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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Longer and better lives for patients with atrial fibrillation

Longer and better lives for patients with atrial fibrillation

15 April 2024

An international panel of experts published recommendations to improve management of atrial fibrillation (AF).

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Carim Maastricht
Carim Maastricht

Chris Reutelingsperger

Professor

Prof. Chris Reutelingsperger studied Biochemistry at the University of Utrecht. As a PhD student, he discovered and patented the anticoagulant annexin A5 (VAscular Anticoagulant) and defended the thesis 'Vascular anticoagulant, a novel anticoagulant mechanism' at Maastricht University in 1987. He was awarded the five-year Senior Fellowship of the Royal Dutch Academy of Sciences (KNAW) and spent part of his post-doc time at the Boehringer Ingelheim Institute für Arzneimittelforschung in Vienna, to work on elucidating the genetic code of annexin A5.

In 1994, he discovered and patented the power of annexin A5 to detect apoptotic cells. In 1992, he received a tenure track at the Department of Biochemistry of Maastricht University, resulting in a tenured position as Associate Professor in 1997. In 2009, he was appointed Professor of Biochemistry of Apoptosis at Maastricht University. He (co-)authored over 200 peer reviewed papers (H-index 68, source Scholar Google). He is (co-)inventor of 12 granted patents and CSO of PharmaTarget, a biotech company which he co-founded in 2006. He was President of the 8th International Conference on Annexins in 2015. Currently, he chairs the Scientific Advisory Board of Matisse Pharmaceuticals (Netherlands), a biotech company developing therapeutic drugs to treat sepsis.

Chris Reutelingsperger's research activities address molecular and cellular mechanisms of vascular remodeling, vasculitis, atherosclerosis and vascular calcification. His interests focus on vascular calcification, cell death programs, phagocytosis, complement, vitamin K-dependent proteins and annexins, with emphasis on annexins A1 and A5. His major experimental approach utilises in vitrocell biology an in-house developed integrated in vitro assay platform (The BioHybrid, 'organ on-a-chip') covering all major vascular cell types and processes in the pathophysiology of vascular diseases. His strategy encompasses linking basic research to clinical application by establishing collaborations with clinical research and with industry.

Chris-reutelingsperger

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.354
T: +31(0)43 388 16 74

  • 2020
    • Timmermans, S. A. M. E. G., Werion, A., Spaanderman, M. E. A., Reutelingsperger, C. P., Damoiseaux, J. G. M. C., Morelle, J., & Paassen, P. (2020). The natural course of pregnancies in women with primary atypical haemolytic uraemic syndrome and asymptomatic relatives. British Journal of Haematology, 190(3), 442-449. https://doi.org/10.1111/bjh.16626
    • Bol, M. E., Beurskens, D. M. H., Delnoij, T. S. R., Roekaerts, P. M. H. J., Reutelingsperger, C. P. M., Delhaas, T., van de Poll, M. C. G., Sels, J.-W. E. M., & Nicolaes, G. A. F. (2020). Variability of Microcirculatory Measurements in Critically Ill Patients. Shock, 54(1), 9-14. https://doi.org/10.1097/SHK.0000000000001470
    • Hebeda, C. B., Sandri, S., Benis, C. M., de Paula-Silva, M., Loiola, R. A., Reutelingsperger, C., Perretti, M., & Farsky, S. H. P. (2020). Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst. Cells, 9(5), Article 1188. https://doi.org/10.3390/cells9051188
    • Beurskens, D. M. H., Bol, M. E., Delhaas, T., van de Poll, M. C. G., Reutelingsperger, C. P. M., Nicolaes, G. A. F., & Sels, J.-W. E. M. (2020). Decreased endothelial glycocalyx thickness is an early predictor of mortality in sepsis. Anaesthesia and Intensive Care, 48(3), 221-228. https://doi.org/10.1177/0310057X20916471
    • McArthur, S., Juban, G., Gobbetti, T., Desgeorges, T., Theret, M., Gondin, J., Toller-Kawahisa, J. E., Reutelingsperger, C. P., Chazaud, B., Perretti, M., & Mounier, R. (2020). Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation. Journal of Clinical Investigation, 130(3), 1156-1167. https://doi.org/10.1172/JCI124635
    • Baues, M., Klinkhammer, B. M., Ehling, J., Gremse, F., van Zandvoort, M. A. M. J., Reutelingsperger, C. P. M., Daniel, C., Amann, K., Babickova, J., Kiessling, F., Floege, J., Lammers, T., & Boor, P. (2020). A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo. Kidney International, 97(3), 609-614. https://doi.org/10.1016/j.kint.2019.08.029
    • Timmermans, S. A. M. E. G., Werion, A., Damoiseaux, J. G. M. C., Morelle, J., Reutelingsperger, C. P., & van Paassen, P. (2020). Diagnostic and Risk Factors for Complement Defects in Hypertensive Emergency and Thrombotic Microangiopathy. Hypertension, 75(2), 422-430. https://doi.org/10.1161/hypertensionaha.119.13714
  • 2019
    • Zub, E., Canet, G., Garbelli, R., Blaquiere, M., Rossini, L., Pastori, C., Sheikh, M., Reutelingsperger, C., Klement, W., de Bock, F., Audinat, E., Givalois, L., Solito, E., & Marchi, N. (2019). The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy. Faseb Journal, 33(12), 13998-14009. https://doi.org/10.1096/fj.201901596R
    • Fontaine, M. A. C., Westra, M. M., Bot, I., Jin, H., Franssen, A. J. P. M., Bot, M., de Jager, S. C. A., Dzhagalov, I., He, Y.-W., van Vlijmen, B. J. M., Gijbels, M. J. J., Reutelingsperger, C. P., van Berkel, T. J. C., Sluimer, J. C., Temmerman, L., & Biessen, E. A. L. (2019). Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells. Scientific Reports, 9, Article 14547. https://doi.org/10.1038/s41598-019-51020-3
    • Oliveira da Rocha, G. H., Loiola, R. A., Pantaleao, L. D. N., Reutelingsperger, C., Solito, E., & Poliselli Farsky, S. H. (2019). Control of expression and activity of peroxisome proliferated‐activated receptor γ by Annexin A1 on microglia during efferocytosis. Cell Biochemistry and Function, 37(7), 560-568. https://doi.org/10.1002/cbf.3433
    • Barbosa, C. M., Fock, R. A., Hastreiter, A. A., Reutelingsperger, C., Perretti, M., Paredes-Gamero, E. J., & Farsky, S. H. P. (2019). Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway. Cell death discovery, 5, Article 135. https://doi.org/10.1038/s41420-019-0215-1
    • Van Kuijk, K., Theelen, T., Demandt, J., Marsch, E., Gijbels, M., Jin, H., Reutelingsperger, C., Cosemans, J., Schurgers, L., Carmeliet, P., Biessen, E., Daemen, M., & Sluimer, J. (2019). MYELOID PHD2 KNOCKDOWN DRIVES MACROPHAGE APOPTOSIS AND PARACRINE FIBROBLAST/SMOOTH MUSCLE CELL COLLAGEN SECRETION LEADING TO ATHEROSCLEROTIC PLAQUE FIBROSIS. Atherosclerosis, 287, E10-E10. https://doi.org/10.1016/j.atherosclerosis.2019.06.027
    • Everts-Graber, J., Martin, K. R., Thieblemont, N., Mocek, J., Roccabianca, A., Chafey, P., Le Gall, M., Tacnet-Delorme, P., Reutelingsperger, C. P., Naccache, J.-M., Bonnotte, B., Karras, A., Puechal, X., Guillevin, L., Terrier, B., Frachet, P., Perretti, M., Mouthon, L., & Witko-Sarsat, V. (2019). Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance. Kidney International, 96(2), 397-408. https://doi.org/10.1016/j.kint.2019.02.017
    • Zhou, Q., Zeng, Y., Xiong, Q., Zhong, S., Li, P., Ran, H., Yin, Y., Reutelingsperger, C., Prinze, F. W., & Ling, Z. (2019). Construction of CNA35 Collagen-Targeted Phase-Changeable Nanoagents for Low-Intensity Focused Ultrasound-Triggered Ultrasound Molecular Imaging of Myocardial Fibrosis in Rabbits. ACS Applied Materials & Interfaces, 11(26), 23006-23017. https://doi.org/10.1021/acsami.9b05999
    • Petsophonsakul, P., Furmanik, M., Forsythe, R., Dweck, M., Schurink, G. W., Natour, E., Reutelingsperger, C., Jacobs, M., Mees, B., & Schurgers, L. (2019). Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation Involvement of Vitamin K-Dependent Processes. Arteriosclerosis Thrombosis and Vascular Biology, 39(7), 1351-1368. https://doi.org/10.1161/ATVBAHA.119.312787
    • Ferraro, B., Leoni, G., Hinkel, R., Ormanns, S., Paulin, N., Ortega-Gomez, A., Viola, J. R., de Jong, R., Bongiovanni, D., Bozoglu, T., Maas, S. L., D'Amico, M., Kessler, T., Zeller, T., Hristov, M., Reutelingsperger, C., Sager, H. B., Doering, Y., Nahrendorf, M., ... Soehnlein, O. (2019). Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair. Journal of the American College of Cardiology, 73(23), 2990-3002. https://doi.org/10.1016/j.jacc.2019.03.503
    • Purvis, G. S. D., Collino, M., Loiola, R. A., Baragetti, A., Chiazza, F., Brovelli, M., Sheikh, M. H., Collotta, D., Cento, A., Mastrocola, R., Aragno, M., Cutrin, J. C., Reutelingsperger, C., Grigore, L., Catapano, A. L., Yaqoob, M. M., Norata, G. D., Solito, E., & Thiemermann, C. (2019). Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes. Frontiers in Immunology, 10, Article 571. https://doi.org/10.3389/fimmu.2019.00571
    • Gussenhoven, R., Klein, L., Ophelders, D. R. M. G., Habets, D. H. J., Giebel, B., Kramer, B. W., Schurgers, L. J., Reutelingsperger, C. P. M., & Wolfs, T. G. A. M. (2019). Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy. Journal of Clinical Medicine, 8(2), Article 137. https://doi.org/10.3390/jcm8020137
  • 2018
    • Stoehr, R., Deckers, N., Schurgers, L., Marx, N., & Reutelingsperger, C. P. (2018). AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis. Scientific Reports, 8, Article 17731. https://doi.org/10.1038/s41598-018-35995-z
    • Reutelingsperger, C., & Schurgers, L. (2018). Coronary Artery Calcification A Janus-Faced Biomarker?JACC-Cardiovascular Imaging, 11(9), 1324-1326. https://doi.org/10.1016/j.jcmg.2017.04.009
    • Timmermans, S. A. M. E. G., Abdul-Hamid, M. A., Potjewijd, J., Theunissen, R. O. M. F. I. H., Damoiseaux, J. G. M. C., Reutelingsperger, C. P., van Paassen, P., & Limburg Renal Registry (2018). C5b9 Formation on Endothelial Cells Reflects Complement Defects among Patients with Renal Thrombotic Microangiopathy and Severe Hypertension. Journal of the American Society of Nephrology, 29(8), 2234-2243. https://doi.org/10.1681/ASN.2018020184
    • Pantaleao, L., Rocha, G. H., Reutelingsperger, C., Tiago, M., Maria-Engler, S. S., Solito, E., & Farsky, S. P. (2018). Connections of annexin A1 and translocator protein-18 kDa on toll like receptor stimulated BV-2 cells. Experimental Cell Research, 367(2), 282-290. https://doi.org/10.1016/j.yexcr.2018.04.008
    • Eersels, K., Diliën, H., Lowdon, J., Steen Redeker, E., Rogosic, R., Heidt, B., Peeters, M., Cornelis, P., Lux, P., Reutelingsperger, C., Schurgers, L., Cleij, T., & van Grinsven, B. (2018). A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers. Nutrients, 10(6), Article 751. https://doi.org/10.3390/nu10060751
    • Willems, B. A., Furmanik, M., Caron, M. M. J., Chatrou, M. L. L., Kusters, D. H. M., Welting, T. J. M., Stock, M., Rafael, M. S., Viegas, C. S. B., Simes, D. C., Vermeer, C., Reutelingsperger, C. P. M., & Schurgers, L. J. (2018). Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling. Scientific Reports, 8, Article 4961. https://doi.org/10.1038/s41598-018-23353-y
    • Shekhar, A., Heeger, P., Reutelingsperger, C., Arbustini, E., Narula, N., Hofstra, L., Bax, J. J., & Narula, J. (2018). Targeted Imaging for Cell Death in Cardiovascular Disorders. JACC-Cardiovascular Imaging, 11(3), 476-493. https://doi.org/10.1016/j.jcmg.2017.11.018
    • Purvis, G. S. D., Chiazza, F., Chen, J., Azevedo-Loiola, R., Martin, L., Kusters, D. H. M., Reutelingsperger, C., Fountoulakis, N., Gnudi, L., Yaqoob, M. M., Collino, M., Thiemermann, C., & Solito, E. (2018). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia, 61(2), 482-495. https://doi.org/10.1007/s00125-017-4469-y
    • Ercig, B., Wichapong, K., Reutelingsperger, C. P. M., Vanhoorelbeke, K., Voorberg, J., & Nicolaes, G. A. F. (2018). Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura. Thrombosis and Haemostasis, 118(1), 28-41. https://doi.org/10.1160/TH17-06-0404
  • 2017
    • Timmermans, S. A. M. E. G., Abdul-Hamid, M. A., Vanderlocht, J., Damoiseaux, J. G. M. C., Reutelingsperger, C. P., van Paassen, P., & Registry, L. R. (2017). Patients with hypertension-associated thrombotic microangiopathy may present with complement abnormalities. Kidney International, 91(6), 1420-1425. https://doi.org/10.1016/j.kint.2016.12.009
    • van Smaalen, T. C., Beurskens, D. M. H., Hoogland, E. R. P., Winkens, B., Christiaans, M. H. L., Reutelingsperger, C. P., van Heurn, L. W. E., & Nicolaes, G. A. F. (2017). Presence of Cytotoxic Extracellular Histones in Machine Perfusate of Donation After Circulatory Death Kidneys. Transplantation, 101(4), e93-e101. https://doi.org/10.1097/TP.0000000000001590
  • 2016
    • Burgmaier, M., Schurgers, L., & Reutelingsperger, C. (2016). Response to letter to the editor: annexin A5 levels or circulating microparticles: what we see depends mainly on what we look for. Journal of Internal Medicine, 279(6), 606-607. https://doi.org/10.1111/joim.12459
    • Schurgers, L. J., Burgmaier, M., Ueland, T., Schutters, K., Aakhus, S., Hofstra, L., Gullestad, L., Aukrust, P., Hellmich, M., Narula, J., & Reutelingsperger, C. P. (2016). Circulating annexin A5 predicts mortality in patients with heart failure. Journal of Internal Medicine, 279(1), 89-97. https://doi.org/10.1111/joim.12396
    • Maggioli, E., McArthur, S., Mauro, C., Kieswich, J., Kusters, D. H. M., Reutelingsperger, C. P. M., Yaqoob, M., & Solito, E. (2016). Estrogen protects the blood-brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Brain Behavior and Immunity, 51, 212-222. https://doi.org/10.1016/j.bbi.2015.08.020
    • Schlieper, G., Schurgers, L., Brandenburg, V., Reutelingsperger, C., & Floege, J. (2016). Vascular calcification in chronic kidney disease: an update. Nephrology Dialysis Transplantation, 31(1), 31-39. https://doi.org/10.1093/ndt/gfv111
  • 2015
    • Kusters, D. H., Chatrou, M. L., Willems, B. A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E. A., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. P. (2015). Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. PLOS ONE, 10(6), Article e0130484. https://doi.org/10.1371/journal.pone.0130484
  • 2014
    • Burgmaier, M., Schutters, K., Willems, B., Van der Vorst, E. P. C., Kusters, D., Chatrou, M., Norling, L., Biessen, E. A. L., Cleutjens, J., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine, 18(10), 2117-2124. https://doi.org/10.1111/jcmm.12374
    • De Saint-Hubert, M., Bauwens, M., Deckers, N., Drummen, M., Douma, K., Granton, P., Hendrikx, G., Kusters, D., Bucerius, J., Reutelingsperger, C. P. M., & Mottaghy, F. M. (2014). In Vivo Molecular Imaging of Apoptosisand Necrosis in Atherosclerotic PlaquesUsing MicroSPECT-CT and MicroPET-CT Imaging. Molecular Imaging and Biology, 16(2), 246-254. https://doi.org/10.1007/s11307-013-0677-0
    • Ungethüm, L., Chatrou, M., Kusters, D., Schurgers, L., & Reutelingsperger, C. P. (2014). Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake. PLOS ONE, 9(5), e96749. https://doi.org/10.1371/journal.pone.0096749
  • 2013
    • Arends, S. J., Damoiseaux, J. G., Duijvestijn, A. M., Debrus-Palmans, L., Vroomen, M., Boomars, K. A., Brunner-La Rocca, H. P., Reutelingsperger, C. P., Tervaert, J. W., & van Paassen, P. (2013). Immunoglobulin G anti-endothelial cell antibodies: inducers of endothelial cell apoptosis in pulmonary arterial hypertension?Clinical and Experimental Immunology, 174(3), 433-440. https://doi.org/10.1111/cei.12166
    • Bauwens, M., De Saint-Hubert, M., Cleynhens, J., Vandeputte, C., Li, J., Devos, E., Hendrickx, S., Ni, Y., Reutelingsperger, C. P., Mortelmans, L., Mottaghy, F. M., & Verbruggen, A. (2013). In vitro and in vivo comparison of 18F and 123I-labeled ML10 with 68Ga-Cys2-AnxA5 for molecular imaging of apoptosis.Quarterly Journal of Nuclear Medicine and Molecular Imaging, 57(2), 187-200. http://www.ncbi.nlm.nih.gov/pubmed/23389693
    • Schutters, K., Kusters, D. H. M., Chatrou, M. L. L., Montero-Melendez, T., Donners, M., Deckers, N. M., Krysko, D. V., Vandenabeele, P., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. P. M. (2013). Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death and Differentiation, 20(1), 49-56. https://doi.org/10.1038/cdd.2012.107
  • 2011
    • Chatrou, M. L. L., Reutelingsperger, C. P., & Schurgers, L. J. (2011). Role of vitamin K-dependent proteins in the arterial vessel wall. Hämostaseologie, 31(4), 251-257. https://doi.org/10.5482/ha-1157
    • de Saint Hubert, M., Wang, H., Devos, E., Vunckx, K., Zhou, L., Reutelingsperger, C. P., Verbruggen, A., Mortelmans, L., Ni, Y., & Mottaghy, F. M. (2011). Preclinical imaging of therapy response using metabolic and apoptosis molecular imaging. Molecular Imaging and Biology, 13(5), 995-1002. https://doi.org/10.1007/s11307-010-0412-z
  • 2005
    • Asai, K., Buurman, W. A., Reutelingsperger, C. P. M., Schutte, B., & Kaminishi, M. (2005). Modular effects of estradiol on ethanol-induced apoptosis in human intestinal epithelial cells. Scandinavian Journal of Gastroenterology, 40(3), 326-335. https://doi.org/10.1080/00365520510011605
  • 2003
    • Asai, K., Buurman, W. A., Reutelingsperger, C. P. M., Schutte, B., & Kaminishi, M. (2003). Low concentrations of ethanol induce apoptosis in human intestinal cells. Scandinavian Journal of Gastroenterology, 38(11), 1154-1161. https://doi.org/10.1080/00365520310006252
    • Notenboom, R. G., van den Bergh, M. A., Dingemans, K. P., Vermeulen, J. L., van den Eijnde, S. M., Reutelingsperger, C. P. M., Hut, H., Willemsen, R., Offerhaus, G. J., & Lamers, W. H. (2003). Timing and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage. Hepatology, 38(3), 683-691. https://doi.org/10.1053/jhep.2003.50365
  • 2002
    • Franssen, E. J., Rombout-Sestrienkova, E., van Pampus, E. C. M., Buurman, W. A., Reutelingsperger, C. P. M., & Maessen, J. G. (2002). Prestorage leucocyte reduction of red cell components prevents release of bactericidal permeability increasing protein and defensins. Vox Sanguinis, 83(2), 119-124. https://doi.org/10.1046/j.1423-0410.2002.00193.x
  • 2001
    • van den Eijnde, S. M., van den Hoff, M. J. B., Reutelingsperger, C. P. M., van Heerde, W. L., Henfling, M. E. R., Vermeij-Keers, C., Schutte, B., Borgers, M., & Ramaekers, F. C. S. (2001). Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation. Journal of Cell Science, 114(20), 3631-3642. https://doi.org/10.1242/jcs.114.20.3631
  • 2000
    • Terwel, D., Nieland, L. J. W., Schutte, B., Reutelingsperger, C. P. M., Ramaekers, F. C. S., & Steinbusch, H. W. M. (2000). S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules.European Journal of Pharmacology, 400, 400-400. https://doi.org/10.1016/S0014-2999(00)00379-4
  • 1999
    • Heemskerk, J. W. M., Siljander, P. R. M., Vuist, M. W. J., Breikers, G., Reutelingsperger, C. P. M., Barnes, M. J., Knight, C. G., Lassila, R., & Farndale, R. W. (1999). Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent platelets.Thrombosis and Haemostasis, 81(5), 782-792. https://doi.org/10.1055/s-0037-1614571
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