Frits Prinzen

Professor

Frits Prinzen is professor of Physiology. He studied Medical Biology in Utrecht and defended his PhD in Maastricht in 1982. His research focusses on the relation between the electrical activation and mechanical contraction and pump function of the heart, with specific application to pacemaker therapies in heart failure. His work is highly translational, ranging from preclinical to clinical research and more recently also using computer simulations. Results from his work provided new insights in and opportunities for pacemaker therapies. He has participated in the CTMM-COHFAR consortium and has been and is workpackage leader in several EU-funded projects, including an International Training Network (Personalised in silico Cardiology). Several of his team members achieved personal grants (ZonMw Veni, Vidi, Clinical Fellow; Netherlands Heart Foundation junior and senior postdoc; young staff member). Besides, he ran multiple investigator-initiated studies that were funded by industry. He has been chairman of the Cardiovascular System Dynamics Society and of the Innovation Committee of the European Heart Rhythm Association (EHRA). Currently he is member of the Scientific Initiatives Committee of EHRA. He is (co-)author on 280 scientific articles, with 7740 citations and H-index of 50.

His main research topic is regional cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation. Primarily animal experimental work, but with important links to Biomedical Engineering (computer models of cardiac electrophysiology and mechanics) and Cardiology (patients with pacemakers, bundle branch block, heart failure). With this background Prof. Frits Prinzen is a world expert on pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 3881080
  • 2014
    • van Boxtel, A. G. M., Houthuizen, P., Hamad, M. A. S., Sjatskig, J., Tan, E., Prinzen, F. W., & van Straten, A. H. M. (2014). Postoperative Conduction Disorders after Implantation of the Self-Expandable Suture less Perceval S Bioprosthesis. Journal of Heart Valve Disease, 23(3), 319-324.
    • Sohal, M., Shetty, A., Niederer, S., Chen, Z., Jackson, T., Sammut, E., Bostock, J., Razavi, R., Prinzen, F., & Rinaldi, C. A. (2014). Delayed Trans-Septal Activation Results in Comparable Hemodynamic Effect of Left Ventricular and Biventricular Endocardial Pacing Insights From Electroanatomical Mapping. Circulation-Arrhythmia and Electrophysiology, 7(2), 251-258. https://doi.org/10.1161/CIRCEP.113.001152
    • Pluijmert, M., Bovendeerd, P. H. M., Kroon, W., Prinzen, F. W., & Delhaas, T. (2014). Effects of activation pattern and active stress development on myocardial shear in a model with adaptive myofiber reorientation. American Journal of Physiology-heart and Circulatory Physiology, 306(4), H538-H546. https://doi.org/10.1152/ajpheart.00571.2013
    • Houthuizen, P., van der Boon, R. M. A., Urena, M., Van Mieghem, N., Brueren, G. B. R., Poels, T. T., Van Garsse, L. A. F. M., Rodes-Cabau, J., Prinzen, F. W., & de Jaegere, P. (2014). Occurrence, fate and consequences of ventricular conduction abnormalities after transcatheter aortic valve implantation. Eurointervention, 9(10), 1142-1150. https://doi.org/10.4244/EIJV9I10A194
    • Ploux, S., Strik, M., van Hunnik, A., van Middendorp, L., Kuiper, M., & Prinzen, F. W. (2014). Acute electrical and hemodynamic effects of multisite left ventricular pacing for cardiac resynchronization therapy in the dyssynchronous canine heart. Heart Rhythm, 11(1), 119-125. https://doi.org/10.1016/j.hrthm.2013.10.018
    • van der Boon, R. M. A., Houthuizen, P., Nuis, R-J., van Mieghem, N. M., Prinzen, F., & de Jaegere, P. P. T. (2014). Clinical Implications of Conduction Abnormalities and Arrhythmias After Transcatheter Aortic Valve Implantation. Current Cardiology Reports, 16(1), [429]. https://doi.org/10.1007/s11886-013-0429-4
    • van Middendorp, L. B., Strik, M., Houthuizen, P., Kuiper, M., Maessen, J. G., Auricchio, A., & Prinzen, F. W. (2014). Electrophysiological and Hemodynamic Effects of Vernakalant and Flecainide During Cardiac Resynchronization in Dyssynchronous Canine Hearts. Journal of Cardiovascular Pharmacology, 63(1), 25-32. https://doi.org/10.1097/FJC.0000000000000020
    • Potse, M., Krause, D., Kroon, W., Murzilli, R., Muzzarelli, S., Regoli, F., Caiani, E., Prinzen, F., Krause, R., & Auricchio, A. (2014). Patient-specific modelling of cardiac electrophysiology in heart-failure patients. EP Europace, 16(S4), iv56–iv61. https://doi.org/10.1093/europace/euu257
    • van Deursen, C. J. M., Blaauw, Y., Witjens, M. I., Debie, L., Wecke, L., Crijns, H. J. G. M., Prinzen, F. W., & Vernooy, K. (2014). The value of the 12-lead ECG for evaluation and optimization of cardiac resynchronization therapy in daily clinical practice. Journal of Electrocardiology, 47(2), 202-211. https://doi.org/10.1016/j.jelectrocard.2014.01.007
  • 2013
    • Lumens, J., Ploux, S., Strik, M., Gorcsan, J. III., Cochet, H., Derval, N., Strom, M., Ramanathan, C., Ritter, P., Haissaguerre, M., Jais, P., Arts, T., Delhaas, T., Prinzen, F. W., & Bordachar, P. (2013). Comparative Electromechanical and Hemodynamic Effects of Left Ventricular and Biventricular Pacing in Dyssynchronous Heart Failure Electrical Resynchronization Versus Left-Right Ventricular Interaction. Journal of the American College of Cardiology, 62(25), 2395-2403. https://doi.org/10.1016/j.jacc.2013.08.715
    • Sohaib, S. M. A., Whinnett, Z. I., Ellenbogen, K. A., Stellbrink, C., Quinn, T. A., Bogaard, M. D., Bordachar, P., van Gelder, B. M., van Geldorp, I. E., Linde, C., Meine, M., Prinzen, F. W., Turcott, R. G., Spotnitz, H. M., Wichterle, D., Francis, D. P., & International Working Group on Quantitative Optimization: (2013). Cardiac resynchronisation therapy optimisation strategies: systematic classification, detailed analysis, minimum standards and a roadmap for development and testing. International Journal of Cardiology, 170(2), 118-31. https://doi.org/10.1016/j.ijcard.2013.10.069
    • Prinzen, F. W., Vernooy, K., & Auricchio, A. (2013). Cardiac Resynchronization Therapy State-of-the-Art of Current Applications, Guidelines, Ongoing Trials, and Areas of Controversy. Circulation, 128(22), 2407-2418. https://doi.org/10.1161/CIRCULATIONAHA.112.000112
    • Strik, M., van Middendorp, L. B., Houthuizen, P., Ploux, S., van Hunnik, A., Kuiper, M., Auricchio, A., & Prinzen, F. W. (2013). Interplay of electrical wavefronts as determinant of the response to cardiac resynchronization therapy in dyssynchronous canine hearts. Circulation. Arrhythmia and electrophysiology, 6(5), 924-31. https://doi.org/10.1161/CIRCEP.113.000753
    • Blaauw, E., Lorenzen-Schmidt, I., Babiker, F. A., Munts, C., Prinzen, F. W., Snoeckx, L. H., van Bilsen, M., van der Vusse, G. J., & van Nieuwenhoven, F. A. (2013). Stretch-Induced Upregulation of Connective Tissue Growth Factor in Rabbit Cardiomyocytes. Journal of Cardiovascular Translational Research, 6(5), 861-869. https://doi.org/10.1007/s12265-013-9489-5
    • Strik, M., van Deursen, C. J. M., van Middendorp, L. B., van Hunnik, A., Kuiper, M., Auricchio, A., & Prinzen, F. W. (2013). Transseptal Conduction as an Important Determinant for Cardiac Resynchronization Therapy, as Revealed by Extensive Electrical Mapping in the Dyssynchronous Canine Heart. Circulation-Arrhythmia and Electrophysiology, 6(4), 682-689. https://doi.org/10.1161/CIRCEP.111.000028
    • Cardinaels, E. P. M., Mingels, A. M. A., van Rooij, T., Collinson, P. O., Prinzen, F. W., & van Dieijen-Visser, M. P. (2013). Time-Dependent Degradation Pattern of Cardiac Troponin T Following Myocardial Infarction. Clinical Chemistry, 59(7), 1083-1090. https://doi.org/10.1373/clinchem.2012.200543
    • van Geldorp, I. E., Bordachar, P., Lumens, J., de Guillebon, M., Whinnett, Z. I., Prinzen, F. W., Haissaguerre, M., Delhaas, T., & Thambo, J-B. (2013). Acute hemodynamic benefits of biventricular and single-site systemic ventricular pacing in patients with a systemic right ventricle. Heart Rhythm, 10(5), 676-682. https://doi.org/10.1016/j.hrthm.2013.01.017
    • Wieneke, H., Rickers, S., Velleuer, J., Bruck, G., Bai, Z., Kocks, C., Grandjean, P-A., Lenihan, T., Jung, P., Erbel, R., Prinzen, F. W., & Kisker, E. (2013). Leadless pacing using induction technology: impact of pulse shape and geometric factors on pacing efficiency. EP Europace, 15(3), 453-459. https://doi.org/10.1093/europace/eus308
    • Janousek, J., van Geldorp, I. E., Krupickova, S., Rosenthal, E., Nugent, K., Tomaske, M., Fruh, A., Elders, J., Hiippala, A., Kerst, G., Gebauer, R. A., Kubus, P., Frias, P., Gabbarini, F., Clur, S-A., Nagel, B., Ganame, J., Papagiannis, J., Marek, J., ... Delhaas, T. (2013). Permanent Cardiac Pacing in Children: Choosing the Optimal Pacing Site A Multicenter Study. Circulation, 127(5), 613-623. https://doi.org/10.1161/CIRCULATIONAHA.112.115428
    • de Haan, J. J., Vermeulen Windsant, I. C., Lubbers, T., Hanssen, S. J., Hadfoune, M., Prinzen, F. W., Greve, J. W., & Buurman, W. A. (2013). Prevention of hemolysis-induced organ damage by nutritional activation of the vagal anti-inflammatory reflex*. Critical Care Medicine, 41(11), e361-367. https://doi.org/10.1097/CCM.0b013e31828e9262
  • 2012
    • Potse, M., Krause, D., Bacharova, L., Krause, R., Prinzen, F. W., & Auricchio, A. (2012). Similarities and differences between electrocardiogram signs of left bundle-branch block and left-ventricular uncoupling. EP Europace, 14, V33-V39. https://doi.org/10.1093/europace/eus272
    • Babiker, F. A., van Golde, J., Vanagt, W. Y., & Prinzen, F. W. (2012). Pacing Postconditioning: Impact of Pacing Algorithm, Gender, and Diabetes on Its Myocardial Protective Effects. Journal of Cardiovascular Translational Research, 5(5), 727-734. https://doi.org/10.1007/s12265-012-9390-7
    • Daubert, J-C., Saxon, L., Adamson, P. B., Auricchio, A., Berger, R. D., Beshai, J. F., Breithard, O., Brignole, M., Cleland, J. G. F., DeLurgio, D. B., Dickstein, K., Exner, D. V., Gold, M., Grimm, R. A., Hayes, D. L., Israel, C., Leclercq, C., Linde, C., Lindenfeld, J., ... Torp-Pedersen, C. T. (2012). 2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. EP Europace, 14(9), 1236-1286. https://doi.org/10.1093/europace/eus222
    • Daubert, J-C., Saxon, L., Adamson, P. B., Auricchio, A., Berger, R. D., Beshai, J. F., Breithard, O., Brignole, M., Cleland, J. G. F., DeLurgio, D. B., Dickstein, K., Exner, D. V., Gold, M., Grimm, R. A., Hayes, D. L., Israel, C., Leclercq, C., Linde, C., Lindenfeld, J., ... Zamorano, J. L. (2012). 2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Heart Rhythm, 9(9), 1524-1576. https://doi.org/10.1016/j.hrthm.2012.07.025
    • Houthuizen, P., Van Garsse, L. A. F. M., Poels, T. T., de Jaegere, P., van der Boon, R. M. A., Swinkels, B. M., ten Berg, J. M., van der Kley, F., Schalij, M. J., Baan, J. J., Cocchieri, R., Brueren, G. R. G., van Straten, A. H. M., den Heijer, P., Bentala, M., van Ommen, V., Kluin, J., Stella, P. R., Prins, M. H., ... Prinzen, F. W. (2012). Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. Circulation, 126(6), 720-728. https://doi.org/10.1161/CIRCULATIONAHA.112.101055
    • Gorcsan, J. III., & Prinzen, F. W. (2012). Understanding the cardiac substrate and the underlying physiology: Implications for individualized treatment algorithm. Heart Rhythm, 9(8), S18-S26. https://doi.org/10.1016/j.hrthm.2012.04.027
    • Lumens, J., Leenders, G. E., Cramer, M. J., De Boeck, B. W. L., Doevendans, P. A., Prinzen, F. W., & Delhaas, T. (2012). Mechanistic Evaluation of Echocardiographic Dyssynchrony Indices Patient Data Combined With Multiscale Computer Simulations. Circulation-Cardiovascular Imaging, 5(4), 491-499. https://doi.org/10.1161/CIRCIMAGING.112.973446
    • Svendsen, M., Prinzen, F. W., Das, M. K., Berwick, Z., Rybka, M., Tune, J. D., Combs, W., Berbari, E. J., & Kassab, G. S. (2012). Bi-ventricular pacing improves pump function only with adequate myocardial perfusion in canine hearts with pseudo-left bundle branch block. Experimental Biology and Medicine, 237(6), 644-651. https://doi.org/10.1258/ebm.2012.012023
    • van Deursen, C. J. M., Strik, M., Rademakers, L. M., van Hunnik, A., Kuiper, M., Wecke, L., Crijns, H. J. G. M., Vernooy, K., & Prinzen, F. W. (2012). Vectorcardiography as a Tool for Easy Optimization of Cardiac Resynchronization Therapy in Canine Left Bundle Branch Block Hearts. Circulation-Arrhythmia and Electrophysiology, 5(3), 544-552. https://doi.org/10.1161/CIRCEP.111.966358
    • Wecke, L., van Hunnik, A., Thompson, T., DiCarlo, L., Zdeblick, M., Auricchio, A., & Prinzen, F. W. (2012). Networked multielectrode left ventricular pacing lead for avoidance of phrenic nerve stimulation in a canine model. Heart Rhythm, 9(5), 789-795. https://doi.org/10.1016/j.hrthm.2011.11.052
    • Leenders, G. E., De Boeck, B. W. L., Teske, A. J., Meine, M., Bogaard, M. D., Prinzen, F. W., Doevendans, P. A., & Cramer, M. J. (2012). Septal Rebound Stretch is a Strong Predictor of Outcome After Cardiac Resynchronization Therapy. Journal of Cardiac Failure, 18(5), 404-412. https://doi.org/10.1016/j.cardfail.2012.02.001
    • Strik, M., Regoli, F., Auricchio, A., & Prinzen, F. (2012). Electrical and Mechanical Ventricular Activation During Left Bundle Branch Block and Resynchronization. Journal of Cardiovascular Translational Research, 5(2), 117-126. https://doi.org/10.1007/s12265-012-9351-1
    • Kuijpers, N. H. L., Hermeling, E., Bovendeerd, P. H. M., Delhaas, T., & Prinzen, F. W. (2012). Modeling Cardiac Electromechanics and Mechanoelectrical Coupling in Dyssynchronous and Failing Hearts. Journal of Cardiovascular Translational Research, 5(2), 159-169. https://doi.org/10.1007/s12265-012-9346-y
    • Prinzen, F. W., & Auricchio, A. (2012). The "Missing" Link Between Acute Hemodynamic Effect and Clinical Response. Journal of Cardiovascular Translational Research, 5(2), 188-195. https://doi.org/10.1007/s12265-011-9331-x
    • Strik, M., Rademakers, L. M., van Deursen, C. J. M., van Hunnik, A., Kuiper, M., Klersy, C., Auricchio, A., & Prinzen, F. W. (2012). Endocardial Left Ventricular Pacing Improves Cardiac Resynchronization Therapy in Chronic Asynchronous Infarction and Heart Failure Models. Circulation-Arrhythmia and Electrophysiology, 5(1), 191-200. https://doi.org/10.1161/CIRCEP.111.965814
    • Kalder, J., Keschenau, P., Hanssen, S. J. P., Greiner, A., Vermeulen Windsant, I. C., Kennes, L. N., Tolba, R., Prinzen, F. W., Buurman, W. A., Jacobs, M. J. H. M., & Koeppel, T. A. (2012). The impact of selective visceral perfusion on intestinal macrohemodynamics and microhemodynamics in a porcine model of thoracic aortic cross-clamping.Journal of Vascular Surgery, 56(1), 149-158. https://doi.org/10.1016/j.jvs.2011.11.126
    • Leenders, G. E., Lumens, J., Cramer, M. J., De Boeck, B. W. L., Doevendans, P. A., Delhaas, T., & Prinzen, F. W. (2012). Septal Deformation Patterns Delineate Mechanical Dyssynchrony and Regional Differences in Contractility Analysis of Patient Data Using a Computer Model. Circulation-Heart Failure, 5(1), 87-96. https://doi.org/10.1161/CIRCHEARTFAILURE.111.962704
    • Hermeling, E., Delhaas, T., Prinzen, F. W., & Kuijpers, N. H. L. (2012). Mechano-electrical feedback explains T-wave morphology and optimizes cardiac pump function: Insight from a multi-scale model. Progress in Biophysics & Molecular Biology, 110(2-3), 359-371. https://doi.org/10.1016/j.pbiomolbio.2012.07.008
  • 2011
    • van Geldorp, I. E., Delhaas, T., Gebauer, R. A., Frias, P., Tomaske, M., Friedberg, M. K., Tisma-Dupanovic, S., Elders, J., Fruh, A., Gabbarini, F., Kubus, P., Illikova, V., Tsao, S., Blank, A. C., Hiippala, A., Sluysmans, T., Karpawich, P., Clur, S-A., Ganame, X., ... Janousek, J. (2011). Impact of the permanent ventricular pacing site on left ventricular function in children: a retrospective multicentre survey. Heart, 97(24), 2051-2055. https://doi.org/10.1136/heartjnl-2011-300197
    • Bogaard, M. D., Houthuizen, P., Bracke, F. A., Doevendans, P. A., Prinzen, F. W., Meine, M., & van Gelder, B. M. (2011). Baseline left ventricular dP/dt(max) rather than the acute improvement in dP/dt(max) predicts clinical outcome in patients with cardiac resynchronization therapy. European journal of heart failure, 13(10), 1126-1132. https://doi.org/10.1093/eurjhf/hfr094
    • Foley, P. W. X., Chalil, S., Ratib, K., Smith, R., Prinzen, F., Auricchio, A., & Leyva, F. (2011). Fluoroscopic Left Ventricular Lead Position and the Long-Term Clinical Outcome of Cardiac Resynchronization Therapy. Pacing and Clinical Electrophysiology, 34(7), 785-797. https://doi.org/10.1111/j.1540-8159.2011.03114.x
    • Leyva, F., Foley, P. W. X., Chalil, S., Ratib, K., Smith, R. E. A., Prinzen, F., & Auricchio, A. (2011). Cardiac resynchronization therapy guided by late gadolinium-enhancement cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 13, 9. https://doi.org/10.1186/1532-429X-13-29
    • Strik, M., Ploux, S., Vernooy, K., & Prinzen, F. W. (2011). Cardiac Resynchronization Therapy - Refocus on the Electrical Substrate. Circulation Journal, 75(6), 1297-1304. https://doi.org/10.1253/circj.CJ-11-0356
    • van Geldorp, I. E., Vanagt, W. Y., Prinzen, F. W., & Delhaas, T. (2011). Chronic ventricular pacing in children: toward prevention of pacing-induced heart disease. Heart Failure Reviews, 16(3), 305-314. https://doi.org/10.1007/s10741-010-9207-1
    • Cornelussen, R. N., Splett, V., Klepfer, R. N., Stegemann, B., Kornet, L., & Prinzen, F. W. (2011). Electrical modalities beyond pacing for the treatment of heart failure. Heart Failure Reviews, 16(3), 315-325. https://doi.org/10.1007/s10741-010-9206-2
    • Prinzen, F. W., Vernooy, K., DeBoeck, B. W. L., & Delhaas, T. (2011). Mechano-energetics of the asynchronous and resynchronized heart. Heart Failure Reviews, 16(3), 215-224. https://doi.org/10.1007/s10741-010-9205-3
    • Kuijpers, N. H. L., Potse, M., van Dam, P. M., ten Eikelder, H. M. M., Verheule, S., Prinzen, F. W., & Schotten, U. (2011). Mechanoelectrical coupling enhances initiation and affects perpetuation of atrial fibrillation during acute atrial dilation. Heart Rhythm, 8(3), 429-436. https://doi.org/10.1016/j.hrthm.2010.11.020
    • Auricchio, A., & Prinzen, F. W. (2011). Non-Responders to Cardiac Resynchronization Therapy - The Magnitude of the Problem and the Issues. Circulation Journal, 75(3), 521-527. https://doi.org/10.1253/circj.CJ-10-1268
    • Klimusina, J., De Boeck, B. W. L., Leenders, G. E. H., Faletra, F. F., Prinzen, F., Averaimo, M., Pasotti, E., Klersy, C., Moccetti, T., & Auricchio, A. (2011). Redistribution of left ventricular strain by cardiac resynchronization therapy in heart failure patients. European journal of heart failure, 13(2), 186-194. https://doi.org/10.1093/eurjhf/hfq197
    • Hanssen, S. J. P., Lubbers, T., Hodin, C. M. I., Prinzen, F. W., Buurman, W. A., & Jacobs, M. J. H. M. (2011). Hemolysis results in impaired intestinal microcirculation and intestinal epithelial cell injury. World Journal of Gastroenterology, 17(2), 213-218. https://doi.org/10.3748/wjg.v17.i2.213