Hans-Peter Brunner-La Rocca


Prof. Hans-Peter Brunner-La Rocca has graduated in medicine at the University of Zurich, Switzerland. He was trained in Internal Medicine and Cardiology in Switzerland. After doing a post-doc in Melbourne, Australia, for two years, he had been working as cardiologist and heart failure specialist in Zurich. In 2002, he moved to Basel, where he was responsible for the heart failure and heart transplant services. He has obtained his lecture qualification both in Zurich and in Basel and was announced as Professor in Basel Switzerland in 2008. Since 2009, he has been working at Maastricht UMC+ as Professor of Clinical Heart Failure. He is head of the heart failure clinic and head of the division of structural heart diseases.

He has been involved in numerous research projects since many years. In particular, he has a special interest in personalised medicine in heart failure using biomarkers and has successfully led international studies related to this topic. In addition, eHealth is an important focus of research. He has published >250 research articles.

He has been working as member of different working groups of the Heart Failure Association of the European Society of Cardiology and is board member of working group on heart failure in the Netherlands.

On the one hand, he is continuing his research on biomarker in heart failure for therapy guidance. He is collaborating internationally on this topic and is participating in several large international projects in this regard. On the other hand, he is leading an international consortium, aiming to develop a personalized eHealth application to enable patients with heart failure to perform self-care, i.e. including self-prescription of medication. Recently, the consortium received 4.4 M€ to support this project from INTERREG-NWE (budget Maastricht UMC+ > 2.0 M€).

He is additionally involved in national research projects (e.g. heart-brain connection, supported by CVON) and is the local PI of several large industry sponsored RCTs. In one of them, he is the national coordinator for the Netherlands.

Department of Cardiology
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
Room number: 3.B2.031
T: +31(0)43 387 70 97

  • 2018
    • Hazebroek, M. R., Krapels, I., Verdonschot, J., van den Wijngaard, A., Vanhoutte, E., Hoos, M., Snijders, L., van Montfort, L., Witjens, M., Dennert, R., Crijns, H. J. G. M., Brunner-La Rocca, H-P., Brunner, H. G., & Heymans, S. (2018). Prevalence of Pathogenic Gene Mutations and Prognosis Do Not Differ in Isolated Left Ventricular Dysfunction Compared With Dilated Cardiomyopathy. Circulation-Heart Failure, 11(3), [e004682 ]. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004682
    • Merken, J., Hazebroek, M., Van Paassen, P., Verdonschot, J., Van Empel, V., Knackstedt, C., Hamid, M. A., Seiler, M., Kolb, J., Hoermann, P., Ensinger, C., Brunner-La Rocca, H-P., Poelzl, G., & Heymans, S. (2018). Immunosuppressive Therapy Improves Both Short- and Long-Term Prognosis in Patients With Virus-Negative Nonfulminant Inflammatory Cardiomyopathy. Circulation-Heart Failure, 11(2), [004228]. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004228
    • Aimo, A., Januzzi, J. L., Vergaro, G., Ripoli, A., Latini, R., Masson, S., Magnoli, M., Anand, I. S., Cohn, J. N., Tavazzi, L., Tognoni, G., Gravning, J., Ueland, T., Nymo, S. H., Brunner-La Rocca, H-P., Genis, A. B., Lupon, J., de Boer, R. A., Yoshihisa, A., ... Emdin, M. (2018). Prognostic Value of High-Sensitivity Troponin T in Chronic Heart Failure An Individual Patient Data Meta-Analysis. Circulation, 137(3), 286-297. https://doi.org/10.1161/CIRCULATIONAHA.117.031560
    • Smulders, M., Bekkers, B., VAN Cauteren, Y., Liefhebber, A., Vermeer, J. R., Vervuurt, J., van Dieijen - Visser, M. P., Mingels, A., Brunner-La Rocca, H., Dagnelie, P., Wildberger, J., Crijns, H., & Kietselaer, B. (2018). Acute pijn op de borst zonder afwijkend troponine: Is aanvullende niet-invasieve diagnostiek zinvol?Nederlands Tijdschrift voor Geneeskunde, 162, 1-7. [D3568]. https://www.ntvg.nl/system/files/publications/d3568.pdf
  • 2017
    • Rickenbacher, P., Kaufmann, B. A., Maeder, M. T., Bernheim, A., Goetschalckx, K., Pfister, O., Pfisterer, M., Brunner-La Rocca, H-P., & Investigators, TIME-CHF. (2017). Heart failure with mid-range ejection fraction: a distinct clinical entity? Insights from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF). European journal of heart failure, 19(12), 1586-1596. https://doi.org/10.1002/ejhf.798
    • Baldewijns, K., Bektas, S., Boyne, J., Rohde, C., De Maesschalck, L., De Bleser, L., Brandenburg, V., Knackstedt, C., Deville, A., Sanders-Van Wijk, S., & La Rocca, H-P. B. (2017). Improving kNowledge Transfer to Efficaciously RAise the level of Contemporary Treatment in Heart Failure (INTERACT-in-HF): Study protocol of a mixed methods study. International Journal of Care Coordination, 20(4), 171-182. https://doi.org/10.1177/2053434517726318
    • van Vark, L. C., Lesman-Leegte, I., Baart, S. J., Postmus, D., Pinto, Y. M., Orsel, J. G., Westenbrink, B. D., Rocca, H. P. B., van Miltenburg, A. J. M., Boersma, E., Hillege, H. L., Akkerhuis, K. M., & TRIUMPH Investigators (2017). Prognostic Value of Serial ST2 Measurements in Patients With Acute Heart Failure. Journal of the American College of Cardiology, 70(19), 2378-2388. https://doi.org/10.1016/j.jacc.2017.09.026
    • Uszko-Lencer, N. H. M. K., Mesquita, R., Janssen, E., Werter, C., Rocca, H-P. B-L., Pitta, F., Wouters, E. F. M., & Spruit, M. A. (2017). Reliability, construct validity and determinants of 6-minute walk test performance in patients with chronic heart failure. International Journal of Cardiology, 240, 285-290. https://doi.org/10.1016/j.ijcard.2017.02.109
    • Harjola, V-P., Mullens, W., Banaszewski, M., Bauersachs, J., Brunner-La Rocca, H-P., Chioncel, O., Collins, S. P., Doehner, W., Filippatos, G. S., Flammer, A. J., Fuhrmann, V., Lainscak, M., Lassus, J., Legrand, M., Masip, J., Mueller, C., Papp, Z., Parissis, J., Platz, E., ... Mebazaa, A. (2017). Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European journal of heart failure, 19(7), 821-836. https://doi.org/10.1002/ejhf.872
    • Bektas, S., Franssen, F. M. E., van Empel, V., Uszko-Lencer, N., Boyne, J., Knackstedt, C., & Brunner-La Rocca, H. P. (2017). Impact of airflow limitation in chronic heart failure. Netherlands Heart Journal, 25(5), 335-342. https://doi.org/10.1007/s12471-017-0965-4
    • Davarzani, N., van Wijk, S., Karel, J., Maeder, M. T., Leibundgut, G., Gutmann, M., Pfisterer, M. E., Rickenbacher, P., Peeters, R., & Brunner-La Rocca, H. (2017). N-Terminal Pro-B-Type Natriuretic Peptide-Guided Therapy in Chronic Heart Failure Reduces Repeated Hospitalizations-Results From TIME-CHF. Journal of Cardiac Failure, 23(5), 382-389. https://doi.org/10.1016/j.cardfail.2017.02.001
    • Veugen, M. G. J., Henry, R. M. A., van Sloten, T. T., Hermeling, E., Brunner-La Rocca, H-P., Schram, M. T., Dagnelie, P. C., Schalkwijk, C. G., Kroon, A. A., Stehouwer, C. D. A., & Reesink, K. D. (2017). The systolic-diastolic difference in carotid stiffness is increased in type 2 diabetes: The Maastricht Study. Journal of Hypertension, 35(5), 1052-1060. https://doi.org/10.1097/HJH.0000000000001298
    • van Empel, V., Knackstedt, C., van Paassen, P., & Brunner-La Rocca, H-P. (2017). Just air good enough in pulmonary hypertension?European Heart Journal, 38(15), 1169-1171. https://doi.org/10.1093/eurheartj/ehx117
    • Aimo, A., Vergaro, G., Ripoli, A., Bayes-Genis, A., Figal, D. A. P., de Boer, R. A., Lassus, J., Mebazaa, A., Gayat, E., Breidthardt, T., Sabti, Z., Mueller, C., Brunner-La Rocca, H-P., Tang, W. H. W., Grodin, J. L., Zhang, Y., Bettencourt, P., Maisel, A. S., Passino, C., ... Emdin, M. (2017). Meta-Analysis of Soluble Suppression of Tumorigenicity-2 and Prognosis in Acute Heart Failure. JACC-Heart Failure, 5(4), 287-296. https://doi.org/10.1016/j.jchf.2016.12.016
    • Daamen, M. A. M. J., Brunner-la Rocca, H. -P., Tan, F. E. S., Hamers, J. P. H., & Schols, J. M. G. A. (2017). Clinical diagnosis of heart failure in nursing home residents based on history, physical exam, BNP and ECG: Is it reliable?European Geriatric Medicine, 8(1), 59-65. https://doi.org/10.1016/j.eurger.2016.10.003
    • Uszko-Lencer, N. H. M. K., Frankenstein, L., Spruit, M. A., Maeder, M. T., Gutmann, M., Muzzarelli, S., Osswald, S., Pfisterer, M. E., Zugck, C., Brunner-La Rocca, H-P., & Investigators, TIME-CHF. (2017). Predicting hospitalization and mortality in patients with heart failure: The BARDICHE-index. International Journal of Cardiology, 227, 901-907. https://doi.org/10.1016/j.ijcard.2016.11.122
    • Knackstedt, C., Heymans, S., & Brunner-La Rocca, H-P. (2017). ICD Implantation in Patients with Nonischemic Heart Failure. New England Journal of Medicine, 376(1), 91-92. https://doi.org/10.1056/NEJMc1614441
    • van Kimmenade, R. R. J., ten Cate, T. J., & Rocca, H-P. B-L. (2017). Worsening Renal Function in Heart Failure It Takes 2 to Tangle. Journal of the American College of Cardiology, 69(1), 70-72. https://doi.org/10.1016/j.jacc.2016.11.016
    • Breetveld, N. M., Ghossein-Doha, C., Van Kuijk, S. M. J., Van Dijk, A. P., Van Der Vlugt, M. J., Heidema, W. M., Van Neer, J., Van Empel, V., Brunner-La Rocca, H. -P., Scholten, R. R., & Spaanderman, M. E. A. (2017). Prevalence of asymptomatic heart failure in formerly pre-eclamptic women: a cohort study. Ultrasound in Obstetrics & Gynecology, 49(1), 134-142. https://doi.org/10.1002/uog.16014
    • Hooghiemstra, A. M., Bertens, A. S., Leeuwis, A. E., Bron, E. E., Bots, M. L., Brunner-La Rocca, H-P., de Craen, A. J. M., van der Geest, R. J., Greving, J. P., Kappelle, L. J., Niessen, W. J., van Oostenbrugge, R. J., van Osch, M. J. P., de Roos, A., van Rossum, A. C., Biessels, G. J., van Buchem, M. A., Daemen, M. J. A. P., van der Flier, W. M., & Heart-Brain Connection Consortium (2017). The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study. Cerebrovascular Diseases Extra, 7(3), 140-152. https://doi.org/10.1159/000480738
  • 2016
    • Verdonschot, J., Hazebroek, M., Merken, J., Debing, Y., Dennert, R., Brunner-La Rocca, H., & Heymans, S. (2016). Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: review of the literature. European journal of heart failure, 18(12), 1430-1441. https://doi.org/10.1002/ejhf.665
    • Ferreira, J. P., Girerd, N., Pellicori, P., Duarte, K., Girerd, S., Pfeffer, M. A., McMurray, J. J. V., Pitt, B., Dickstein, K., Jacobs, L., Staessen, J. A., Butler, J., Latini, R., Masson, S., Mebazaa, A., Brunner-La Rocca, H., Delles, C., Heymans, S., Sattar, N., ... Rossignol, P. (2016). Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC Medicine, 14, [181]. https://doi.org/10.1186/s12916-016-0731-2
    • Brandenburg, V. M., Brunner-La Rocca, H., & Marx, N. (2016). Heart Failure Therapy in Patients with Diabetes The new Benefit-Risk-Assessment of Sacubitril/Valsartan. Deutsche Medizinische Wochenschrift, 141(22), 1647-1649. https://doi.org/10.1055/s-0042-000001
    • Maeder, M. T., Zurek, M., Rickli, H., Tobler, D., Kiencke, S., Suter, T., Yoon, S-I., Julius, B., Pfisterer, M. E., & Brunner-La Rocca, H. (2016). Prognostic Value of the Change in Heart Rate From the Supine to the Upright Position in Patients With Chronic Heart Failure. Journal of the American Heart Association, 5(8), [e003524]. https://doi.org/10.1161/JAHA.116.003524
    • Vurma, M., Dang, L., Brunner-La Rocca, H., Sutsch, G., Attenhofer-Jost, C. H., Duru, F., & Scharf, C. (2016). Safety and efficacy of the nMARQ catheter for paroxysmal and persistent atrial fibrillation. EP Europace, 18(8), 1164-1169. https://doi.org/10.1093/europace/euw048
    • Smulders, M. W., Kietselaer, B. L. J. H., Schalla, S., Bucerius, J., Jaarsma, C., van Dieijen-Visser, M. P., Mingels, A. M. A., Brunner-La Rocca, H., Post, M., Das, M., Crijns, H. J. G. M., Wildberger, J. E., & Bekkers, B. (2016). Acute chest pain in the high-sensitivity cardiac troponin era: A changing role for noninvasive imaging?American Heart Journal, 177, 102-111. https://doi.org/10.1016/j.ahj.2016.03.025
    • Linssen, P. B. C., Henry, R. M. A., Schalkwijk, C. G., Dekker, J. M., Nijpels, G., Brunner-La Rocca, H., & Stehouwer, C. D. A. (2016). Serum advanced glycation endproducts are associated with left ventricular dysfunction in normal glucose metabolism but not in type 2 diabetes: The Hoorn Study. Diabetes & Vascular Disease Research, 13(4), 278-285. https://doi.org/10.1177/1479164116640680
    • Sanders-van Wijk, S., Masson, S., Milani, V., Rickenbacher, P., Gorini, M., Tavazzi, L. T., Tobler, D., Rickli, H., Latini, R., & Brunner-La Rocca, H. (2016). Interaction of Galectin-3 Concentrations with the Treatment Effects of beta-Blockers and RAS Blockade in Patients with Systolic Heart Failure: A Derivation-Validation Study from TIME-CHF and GISSI-HF. Clinical Chemistry, 62(4), 605-616. https://doi.org/10.1373/clinchem.2015.246850
    • Lupon, J., Sanders-van Wijk, S., Januzzi, J. L., de Antonio, M., Gaggin, H. K., Pfisterer, M., Galan, A., Shah, R., Brunner-La Rocca, H., & Bayes-Genis, A. (2016). Prediction of survival and magnitude of reverse remodeling using the ST2-R2 score in heart failure: A multicenter study. International Journal of Cardiology, 204, 242-247. https://doi.org/10.1016/j.ijcard.2015.11.163
    • Kriemler, S., Radtke, T., Bürgi, F., Lambrecht, J., Zehnder, M., & Brunner-La Rocca, H. (2016). Short-term cardiorespiratory adaptation to high altitude in children compared with adults. Scandinavian Journal of Medicine & Science in Sports, 26(2), 147-155. https://doi.org/10.1111/sms.12422
    • Brunner-La Rocca, H., Fleischhacker, L., Golubnitschaja, O., Heemskerk, F., Helms, T., Hoedemakers, T., Allianses, S. H., Jaarsma, T., Kinkorova, J., Ramaekers, J., Ruff, P., Schnur, I., Vanoli, E., Verdu, J., & Zippel-Schultz, B. (2016). Challenges in personalised management of chronic diseases-heart failure as prominent example to advance the care process. The EPMA Journal, 7, [2]. https://doi.org/10.1186/s13167-016-0051-9
    • Daamen, M. A. M. J., Hamers, J. P. H., Gorgels, A. P. M., Tan, F. E. S., Schols, J. M. G. A., & Brunner-La Rocca, H. (2016). Treatment of heart failure in nursing home residents. Journal of Geriatric Cardiology, 13(1), 44-50. https://doi.org/10.11909/j.issn.1671-5411.2016.01.001
    • van der Velden - Daamen, M., Hamers, J., Brunner-La Rocca, H., & Schols, J. (2016). Hartfalen bij verpleeghuisbewoners: Een moeilijke diagnose. Nederlands Tijdschrift voor Geneeskunde, 160, [D390]. https://www.ntvg.nl/system/files/publications/d390.pdf
  • 2015
    • Hazebroek, M. R., Kemna, M. J., Schalla, S., Sanders-van Wijk, S., Gerretsen, S. C., Dennert, R., Merken, J., Kuznetsova, T., Staessen, J. A., Brunner-La Rocca, H. P., van Paassen, P., Tervaert, J. W. C., & Heymans, S. (2015). Prevalence and prognostic relevance of cardiac involvement in ANCA-associated vasculitis: Eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis. International Journal of Cardiology, 199, 170-179. https://doi.org/10.1016/j.ijcard.2015.06.087
    • Van Wijk, S., Van Empel, V., Davarzani, N., Maeder, M. T., Muzzarelli, S., Jeker, U., Dieterle, T., Handschin, R., Kiencke, S., Pfisterer, M. E., Brunner-La Rocca, H. P., & investigators, F. T. TIME-CHF. (2015). Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction. European journal of heart failure, 17(10), 1006-1014. https://doi.org/10.1002/ejhf.414
    • Brunner-La Rocca, H., & Bektas, S. (2015). Biomarker guided therapy in chronic heart failure. Cardiac Failure Review, 1(2), 96-101. https://doi.org/10.15420/cfr.2015.1.2.96
  • 2014
    • Bekkers, S. C. A. M., & Brunner-La Rocca, H. P. (2014). Elderly primary care hypertension patients-who to refer for echocardiography?Netherlands Heart Journal, 22(5), 231-233. https://doi.org/10.1007/s12471-014-0550-z
    • Peeters, J. M. P. W. U., Sanders-van Wijk, S., Bektas, S., Knackstedt, C., Rickenbacher, P., Nietlispach, F., Handschin, R., Maeder, M. T., Muzzarelli, S. F., Pfisterer, M. E., & Brunner-La Rocca, H. P. (2014). Biomarkers in outpatient heart failure management; Are they correlated to and do they influence clinical judgment?Netherlands Heart Journal, 22(3), 115-121. https://doi.org/10.1007/s12471-013-0503-y
    • Burkard, T., Pfister, O., Rickli, H., Follath, F., Hack, D., Zaker, R., Pittl, U., Handschin, R., Pfisterer, M., & Brunner-La Rocca, H. -P. (2014). Prognostic impact of systemic inflammatory diseases in elderly patients with congestive heart failure. QJM: An International Journal of Medicine, 107(2), 131-138. https://doi.org/10.1093/qjmed/hct205
    • Mafi Rad, M., Blaauw, Y., Debie, L., Brunner-La Rocca, H., & Vernooy, K. (2014). Evaluation of Left Ventricular Endocardial Cardiac Resynchronization Therapy in a Non-responder with Ventricular Arrhythmias. Indian pacing and electrophysiology journal, 14(1), 32-6. https://doi.org/10.1016/S0972-6292(16)30713-6
    • van Dongen, M., van Kraaij, D., Schalla, S., Brunner-La Rocca, H., & Driessen, R. (2014). Severe mitral regurgitation caused by eosinophilic endocarditis. Journal of Cardiology Cases, 10(3). https://doi.org/10.1016/j.jccase.2014.05.012
  • 2012
    • Scharf, C., Ng, G. A., Wieczorek, M., Deneke, T., Furniss, S. S., Murray, S., Debruyne, P., Hobson, N., Berntsen, R. F., Schneider, M. A., Hauer, H. A., Halimi, F., Boveda, S., Asbach, S., Boesche, L., Zimmermann, M., Brigadeau, F., Taieb, J., Merkel, M., ... Boersma, L. V. A. (2012). European survey on efficacy and safety of duty-cycled radiofrequency ablation for atrial fibrillation. EP Europace, 14(12), 1700-1707. https://doi.org/10.1093/europace/eus188
    • Burkard, T., Kaiser, C. A., Brunner-La Rocca, H., Osswald, S., Pfisterer, M. E., & Jeger, R. V. (2012). Combined clopidogrel and proton pump inhibitor therapy is associated with higher cardiovascular event rates after percutaneous coronary intervention: a report from the BASKET trial. Journal of Internal Medicine, 271(3), 257-263. https://doi.org/10.1111/j.1365-2796.2011.02423.x
    • Octavia, Y., Rocca, H. P. B-L., & Moens, A. L. (2012). NADPH oxidase-dependent oxidative stress in the failing heart: From pathogenic roles to therapeutic approach. Free Radical Biology and Medicine, 52(2), 291-297. https://doi.org/10.1016/j.freeradbiomed.2011.10.482
  • 2011
    • Muzzarelli, S., Stricker, B. H., Pfister, O., Foglia, P., Moschovitis, G., Mombelli, G., & Brunner-La Rocca, H. (2011). Individual dosage of digoxin in patients with heart failure. QJM: An International Journal of Medicine, 104(4), 309-317. https://doi.org/10.1093/qjmed/hcq196
    • Leventhal, M. E., Denhaerynck, K., Brunner-La Rocca, H-P., Burnand, B., Conca, A., Bernasconi, A. T., Mahrer-Imhof, R., Froelicher, E. S., & De Geest, S. (2011). Swiss Interdisciplinary Management Programme for Heart Failure (SWIM-HF). Swiss Medical Weekly, 141, 10. https://doi.org/10.4414/smw.2011.13171
    • Bläuer, C., Mahrer-Imhof, R., Brunner-La Rocca, H., Mueller, C. P., Eze, G., Milbich, I., & Spirig, R. (2011). Development and Implementation of a multidisciplinary nurse-led educational programme for inpatients with heart failure: The Basel-HF-Programme: Entwicklung und Implementierung eines multidisziplinären pflegegeleiteten Programms zur stationären Betreuung von Patientinnen und Patienten mit Herzinsuffizienz: Das Basler HI-Programm. Pflege, 24(1), 29-41. https://doi.org/10.1024/1012-5302/a000089
    • Alzand, B. S. N., Mihl, C., & La Rocca, H. P. B. (2011). Dehydration with High Natriuretic Peptide Levels! A Word of Caution. Cardiology, 118(2), 75-78. https://doi.org/10.1159/000326855
  • 2010
    • Kaiser, C. A., Galatius, S., Erne, P., Eberli, F., Alber, H., Rickli, H., Pedrazzini, G., Hornig, B., Bertel, O., Bonetti, P., De Servi, S., Brunner-La Rocca, H-P., Ricard, I., & Pfisterer, M. E. (2010). Drug-Eluting versus Bare-Metal Stents in Large Coronary Arteries. New England Journal of Medicine, 363(24), 2310-2319. https://doi.org/10.1056/NEJMoa1009406