Frits Prinzen


Frits Prinzen is professor of Physiology. He studied Medical Biology in Utrecht and defended his PhD in Maastricht in 1982. His research focusses on the relation between the electrical activation and mechanical contraction and pump function of the heart, with specific application to pacemaker therapies in heart failure. His work is highly translational, ranging from preclinical to clinical research and more recently also using computer simulations. Results from his work provided new insights in and opportunities for pacemaker therapies. He has participated in the CTMM-COHFAR consortium and has been and is workpackage leader in several EU-funded projects, including an International Training Network (Personalised in silico Cardiology). Several of his team members achieved personal grants (ZonMw Veni, Vidi, Clinical Fellow; Netherlands Heart Foundation junior and senior postdoc; young staff member). Besides, he ran multiple investigator-initiated studies that were funded by industry. He has been chairman of the Cardiovascular System Dynamics Society and of the Innovation Committee of the European Heart Rhythm Association (EHRA). Currently he is member of the Scientific Initiatives Committee of EHRA. He is (co-)author on 280 scientific articles, with 7740 citations and H-index of 50.

His main research topic is regional cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation. Primarily animal experimental work, but with important links to Biomedical Engineering (computer models of cardiac electrophysiology and mechanics) and Cardiology (patients with pacemakers, bundle branch block, heart failure). With this background Prof. Frits Prinzen is a world expert on pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 3881080
  • 2011
    • van Geldorp, I. E., Delhaas, T., Hermans, B., Vernooy, K., Broers, B., Klimusina, J., Regoli, F., Faletra, F. F., Moccetti, T., Gerritse, B., Cornelussen, R., Settels, J. J., Crijns, H. J. G. M., Auricchio, A., & Prinzen, F. W. (2011). Comparison of a non-invasive arterial pulse contour technique and echo Doppler aorta velocity-time integral on stroke volume changes in optimization of cardiac resynchronization therapy. EP Europace, 13(1), 87-95.
    • Bacharova, L., Mateasik, A., Krause, R., Prinzen, F. W., Auricchio, A., & Potse, M. (2011). The effect of reduced intercellular coupling on electrocardiographic signs of left ventricular hypertrophy. Journal of Electrocardiology, 44(5), 571-576.
  • 2010
    • Blaauw, E., van Nieuwenhoven, F. A., Willemsen, P., Delhaas, T., Prinzen, F. W., Snoeckx, L. H., van Bilsen, M., & van der Vusse, G. J. (2010). Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes. American Journal of Physiology-heart and Circulatory Physiology, 299(3), H780-H787.
    • De Boeck, B. W. L., Teske, A. J., Leenders, G. E., Hoesein, F. A. A. M., Loh, P., van Driel, V. J., Doevendans, P. A., Prinzen, F. W., & Cramer, M. J. (2010). Detection and Quantification by Deformation Imaging of the Functional Impact of Septal Compared to Free Wall Preexcitation in the Wolff-Parkinson-White Syndrome. American Journal of Cardiology, 106(4), 539-546.
    • Rademakers, L. M., van Kerckhoven, R., van Deursen, C. J. M., Strik, M., van Hunnik, A., Kuiper, M., Lampert, A., Klersy, C., Leyva, F., Auricchio, A., Maessen, J. G., & Prinzen, F. W. (2010). Myocardial Infarction Does Not Preclude Electrical and Hemodynamic Benefits of Cardiac Resynchronization Therapy in Dyssynchronous Canine Hearts. Circulation-Arrhythmia and Electrophysiology, 3(4), 361-368.
    • Babiker, F. A., Lorenzen-Schmidt, I., Mokelke, E., Vanagt, W. Y., Delhaas, T., Waltenberger, J., Cleutjens, J. P., & Prinzen, F. W. (2010). Long-term protection and mechanism of pacing-induced postconditioning in the heart. Basic Research in Cardiology, 105(4), 523-533.
    • Arts, T., Prinzen, F. W., Delhaas, T., Milles, J. R., Rossi, A. C., & Clarysse, P. (2010). Mapping Displacement and Deformation of the Heart With Local Sine-Wave Modeling. Ieee Transactions on Medical Imaging, 29(5), 1114-1123.
    • Porciani, C. M., Lilli, A., Cappelli, F., Pappone, A., Perini, A. P., Pieragnoli, P., Ricciardi, G., Rao, C. M., Prinzen, F. W., Michelucci, A., & Padeletti, L. (2010). Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy. Journal of Cardiovascular Medicine, 11(3), 157-163.
    • van Geldorp, I. E., Vernooy, K., Delhaas, T., Prins, M. H., Crijns, H. J., Prinzen, F. W., & Dijkman, B. (2010). Beneficial effects of biventricular pacing in chronically right ventricular paced patients with mild cardiomyopathy. EP Europace, 12(2), 223-229.
  • 2009
    • Driesen, R. B., Verheyen, F. K., Schaart, G., de Maziere, A., Viebahn, C., Prinzen, F. W., Lenders, M. H., Debie, W., Totzeck, A., Borgers, M., & Ramaekers, F. C. (2009). Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation. Cardiovascular Pathology, 18(1), 19-27.
  • 2006
    • Sen, S., Rose, C., Ytrebo, L. M., Davies, N. A., Nedredal, G. I., Drevland, S. S., Kjonno, M., Prinzen, F. W., Hodges, S. J., Deutz, N. E. P., Williams, R., Butterworth, R. F., Revhaug, A., & Jalan, R. A. (2006). Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Critical Care Medicine, 34(1), 158-164.
    • Ytrebo, L. M., Sen, S., Rose, C., Davies, N. A., Nedredal, G. I., Fuskevaag, O. M., ten Have, G. A. M., Prinzen, F. W., Williams, R., Deutz, N. E., Jalan, R., & Revhaug, A. (2006). Systemic and regional haemodynamics in pigs with acute liver failure and the effect of albumin dialysis. Scandinavian Journal of Gastroenterology, 41(11), 1350-1360.