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Fellowships EmbRACE consortium

Fellowships EmbRACE consortium

21 May 2026

The EmbRACE consortium, coordinated by CARIM, has awarded three fellowships, including two to CARIM researchers.

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NWO grant for project 'Laminomics'

NWO grant for project 'Laminomics'

21 May 2026

Tim van de Wiel, Dr Magdalena Harakalova, and Dr Rogier Veltrop (Dept of Biochemistry) have been awarded an NWO grant for large-scale high-performance computing time.

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Carim Maastricht
Carim Maastricht

Chris Reutelingsperger

Professor

Prof. Chris Reutelingsperger studied Biochemistry at the University of Utrecht. As a PhD student, he discovered and patented the anticoagulant annexin A5 (VAscular Anticoagulant) and defended the thesis 'Vascular anticoagulant, a novel anticoagulant mechanism' at Maastricht University in 1987. He was awarded the five-year Senior Fellowship of the Royal Dutch Academy of Sciences (KNAW) and spent part of his post-doc time at the Boehringer Ingelheim Institute für Arzneimittelforschung in Vienna, to work on elucidating the genetic code of annexin A5.

In 1994, he discovered and patented the power of annexin A5 to detect apoptotic cells. In 1992, he received a tenure track at the Department of Biochemistry of Maastricht University, resulting in a tenured position as Associate Professor in 1997. In 2009, he was appointed Professor of Biochemistry of Apoptosis at Maastricht University. He (co-)authored over 200 peer reviewed papers (H-index 68, source Scholar Google). He is (co-)inventor of 12 granted patents and CSO of PharmaTarget, a biotech company which he co-founded in 2006. He was President of the 8th International Conference on Annexins in 2015. Currently, he chairs the Scientific Advisory Board of Matisse Pharmaceuticals (Netherlands), a biotech company developing therapeutic drugs to treat sepsis.

Chris Reutelingsperger's research activities address molecular and cellular mechanisms of vascular remodeling, vasculitis, atherosclerosis and vascular calcification. His interests focus on vascular calcification, cell death programs, phagocytosis, complement, vitamin K-dependent proteins and annexins, with emphasis on annexins A1 and A5. His major experimental approach utilises in vitrocell biology an in-house developed integrated in vitro assay platform (The BioHybrid, 'organ on-a-chip') covering all major vascular cell types and processes in the pathophysiology of vascular diseases. His strategy encompasses linking basic research to clinical application by establishing collaborations with clinical research and with industry.

Chris-reutelingsperger

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.354
T: +31(0)43 388 16 74

  • 2015
    • Kusters, D. H., Chatrou, M. L., Willems, B. A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E. A., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. P. (2015). Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. PLOS ONE, 10(6), Article e0130484. https://doi.org/10.1371/journal.pone.0130484
    • Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., Furmanik, M., Sanchis, P., De Rosales, R. T. M., Alvarez-Hernandez, D., Shroff, R., Yin, X., Muller, K., Skepper, J. N., Mayr, M., Reutelingsperger, C. P., Chester, A., Bertazzo, S., Schurgers, L. J., & Shanahan, C. M. (2015). Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion. Circulation Research, 116(8), 1312-1323. https://doi.org/10.1161/CIRCRESAHA.116.305012
    • Leoni, G., Neumann, P.-A., Kamaly, N., Quiros, M., Nishio, H., Jones, H. R., Sumagin, R., Hilgarth, R. S., Alam, A., Fredman, G., Argyris, I., Rijcken, E., Kusters, D., Reutelingsperger, C., Perretti, M., Parkos, C. A., Farokhzad, O. C., Neish, A. S., & Nusrat, A. (2015). Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. Journal of Clinical Investigation, 125(3), 1215-1227. https://doi.org/10.1172/JCI76693
  • 2014
    • Tahara, N., Zandbergen, H. R., de Haas, H. J., Petrov, A., Pandurangi, R., Yamaki, T., Zhou, J., Imaizumi, T., Slart, R. H. J. A., Dyszlewski, M., Scarabelli, T., Kini, A., Reutelingsperger, C., Narula, N., Fuster, V., & Narula, J. (2014). Noninvasive Molecular Imaging of Cell Death in Myocardial Infarction using In-111-GSAO. Scientific Reports, 4, Article 6826. https://doi.org/10.1038/srep06826
    • Burgmaier, M., Schutters, K., Willems, B., Van der Vorst, E. P. C., Kusters, D., Chatrou, M., Norling, L., Biessen, E. A. L., Cleutjens, J., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine, 18(10), 2117-2124. https://doi.org/10.1111/jcmm.12374
    • Zille, M., Harhausenl, D., De Saint-Hubert, M., Michel, R., Reutelingsperger, C. P., Dirnagl, U., & Wunder, A. (2014). A dual-labeled Annexin A5 is not suited for SPECT imaging of brain cell death in experimental murine stroke. Journal of Cerebral Blood Flow and Metabolism, 34(9), 1568-1570. https://doi.org/10.1038/jcbfm.2014.115
    • Locatelli, I., Sutti, S., Jindal, A., Vacchiano, M., Bozzola, C., Reutelingsperger, C., Kusters, D., Bena, S., Parola, M., Paternostro, C., Bugianesi, E., McArthur, S., Albano, E., & Perretti, M. (2014). Endogenous Annexin A1 Is a Novel Protective Determinant in Nonalcoholic Steatohepatitis in Mice. Hepatology, 60(2), 531-544. https://doi.org/10.1002/hep.27141
    • Willems, B. A. G., Vermeer, C., Reutelingsperger, C. P. M., & Schurgers, L. J. (2014). The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification. Molecular Nutrition & Food Research, 58(8), 1620-1635. https://doi.org/10.1002/mnfr.201300743
    • Wildhagen, K. C. A. A., Schrijver, R., Beckers, L., ten Cate, H., Reutelingsperger, C. P. M., Lutgens, E., & Nicolaes, G. A. F. (2014). Effects of Exogenous Recombinant APC in Mouse Models of Ischemia Reperfusion Injury and of Atherosclerosis. PLOS ONE, 9(7), Article e101446. https://doi.org/10.1371/journal.pone.0101446
    • Wildhagen, K. C. A. A., Garcia de Frutos, P., Reutelingsperger, C. P., Schrijver, R., Areste, C., Ortega-Gomez, A., Deckers, N. M., Hemker, H. C., Soehnlein, O., & Nicolaes, G. A. F. (2014). Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood, 123(7), 1098-1101. https://doi.org/10.1182/blood-2013-07-514984
    • De Saint-Hubert, M., Bauwens, M., Deckers, N., Drummen, M., Douma, K., Granton, P., Hendrikx, G., Kusters, D., Bucerius, J., Reutelingsperger, C. P. M., & Mottaghy, F. M. (2014). In Vivo Molecular Imaging of Apoptosisand Necrosis in Atherosclerotic PlaquesUsing MicroSPECT-CT and MicroPET-CT Imaging. Molecular Imaging and Biology, 16(2), 246-254. https://doi.org/10.1007/s11307-013-0677-0
    • Ungethüm, L., Chatrou, M., Kusters, D., Schurgers, L., & Reutelingsperger, C. P. (2014). Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake. PLOS ONE, 9(5), e96749. https://doi.org/10.1371/journal.pone.0096749
  • 2013
    • Arends, S. J., Damoiseaux, J. G., Duijvestijn, A. M., Debrus-Palmans, L., Vroomen, M., Boomars, K. A., Brunner-La Rocca, H. P., Reutelingsperger, C. P., Tervaert, J. W., & van Paassen, P. (2013). Immunoglobulin G anti-endothelial cell antibodies: inducers of endothelial cell apoptosis in pulmonary arterial hypertension?Clinical and Experimental Immunology, 174(3), 433-440. https://doi.org/10.1111/cei.12166
    • Schurgers, L. J., Uitto, J., & Reutelingsperger, C. P. (2013). Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization. Trends in Molecular Medicine, 19(4), 217-226. https://doi.org/10.1016/j.molmed.2012.12.008
    • Bauwens, M., De Saint-Hubert, M., Cleynhens, J., Vandeputte, C., Li, J., Devos, E., Hendrickx, S., Ni, Y., Reutelingsperger, C. P., Mortelmans, L., Mottaghy, F. M., & Verbruggen, A. (2013). In vitro and in vivo comparison of 18F and 123I-labeled ML10 with 68Ga-Cys2-AnxA5 for molecular imaging of apoptosis.Quarterly Journal of Nuclear Medicine and Molecular Imaging, 57(2), 187-200. http://www.ncbi.nlm.nih.gov/pubmed/23389693
    • Leoni, G., Alam, A., Neumann, P.-A., Lambeth, J. D., Cheng, G., McCoy, J., Hilgarth, R. S., Kundu, K., Murthy, N., Kusters, D., Reutelingsperger, C., Perretti, M., Parkos, C. A., Neish, A. S., & Nusrat, A. (2013). Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. Journal of Clinical Investigation, 123(1), 443-454. https://doi.org/10.1172/JCI65831
    • Schutters, K., Kusters, D. H. M., Chatrou, M. L. L., Montero-Melendez, T., Donners, M., Deckers, N. M., Krysko, D. V., Vandenabeele, P., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. P. M. (2013). Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death and Differentiation, 20(1), 49-56. https://doi.org/10.1038/cdd.2012.107
  • 2012
    • Kusters, D. H. M., Tegtmeier, J., Schurgers, L. J., & Reutelingsperger, C. P. M. (2012). Molecular Imaging to Identify the Vulnerable Plaque-From Basic Research to Clinical Practice. Molecular Imaging and Biology, 14(5), 523-533. https://doi.org/10.1007/s11307-012-0586-7
    • Schurgers, L. J., Joosen, I. A., Laufer, E. M., Chatrou, M. L. L., Herfs, M., Winkens, M. H. M., Westenfeld, R., Veulemans, V., Krueger, T., Shanahan, C. M., Jahnen-Dechent, W., Biessen, E., Narula, J., Vermeer, C., Hofstra, L., & Reutelingsperger, C. P. (2012). Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype. PLOS ONE, 7(8), Article e43229. https://doi.org/10.1371/journal.pone.0043229
    • Chatrou, M. L. L., Winckers, K., Hackeng, T. M., Reutelingsperger, C. P. M., & Schurgers, L. J. (2012). Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists. Blood Reviews, 26(4), 155-166. https://doi.org/10.1016/j.blre.2012.03.002
    • Mees, G., Dierckx, R., Mertens, K., Vermeire, S., Van Steenkiste, M., Reutelingsperger, C., D'Asseler, Y., Peremans, K., Van Damme, N., & Van de Wiele, C. (2012). Tc-99m-Labeled Tricarbonyl His-CNA35 as an Imaging Agent for the Detection of Tumor Vasculature. Journal of Nuclear Medicine, 53(3), 464-471. https://doi.org/10.2967/jnumed.111.095794
    • Vangestel, C., Van de Wiele, C., Mees, G., Mertens, K., Staelens, S., Reutelingsperger, C., Pauwels, P., Van Damme, N., & Peeters, M. (2012). Single-Photon Emission Computed Tomographic Imaging of the Early Time Course of Therapy-Induced Cell Death Using Technetium 99m Tricarbonyl His-Annexin A5 in a Colorectal Cancer Xenograft Model. Molecular Imaging, 11(2), 135-147. https://doi.org/10.2310/7290.2011.00034
  • 2011
    • Vangestel, C., Van de Wiele, C., Van Damme, N., Staelens, S., Pauwels, P., Reutelingsperger, C. P. M., & Peeters, M. (2011). Tc-99m-(CO)(3) His-Annexin A5 Micro-SPECT Demonstrates Increased Cell Death by Irinotecan During the Vascular Normalization Window Caused by Bevacizumab. Journal of Nuclear Medicine, 52(11), 1786-1794. https://doi.org/10.2967/jnumed.111.092650
    • Chatrou, M. L. L., Reutelingsperger, C. P., & Schurgers, L. J. (2011). Role of vitamin K-dependent proteins in the arterial vessel wall. Hämostaseologie, 31(4), 251-257. https://doi.org/10.5482/ha-1157
    • de Saint Hubert, M., Wang, H., Devos, E., Vunckx, K., Zhou, L., Reutelingsperger, C. P., Verbruggen, A., Mortelmans, L., Ni, Y., & Mottaghy, F. M. (2011). Preclinical imaging of therapy response using metabolic and apoptosis molecular imaging. Molecular Imaging and Biology, 13(5), 995-1002. https://doi.org/10.1007/s11307-010-0412-z
    • Bahmani, P., Schellenberger, E., Klohs, J., Steinbrink, J., Cordell, R., Zille, M., Mueller, J., Harhausen, D., Hofstra, L., Reutelingsperger, C. P. M., Farr, T. D., Dirnagl, U., & Wunder, A. (2011). Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining. Journal of Cerebral Blood Flow and Metabolism, 31(5), 1311-1320. https://doi.org/10.1038/jcbfm.2010.233
    • Bauwens, M., De Saint-Hubert, M., Devos, E., Deckers, N., Reutelingsperger, C. P. M., Mortelmans, L., Himmelreich, U., Mottaghy, F. M., & Verbruggen, A. M. (2011). Site-specific Ga-68-labeled Annexin A5 as a PET imaging agent for apoptosis. Nuclear Medicine and Biology, 38(3), 381-392. https://doi.org/10.1016/j.nucmedbio.2010.09.008
    • Ungethum, L., Kenis, H., Nicolaes, G. A., Autin, L., Stoilova-McPhie, S., & Reutelingsperger, C. P. M. (2011). Engineered Annexin A5 Variants Have Impaired Cell Entry for Molecular Imaging of Apoptosis Using Pretargeting Strategies. Journal of Biological Chemistry, 286(3), 1903-1910. https://doi.org/10.1074/jbc.M110.163527
    • Vangestel, C., Peeters, M., Mees, G., Oltenfreiter, R., Boersma, H. H., Elsinga, P. H., Reutelingsperger, C. P. M., Van Damme, N., De Spiegeleer, B., & Van de Wiele, C. (2011). In Vivo Imaging of Apoptosis in Oncology: An Update. Molecular Imaging, 10(5), 340-358. https://doi.org/10.2310/7290.2010.00058
  • 2010
    • Vangestel, C., Peeters, M., Oltenfreiter, R., D'Asseler, Y., Staelens, S., Van Steenkiste, M., Philippe, J., Kusters, D., Reutelingsperger, C. P. M., Van Damme, N., & Van de Wiele, C. (2010). In vitro and in vivo evaluation of [Tc-99m]-labeled tricarbonyl His-annexin A5 as an imaging agent for the detection of phosphatidylserine-expressing cells. Nuclear Medicine and Biology, 37(8), 965-975. https://doi.org/10.1016/j.nucmedbio.2010.06.007
    • van Tilborg, G. A. F., Vucic, E., Strijkers, G. J., Cormode, D. P., Mani, V., Skajaa, T., Reutelingsperger, C. P. M., Fayad, Z. A., Mulder, W. J. M., & Nicolay, K. (2010). Annexin A5-Functionalized Bimodal Nanoparticles for MRI and Fluorescence Imaging of Atherosclerotic Plaques. Bioconjugate Chemistry, 21(10), 1794-1803. https://doi.org/10.1021/bc100091q
    • Dumont, E. A. W. J., Lutgens, S. P. M., Reutelingsperger, C. P. M., Bos, G. M. J., & Hofstra, L. (2010). Minocycline Inhibits Apoptotic Cell Death in a Murine Model of Partial Flap Loss. Journal of Reconstructive Microsurgery, 26(8), 523-528. https://doi.org/10.1055/s-0030-1262952
    • Schutters, K., & Reutelingsperger, C. P. M. (2010). Phosphatidylserine targeting for diagnosis and treatment of human diseases. Apoptosis, 15(9), 1072-1082. https://doi.org/10.1007/s10495-010-0503-y
    • Jellema, R. K., Bomans, P., Deckers, N., Ungethum, L., Reutelingsperger, C. P. M., Hofstra, L., & Frederik, P. M. (2010). Transfection efficiency of lipoplexes for site-directed delivery. Journal of Liposome Research, 20(3), 258-267. https://doi.org/10.3109/08982100903384137
    • Kenis, H., Zandbergen, H. R., Hofstra, L., Petrov, A. D., Dumont, E. A., Blankenberg, F. D., Haider, N., Bitsch, N., Gijbels, M., Verjans, J. W. H., Narula, N., Narula, J., & Reutelingsperger, C. P. M. (2010). Annexin A5 Uptake in Ischemic Myocardium: Demonstration of Reversible Phosphatidylserine Externalization and Feasibility of Radionuclide Imaging. Journal of Nuclear Medicine, 51(2), 259-267. https://doi.org/10.2967/jnumed.109.068429
    • De Saint-Hubert, M., Mottaghy, F. M., Vunckx, K., Nuyts, J., Fonge, H., Prinsen, K., Stroobants, S., Mortelmans, L., Deckers, N., Hofstra, L., Reutelingsperger, C. P. M., Verbruggen, A. M., & Rattat, D. (2010). Site-specific labeling of 'second generation' annexin V with Tc-99m(CO)(3) for improved imaging of apoptosis in vivo. Bioorganic & Medicinal Chemistry, 18(3), 1356-1363. https://doi.org/10.1016/j.bmc.2009.12.021
  • 2007
    • Prinzen, L., Miserus, R.-J. J. H. M., Dirksen, A., Hackeng, T. M., Deckers, N., Bitsch, N. J., Megens, R. T. A., Douma, K., Heemskerk, J. W., Kooi, M. E., Frederik, P. M., Slaaf, D. W., van Zandvoort, M. A. M. J., & Reutelingsperger, C. P. M. (2007). Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. Nano Letters, 7(1), 93-100. https://doi.org/10.1021/nl062226r
  • 2005
    • Schurgers, L. J., Teunissen, K. J. F., Knapen, M. H. J., Kwaijtaal, M., van Diest, R., Appels, A., Reutelingsperger, C. P., Cleutjens, J. P. M., & Vermeer, C. (2005). Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arteriosclerosis Thrombosis and Vascular Biology, 25(8), 1629-33. https://doi.org/10.1161/01.ATV.0000173313.46222.43
    • Ravassa, S., Bennaghmouch, A., Kenis, H., Lindhout, T., Hackeng, T., Narula, J., Hofstra, L., & Reutelingsperger, C. (2005). Annexin A5 down-regulates surface expression of tissue factor. Journal of Biological Chemistry, 280(7), 6028-6035. https://doi.org/10.1074/jbc.M411710200
    • Asai, K., Buurman, W. A., Reutelingsperger, C. P. M., Schutte, B., & Kaminishi, M. (2005). Modular effects of estradiol on ethanol-induced apoptosis in human intestinal epithelial cells. Scandinavian Journal of Gastroenterology, 40(3), 326-335. https://doi.org/10.1080/00365520510011605
  • 2003
    • Asai, K., Buurman, W. A., Reutelingsperger, C. P. M., Schutte, B., & Kaminishi, M. (2003). Low concentrations of ethanol induce apoptosis in human intestinal cells. Scandinavian Journal of Gastroenterology, 38(11), 1154-1161. https://doi.org/10.1080/00365520310006252
    • Notenboom, R. G., van den Bergh, M. A., Dingemans, K. P., Vermeulen, J. L., van den Eijnde, S. M., Reutelingsperger, C. P. M., Hut, H., Willemsen, R., Offerhaus, G. J., & Lamers, W. H. (2003). Timing and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage. Hepatology, 38(3), 683-691. https://doi.org/10.1053/jhep.2003.50365
  • 2002
    • Franssen, E. J., Rombout-Sestrienkova, E., van Pampus, E. C. M., Buurman, W. A., Reutelingsperger, C. P. M., & Maessen, J. G. (2002). Prestorage leucocyte reduction of red cell components prevents release of bactericidal permeability increasing protein and defensins. Vox Sanguinis, 83(2), 119-124. https://doi.org/10.1046/j.1423-0410.2002.00193.x
  • 2001
    • van den Eijnde, S. M., van den Hoff, M. J. B., Reutelingsperger, C. P. M., van Heerde, W. L., Henfling, M. E. R., Vermeij-Keers, C., Schutte, B., Borgers, M., & Ramaekers, F. C. S. (2001). Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation. Journal of Cell Science, 114(20), 3631-3642. https://doi.org/10.1242/jcs.114.20.3631
  • 2000
    • Terwel, D., Nieland, L. J. W., Schutte, B., Reutelingsperger, C. P. M., Ramaekers, F. C. S., & Steinbusch, H. W. M. (2000). S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules.European Journal of Pharmacology, 400, 400-400. https://doi.org/10.1016/S0014-2999(00)00379-4
  • 1999
    • Heemskerk, J. W. M., Siljander, P. R. M., Vuist, M. W. J., Breikers, G., Reutelingsperger, C. P. M., Barnes, M. J., Knight, C. G., Lassila, R., & Farndale, R. W. (1999). Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent platelets.Thrombosis and Haemostasis, 81(5), 782-792. https://doi.org/10.1055/s-0037-1614571
    • van Gorp Beisser, R. M. A., Broers, J. L. V., Reutelingsperger, C. P. M., Bronnenberg, N. M. H. J., Hornstra, G., Mieras-van Dam, M. C. E., & Heemskerk, J. W. M. (1999). Peroxide-induced membrane blebbing in endothelial cells associated with glutathione oxidation but not apoptosis.American Journal of Physiology (Consolidated), 277(1 Pt 1), C20-C28. https://doi.org/10.1152/ajpcell.1999.277.1.C20
  • 1997
    • Heemskerk, J. W. M., Vuist, M. W. J., Feijge, M. A. H., Reutelingsperger, C. P. M., & Lindhout, T. (1997). Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses.Blood, 90(7), 2615-2625. https://doi.org/10.1182/BLOOD.V90.7.2615
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