Stephane Heymans

Professor

Stephane Heymans is Professor of Cardiomyopathies and Head of the Centre for Heart Failure Research, Department of Cardiology, Maastricht University. He obtained his Medical Degree from the KU Leuven (Belgium) in 1995 and went on to get a PhD in Medical Sciences in 2000, studying the role of proteinases in acute myocardial infarction. In 2003, he joined the Department of Cardiology of Maastricht UMC+ as an academic medical specialist and in 2006 he took over the Multidisciplinary Cardiomyopathy Program (Genetics, Immunology, Microbiology and Pathology departments).

In 2008, he established his independent research laboratory at Cardiovascular Research Institute Maastricht. His research interests focus on the molecular mechanisms of heart failure, looking at the interplay between inflammatory cells, fibroblasts and cardiomyocytes. Particular focus is on the role of non-structural matrix proteins, matrix turnover and non-coding RNAs.

Furthermore, he is Professor of 'Inflammation and Matrix Biology in Cardiomyopathies' at the University of Leuven and he is a board member of the ESC Heart Failure Association, ESC Working Group of Myocardial Function, ESC Heart Failure Association Committee on Diastolic Heart Failure and ESC Heart Failure Association Committee on Translational Research.

Website www.hfresearch.eu

Department of Cardiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G3.230
T: +31(0)43 388 43 04

  • 2020
    • Verdonschot, J. A. J., Merken, J. J., van Stipdonk, A. M. W., Pliger, P., Derks, K. W. J., Wang, P., Henkens, M. T. H. M., van Paassen, P., Hamid, M. A. A., van Empel, V. P. M., Knackstedt, C., Luermans, J. G. L. M., Crijns, H. J. G. M., Brunner-La Rocca, H-P., Brunner, H. G., Poelzl, G., Vernooy, K., Heymans, S. R. B., & Hazebroek, M. R. (2020). Cardiac Inflammation Impedes Response to Cardiac Resynchronization Therapy in Patients With Idiopathic Dilated Cardiomyopathy. Circulation-Arrhythmia and Electrophysiology, 13(11), 1311-1320. https://doi.org/10.1161/CIRCEP.120.008727
    • Seferovic, P. M., Fragasso, G., Petrie, M., Mullens, W., Ferrari, R., Thum, T., Bauersachs, J., Anker, S. D., Ray, R., Cavusoglu, Y., Polovina, M., Metra, M., Ambrosio, G., Prasad, K., Seferovic, J., Jhund, P. S., Dattilo, G., Celutkiene, J., Piepoli, M., ... Rosano, G. M. C. (2020). Heart Failure Association of the European Society of Cardiology update on sodium-glucose co-transporter 2 inhibitors in heart failure (an update on the sodium-glucose co-transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology). European journal of heart failure, 22(11), 1984-1986. https://doi.org/10.1002/ejhf.2026
    • Remmelzwaal, S., van Ballegooijen, A. J., Schoonmade, L. J., Dal Canto, E., Handoko, M. L., Henkens, M. T. H. M., van Empel, V., Heymans, S. R. B., & Beulens, J. W. J. (2020). Natriuretic peptides for the detection of diastolic dysfunction and heart failure with preserved ejection fraction-a systematic review and meta-analysis. BMC Medicine, 18(1), [290]. https://doi.org/10.1186/s12916-020-01764-x
    • Selevsek, N., Caiment, F., Nudischer, R., Gmuender, H., Agarkova, I., Atkinson, F. L., Bachmann, I., Baier, V., Barel, G., Bauer, C., Boerno, S., Bosc, N., Clayton, O., Cordes, H., Deeb, S., Gotta, S., Guye, P., Hersey, A., Hunter, F. M. I., ... Kleinjans, J. (2020). Network integration and modelling of dynamic drug responses at multi-omics levels. Communications Biology, 3(1), [573]. https://doi.org/10.1038/s42003-020-01302-8
    • Verdonschot, J. A. J., Hazebroek, M. R., Krapels, I. P. C., Henkens, M. T. H. M., Raafs, A., Wang, P., Merken, J. J., Claes, G. R. F., Vanhoutte, E. K., van den Wijngaard, A., Heymans, S. R. B., & Brunner, H. G. (2020). Implications of Genetic Testing in Dilated Cardiomyopathy. Circulation: Genomic and Precision Medicine, 13(5), 476-487. [003031]. https://doi.org/10.1161/CIRCGEN.120.003031
    • Timmermans, P., Barradas-Pires, A., Ali, O., Henkens, M., Heymans, S., & Negishi, K. (2020). Prednisone and azathioprine in patients with inflammatory cardiomyopathy: systematic review and meta-analysis. Esc heart failure, 7(5), 2278-2296. https://doi.org/10.1002/ehf2.12762
    • Verdonschot, J. A. J., Derks, K. W. J., Hazebroek, M. R., Wang, P., Robinson, E. L., Adriaens, M. E., Krapels, I. P. C., van den Wijngaard, A., Brunner, H. G., & Heymans, S. R. B. (2020). Distinct Cardiac Transcriptomic Clustering in Titin and Lamin A/C-Associated Dilated Cardiomyopathy Patients. Circulation, 142(12), 1230-1232. https://doi.org/10.1161/CIRCULATIONAHA.119.045118
    • Tocchetti, C. G., Ameri, P., de Boer, R. A., D'Alessandra, Y., Russo, M., Sorriento, D., Ciccarelli, M., Kiss, B., Bertrand, L., Dawson, D., Falcao-Pires, I., Giacca, M., Hamdani, N., Linke, W. A., Mayr, M., van der Velden, J., Zacchigna, S., Ghigo, A., Hirsch, E., ... Thum, T. (2020). Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovascular Research, 116(11), 1820-1834. https://doi.org/10.1093/cvr/cvaa222
    • Bar, C., Chatterjee, S., Pires, I. F., Rodrigues, P., Sluijter, J. P. G., Boon, R. A., Nevado, R. M., Andres, V., Sansonetti, M., de Windt, L., Ciccarelli, M., Hamdani, N., Heymans, S., Videira, R. F., Tocchetti, C. G., Giacca, M., Zacchigna, S., Engelhardt, S., Dimmeler, S., ... Thum, T. (2020). Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovascular Research, 116(11), 1805-1819. https://doi.org/10.1093/cvr/cvaa195
    • Pellicori, P., Ferreira, J. P., Mariottoni, B., Brunner-La Rocca, H-P., Ahmed, F. Z., Verdonschot, J., Collier, T., Cuthbert, J. J., Petutschnigg, J., Mujaj, B., Girerd, N., Gonzalez, A., Clark, A. L., Cosmi, F., Staessen, J. A., Heymans, S., Latini, R., Rossignol, P., Zannad, F., & Cleland, J. G. F. (2020). Effects of spironolactone on serum markers of fibrosis in people at high risk of developing heart failure: rationale, design and baseline characteristics of a proof-of-concept, randomised, precision-medicine, prevention trial. The Heart OMics in AGing (HOMAGE) trial. European journal of heart failure, 22(9), 1711-1723. https://doi.org/10.1002/ejhf.1716
    • Henkens, M. T. H. M., Remmelzwaal, S., Robinson, E. L., van Ballegooijen, A. J., Aizpurua, A. B., Verdonschot, J. A. J., Raafs, A. G., Weerts, J., Hazebroek, M. R., Wijk, S. S., Handoko, M. L., den Ruijter, H. M., Lam, C. S. P., de Boer, R. A., Paulus, W. J., van Empel, V. P. M., Vos, R., Rocca, H-P. B-L., Beulens, J. W. J., & Heymans, S. R. B. (2020). Risk of bias in studies investigating novel diagnostic biomarkers for heart failure with preserved ejection fraction. A systematic review. European journal of heart failure, 22(9), 1586-1597. https://doi.org/10.1002/ejhf.1944
    • Celutkiene, J., Pudil, R., Lopez-Fernandez, T., Grapsa, J., Nihoyannopoulos, P., Bergler-Klein, J., Cohen-Solal, A., Farmakis, D., Tocchetti, C. G., von Haehling, S., Barberis, V., Flachskampf, F. A., Ceponiene, I., Haegler-Laube, E., Suter, T., Lapinskas, T., Prasad, S., de Boer, R. A., Wechalekar, K., ... Lyon, A. R. (2020). Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC). European journal of heart failure, 22(9), 1504-1524. https://doi.org/10.1002/ejhf.1957
    • Seferovic, P. M., Fragasso, G., Petrie, M., Mullens, W., Ferrari, R., Thum, T., Bauersachs, J., Anker, S. D., Ray, R., Cavusoglu, Y., Polovina, M., Metra, M., Ambrosio, G., Prasad, K., Seferovic, J., Jhund, P. S., Dattilo, G., Celutkiene, J., Piepoli, M., ... Rosano, G. M. C. (2020). Sodium-glucose co-transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 22(9), 1495-1503. https://doi.org/10.1002/ejhf.1954
    • Wagner, M., Bertero, E., Nickel, A., Kohlhaas, M., Gibson, G. E., Heggermont, W., Heymans, S., & Maack, C. (2020). Selective NADH communication from alpha-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart. Basic Research in Cardiology, 115(5), [53]. https://doi.org/10.1007/s00395-020-0815-1
    • Summer, G., Kuhn, A. R., Munts, C., Miranda-Silva, D., Leite-Moreira, A. F., Lourenco, A. P., Heymans, S., Falcao-Pires, I., & van Bilsen, M. (2020). A directed network analysis of the cardiome identifies molecular pathways contributing to the development of HFpEF. Journal of Molecular and Cellular Cardiology, 144, 66-75. https://doi.org/10.1016/j.yjmcc.2020.05.008
    • Verdonschot, J. A. J., Vanhoutte, E. K., Claes, G. R. F., van den Enden, A. T. J. M. H., Hoeijmakers, J. G. J., Hellebrekers, D. M. E. I., Haan, A. D., Christiaans, I., Deprez, R. H. L., Boen, H. M., Craenenbroeck, E. M. V., Loeys, B. L., Hoedemaekers, Y. M., Marcelis, C., Kempers, M., Brusse, E., Waning, J. I., Baas, A. F., Dooijes, D., ... Brunner, H. G. (2020). A mutation update for the FLNC gene in myopathies and cardiomyopathies. Human Mutation, 41(6), 1091-1111. https://doi.org/10.1002/humu.24004
    • Suthahar, N., Meems, L. M. G., van Veldhuisen, D. J., Walter, J. E., Gansevoort, R. T., Heymans, S., Schroen, B., van der Harst, P., Kootstra-Ros, J. E., van Empel, V., Mueller, C., Bakker, S. J. L., & de Boer, R. A. (2020). High-Sensitivity Troponin-T and Cardiovascular Outcomes in the Community: Differences Between Women and Men. Mayo Clinic Proceedings, 95(6), 1158-1168. https://doi.org/10.1016/j.mayocp.2020.01.017
    • Cuijpers, I., Simmonds, S. J., van Bilsen, M., Czarnowska, E., Miqueo, A. G., Heymans, S., Kuhn, A. R., Mulder, P., Ratajska, A., Jones, E. A., & Brakenhielm, E. (2020). Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities. Basic Research in Cardiology, 115(4), [39]. https://doi.org/10.1007/s00395-020-0798-y
    • Cannata, A., De Angelis, G., Boscutti, A., Normand, C., Artico, J., Gentile, P., Zecchin, M., Heymans, S., Merlo, M., & Sinagra, G. (2020). Arrhythmic risk stratification in non-ischaemic dilated cardiomyopathy beyond ejection fraction. Heart, 106(9), 656-664. https://doi.org/10.1136/heartjnl-2019-315942
    • Seferovic, P. M., Piepoli, M. F., Lopatin, Y., Jankowska, E., Polovina, M., Anguita-Sanchez, M., Stoerk, S., Lainscak, M., Milicic, D., Milinkovic, I., Filippatos, G., Coats, A. J. S., Anker, S., Backs, J., Bauersachs, J., Ben Gal, T., de Boer, R. A., Doehner, W., Celutkiene, J., ... Heart Failure Association Board of the European Society of Cardiology (2020). Heart Failure Association of the European Society of Cardiology Quality of Care Centres Programme: design and accreditation document. European journal of heart failure, 22(5), 763-774. https://doi.org/10.1002/ejhf.1784
    • Verdonschot, J. A. J., Wang, P., Van Bilsen, M., Hazebroek, M. R., Merken, J. J., Vanhoutte, E. K., Henkens, M. T. H. M., Van Den Wijngaard, A., Glatz, J. F. C., Krapels, I. P. C., Brunner, H. G., Heymans, S. R. B., & Bierau, J. (2020). Metabolic Profiling Associates with Disease Severity in Nonischemic Dilated Cardiomyopathy. Journal of Cardiac Failure, 26(3), 212-222. https://doi.org/10.1016/j.cardfail.2019.09.004
    • Stienen, S., Ferreira, J. P., Kobayashi, M., Preud'homme, G., Dobre, D., Machu, J-L., Duarte, K., Bresso, E., Devignes, M-D., Lopez, N., Girerd, N., Aakhus, S., Ambrosio, G., Brunner-La Rocca, H-P., Fontes-Carvalho, R., Fraser, A. G., Van Heerebeek, L., Heymans, S., De Keulenaer, G., ... Rossignol, P. (2020). Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure). Biomarkers, 25(2), 201-211. https://doi.org/10.1080/1354750X.2020.1727015
    • Verdonschot, J. A. J., Robinson, E. L., James, K. N., Mohamed, M. W., Claes, G. R. F., Casas, K., Vanhoutte, E. K., Hazebroek, M. R., Kringlen, G., Pasierb, M. M., van den Wijngaard, A., Glatz, J. F. C., Heymans, S. R. B., Krapels, I. P. C., Nahas, S., Brunner, H. G., & Szklarczyk, R. (2020). Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers. Molecular genetics & genomic medicine, 8(2), [e1049]. https://doi.org/10.1002/mgg3.1049
    • Verdonschot, J. A. J., Merken, J. J., Brunner-La Rocca, H-P., Hazebroek, M. R., Eurlings, C. G. M. J., Thijssen, E., Wang, P., Weerts, J., van Empel, V., Schummers, G., Schreckenberg, M., van den Wijngaard, A., Lumens, J., Brunner, H. G., Heymans, S. R. B., Krapels, I. P. C., & Knackstedt, C. (2020). Value of Speckle Tracking-Based Deformation Analysis in Screening Relatives of Patients With Asymptomatic Dilated Cardiomyopathy. JACC-Cardiovascular Imaging, 13(2), 549-558. https://doi.org/10.1016/j.jcmg.2019.02.032
    • Gomes, C. P. C., Schroen, B., Kuster, G. M., Robinson, E. L., Ford, K., Squire, I. B., Heymans, S., Martelli, F., Emanueli, C., Devaux, Y., & EU-CardioRNA COST Action (CA17129) (2020). Regulatory RNAs in Heart Failure. Circulation, 141(4), 313-328. https://doi.org/10.1161/CIRCULATIONAHA.119.042474
    • Azodi, M., Kamps, R., Heymans, S., & Robinson, E. L. (2020). The Missing "lnc" between Genetics and Cardiac Disease. Non-coding RNA, 6(1), [3]. https://doi.org/10.3390/ncrna6010003
    • Bertero, E., Sequeira, V., Heymans, S., & Maack, C. (2020). Response to 'The possible role of insulin and glucagon in patients with heart failure and Type 2 diabetes'. European Heart Journal, 41(2), 326-327. https://doi.org/10.1093/eurheartj/ehz243
    • Simmonds, S. J., Cuijpers, I., Heymans, S., & Jones, E. A. V. (2020). Cellular and Molecular Differences between HFpEF and HFrEF: A Step Ahead in an Improved Pathological Understanding. Cells, 9(1), [242]. https://doi.org/10.3390/cells9010242
    • Ferreira, J. P., Pizard, A., Machu, J-L., Bresso, E., Brunner-La Rocca, H-P., Girerd, N., Leroy, C., Gonzalez, A., Diez, J., Heymans, S., Devignes, M-D., Rossignol, P., Zannad, F., & FIBRO-TARGETS investigators (2020). Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses. Clinical research in cardiology, 109(1), 22-33. https://doi.org/10.1007/s00392-019-01480-4
  • 2019
    • Lewalle, A., Land, S., Merken, J. J., Raafs, A., Sepulveda, P., Heymans, S., Kleinjans, J., & Niederer, S. A. (2019). Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure. Biophysical Journal, 117(12), 2337-2348. https://doi.org/10.1016/j.bpj.2019.07.033
    • Maack, C., Eschenhagen, T., Hamdani, N., Heinzel, F. R., Lyon, A. R., Manstein, D. J., Metzger, J., Papp, Z., Tocchetti, C. G., Yilmaz, M. B., Anker, S. D., Balligand, J-L., Bauersachs, J., Brutsaert, D., Carrier, L., Chlopicki, S., Cleland, J. G., de Boer, R. A., Dietl, A., ... Mebazaa, A. (2019). Treatments targeting inotropy. European Heart Journal, 40(44), 3626-3640. https://doi.org/10.1093/eurheartj/ehy600
    • Iborra-Egea, O., Santiago-Vacas, E., Yurista, S. R., Lupón, J., Packer, M., Heymans, S., Zannad, F., Butler, J., Pascual-Figal, D., Lax, A., Núñez, J., de Boer, R. A., & Bayés-Genís, A. (2019). Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes. JACC: Basic to Translational Science, 4(7), 831-840. https://doi.org/10.1016/j.jacbts.2019.07.010
    • Triposkiadis, F., Butler, J., Abboud, F. M., Armstrong, P. W., Adamopoulos, S., Atherton, J. J., Backs, J., Bauersachs, J., Burkhoff, D., Bonow, R. O., Chopra, V. K., de Boer, R. A., de Windt, L., Hamdani, N., Hasenfuss, G., Heymans, S., Hulot, J-S., Konstam, M., Lee, R. T., ... De Keulenaer, G. (2019). The continuous heart failure spectrum: moving beyond an ejection fraction classification. European Heart Journal, 40(26), 2155-2163. https://doi.org/10.1093/eurheartj/ehz158
    • Bauersachs, J., Koenig, T., van der Meer, P., Petrie, M. C., Hilfiker-Kleiner, D., Mbakwem, A., Hamdan, R., Jackson, A. M., Forsyth, P., de Boer, R. A., Mueller, C., Lyon, A. R., Lund, L. H., Piepoli, M. F., Heymans, S., Chioncel, O., Anker, S. D., Ponikowski, P., Seferovic, P. M., ... Sliwa, K. (2019). Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy. European journal of heart failure, 21(7), 827-843. https://doi.org/10.1002/ejhf.1493
    • Verdonschot, J. A. J., Hazebroek, M. R., Ware, J. S., Prasad, S. K., & Heymans, S. R. B. (2019). Role of Targeted Therapy in Dilated Cardiomyopathy: The Challenging Road Toward a Personalized Approach. Journal of the American Heart Association, 8(11), [012514]. https://doi.org/10.1161/JAHA.119.012514
    • Gomes, C. P. D. C., Agg, B., Andova, A., Arslan, S., Baker, A., Bartekova, M., Beis, D., Betsou, F., Wettinger, S. B., Bugarski, B., Condorelli, G., da Silva, G. J. J., Danilin, S., de Gonzalo-Calvo, D., Buil, A., Carmo-Fonseca, M., Enguita, F. J., Felekkis, K., Ferdinandy, P., ... Devaux, Y. (2019). Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129. Non-coding RNA research, 5(2), [31]. https://doi.org/10.3390/ncrna5020031
    • Ferreira, J. P., Verdonschot, J., Collier, T., Wang, P., Pizard, A., Bar, C., Bjorkman, J., Boccanelli, A., Butler, J., Clark, A., Cleland, J. G., Delles, C., Diez, J., Girerd, N., Gonzalez, A., Hazebroek, M., Huby, A-C., Jukema, W., Latini, R., ... Zannad, F. (2019). Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure The HOMAGE Study. Circulation-Heart Failure, 12(5), [005897]. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005897
    • Verjans, R., Derks, W. J. A., Korn, K., Soennichsen, B., van Leeuwen, R. E. W., Schroen, B., van Bilsen, M., & Heymans, S. (2019). Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure. Scientific Reports, 9, [6055]. https://doi.org/10.1038/s41598-019-41491-9
    • Deckx, S., Johnson, D. M., Rienks, M., Carai, P., Van Deel, E., Van der Velden, J., Sipido, K. R., Heymans, S., & Papageorgiou, A-P. (2019). Extracellular SPARC increases cardiomyocyte contraction during health and disease. PLOS ONE, 14(4), [0209534]. https://doi.org/10.1371/journal.pone.0209534
    • Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M., & Schroen, B. (2019). AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism. Molecular Therapy - Nucleic Acids, 14, 424-437. https://doi.org/10.1016/j.omtn.2018.12.010
    • de Boer, R. A., De Keulenaer, G., Bauersachs, J., Brutsaert, D., Cleland, J. G., Diez, J., Du, X-J., Ford, P., Heinzel, F. R., Lipson, K. E., McDonagh, T., Lopez-Andres, N., Lunde, I. G., Lyon, A. R., Pollesello, P., Prasad, S. K., Tocchetti, C. G., Mayr, M., Sluijter, J. P. G., ... Heymans, S. (2019). Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology. European journal of heart failure, 21(3), 272-285. https://doi.org/10.1002/ejhf.1406
    • Verdonschot, J. A. J., Cooper, L. T., & Heymans, S. R. B. (2019). Parvovirus B19 in Dilated Cardiomyopathy: There Is More Than Meets the Eye. Journal of Cardiac Failure, 25(1), 64-66. https://doi.org/10.1016/j.cardfail.2018.11.017
  • 2018
    • Maack, C., Lehrke, M., Backs, J., Heinzel, F. R., Hulot, J-S., Marx, N., Paulus, W. J., Rossignol, P., Taegtmeyer, H., Bauersachs, J., Bayes-Genis, A., Brutsaert, D., Bugger, H., Clarke, K., Cosentino, F., De Keulenaer, G., Dei Cas, A., Gonzalez, A., Huelsmann, M., ... Heymans, S. (2018). Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology. European Heart Journal, 39(48), 4243–4254. https://doi.org/10.1093/eurheartj/ehy596
    • Steklov, M., Pandolf, S., Baietti, M. F., Batiuk, A., Carai, P., Najm, P., Zhang, M., Jang, H., Renzi, F., Cai, Y., Asbagh, L. A., Pastor, T., De Troyer, M., Simicek, M., Radaelli, E., Brems, H., Legius, E., Tavernier, J., Gevaert, K., ... Sablina, A. A. (2018). Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. Science, 362(6419), 1177-1182. https://doi.org/10.1126/science.aap7607
    • Rienks, M., Carai, P., van Teeffelen, J., Eskens, B., Verhesen, W., Hemmeryckx, B., Johnson, D. M., van Leeuwen, R., Jones, E. A., Heymans, S., & Papageorgiou, A-P. (2018). SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis. Matrix Biology, 74, 21-34. https://doi.org/10.1016/j.matbio.2018.04.015
    • Verdonschot, J. A. J., Hazebroek, M. R., Wang, P., Sanders-van Wijk, S., Merken, J. J., Adriaansen, Y. A., van den Wijngaard, A., Krapels, I. P. C., Brunner-La Rocca, H-P., Brunner, H. G., & Heymans, S. R. B. (2018). Clinical Phenotype and Genotype Associations With Improvement in Left Ventricular Function in Dilated Cardiomyopathy. Circulation-Heart Failure, 11(11), [005220]. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005220
    • Merken, J., Brunner-La Rocca, H-P., Weerts, J., Verdonschot, J., Hazebroek, M., Schummers, G., Schreckenberg, M., Lumens, J., Heymans, S., & Knackstedt, C. (2018). Heart Failure With Recovered Ejection Fraction. Journal of the American College of Cardiology, 72(13), 1556-1557. https://doi.org/10.1016/j.jacc.2018.06.070
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