Guido Haenen

Assistant Professor

Prof/ Guido Haenen is currently Professor in 'Redox Modulation of Pharmacological and Toxicological Processes'. He was registered as Pharmacist in 1985 (with honours), and he obtained his PhD in Medicinal Chemistry in 1989. He was awarded the ‘Shell Prize’ for his thesis entitled ‘Thiols in Oxidative Stress’. Prof. Haenen is registered as Toxicologist and Clinical Pharmacologist. In 2015, he received the 'Grote Onderwijsprijs' (education prize) for being the best teacher in Biomedical Sciences at Maastricht University. He is Editor-in-Chief of the Molecular Toxicology section of the International Journal of Molecular Sciences.

Department of Pharmacology & Toxicology
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.230
T: +31 (0)43 388 21 09

  • 2019
    • Severens-Rijvers, C. A. H., Al-Nasiry, S., Vincken, A., Haenen, G., Winkens, B., Ghossein-Doha, C., Spaanderman, M. A. E., & Peeters, L. L. H. (2019). Early-Pregnancy Circulating Antioxidant Capacity and Hemodynamic Adaptation in Recurrent Placental Syndrome: An Exploratory Study. Gynecologic and Obstetric Investigation, 84(6), 616-622. https://doi.org/10.1159/000501254
    • Zhang, M., Moalin, M., & Haenen, G. R. M. M. (2019). Connecting West and East. International journal of molecular sciences, 20(9), [2333]. https://doi.org/10.3390/ijms20092333
    • Zhang, M., Moalin, M., Vervoort, L., Li, Z. W., Wu, W. B., & Haenen, G. (2019). Connecting Western and Eastern Medicine from an Energy Perspective. International journal of molecular sciences, 20(6), [1512]. https://doi.org/10.3390/ijms20061512
    • Astuti, P., Beurskens, D., Vajen, T., Nicolaes, G., Zhang, M., & Guido, H. (2019). Protection against neutrophil extracellular trap (NET) toxicity by antioxidant monoHER. Makara Journal of Health Research, 23(2), 108-115. https://doi.org/10.7454/msk.v23i2.10453
  • 2018
    • Zhang, M., Vervoort, L., Moalin, M., Mommers, A., Douny, C., den Hartog, G. J. M., & Haenen, G. R. M. M. (2018). The chemical reactivity of (-)-epicatechin quinone mainly resides in its Bring. Free Radical Biology and Medicine, 124, 31-39. https://doi.org/10.1016/j.freeradbiomed.2018.05.087
    • Zhang, M., Schiffers, P., Janssen, G., Vrolijk, M., Vangrieken, P., & Haenen, G. R. M. M. (2018). The cardiovascular side effects of Ma Huang due to its use in isolation in the Western world. European Journal of Integrative Medicine, 18, 18-22. https://doi.org/10.1016/j.eujim.2018.01.007
    • Zhang, M., Vrolijk, M., & Haenen, G. R. M. M. (2018). The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine. International journal of molecular sciences, 19(1), [18]. https://doi.org/10.3390/ijms19010018
  • 2017
    • Baumgartner, S., Mensink, R. P., Haenen, G. R., Bast, A., Binder, C. J., Bekers, O., Husche, C., Luetjohann, D., & Plat, J. (2017). The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial. Scientific Reports, 7, [15288]. https://doi.org/10.1038/s41598-017-15615-y
    • Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Hageman, G. J., Bast, A., & Haenen, G. R. M. M. (2017). The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicology in Vitro, 44, 206-212. https://doi.org/10.1016/j.tiv.2017.07.009
    • Sthijns, M. M. J. P. E., den Hartog, G. J. M., Scasso, C., Haenen, J. P., Bast, A., & Haenen, G. R. M. M. (2017). Activation versus inhibition of microsomal glutathione S-transferase activity by acrolein. Dependence on the concentration and time of acrolein exposure. Chemico-Biological Interactions, 275, 116-120. https://doi.org/10.1016/j.cbi.2017.08.001
    • van Gisbergen, M. W., Voets, A. M., Biemans, R., Hoffmann, R. F., Drittij-Reijnders, M-J., Haenen, G. R. M. M., Heijink, I. H., Rouschop, K. M. A., Dubois, L. J., & Lambin, P. (2017). Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress. PLOS ONE, 12(8), [0182508]. https://doi.org/10.1371/journal.pone.0182508
    • Benedikter, B. J., Volgers, C., van Eijck, P. H., Wouters, E. F. M., Savelkoul, P. H. M., Reynaert, N. L., Haenen, G. R. M. M., Rohde, G. G. U., Weseler, A. R., & Stassen, F. R. M. (2017). Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants. Free Radical Biology and Medicine, 108, 334-344. https://doi.org/10.1016/j.freeradbiomed.2017.03.026
    • Sthijns, M. M. J. P. E., Schiffers, P. M., Janssen, G. M., Lemmens, K. J. A., Ides, B., Vangrieken, P., Bouwman, F. G., Mariman, E. C., Pader, I., Arner, E. S. J., Johansson, K., Bast, A., & Haenen, G. R. M. M. (2017). Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress. Biochimica et Biophysica Acta-general Subjects, 1861(5), 1177-1189. https://doi.org/10.1016/j.bbagen.2017.03.004
    • Shi, Q., Boots, A. W., Maas, L., Veith, C., van Kuijk, K., Haenen, G. R., Godschalk, R. W., & Van Schooten, F. J. (2017). Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells. Toxicology, 381, 64-74. https://doi.org/10.1016/j.tox.2017.02.013
    • Sthijns, M. M. J. P. E., Thongkam, W., Albrecht, C., Hellack, B., Bast, A., Haenen, G. R. M. M., & Schins, R. P. F. (2017). Silver nanoparticles induce hormesis in A549 human epithelial cells. Toxicology in Vitro, 40, 223-233. https://doi.org/10.1016/j.tiv.2017.01.010
    • van de Wier, B., Koek, G. H., Bast, A., & Haenen, G. R. M. (2017). The Potential of Flavonoids in the Treatment of Non-alcoholic Fatty Liver Disease. Critical Reviews in Food Science and Nutrition, 57(4), 834-855. https://doi.org/10.1080/10408398.2014.952399
  • 2016
    • Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Bast, A., & Haenen, G. R. M. M. (2016). Iron Supplements and Magnesium Peroxide: An Example of a Hazardous Combination in Self-Medication. Basic & Clinical Pharmacology & Toxicology, 119(4), 412-417. https://doi.org/10.1111/bcpt.12603
    • Sthijns, M. M. J. P. E., Weseler, A. R., Bast, A., & Haenen, G. R. M. M. (2016). Time in Redox Adaptation Processes: From Evolution to Hormesis. International journal of molecular sciences, 17(10), [1649]. https://doi.org/10.3390/ijms17101649
    • Shi, Q., Haenen, G. R., Maas, L. M., Arlt, V. M., Spina, D., Vasquez, Y. R., Moonen, E., Veith, C., van Schooten, F. J., & Godschalk, R. W. (2016). Inflammation-associated extracellular beta-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene. Archives of Toxicology, 90(9), 2261-2273. https://doi.org/10.1007/s00204-015-1593-7
    • van Kuijk, S. J. A., Gieling, R. G., Niemans, R., Lieuwes, N. G., Biemans, R., Telfer, B. A., Haenen, G. R. M. M., Yaromina, A., Lambin, P., Dubois, L. J., & Williams, K. J. (2016). The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy. PLOS ONE, 11(8), [e0161040]. https://doi.org/10.1371/journal.pone.0161040
    • Godschalk, R. W. L., Vanhees, K., Maas, L., Drittij - Reijnders, M. J., Pachen, D., van Doorn-Khosrovani, S. V. W., van Schooten, F. J., & Haenen, G. R. M. M. (2016). Does Ataxia Telangiectasia Mutated (ATM) protect testicular and germ cell DNA integrity by regulating the redox status?Reproductive Toxicology, 63, 169-173. https://doi.org/10.1016/j.reprotox.2016.06.008
    • Heyninck, K., Sabbe, L., Chirumamilla, C. S., Szic, K. S. V., Veken, P. V., Lemmens, K. J. A., Lahtela-Kakkonen, M., Naulaerts, S., de Beeck, K. O., Laukens, K., Van Camp, G., Weseler, A. R., Bast, A., Haenen, G. R. M. M., Haegeman, G., & Berghe, W. V. (2016). Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway. Biochemical Pharmacology, 109, 48-61. https://doi.org/10.1016/j.bcp.2016.03.026
    • van Gisbergen, M. W., Cebula, M., Zhang, J., Ottosson-Wadlund, A., Dubois, L., Lambin, P., Tew, K. D., Townsend, D. M., Haenen, G. R. M. M., Drittij - Reijnders, M. J., Saneyoshi, H., Araki, M., Shishido, Y., Ito, Y., Arner, E. S. J., Abe, H., Morgenstern, R., & Johansson, K. (2016). Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. Molecular Pharmaceutics, 13(6), 2010-2025. https://doi.org/10.1021/acs.molpharmaceut.6b00140
    • Ruijters, E., Haenen, G. R., Willemsen, M., Weseler, A. R., & Bast, A. (2016). Food-Derived Bioactives Can Protect the Anti-Inflammatory Activity of Cortisol with Antioxidant-Dependent and -Independent Mechanisms. International journal of molecular sciences, 17(2), [239]. https://doi.org/10.3390/ijms17020239
    • Marsch, E., Theelen, T., Janssen, B. J., Briedé, J. J., Haenen, G. R., Senden, J., van Loon, L. J., Poeze - van Bokhoven, M., Bierau, J., Gijbels, M. J., Daemen, M. J., & Sluimer, J. (2016). The effect of prolonged dietary nitrate supplementation on atherosclerosis development. Atherosclerosis, 245, 212-221. https://doi.org/10.1016/j.atherosclerosis.2015.11.031
    • Randall, M., Haenen, G. R., Bouwman, F. G., Vliet, A. V., & Bast, A. (2016). The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase. Toxicology Letters, 240(1), 43-49. https://doi.org/10.1016/j.toxlet.2015.10.009
    • Pijls, K., Jonkers, D., Elizalde Vilalta, M., Drittij - Reijnders, M. J., Haenen, G., Bast, A., Masclee, A., & Koek, G. (2016). Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?Annals of Hepatology, 15(3), 402-409. https://doi.org/10.5604/16652681.1198816
  • 2015
    • van de Wier, B., Balk, J. M., Bast, A., Koek, G. H., & Haenen, G. R. (2015). Chemical characteristics for optimizing CYP2E1 inhibition. Chemico-Biological Interactions, 242, 139-144. https://doi.org/10.1016/j.cbi.2015.09.024
    • Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Bast, A., & Haenen, G. R. (2015). Anticholinergic Accumulation: A Slumbering Interaction between Drugs and Food Supplements. Basic & Clinical Pharmacology & Toxicology, 117(6), 427-432. https://doi.org/10.1111/bcpt.12437
    • Salden, B. N., Montserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F., & Masclee, A. A. (2015). Letter: gluten digestion in the stomach and duodenum by Aspergillus niger-derived enzyme - things to ponder. Authors' reply. Alimentary Pharmacology & Therapeutics, 42(7), 946-947. https://doi.org/10.1111/apt.13382
    • Bartholomé, R., Salden, B., Vrolijk, M. F., Troost, F. J., Masclee, A., Bast, A., & Haenen, G. R. M. M. (2015). Paracetamol as a Post Prandial Marker for Gastric Emptying, A Food-Drug Interaction on Absorption. PLOS ONE, 10(9), [e0136618]. https://doi.org/10.1371/journal.pone.0136618
    • Lemmens, K. J., Herst, P. M., Housmans, B. A., Moalin, M., van der Vijgh, W. J., Bast, A., & Haenen, G. R. (2015). The contribution of the major metabolite 4'-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER. Chemico-Biological Interactions, 239, 146-152. https://doi.org/10.1016/j.cbi.2015.07.004
    • Benedikter, B. J., Volgers, C., Haenen, G. R. M. M., Savelkoul, P. H. M., Wouters, E. F. M., Rohde, G. G. U., Weseler, A. R., & Stassen, F. R. M. (2015). Cigarette smoke extract induces the release of extracellular vesicles by airway epithelial cells via cellular carbonyl stress. European Respiratory Journal, 46(suppl 59). https://doi.org/10.1183/13993003.congress-2015.PA5113
    • Salden, B. N., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F., & Masclee, A. A. (2015). Editorial: enhancing gluten digestion in the stomach- a further help to minimise unintentional ingestion? Authors' reply. Alimentary Pharmacology & Therapeutics, 42(4), 485. https://doi.org/10.1111/apt.13296
    • Vrolijk, M. F., Haenen, G. R., Opperhuizen, A., Jansen, E. H., Schiffers, P. M., & Bast, A. (2015). The supplement-drug interaction of quercetin with tamsulosin on vasorelaxation. European Journal of Pharmacology, 746, 132-137. https://doi.org/10.1016/j.ejphar.2014.11.006
    • Vrolijk, M. F., Haenen, G., Bast, A., Opperhuizen, A., & Jansen, E. (2015). Een voorbeeld van onderbelichte geneesmiddel-voedingssupplement interactie. Orthostatische hypotensie door tamsulosine en quercetine. PiL, 2015(3), 20-23. https://www.pil-nascholing.nl/tijdschrift/editie/artikel/t/een-voorbeeld-van-onderbelichte-geneesmiddel-voedingssupplement-interactie
    • Balk, J. M., Haenen, G. R. M., Koc, O. M., Peters, R., Bast, A., van der Vijgh, W. J. F., & Koek, G. H. (2015). Once-daily dose regimen of ribavirin is interchangeable with a twice-daily dose regimen: randomized open clinical trial. Pharmacogenomics and personalized medicine, 8, 137-144. https://doi.org/10.2147/pgpm.s82782
    • Salden, B., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F., & Masclee, A. A. (2015). Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers. Alimentary Pharmacology & Therapeutics, 42(3), 273-285. https://doi.org/10.1111/apt.13266
    • Lemmens, K., van de Wier, B., Koek, G. H., Köhler, E. S., Drittij, M. J., van der Vijgh, W., Bast, A., & Haenen, G. R. (2015). The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD. Biochemical and Biophysical Research Communications, 456(1), 179-182. https://doi.org/10.1016/j.bbrc.2014.11.055
    • Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Godschalk, R. W., van Schooten, F. J., Bast, A., & Haenen, G. R. (2015). The shifting perception on antioxidants: The case of vitamin E and beta-carotene. Redox Biology, 4C, 272-278. https://doi.org/10.1016/j.redox.2014.12.017
    • Rezk, B., van der Vijgh, W. J. F., Bast, A., & Haenen, G. R. (2015). Toxicity of Antioxidants. Toxicology and Forensic Medicine, 1(1), [1000TFMOJ1e002]. http://openventio.org/Volume1_Issue1/Toxicity_of_Antioxidants_TFMOJ_1_e002.pdf
    • Rezk, B. M., van der Vijgh, W., Bast, A., & Haenen, G. (2015). Toxicity of the anti-oxidants. Toxicology and Forensic Medicine, 1(1), e3-e4. https://doi.org/10.17140/TFMOJ-1-e002
  • 2014
    • Haenen, G. R. M., & Bast, A. (2014). Glutathione revisited: a better scavenger than previously thought. Frontiers in Pharmacology, 5, [260]. https://doi.org/10.3389/fphar.2014.00260
    • Lemmens, K. J., van de Wier, B., Vaes, N., Ghosh, M., van Zandvoort, M. A., van der Vijgh, W., Bast, A., & Haenen, G. R. (2014). The flavonoid 7-mono-O-(beta-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect. Toxicology in Vitro, 28(4), 538-543. https://doi.org/10.1016/j.tiv.2013.12.019
    • Milenkovic, D., Vanden Berghe, W., Boby, C., Leroux, C., Declerck, K., Szarc Vel Szic, K., Heyninck, K., Laukens, K., Bizet, M., Defrance, M., Dedeurwaerder, S., Calonne, E., Fuks, F., Haegeman, G., Haenen, G. R., Bast, A., & Weseler, A. R. (2014). Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State. PLOS ONE, 9(4), [e95527]. https://doi.org/10.1371/journal.pone.0095527
    • Kelly, E. R., Plat, J., Haenen, G. R., Kijlstra, A., & Berendschot, T. T. (2014). The effect of modified eggs and an egg-yolk based beverage on serum lutein and zeaxanthin concentrations and macular pigment optical density: results from a randomized trial. PLOS ONE, 9(3), [92659]. https://doi.org/10.1371/journal.pone.0092659
    • Sthijns, M. M., Randall, M. J., Bast, A., & Haenen, G. R. (2014). Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept.Biochemical and Biophysical Research Communications, 446(4), 1029-1034. https://doi.org/10.1016/j.bbrc.2014.03.081
    • Hazewindus, M., Haenen, G. R., Weseler, A. R., & Bast, A. (2014). Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup. PLOS ONE, 9(12), [e114387]. https://doi.org/10.1371/journal.pone.0114387