Section Miranda Nabben
- 2026
- Glatz, J. F. C., Heather, L. C., Larsen, T. S., Nabben, M., & Luiken, J. J. F. P. (2026). The metabolic balancing act between fatty acid and glucose substrate use for optimal myocardial function: key role for membrane substrate transporters. American Journal of Physiology-heart and Circulatory Physiology, 330(4), H1195-H1207. https://doi.org/10.1152/ajpheart.00868.2025
- Tie, H., Hou, M., Zhang, J., Hoes, M. F., Neumann, D., Luiken, J. J. F. P., & Wang, S. (2026). Comprehensive methodological evaluation of V-ATPase assembly in the context of cardiac lipid overload: implications for (endo)lysosomal function and autophagy. Autophagy, 22(4), 830-846. https://doi.org/10.1080/15548627.2025.2608963
- Schianchi, F., Guns, J., Bouwman, F. G., Bogie, J. F. J., Nabben, M., Strzelecka, A., Van Leeuwen, R., Kapsokalyvas, D., Dennis, K. M. J. H., Heather, L. C., Wang, S., Glatz, J. F. C., Neumann, D., & Luiken, J. J. F. P. (2026). Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart. Cellular and Molecular Life Sciences, 83(1), Article 187. https://doi.org/10.1007/s00018-026-06179-0
- Torfs, T., Veltrop, R. J. A., Lezzoche, G., Heymans, S. R. B., Verdonschot, J. A. J., & Nabben, M. (2026). Metabolic Dysregulation in Laminopathies: Implications for Heart Failure and Cardiac Health. Current Heart Failure Reports, 23(1), Article 6. https://doi.org/10.1007/s11897-025-00735-8
- Willemars, M. M. A., Sun, A., Wang, S., Simsek Papur, O., Brouns-Strzelecka, A., Van Leeuwen, R., Vanherle, S. J. V., Kapsokalyvas, D., Glatz, J. F. C., Neumann, D., Nabben, M., & Luiken, J. J. F. P. (2026). Phosphatidylinositol 4-Kinase IIIβ: A Therapeutic Target for Contractile Dysfunction in Hypertrophic Cardiomyocytes. International Journal of Molecular Sciences, 27(2), Article 595. https://doi.org/10.3390/ijms27020595
- 2025
- Hoes, M. F., Wang, S., & Luiken, J. J. F. P. (2025). Endosomal Mechanisms in Heart Failure Pathophysiology. Current Heart Failure Reports, 22(1), Article 38. https://doi.org/10.1007/s11897-025-00728-7
- Stroeks, S. L. V. M., Merlo, M., Mora-Ayestaran, N., Jason, M., Tayal, U., Wang, P., Cannatà, A., Sikking, M. A., Dal Ferro, M., Peiro, B., Willemars, M., Hellebrekers, D. M. E. I., van Leeuwen, R. E. W., Setti, M., Gonzalez-Lopez, E., Krapels, I. P. C., Pio Loco Detto Gava, C., van den Wijngaard, A., Henkens, M. T. H. M., ... Verdonschot, J. A. J. (2025). Sex Differences in Prognosis of Patients With Genetic Dilated Cardiomyopathy. Circulation-Heart Failure, 18(11), e012592. Article 012592. https://doi.org/10.1161/CIRCHEARTFAILURE.124.012592
- Beverborg, N. G., Alnuwaysir, R. I. S., Markousis-Mavrogenis, G., Hoes, M. F., van Der Wal, H. H., Romaine, S. P. R., Nath, M., Koekoemoer, A., Cleland, J. G. F., Lang, C. C., Anker, S. D., Dickstein, K., Metra, M., Ng, L. L., van Veldhuisen, D. J., Voors, A. A., Samani, N. J., & van Der Meer, P. (2025). The transcriptional profile of iron deficiency in patients with heart failure: Heme-sparing and reduced immune processes. European journal of heart failure, 27(11), 2313-2324. https://doi.org/10.1002/ejhf.3562
- Wong, L. Y., Torfs, T., Vanherle, S. J. V., Janssen, J., Claes, G. R. F., Stroeks, S. L. V. M., Willemars, M. M. A., Schianchi, F., Kapsokalyvas, D., Weltjens, E., Swinnen, A., Strzelecka, A., Krapels, I. P. C., Heymans, S. R. B., Glatz, J., van den Wijngaard, A., Brunner, H. G., Broers, J., Luiken, J. F. P., ... Nabben, M. (2025). Clinical and metabolic consequences of a historic pathogenic lamin A/C founder variant. Scientific Reports, 15(1), Article 23842. https://doi.org/10.1038/s41598-025-08495-0
- Michel, L. Y. M., Esfahani, H., De Mulder, D., Verdoy, R., Ambroise, J., Roelants, V., Bouchard, B., Fabian, N., Savary, J., Dewulf, J. P., Doumont, T., Bouzin, C., Haufroid, V., Luiken, J. J. F. P., Nabben, M., Singleton, M. L., Bertrand, L., Ruiz, M., Des Rosiers, C., & Balligand, J.-L. (2025). An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress. Circulation, 151(18), 1312-1328. https://doi.org/10.1161/CIRCULATIONAHA.124.067876
- 2024
- Wang, F., Neumann, D., Kapsokalyvas, D., Hoes, M. F., Schianchi, F., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2024). Specific Compounds Derived from Traditional Chinese Medicine Ameliorate Lipid-Induced Contractile Dysfunction in Cardiomyocytes. International Journal of Molecular Sciences, 25(15), Article 8131. https://doi.org/10.3390/ijms25158131
- Collins, H. E., Alexander, B. T., Care, A. S., Davenport, M. H., Davidge, S. T., Eghbali, M., Giussani, D. A., Hoes, M. F., Julian, C. G., LaVoie, H. A., Olfert, I. M., Ozanne, S. E., Bytautiene Prewit, E., Warrington, J. P., Zhang, L., & Goulopoulou, S. (2024). Guidelines for Assessing Maternal Cardiovascular Physiology During Pregnancy and Postpartum. American Journal of Physiology-heart and Circulatory Physiology, 327(1), H191-H220. https://doi.org/10.1152/ajpheart.00055.2024
- Wang, S., Han, Y., Liu, R., Hou, M., Neumann, D., Zhang, J., Wang, F., Li, Y., Zhao, X., Schianchi, F., Dai, C., Liu, L., Nabben, M., Glatz, J. F. C., Wu, X., Lu, X., Li, X., & Luiken, J. J. F. P. (2024). Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis. Circulation Research, 134(5), 505-525. https://doi.org/10.1161/CIRCRESAHA.123.322910
- Oberman, K., van Leeuwen, B. L., Nabben, M., Villafranca, J. E., & Schoemaker, R. G. (2024). J147 Affects Cognition And Anxiety After Surgery In Zucker Rats. Physiology & Behavior, 273, Article 114413. https://doi.org/10.1016/j.physbeh.2023.114413
- 2023
- Vinke, J. S. J., Gorter, A. R., Eisenga, M. F., Dam, W. A., van der Meer, P., van den Born, J., Bakker, S. J. L., Hoes, M. F., & de Borst, M. H. (2023). Iron deficiency is related to lower muscle mass in community-dwelling individuals and impairs myoblast proliferation. Journal of cachexia, sarcopenia and muscle, 14(4), 1865-1879. https://doi.org/10.1002/jcsm.13277
- Linders, A. N., Dias, I. B., Ovchinnikova, E. S., Vermeer, M. C. S. C., Hoes, M. F., Mavrogenis, G. M., Deiman, F. E., Gomez, K. F. A., Bliley, J. M., Nehme, J., Vink, A., Gietema, J., de Boer, R. A., Westenbrink, D., Sillje, H. H. W., Hilfiker-Kleiner, D., van Laake, L. W., Feinberg, A. W., Demaria, M., ... van der Meer, P. (2023). Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues. JACC: CardioOncology, 5(3), 298-315. https://doi.org/10.1016/j.jaccao.2023.03.012
- Vermeer, M. C. S. C., Arevalo Gomez, K. F., Hoes, M. F., Tromp, J., Verdonschot, J. A. J., Henkens, M. T. H. M., Silljé, H. H. W., Bolling, M. C., & van der Meer, P. (2023). Clinical Outcome in KLHL24 Cardiomyopathy. Circulation: Genomic and Precision Medicine, 16(4), 401-403. https://doi.org/10.1161/CIRCGEN.122.003998
- Verdonschot, J. A. J., Wang, P., Derks, K. W. J., Adriaens, M. E., Stroeks, S. L. V. M., Henkens, M. T. H. M., Raafs, A. G., Sikking, M., de Koning, B., van den Wijngaard, A., Krapels, I. P. C., Nabben, M., Brunner, H. G., & Heymans, S. R. B. (2023). Clustering of Cardiac Transcriptome Profiles Reveals Unique Subgroups of Dilated Cardiomyopathy Patients. JACC: Basic to Translational Science, 8(4), 406-418. https://doi.org/10.1016/j.jacbts.2022.10.010
- Stroeks, S. L. V. M., Lunde, I. G. G., Hellebrekers, D. M. E. I., Claes, G. R. F., Wakimoto, H., Gorham, J., Krapels, I. P. C., Vanhoutte, E. K. K., van den Wijngaard, A., Henkens, M. T. H. M., Raafs, A. G. G., Sikking, M. A. A., Broers, J. L. V., Nabben, M., Jones, E. A. V., Heymans, S. R. B., Brunner, H. G. G., & Verdonschot, J. A. J. (2023). Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy. Circulation: Genomic and Precision Medicine, 16(2), Article e003788. https://doi.org/10.1161/CIRCGEN.122.003788
- Sanchez-Aguilera, P., Lopez-Crisosto, C., Norambuena-Soto, I., Penannen, C., Zhu, J. M., Bomer, N., Hoes, M. F., van der Meer, P., Chiong, M., Westenbrink, B. D., & Lavandero, S. (2023). IGF-1 boosts mitochondrial function by a Ca2+ uptake-dependent mechanism in cultured human and rat cardiomyocytes. Frontiers in physiology, 14(1), Article 1106662. https://doi.org/10.3389/fphys.2023.1106662
- 2022
- Wang, S., Neumann, D., Westenbrink, B. D., Schianchi, F., Wong, L.-Y., Sun, A., Strzelecka, A., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2022). Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H+-ATPase Disassembly-Rescue by Specific Amino Acid Supplementation. International journal of molecular sciences, 23(21), Article 12909. https://doi.org/10.3390/ijms232112909
- Willemars, M. M. A., Nabben, M., Verdonschot, J. A. J., & Hoes, M. F. (2022). Evaluation of the Interaction of Sex Hormones and Cardiovascular Function and Health. Current Heart Failure Reports, 19(4), 200-212. https://doi.org/10.1007/s11897-022-00555-0
- Vuckovic, S., Dinani, R., Nollet, E. E., Kuster, D. W. D., Buikema, J. W., Houtkooper, R. H., Nabben, M., van der Velden, J., & Goversen, B. (2022). Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling. Stem Cell Research & Therapy, 13(1), Article 332. https://doi.org/10.1186/s13287-022-03021-9
- Wang, S. J., Han, Y. Y., Nabben, M., Neumann, D., Luiken, J. J. F. P., & Glatz, J. F. C. (2022). Endosomal v-ATPase as a Sensor Determining Myocardial Substrate Preference. Metabolites, 12(7), Article 579. https://doi.org/10.3390/metabo12070579
- Heather, L. C., Hafstad, A. D., Halade, G. V., Harmancey, R., Mellor, K. M., Mishra, P. K., Mulvihill, E. E., Nabben, M., Nakamura, M., Rider, O. J., Ruiz, M., Wende, A. R., & Ussher, J. R. (2022). Guidelines on Models of Diabetic Heart Disease. American Journal of Physiology-heart and Circulatory Physiology, 323(1), H176-H200. https://doi.org/10.1152/ajpheart.00058.2022
- Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2022). CD36 (SR-B2) as master regulator of cellular fatty acid homeostasis. Current Opinion in Lipidology, 33(2), 103-111. https://doi.org/10.1097/MOL.0000000000000819
- Glatz, J., Wang, F., Nabben, M., & Luiken, J. (2022). Myocardial lipid metabolism: Targeting CD36 to treat cardiac disease. Research Outreach, (128), 86-89. https://researchoutreach.org/publications/issue-128/
- 2021
- Wang, S. J., Schianchi, F., Neumann, D., Wong, L. Y., Sun, A. M., van Nieuwenhoven, F. A., Zeegers, M. P., Strzelecka, A., Col, U., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2021). Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis. Molecular Metabolism, 53, Article 101293. https://doi.org/10.1016/j.molmet.2021.101293
- Kapsokalyvas, D., Rosas, R., Janssen, R. W. A., Vanoevelen, J. M., Nabben, M., Strauch, M., Merhof, D., & van Zandvoort, M. A. M. J. (2021). Multiview deconvolution approximation multiphoton microscopy of tissues and zebrafish larvae. Scientific Reports, 11(1), Article 10160. https://doi.org/10.1038/s41598-021-89566-w
- Glatz, J. F. C., Wang, F., Nabben, M., & Luiken, J. J. F. P. (2021). CD36 as a target for metabolic modulation therapy in cardiac disease. Expert Opinion on Therapeutic Targets, 25(5), 393-400. https://doi.org/10.1080/14728222.2021.1941865
- Wong, L., Glatz, J. F. C., Wang, S., Geraets, I. M. E., Vanherle, S., van den Wijngaard, A., Brunner, H., Luiken, J. J. F. P., & Nabben, M. (2021). Comparison of human and rodent cell models to study myocardial lipid-induced insulin resistance. Prostaglandins Leukotrienes and Essential Fatty Acids, 167, Article 102267. https://doi.org/10.1016/j.plefa.2021.102267
- Geraets, I. M. E., Coumans, W. A., Strzelecka, A., Schonleitner, P., Antoons, G., Schianchi, F., Willemars, M. M. A., Kapsokalyvas, D., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2021). Metabolic Interventions to Prevent Hypertrophy-Induced Alterations in Contractile Properties In Vitro. International journal of molecular sciences, 22(7), Article 3620. https://doi.org/10.3390/ijms22073620
- Sun, A., Simsek Papur, O., Dirkx, E., Wong, L., Sips, T., Wang, S., Strzelecka, A., Nabben, M., Glatz, J. F. C., Neumann, D., & Luiken, J. J. F. P. (2021). Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes. Cellular and Molecular Life Sciences, 78(6), 2839-2856. https://doi.org/10.1007/s00018-020-03669-7
- 2020
- Schianchi, F., Glatz, J. F. C., Navarro Gascon, A., Nabben, M., Neumann, D., & Luiken, J. J. F. P. (2020). Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance. International journal of molecular sciences, 21(24), Article 9438. https://doi.org/10.3390/ijms21249438
- Luiken, J. J. F. P., Nabben, M., Neumann, D., & Glatz, J. F. C. (2020). Understanding the distinct subcellular trafficking of CD36 and GLUT4 during the development of myocardial insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1866(7), Article 165775. https://doi.org/10.1016/j.bbadis.2020.165775
- Glatz, J. F. C., Nabben, M., Young, M. E., Schulze, P. C., Taegtmeyer, H., & Luiken, J. J. F. P. (2020). Re-balancing cellular energy substrate metabolism to mend the failing heart. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1866(5), Article 165579. https://doi.org/10.1016/j.bbadis.2019.165579
- Holwerda, A. M., Bouwman, F. G., Nabben, M., Wang, P., van Kranenburg, J., Gijsen, A. P., Burniston, J. G., Mariman, E. C. M., & van Loon, L. J. C. (2020). Endurance-Type Exercise Increases Bulk and Individual Mitochondrial Protein Synthesis Rates in Rats. International Journal of Sport Nutrition and Exercise Metabolism, 30(2), 153-164. https://doi.org/10.1123/ijsnem.2019-0281
- Wang, S., Wong, L.-Y., Neumann, D., Liu, Y., Sun, A., Antoons, G., Strzelecka, A., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2020). Augmenting Vacuolar H+-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction. International journal of molecular sciences, 21(4), Article 1520. https://doi.org/10.3390/ijms21041520
- Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2020). CD36 (SR-B2) as a Target to Treat Lipid Overload-Induced Cardiac Dysfunction. Journal of lipid and atherosclerosis, 9(1), 66-78. https://doi.org/10.12997/jla.2020.9.1.66
- Glatz, J., Luiken, J., & Nabben, M. (2020). Metabolic Modulation to Treat Cardiac Diseases: Role for Membrane Substrate Transporters. Journal of Cardiology and Cardiovascular Sciences, 4(1), 24-29. https://doi.org/10.29245/2578-3025/2020/1.1187
- Glatz, J., Nabben, M., & Luiken, J. (2020). Myocardial Fatty Acid-Glucose Fuel Balance as Target to Treat Cardiac Diseases. Cardiology and Cardiovascular Medicine, 4(5), 584-590. https://doi.org/10.26502/fccm.92920154
- 2019
- Geraets, I. M. E., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2019). Pivotal role of membrane substrate transporters on the metabolic alterations in the pressure-overloaded heart. Cardiovascular Research, 115(6), 1000-1012. https://doi.org/10.1093/cvr/cvz060
- Zhong, X., Zhang, Z., Wang, S., Cao, L., Zhou, L., Sun, A., Zhong, Z., & Nabben, M. (2019). Microbial-Driven Butyrate Regulates Jejunal Homeostasis in Piglets During the Weaning Stage. Frontiers in microbiology, 9, Article 3335. https://doi.org/10.3389/fmicb.2018.03335
- 2018
- van Weeghel, M., Abdurrachim, D., Nederlof, R., Argmann, C. A., Houtkooper, R. H., Hagen, J., Nabben, M., Denis, S., Ciapaite, J., Kolwicz, S. C., Lopaschuk, G. D., Auwerx, J., Nicolay, K., Des Rosiers, C., Wanders, R. J., Zuurbier, C. J., Prompers, J. J., & Houten, S. M. (2018). Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B. Cardiovascular Research, 114(10), 1324-1334. https://doi.org/10.1093/cvr/cvy089
- Papur, O. S., Sun, A., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2018). Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism. Frontiers in Cardiovascular Medicine, 5, Article 65. https://doi.org/10.3389/fcvm.2018.00065
- Geraets, I. M. E., Chanda, D., van Tienen, F. H. J., van den Wijngaard, A., Kamps, R., Neumann, D., Liu, Y., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2018). Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(5), 1960-1967. https://doi.org/10.1016/j.bbadis.2017.12.025
- Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B., & Nabben, M. (2018). Assessing fatty acid oxidation flux in rodent cardiomyocyte models. Scientific Reports, 8(1), Article 1505. https://doi.org/10.1038/s41598-018-19478-9
- Nabben, M., Luiken, J. J. F. P., & Glatz, J. F. C. (2018). Metabolic remodelling in heart failure revisited. Nature Reviews Cardiology, 15(12), 780-780. https://doi.org/10.1038/s41569-018-0115-8
- 2017
- Abdurrachim, D., Nabben, M., Hoerr, V., Kuhlmann, M. T., Bovenkamp, P., Ciapaite, J., Geraets, I. M. E., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C., Schaefers, M., Nicolay, K., Faber, C., Hermann, S., & Prompers, J. J. (2017). Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovascular Research, 113(10), 1148-1160. https://doi.org/10.1093/cvr/cvx100



