., Weerwind, P. W., Lorusso, R., & Maessen, J. G. (2022). Patterns of oxygen debt repayment in cardiogenic shock patients sustained with extracorporeal life support: A retrospective study. Journal of Critical Care, 71, Article 154044. https://doi.org/10.1016/j.jcrc.2022.154044
    • Wolbrink, D. R. J., van de Poll, M. C. G., Termorshuizen, F., de Keizer, N. F., van der Horst, I. C. C., Schnabel, R., Dejong, C. H. C., van Santvoort, H. C., Besselink, M. G., van Goor, H., Bouwense, S. A. W., van Bussel, B. C. T., Dutch Pancreatitis Study Group, & Dutch National Intensive Care Evaluation (NICE) Collaborators (2022). Trends in Early and Late Mortality in Patients With Severe Acute Pancreatitis Admitted to ICUs: A Nationwide Cohort Study. Critical Care Medicine, 50(10), 1513-1521. https://doi.org/10.1097/CCM.0000000000005629
    • van der Horst, I. C. C. (2022). Forecast with eyes wide open – a perspective on the upcoming winter. Netherlands Journal of Critical Care, 30(5), 150-151.
    • Tas, J., Bos, K. D. J., le Feber, J., Beqiri, E., Czosnyka, M., Haeren, R., van der Horst, I. C. C., van Kuijk, S. M. J., Strauch, U., Brady, K. M., Smielewski, P., & Aries, M. J. H. (2022). Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury. Journal of Applied Physiology, 133(3), 585-592. https://doi.org/10.1152/japplphysiol.00199.2022
    • Heines, S. J. H., van Bussel, B. C. T., Jong, M. J. A., Bennis, F. C., van Gassel, R. J. J., Groven, R. V. M., Heijnen, N. F. L., Hermans, B. J. M., Hounjet, R., van Koll, J., Mulder, M. M. G., van de Poll, M. C. G., van Rosmalen, F., Segers, R., Steyns, S., Strauch, U., Tas, J., van der Horst, I. C. C., van Kuijk, S. M. J., & Bergmans, D. C. J. J. (2022). Pulmonary pathophysiology development of COVID-19 assessed by serial Electrical Impedance Tomography in the MaastrICCht cohort. Scientific Reports, 12(1), Article 14517. https://doi.org/10.1038/s41598-022-18843-z
    • Heines, S. J. H., de Jongh, S. A. M., Strauch, U., van der Horst, I. C. C., van de Poll, M. C. G., & Bergmans, D. C. J. J. (2022). The global inhomogeneity index assessed by electrical impedance tomography overestimates PEEP requirement in patients with ARDS: an observational study. BMC Anesthesiology, 22(1), Article 258. https://doi.org/10.1186/s12871-022-01801-7
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