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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Longer and better lives for patients with atrial fibrillation

Longer and better lives for patients with atrial fibrillation

15 April 2024

An international panel of experts published recommendations to improve management of atrial fibrillation (AF).

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Carim Maastricht
Carim Maastricht

Tammo Delhaas

Professor

Tammo Delhaas is Pediatric Cardiologist and Professor of Biomedical Engineering. He obtained his MD at the University of Groningen and received his PhD degree from Maastricht University in 1993 for a thesis on cardiac mechanics. After his training in Pediatrics in Maastricht and Utrecht, he received a Fulbright grant/ICIN-Fellowship and spent one year at the Departments of Bioengineering and Medicine from the UCSD. Thereafter, he trained in Pediatric Cardiology in Aachen and Melbourne. In 2000, he returned to Maastricht as Pediatric Cardiologist and continued his research on the crossroads of (Pediatric) Cardiology, Physiology and Biomedical Engineering. In 2009, he was appointed Professor and Chair of Biomedical Engineering at Maastricht University, where he is involved in projects related to cellular and cardiac mechanics, cardiac pacing, and mathematical modeling of the heart and circulation.

Prof. Tammo Delhaas is heading the CardioVascular System Dynamics Research Group (CVSDRG). With clinical questions regarding (congenital) heart diseases in mind, his research focusses on asynchronous electrical activation, vascular and myocardial structure-function relation, and computer model-assisted diagnosis and treatment of cardiac failure, pulmonary hypertension and congenital heart diseases. Besides standard expertise, CVSDRG uses following techniques/models in which it has expertise of extraordinary quality according to international standards: 1) CircAdapt, a lumped parameter mathematical model of the human heart and circulation that enables real-time simulation of cardiovascular system dynamics in a wide variety of physiological and pathophysiological situations (www.circadapt.org); 2) Finite Element Model of the heart with left and right ventricle, simulating local stress and strain as a function of time with emphasis on adaptation of wall anatomy to local mechanical load; 3) Pulse Wave Propagation and Computational Fluid Dynamics models that predict pressure and flow waveforms after vascular interventions, such as Arterio-Venous Fistula creation for hemodialysis. Prof. Tammo Delhaas serves as a reviewer or member of the editorial board of many journals, and has received grants from, amongst others, the Dutch Heart Foundation, Maastricht UMC+, Province of Limburg, NWO, European Research Council, and the Interuniversity Cardiology Institute of the Netherlands (ICIN).

Tammo-delhaas

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.366
T:+31(0)43 388 16 67

  • 2016
    • Verdurmen, K., Lempersz, C., Vullings, R., Schroer, C., Delhaas, T., van Laar, J. O. E. H., & Oei, S. G. (2016). Normal ranges for fetal electrocardiogram values for the healthy fetus of 18-24 weeks of gestation: a prospective cohort study. BMC Pregnancy and Childbirth, 16, Article 227. https://doi.org/10.1186/s12884-016-1021-x
    • Eck, V. G., Donders, W. P., Sturdy, J., Feinberg, J., Delhaas, T., Hellevik, L. R., & Huberts, W. (2016). A guide to uncertainty quantification and sensitivity analysis for cardiovascular applications. International Journal for Numerical Methods in Biomedical Engineering, 32(8), Article e02755. https://doi.org/10.1002/cnm.2755
    • Holtackers, R. J., Spronck, B., Heusinkveld, M. H. G., Crombag, G., op het Roodt, J., Delhaas, T., Kooi, E., Reesink, K. D., & Hermeling, E. (2016). Head orientation should be considered in ultrasound studies on carotid artery distensibility. Journal of Hypertension, 34(8), 1551-1555. https://doi.org/10.1097/HJH.0000000000000985
    • Tan, I., Spronck, B., Kiat, H., Barin, E., Reesink, K. D., Delhaas, T., Avolio, A. P., & Butlin, M. (2016). Heart Rate Dependency of Large Artery Stiffness. Hypertension, 68(1), 236-242. https://doi.org/10.1161/HYPERTENSIONAHA.116.07462
    • Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W., & Delhaas, T. (2016). Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model. Pediatric Research, 79(6), 907-915. https://doi.org/10.1038/pr.2016.21
    • Ophelders, D. R. M. G., Wolfs, T. G. A. M., Jellema, R. K., Zwanenburg, A., Andriessen, P., Delhaas, T., Ludwig, A.-K., Radtke, S., Peters, V., Janssen, L., Giebel, B., & Kramer, B. W. (2016). Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia. Stem Cells Translational Medicine, 5(6), 754-763. https://doi.org/10.5966/sctm.2015-0197
    • Upendra Walavalkar, V., Evers, E., Pujar, S., Viralam, K., Maiya, S., Frerich, S., John, C., Rao, S., Reddy, C., Spronck, B., Prinzen, F., Delhaas, T., & Vanagt, W. Y. (2016). Preoperative Sildenafil administration in children undergoing cardiac surgery: a randomized controlled preconditioning study. European Journal of Cardio-Thoracic Surgery, 49(5), 1403-1410. https://doi.org/10.1093/ejcts/ezv353
    • Wang, Y., Molin, D. G. M., Sevrin, C., Grandfils, C., van den Akker, N. M. S., Gagliardi, M., Knetsch, M. L., Delhaas, T., & Koole, L. (2016). In vitro and in vivo evaluation of drug-eluting microspheres designed for transarterial chemoembolization therapy. International Journal of Pharmaceutics, 503(1-2), 150-162. https://doi.org/10.1016/j.ijpharm.2016.03.002
    • Spronck, B., Megens, R. T. A., Reesink, K. D., & Delhaas, T. (2016). A method for three-dimensional quantification of vascular smooth muscle orientation: application in viable murine carotid arteries. Biomechanics and modeling in mechanobiology, 15(2), 419-432. https://doi.org/10.1007/s10237-015-0699-4
    • Spronck, B., Delhaas, T., op het Roodt, J., & Reesink, K. D. (2016). Carotid Artery Applanation Tonometry Does Not Cause Significant Baroreceptor Activation. American Journal of Hypertension, 29(3), 299-302. https://doi.org/10.1093/ajh/hpv064
    • Walmsley, J., Huntjens, P. R., Prinzen, F. W., Delhaas, T., & Lumens, J. (2016). Septal flash and septal rebound stretch have different underlying mechanisms. American Journal of Physiology-heart and Circulatory Physiology, 310(3), H394-H403. https://doi.org/10.1152/ajpheart.00639.2015
    • Spronck, B., Walmsley, J., Palau-Caballero, G., Reesink, K. D., & Delhaas, T. (2016). Can significance of aortic sinus vortices be assessed using the assumptions in the model of Aboelkassem et al.?Journal of Theoretical Biology, 389, 304-305. https://doi.org/10.1016/j.jtbi.2015.05.032
    • Willems, M. G. M., Ophelders, D. R. M. G., Nikiforou, M., Jellema, R. K., Butz, A., Delhaas, T., Kramer, B. W., & Wolfs, T. G. A. M. (2016). Systemic interleukin-2 administration improves lung function and modulates chorioamnionitis-induced pulmonary inflammation in the ovine fetus. American Journal of Physiology-Lung Cellular and Molecular Physiology, 310(1), L1-L7. https://doi.org/10.1152/ajplung.00289.2015
  • 2015
    • Jellema, R. K., Ophelders, D. R. M. G., Zwanenburg, A., Nikiforou, M., Delhaas, T., Andriessen, P., Mays, R. W., Deans, R., Germeraad, W. T. V., Wolfs, T. G. A. M., & Kramer, B. W. (2015). Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain. Journal of Neuroinflammation, 12, 241. https://doi.org/10.1186/s12974-015-0459-5
    • Lumens, J., Prinzen, F. W., & Delhaas, T. (2015). Longitudinal Strain "Think Globally, Track Locally". JACC-Cardiovascular Imaging, 8(12), 1360-1363. https://doi.org/10.1016/j.jcmg.2015.08.014
    • Donders, W. P., Huberts, W., van de Vosse, F. N., & Delhaas, T. (2015). Personalization of models with many model parameters: an efficient sensitivity analysis approach. International Journal for Numerical Methods in Biomedical Engineering, 31(10), Article e02727. https://doi.org/10.1002/cnm.2727
    • Lumens, J., Tayal, B., Walmsley, J., Delgado-Montero, A., Huntjens, P. R., Schwartzman, D., Althouse, A. D., Delhaas, T., Prinzen, F. W., & Gorcsan, J. (2015). Differentiating Electromechanical From Non-Electrical Substrates of Mechanical Discoordination to Identify Responders to Cardiac Resynchronization Therapy. Circulation-Cardiovascular Imaging, 8(9), Article e003744. https://doi.org/10.1161/CIRCIMAGING.115.003744
    • Huberts, W., Donders, W. P., Delhaas, T., & van de Vosse, F. N. (2015). Applicability of the polynomial chaos expansion method for personalization of a cardiovascular pulse wave propagation model. International Journal for Numerical Methods in Biomedical Engineering, 31(7), e02720. https://doi.org/10.1002/cnm.2720
    • Walmsley, J., Arts, T., Derval, N., Bordachar, P., Cochet, H., Ploux, S., Prinzen, F. W., Delhaas, T., & Lumens, J. (2015). Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module. PLoS Computational Biology, 11(7), Article e1004284. https://doi.org/10.1371/journal.pcbi.1004284
    • den Boer, S. L., van Osch-Gevers, M., van Ingen, G., Sarvaas, G. J. D. M., van Iperen, G. G., Tanke, R. B., Backx, A. P. C. M., ten Harkel, A. D. J., Helbing, W. A., Delhaas, T., Bogers, A. J. J. C., Rammeloo, L. A. J., & Dalinghaus, M. (2015). Management of children with dilated cardiomyopathy in The Netherlands: Implications of a low early transplantation rate. Journal of Heart and Lung Transplantation, 34(7), 963-969. https://doi.org/10.1016/j.healun.2015.01.980
    • Kroon, W., Lumens, J., Potse, M., Suerder, D., Klersy, C., Regoli, F., Murzilli, R., Moccetti, T., Delhaas, T., Krause, R., Prinzen, F. W., & Auricchio, A. (2015). In vivo electromechanical assessment of heart failure patients with prolonged QRS duration. Heart Rhythm, 12(6), 1259-1267. https://doi.org/10.1016/j.hrthm.2015.03.006
    • Latus, H., Delhaas, T., Schranz, D., & Apitz, C. (2015). Treatment of pulmonary arterial hypertension in children. Nature Reviews Cardiology, 12(4), 244-254. https://doi.org/10.1038/nrcardio.2015.6
    • Spronck, B., Heusinkveld, M. H. G., Donders, W. P., de Lepper, A. G. W., Op't Roodt, J., Kroon, A. A., Delhaas, T., & Reesink, K. D. (2015). A constitutive modeling interpretation of the relationship among carotid artery stiffness, blood pressure, and age in hypertensive subjects. American Journal of Physiology-heart and Circulatory Physiology, 308(6), H568-H582. https://doi.org/10.1152/ajpheart.00290.2014
    • Rossi, A. C., Pluijmert, M., Bovendeerd, P. H. M., Kroon, W., Arts, T., & Delhaas, T. (2015). Assessment and comparison of left ventricular shear in normal and situs inversus totalis hearts by means of magnetic resonance tagging. American Journal of Physiology-heart and Circulatory Physiology, 308(5), H416-H423. https://doi.org/10.1152/ajpheart.00502.2014
    • Zwanenburg, A., Andriessen, P., Jellema, R. K., Niemarkt, H. J., Wolfs, T. G. A. M., Kramer, B. W., & Delhaas, T. (2015). Using trend templates in a neonatal seizure algorithm improves detection of short seizures in a foetal ovine model. Physiological Measurement, 36(3), 369-384. https://doi.org/10.1088/0967-3334/36/3/369
    • Spronck, B., Heusinkveld, M. H. G., Vanmolkot, F. H., 't Roodt, J. O., Hermeling, E., Delhaas, T., Kroon, A. A., & Reesink, K. D. (2015). Pressure-dependence of arterial stiffness: potential clinical implications. Journal of Hypertension, 33(2), 330-338. https://doi.org/10.1097/HJH.0000000000000407
    • Kuypers, E., Willems, M. G. M., Jellema, R. K., Kemp, M. W., Newnham, J. P., Delhaas, T., Kallapur, S. G., Jobe, A. H., Wolfs, T. G. A. M., & Kramer, B. W. (2015). Responses of the spleen to intraamniotic lipopolysaccharide exposure in fetal sheep. Pediatric Research, 77(1), 29-35. https://doi.org/10.1038/pr.2014.152
    • van Everdingen, W. M., Paiman, M.-L., van Deursen, C. J. M., Cramer, M. J., Vernooy, K., Delhaas, T., & Prinzen, F. W. (2015). Comparison of septal strain patterns in dyssynchronous heart failure between speckle tracking echocardiography vendor systems. Journal of Electrocardiology, 48(4), 609-616. https://doi.org/10.1016/j.jelectrocard.2014.12.021
    • Pluijmert, M., Lumens, J., Potse, M., Delhaas, T., Auricchio, A., & Prinzen, F. W. (2015). Computer modelling for better diagnosis and therapy of patients by cardiac resynchronisation therapy. Arrhythmia & Electrophysiology Review, 4(1), 62-67. https://doi.org/10.15420/aer.2015.4.1.62
  • 2014
    • Huberts, W., Donders, W. P., Delhaas, T., & van de Vosse, F. N. (2014). Applicability of the polynomial chaos expansion method for personalization of a cardiovascular pulse wave propagation model. International Journal for Numerical Methods in Biomedical Engineering, 30(12), 1679-1704. https://doi.org/10.1002/cnm.2695
    • Limantoro, I., de Vos, C. B., Delhaas, T., Weijs, B., Blaauw, Y., Schotten, U., Kietselaer, B., Pisters, R., & Crijns, H. J. G. M. (2014). Clinical correlates of echocardiographic tissue velocity imaging abnormalities of the left atrial wall during atrial fibrillation. EP Europace, 16(11), 1546-1553. https://doi.org/10.1093/europace/euu047
    • Huntjens, P. R., Walmsley, J., Ploux, S., Bordachar, P., Prinzen, F. W., Delhaas, T., & Lumens, J. (2014). Influence of left ventricular lead position relative to scar location on response to cardiac resynchronization therapy: a model study. EP Europace, 16 Suppl 4, iv62-iv68. https://doi.org/10.1093/europace/euu231
    • De Vos, C. B., Limantoro, I., Pisters, R., Delhaas, T., Schotten, U., Cheriex, E. C., Tieleman, R. G., & Crijns, H. J. G. M. (2014). The mechanical fibrillation pattern of the atrial myocardium is associated with acute and long-term success of electrical cardioversion in patients with persistent atrial fibrillation. Heart Rhythm, 11(9), 1514-1521. https://doi.org/10.1016/j.hrthm.2014.04.029
    • Kuijpers, N. H. L., Hermeling, E., Lumens, J., ten Eikelder, H. M. M., Delhaas, T., & Prinzen, F. W. (2014). Mechano-electrical coupling as framework for understanding functional remodeling during LBBB and CRT. American Journal of Physiology-heart and Circulatory Physiology, 306(12), H1644-H1659. https://doi.org/10.1152/ajpheart.00689.2013
    • Verdijk, L. B., Snijders, T., Drost, M., Delhaas, T., Kadi, F., & van Loon, L. J. (2014). Satellite cells in human skeletal muscle; from birth to old age.Age, 36(2), 545-557. https://doi.org/10.1007/s11357-013-9583-2
    • Limantoro, I., De Vos, C. B., Delhaas, T., Marcos, E., Blaauw, Y., Weijs, B., Tieleman, R. G., Pisters, R., Schotten, U., Van Gelder, I. C., & Crijns, H. J. G. M. (2014). Tissue velocity imaging of the left atrium predicts response to flecainide in patients with acute atrial fibrillation. Heart Rhythm, 11(3), 478-484. https://doi.org/10.1016/j.hrthm.2013.12.010
    • Kuypers, E., Willems, M. G. M., Collins, J. J. P., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Delhaas, T., Jobe, A. H., Kallapur, S. G., & Kramer, B. W. (2014). Altered canonical Wingless-It signaling in the ovine fetal lung after exposure to intra-amniotic lipopolysaccharide and antenatal betamethasone. Pediatric Research, 75(2), 281-287. https://doi.org/10.1038/pr.2013.226
    • Pluijmert, M., Bovendeerd, P. H. M., Kroon, W., Prinzen, F. W., & Delhaas, T. (2014). Effects of activation pattern and active stress development on myocardial shear in a model with adaptive myofiber reorientation. American Journal of Physiology-heart and Circulatory Physiology, 306(4), H538-H546. https://doi.org/10.1152/ajpheart.00571.2013
    • Spronck, B., Merken, J. J., Reesink, K. D., Kroon, W., & Delhaas, T. (2014). Ureter Smooth Muscle Cell Orientation in Rat Is Predominantly Longitudinal. PLOS ONE, 9(1), Article e86207. https://doi.org/10.1371/journal.pone.0086207
    • Ghossein-Doha, C., Spaanderman, M., van Kuijk, S. M. J., Kroon, A. A., Delhaas, T., & Peeters, L. (2014). Long-Term Risk to Develop Hypertension in Women With Former Preeclampsia: A Longitudinal Pilot Study. Reproductive Sciences, 21(7), 846-853. https://doi.org/10.1177/1933719113518989
    • Spronck, B., Megens, R. T. A., Reesink, K. D., & Delhaas, T. (2014). Three-dimensional vascular smooth muscle orientation as quantitatively assessed by multiphoton microscopy: mouse carotid arteries do show a helix. IEEE Engineering in Medicine and Biology Society, 2014, 202-5. https://doi.org/10.1109/EMBC.2014.6943564
  • 2013
    • Lumens, J., Ploux, S., Strik, M., Gorcsan, J. III., Cochet, H., Derval, N., Strom, M., Ramanathan, C., Ritter, P., Haissaguerre, M., Jais, P., Arts, T., Delhaas, T., Prinzen, F. W., & Bordachar, P. (2013). Comparative Electromechanical and Hemodynamic Effects of Left Ventricular and Biventricular Pacing in Dyssynchronous Heart Failure Electrical Resynchronization Versus Left-Right Ventricular Interaction. Journal of the American College of Cardiology, 62(25), 2395-2403. https://doi.org/10.1016/j.jacc.2013.08.715
    • Ghossein-Doha, C., Peeters, L., van Heijster, S., van Kuijk, S., Spaan, J., Delhaas, T., & Spaanderman, M. (2013). Hypertension After Preeclampsia Is Preceded by Changes in Cardiac Structure and Function. Hypertension, 62(2), 382-390. https://doi.org/10.1161/HYPERTENSIONAHA.113.01319
    • van Geldorp, I. E., Bordachar, P., Lumens, J., de Guillebon, M., Whinnett, Z. I., Prinzen, F. W., Haissaguerre, M., Delhaas, T., & Thambo, J.-B. (2013). Acute hemodynamic benefits of biventricular and single-site systemic ventricular pacing in patients with a systemic right ventricle. Heart Rhythm, 10(5), 676-682. https://doi.org/10.1016/j.hrthm.2013.01.017
    • Zwanenburg, A., Jellema, R. K., Jennekens, W., Ophelders, D., Vullings, R., van Hunnik, A., van Pul, C., Bennet, L., Delhaas, T., Kramer, B. W., & Andriessen, P. (2013). Heart rate-mediated blood pressure control in preterm fetal sheep under normal and hypoxic-ischemic conditions. Pediatric Research, 73(4), 420-426. https://doi.org/10.1038/pr.2013.15
    • van Geldorp, I. E., Vanagt, W. Y., Vugts, G., Willems, R., Rega, F., Gewillig, M., & Delhaas, T. (2013). Late recovery of atrioventricular conduction after postsurgical chronic atrioventricular block is not exceptional. Journal of Thoracic and Cardiovascular Surgery, 145(4), 1028-1032. https://doi.org/10.1016/j.jtcvs.2012.05.012
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