Tammo Delhaas

Professor

Tammo Delhaas is Pediatric Cardiologist and Professor of Biomedical Engineering. He obtained his MD at the University of Groningen and received his PhD degree from Maastricht University in 1993 for a thesis on cardiac mechanics. After his training in Pediatrics in Maastricht and Utrecht, he received a Fulbright grant/ICIN-Fellowship and spent one year at the Departments of Bioengineering and Medicine from the UCSD. Thereafter, he trained in Pediatric Cardiology in Aachen and Melbourne. In 2000, he returned to Maastricht as Pediatric Cardiologist and continued his research on the crossroads of (Pediatric) Cardiology, Physiology and Biomedical Engineering. In 2009, he was appointed Professor and Chair of Biomedical Engineering at Maastricht University, where he is involved in projects related to cellular and cardiac mechanics, cardiac pacing, and mathematical modeling of the heart and circulation.

Prof. Tammo Delhaas is heading the CardioVascular System Dynamics Research Group (CVSDRG). With clinical questions regarding (congenital) heart diseases in mind, his research focusses on asynchronous electrical activation, vascular and myocardial structure-function relation, and computer model-assisted diagnosis and treatment of cardiac failure, pulmonary hypertension and congenital heart diseases. Besides standard expertise, CVSDRG uses following techniques/models in which it has expertise of extraordinary quality according to international standards: 1) CircAdapt, a lumped parameter mathematical model of the human heart and circulation that enables real-time simulation of cardiovascular system dynamics in a wide variety of physiological and pathophysiological situations (www.circadapt.org); 2) Finite Element Model of the heart with left and right ventricle, simulating local stress and strain as a function of time with emphasis on adaptation of wall anatomy to local mechanical load; 3) Pulse Wave Propagation and Computational Fluid Dynamics models that predict pressure and flow waveforms after vascular interventions, such as Arterio-Venous Fistula creation for hemodialysis. Prof. Tammo Delhaas serves as a reviewer or member of the editorial board of many journals, and has received grants from, amongst others, the Dutch Heart Foundation, Maastricht UMC+, Province of Limburg, NWO, European Research Council, and the Interuniversity Cardiology Institute of the Netherlands (ICIN).

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.366
T:+31(0)43 388 16 67

  • 2021
    • Shahmohammadi, M., Luo, H., Westphal, P., Cornelussen, R. N., Prinzen, F. W., & Delhaas, T. (2021). Hemodynamics-driven mathematical model of first and second heart sound generation. PLoS Computational Biology, 17(9), Article e1009361. https://doi.org/10.1371/journal.pcbi.1009361
    • Stevens, R. R. F., Gommer, E. D., Aries, M. J. H., Ertl, M., Mess, W. H., Huberts, W., & Delhaas, T. (2021). Optic nerve sheath diameter assessment by neurosonology: A review of methodologic discrepancies. Journal of Neuroimaging, 31(5), 814-825. https://doi.org/10.1111/jon.12906
    • Vroomen, M., van Rosmalen, F., Schroeder, J., Philippens, S., Delhaas, T., Crijns, H. J., & Pison, L. (2021). Ten-year follow-up after endocardial point-by-point cryoablation for paroxysmal atrial fibrillation. Acta Cardiologica, 76(4), 425-430. https://doi.org/10.1080/00015385.2020.1756087
    • van der Bruggen, M., Spronck, B., Bos, S., Heusinkveld, M. H. G., Taddei, S., Ghiadoni, L., Delhaas, T., Bruno, R. M., & Reesink, K. D. (2021). Pressure-corrected carotid stiffness and Young's modulus: evaluation in an outpatient clinic setting. American Journal of Hypertension, 34(7), 737-743. https://doi.org/10.1093/ajh/hpab028
    • Parikh, S., Ganizada, B., Debeij, G., Natour, E., Maessen, J., Spronck, B., Schurgers, L., Delhaas, T., Huberts, W., Bidar, E., & Reesink, K. (2021). Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta. Biomedicines, 9(6), Article 670. https://doi.org/10.3390/biomedicines9060670
    • ter Meulen, K. J., Hermans, B. J. M., van der Sande, F. M., Canaud, B., Konings, C. J. A. M., Kooman, J. P., & Delhaas, T. (2021). Effect of citric-acid dialysate on the QTC-interval. Scientific Reports, 11(1), Article 9909. https://doi.org/10.1038/s41598-021-89083-w
    • van Rosmalen, F., Delhaas, T., Dagres, N., Arbelo, E., Blomstrom-Lundqvist, C., Crijns, H. J. G. M., Da Costa, A., Pytkowski, M., Sharikov, N., Laroche, C., Tavazzi, L., Brugada, J., Pison, L., & ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry investigators (2021). Adenosine usage during AF ablation in Europe and selected long-term findings from the ESC-EHRA EORP Atrial Fibrillation Ablation Long-Term registry. Journal of Interventional Cardiac Electrophysiology, 60(3), 395-406. https://doi.org/10.1007/s10840-020-00744-8
    • Vink, A. S., Hermans, B. J. M., Pimenta, J., Peltenburg, P. J., Filippini, L. H. P. M., Hofman, N., Clur, S.-A. B., Blom, N. A., Wilde, A. A. M., Delhaas, T., & Postema, P. G. (2021). Diagnostic accuracy of the response to the brief tachycardia provoked by standing in children suspected for long QT syndrome. Heart Rhythm O2, 2(2), 149-159. https://doi.org/10.1016/j.hroo.2021.03.005
    • van Rosmalen, F., Maesen, B., van Hunnik, A., Hermans, B. J. M., Bonizzi, P., Bidar, E., Nijs, J., Maessen, J. G., Verheule, S., Delhaas, T., Schotten, U., & Zeemering, S. (2021). Incidence, prevalence, and trajectories of repetitive conduction patterns in human atrial fibrillation. EP Europace, 23(Supplement_1), i123-i132. https://doi.org/10.1093/europace/euaa403
    • Heusinkveld, M. H. G., Holtackers, R. J., Adriaans, B. P., Op't Roodt, J., Arts, T., Delhaas, T., Reesink, K. D., & Huberts, W. (2021). Complementing sparse vascular imaging data by physiological adaptation rules. Journal of Applied Physiology, 130(3), 571-588. https://doi.org/10.1152/japplphysiol.00250.2019
    • Verzaal, N. J., Masse, S., Downar, E., Nanthakumar, K., Delhaas, T., & Prinzen, F. W. (2021). Exploring the cause of conduction delays in patients with repaired Tetralogy of Fallot. EP Europace, 23, I105-I112. https://doi.org/10.1093/europace/euaa400
    • van Osta, N., Kirkels, F., Lyon, A., Koopsen, T., van Loon, T., Cramer, M.-J., Teske, A. J., Delhaas, T., & Lumens, J. (2021). Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations. EP Europace, 23, I153-I160. https://doi.org/10.1093/europace/euaa407
    • Hermans, B. J. M., Zink, M. D., van Rosmalen, F., Crijns, H. J. G. M., Vernooy, K., Postema, P., Pison, L., Schotten, U., & Delhaas, T. (2021). Pulmonary vein isolation in a real-world population does not influence QTc interval. EP Europace, 23, I48-I54. https://doi.org/10.1093/europace/euaa390
    • Widowski, H., Reynaert, N. L., Ophelders, D. R. M. G., Hütten, M. C., Nikkels, P. G. J., Severens-Rijvers, C. A. H., Cleutjens, J. P. M., Kemp, M. W., Newnham, J. P., Saito, M., Usuda, H., Payne, M. S., Jobe, A. H., Kramer, B. W., Delhaas, T., & Wolfs, T. G. A. M. (2021). Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells. Frontiers in medicine, 8, Article 614239. https://doi.org/10.3389/fmed.2021.614239
    • Quicken, S., Delhaas, T., Mees, B. M. E., & Huberts, W. (2021). Haemodynamic optimisation of a dialysis graft design using a global optimisation approach. International Journal for Numerical Methods in Biomedical Engineering, 37(2), Article e3423. https://doi.org/10.1002/cnm.3423
    • van der Bruggen, M. M., Reesink, K. D., Spronck, P. J. M., Bitsch, N., Hameleers, J., Megens, R. T. A., Schalkwijk, C. G., Delhaas, T., & Spronck, B. (2021). An integrated set-up for ex vivo characterisation of biaxial murine artery biomechanics under pulsatile conditions. Scientific Reports, 11(1), Article 2671. https://doi.org/10.1038/s41598-021-81151-5
    • Bennis, F. C., Andriessen, P., van Pul, C., Kramer, B. W., & Delhaas, T. (2021). Ratio of arterial blood pressures at borders of window surrounding systolic peak indicates patent ductus arteriosus in preterm infants. Physiological Measurement, 42(1), Article 015005. https://doi.org/10.1088/1361-6579/abd5aa
    • Spronck, B., Tan, I., Reesink, K. D., Georgevsky, D., Delhaas, T., Avolio, A. P., & Butlin, M. (2021). Heart rate and blood pressure dependence of aortic distensibility in rats: comparison of measured and calculated pulse wave velocity. Journal of Hypertension, 39(1), 117-126. https://doi.org/10.1097/HJH.0000000000002608
    • Luo, H., Westphal, P., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Cornelussen, R. N., Delhaas, T., & Prinzen, F. W. (2021). Second heart sound splitting as an indicator of interventricular mechanical dyssynchrony using a novel splitting detection algorithm. Physiological Reports, 9(1), e14687. Article 14687. https://doi.org/10.14814/phy2.14687
    • Stevens, R. R. F., Huberts, W., Gommer, E. D., Ertl, M., Aries, M., Mess, W. H., & Delhaas, T. (2021). An Automated Algorithm for Optic Nerve Sheath Diameter Assessment from B-mode Ultrasound Images. Journal of Neuroimaging, 31(4), 724–732. https://doi.org/10.1111/jon.12851
  • 2020
    • Corral-Acero, J., Margara, F., Marciniak, M., Rodero, C., Loncaric, F., Feng, Y., Gilbert, A., Fernandes, J. F., Bukhari, H. A., Wajdan, A., Martinez, M. V., Santos, M. S., Shamohammdi, M., Luo, H., Westphal, P., Leeson, P., DiAchille, P., Gurev, V., Mayr, M., ... Lamata, P. (2020). The 'Digital Twin' to enable the vision of precision cardiology. European Heart Journal, 41(48), 4556-4564. https://doi.org/10.1093/eurheartj/ehaa159
    • Zeemering, S., van Hunnik, A., van Rosmalen, F., Bonizzi, P., Scaf, B., Delhaas, T., Verheule, S., & Schotten, U. (2020). A Novel Tool for the Identification and Characterization of Repetitive Patterns in High-Density Contact Mapping of Atrial Fibrillation. Frontiers in physiology, 11, Article 570118. https://doi.org/10.3389/fphys.2020.570118
    • Bennis, F. C., Teeuwen, B., Zeiler, F. A., Elting, J. W., van der Naalt, J., Bonizzi, P., Delhaas, T., & Aries, M. J. (2020). Improving Prediction of Favourable Outcome After 6 Months in Patients with Severe Traumatic Brain Injury Using Physiological Cerebral Parameters in a Multivariable Logistic Regression Model. Neurocritical Care, 33(2), 542-551. https://doi.org/10.1007/s12028-020-00930-6
    • Sawo, P., Moufarrej, A., Sloff, M., Snoeijs, M. G., Delhaas, T., Tordoir, J. H. M., & Mees, B. M. E. (2020). The Effect of Geometric Graft Modification on Arteriovenous Graft Patency in Haemodialysis Patients: A Systematic Review and Meta-Analysis. European Journal of Vascular and Endovascular Surgery, 60(4), 568-577. https://doi.org/10.1016/j.ejvs.2020.06.023
    • Lyon, A., Dupuis, L. J., Arts, T., Crijns, H. J. G. M., Prinzen, F. W., Delhaas, T., Heijman, J., & Lumens, J. (2020). Differentiating the effects of β-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. American Journal of Physiology-heart and Circulatory Physiology, 319(3), H519-H530. https://doi.org/10.1152/ajpheart.00275.2020
    • Shenthar, J., Singh, B., Banavalikar, B., Chakali, S. S., Delhaas, T., Shivkumar, K., & Bradfield, J. S. (2020). Cardiac perforation complicating cardiac electrophysiology procedures: value of angiography and use of a closure device to avoid cardiac surgery. Journal of Interventional Cardiac Electrophysiology, 58(2), 193-201. https://doi.org/10.1007/s10840-019-00577-0
    • Zonnebeld, N., Tordoir, J. H. M., van Loon, M. M., de Smet, A. A. E. A., Huisman, L. C., Cuypers, P. W. M., Schlosser, F. J., Lemson, S., Heinen, S. G. H., Bouwman, L. H., Toorop, R. J., Huberts, W., Delhaas, T., & Shunt Simulation Study Group (2020). Pre-operative Patient Specific Flow Predictions to Improve Haemodialysis Arteriovenous Fistula Maturation (Shunt Simulation Study): A Randomised Controlled Trial. European Journal of Vascular and Endovascular Surgery, 60(1), 98-106. https://doi.org/10.1016/j.ejvs.2020.03.005
    • Bol, M. E., Beurskens, D. M. H., Delnoij, T. S. R., Roekaerts, P. M. H. J., Reutelingsperger, C. P. M., Delhaas, T., van de Poll, M. C. G., Sels, J.-W. E. M., & Nicolaes, G. A. F. (2020). Variability of Microcirculatory Measurements in Critically Ill Patients. Shock, 54(1), 9-14. https://doi.org/10.1097/SHK.0000000000001470
    • Clayton, R. H., Aboelkassem, Y., Cantwell, C. D., Corrado, C., Delhaas, T., Huberts, W., Lei, C. L., Ni, H. B., Panfilov, A. V., Roney, C., & dos Santos, R. W. (2020). An audit of uncertainty in multi-scale cardiac electrophysiology models. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173), Article 20190335. https://doi.org/10.1098/rsta.2019.0335
    • Lei, C. L., Ghosh, S., Whittaker, D. G., Aboelkassem, Y., Beattie, K. A., Cantwell, C. D., Delhaas, T., Houston, C., Novaes, G. M., Panfilov, A. V., Pathmanathan, P., Riabiz, M., dos Santos, R. W., Walmsley, J., Worden, K., Mirams, G. R., & Wilkinson, R. D. (2020). Considering discrepancy when calibrating a mechanistic electrophysiology model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173), Article 20190349. https://doi.org/10.1098/rsta.2019.0349
    • Niederer, S. A., Aboelkassem, Y., Cantwell, C. D., Corrado, C., Coveney, S., Cherry, E. M., Delhaas, T., Fenton, F. H., Panfilov, A. V., Pathmanathan, P., Plank, G., Riabiz, M., Roney, C. H., dos Santos, R. W., & Wang, L. (2020). Creation and application of virtual patient cohorts of heart models. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173), Article 20190558. https://doi.org/10.1098/rsta.2019.0558
    • van Osta, N., Lyon, A., Kirkels, F., Koopsen, T., van Loon, T., Cramer, M. J., Teske, A. J., Delhaas, T., Huberts, W., & Lumens, J. (2020). Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173), Article 20190347. https://doi.org/10.1098/rsta.2019.0347
    • Beurskens, D. M. H., Bol, M. E., Delhaas, T., van de Poll, M. C. G., Reutelingsperger, C. P. M., Nicolaes, G. A. F., & Sels, J.-W. E. M. (2020). Decreased endothelial glycocalyx thickness is an early predictor of mortality in sepsis. Anaesthesia and Intensive Care, 48(3), 221-228. https://doi.org/10.1177/0310057X20916471
    • Hermans, B. J. M., Bennis, F. C., Vink, A. S., Koopsen, T., Lyon, A., Wilde, A. A. M., Nuyens, D., Robyns, T., Pison, L., Postema, P. G., & Delhaas, T. (2020). Improving long QT syndrome diagnosis by a polynomial-based T-wave morphology characterization. Heart Rhythm, 17(5), 752-758. https://doi.org/10.1016/j.hrthm.2019.12.020
    • Lempersz, C., van Laar, J. O., Clur, S.-A. B., Verdurmen, K. M., Warmerdam, G. J., van der Post, J., Blom, N. A., Delhaas, T., Oei, S. G., & Vullings, R. (2020). The standardized 12-lead fetal electrocardiogram of the healthy fetus in mid-pregnancy: A cross-sectional study. PLOS ONE, 15(4), Article 0232606. https://doi.org/10.1371/journal.pone.0232606
    • Quicken, S., de Bruin, Y., Mees, B., Tordoir, J., Delhaas, T., & Huberts, W. (2020). Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts. Biomechanics and modeling in mechanobiology, 19(2), 713-722. https://doi.org/10.1007/s10237-019-01242-1
    • Stevens, R. R. F., Donders, W. P., Quicken, S., van de Vosse, F. N., Mess, W. H., Delhaas, T., & Huberts, W. (2020). The Role of One-Dimensional Model-Generated Inter-Subject Variations in Systemic Properties on Wall Shear Stress Indices of Intracranial Aneurysms. Ieee Transactions on Biomedical Engineering, 67(4), 1030-1039. https://doi.org/10.1109/TBME.2019.2928416
    • Walavalkar, V., Maiya, S., Pujar, S., Ramachandra, P., Siddaiah, S., Spronck, B., Vanagt, W. Y., & Delhaas, T. (2020). Percutaneous Device Closure of Congenital Isolated Ventricular Septal Defects: A Single-Center Retrospective Database Study Amongst 412 Cases. Pediatric Cardiology, 41(3), 591-598. https://doi.org/10.1007/s00246-020-02315-0
    • Quicken, S., Huberts, W., Tordoir, J., van Loon, M., Delhaas, T., & Mees, B. (2020). Computational Modelling Based Recommendation on Optimal Dialysis Needle Positioning and Dialysis Flow in Patients With Arteriovenous Grafts. European Journal of Vascular and Endovascular Surgery, 59(2), 288-294. https://doi.org/10.1016/j.ejvs.2019.08.013
    • Zonnebeld, N., Huberts, W., van Loon, M. M., Delhaas, T., & Tordoir, J. H. M. (2020). Natural Vascular Remodelling After Arteriovenous Fistula Creation in Dialysis Patients With and Without Previous Ipsilateral Vascular Access. European Journal of Vascular and Endovascular Surgery, 59(2), 277-287. https://doi.org/10.1016/j.ejvs.2019.10.010
    • Heinen, S., Gashi, K., van den Heuvel, D., de Vries, J.-P., van de Vosse, F., Delhaas, T., & Huberts, W. (2020). A Metamodeling Approach for Instant Severity Assessment and Uncertainty Quantification of Iliac Artery Stenoses. Journal of Biomechanical Engineering-Transactions of the Asme, 142(1), Article 011010. https://doi.org/10.1115/1.4044502
    • van Loon, T., Knackstedt, C., Cornelussen, R., Reesink, K., Brunner-La Rocca, H., Delhaas, T., van Empel, V., & Lumens, J. (2020). Increased myocardial stiffness more than impaired relaxation function limits cardiac performance during exercise in heart failure with preserved ejection fraction: a virtual patient study. European Heart Journal - Digital Health, 1(1), 40-50. https://doi.org/10.1093/ehjdh/ztaa009
  • 2019
    • Hulsenboom, A. D. J., Warmerdam, G. J. J., Weijers, J., Blijham, P. J., Oei, S. G., van Laar, J. O. E. H., Vullings, R., & Delhaas, T. (2019). Head orientation and electrode placement potentially influence fetal scalp ECG waveform. PLOS ONE, 14(10), Article e0223282. https://doi.org/10.1371/journal.pone.0223282
    • Polavarapu, K., Preethish-Kumar, V., Sekar, D., Vengalil, S., Nashi, S., Mahajan, N. P., Thomas, P. T., Sadasivan, A., Warrier, M., Gupta, A., Arunachal, G., Debnath, M., Keerthipriya, M. S., Pradeep-Chandra-Reddy, C., Puttegowda, A., John, A. P., Tavvala, A., Gunasekaran, S., Sathyaprabha, T. N., ... Nalini, A. (2019). Mutation pattern in 606 Duchenne muscular dystrophy children with a comparison between familial and non-familial forms: a study in an Indian large single-center cohort. Journal of Neurology, 266(9), 2177-2185. https://doi.org/10.1007/s00415-019-09380-3
    • Delhaas, T., Andriessen, P., van Laar, J. O. E. H., Vullings, R., Hermans, B. J. M., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Kramer, B. W., & Zwanenburg, A. (2019). Why-aVF can be used in STAN as a proxy for scalp electrode-derived signal; reply to comments by Kjellmer et al.PLOS ONE, 14(8), Article 0221220. https://doi.org/10.1371/journal.pone.0221220
    • Heusinkveld, M. H. G., Delhaas, ET., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D., & Reesink, K. D. (2019). Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model. Journal of Applied Physiology, 127(2), 491-500. https://doi.org/10.1152/japplphysiol.00769.2018
    • Heinen, S. G. H., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T., & Huberts, W. (2019). A geometry-based model for non-invasive estimation of pressure gradients over iliac artery stenoses. Journal of Biomechanics, 92, 67-75. https://doi.org/10.1016/j.jbiomech.2019.05.030
    • Heusinkveld, M. H. G., Huberts, W., Lumens, J., Arts, T., Delhaas, T., & Reesink, K. D. (2019). Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction. PLoS Computational Biology, 15(7), Article 1007173. https://doi.org/10.1371/journal.pcbi.1007173
    • Bennis, F. C., van Pul, C., van den Bogaart, J. J. L., Andriessen, P., Kramer, B. W., & Delhaas, T. (2019). Artifacts in pulse transit time measurements using standard patient monitoring equipment. PLOS ONE, 14(6), Article 0218784. https://doi.org/10.1371/journal.pone.0218784