• 2025
    • Perotto, M., Paldino, A., Mazzarotto, F., Barbati, G., Stroeks, S. L. V. M., Verdonschot, J. A. J., Akhtar, M., Elliott, P., Ochoa, J. P., Garcia-Pavia, P., de Frutos, F., Sepp, R., Hategan, L., Prasad, S., Yazdani, M., Morris-Rosendahl, D., Palinkas, E. D., Girolami, F., Olivotto, I., ... Dal Ferro, M. (2025). Genetic and Phenotypic Characterization of Nexilin (NEXN)–Related Cardiomyopathy: Results From a Multicentric Study. JACC: Heart Failure, 13(9), Article 102529. https://doi.org/10.1016/j.jchf.2025.102529
    • Massimi, G., Matteucci, M., De Bonis, M., Kowalewski, M., Formica, F., Russo, C. F., Sponga, S., Vendramin, I., Colli, A., Falcetta, G., Trumello, C., Carrozzini, M., Fischlein, T., Troise, G., Dato, G. A., D'Alessandro, S., Nia, P. S., Lodo, V., Villa, E., ... Lorusso, R. (2025). Repair versus Replacement in mitral valve papillary muscle rupture: a multicenter study. European Journal of Cardio-Thoracic Surgery, 67(9), Article ezaf284. https://doi.org/10.1093/ejcts/ezaf284
    • Kawczynski, M. J., Barili, F., Brophy, J. M., De Caterina, R., Biondi Zoccai, G., Anselmi, A., Boden, W. E., Parolari, A., Heuts, S., & NTEGRITTY initiative (2025). Revascularisation strategies for non-acute myocardial ischaemic syndromes. Heart. Advance online publication. https://doi.org/10.1136/heartjnl-2025-326101
    • Kawczynski, M. J., Gilbers, M. D., Winters, J., Maesen, B., Isaacs, A., Linz, D., Rienstra, M., van Gelder, I., Maessen, J. G., Bidar, E., & Schotten, U. (2025). Right atrial endomysial fibrosis is associated with increased postoperative atrial fibrillation burden during 2.5 years of continuous rhythm monitoring after cardiac surgery including atrial arrhythmia surgery: RACE V Tissue Bank Study. EP Europace, 27(9), Article euaf207. https://doi.org/10.1093/europace/euaf207
    • Heuts, S., Gabrio, A., Bels, J., Mesotten, D., & Van De Poll, M. (2025). The authors reply. Critical Care Medicine, 53(9), e1857-e1858. https://doi.org/10.1097/CCM.0000000000006779
    • Swinnen, B., Kawczynski, M. J., Mingels, A. M. A., Wildberger, J. E., Mihl, C., Smulders, M. W., Maessen, J. G., Gollmann-Tepeköylü, C., & Heuts, S. (2025). The prognostic impact of prevailing definitions of periprocedural myocardial infarction in patients undergoing coronary artery bypass grafting. European heart journal - Quality of care & clinical outcomes, 11(6), 847-856. https://doi.org/10.1093/ehjqcco/qcaf043
    • Supady, A., Belohlávek, J., Combes, A., Hutin, A., Lorusso, R., MacLaren, G., Magnet, I., van de Poll, M., Price, S., Staudacher, D. L., Taccone, F. S., Yannopoulos, D., & Brodie, D. (2025). Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest. The Lancet Respiratory medicine, 13(9), 843-856. https://doi.org/10.1016/S2213-2600(25)00122-5
    • Costa, C., Arjomandi Rad, A., Yu, Y. T., Mayooran, N., Xanthopoulos, A., Koulouroudias, M., Vardanyan, R., Guida, G. A., Wilkinson, L., Schmitto, J., Ruhparwar, A., Zubarevich, A., Weymann, A., Sardari Nia, P., Kourliouros, A., & Athanasiou, T. (2025). Impact of Frailty in Patients With Continuous-Flow Left Ventricular Assist Device Therapy in End-Stage Heart Failure: A Systematic Review and Meta-Analysis. Artificial Organs, 49(9), 1367-1379. https://doi.org/10.1111/aor.14998
    • Romeo, J. L., Vriesendorp, P. A., Gerritsen, K., Nader, M., Mahtab, E., Maessen, J. G., van 't Hof, A. W. J., Gollmann-Tepeköylü, C., van Rosmalen, F., van der Horst, I. C. C., Mingels, A. M. A., & Heuts, S. (2025). Modeling creatine-kinase MB concentrations following coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery, 170(3), 752-760.e3. https://doi.org/10.1016/j.jtcvs.2024.08.019
    • Pölzl, L., Lohmann, R., Theurl, F., Puelacher, C., Sterzinger, P., Eder, J., Sutter, C., Ioannou-Nikolaidou, M., Nägele, F., Hirsch, J., Graber, M., Engler, C., Heim, V., Schmidt, S., Kilo, J., Reinstadler, S. J., Ulmer, H., Heuts, S., Gudbjartsson, T., ... Gollmann-Tepeköylü, C. (2025). Prognostic Implications of Preoperative N-Terminal Pro-B-Type Natriuretic Peptide Dynamics in Patients Undergoing Cardiac Surgery. JACC: Advances, 4(9), 102096. Article 102096. https://doi.org/10.1016/j.jacadv.2025.102096
    • Squiccimarro, E., Lorusso, R., Vetuschi, P., Rauseo, M., Paternoster, G., Speziale, G., Whitlock, R. P., & Paparella, D. (2025). Unsupervised machine learning to explore inflammation following cardiopulmonary bypass. Perfusion. Advance online publication. https://doi.org/10.1177/02676591251372507
    • Coveliers, J., Meani, P., Huizinga, E., Gutta, K., Piccirillo, G., Gasparotti, E., Vignali, E., Mazzoli, M., Kowalewski, M., Huberts, W., Moradi, H., Di Mauro, M., Holtackers, R. J., de Jong, M., Gelsomino, S., Paparella, D., Celi, S., Haxhiademi, D., Körver, E., ... Lorusso, R. (2025). Large-scale computed tomography study of aortic arch and supra-aortic artery morphology: Variations and potential implications for arterial extracorporeal life support access. Perfusion. Advance online publication. https://doi.org/10.1177/02676591251370074
    • van Mourik, N., van Amstel, R. B. E., Slim, M. A., van Vught, L. A., van der Poll, T., Huckriede, J., de Vries, F., de Kimpe, S. J., Crabbe, R., van Leeuwen, S. J. M., Ekhart, P. F., Reutelingsperger, C. P. M., Nicolaes, G. A. F., Vlaar, A. P. J., & Mueller, M. C. A. (2025). A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients. Intensive Care Medicine Experimental, 13(1), Article 84. https://doi.org/10.1186/s40635-025-00790-4
    • Zancanaro, E., Di Mauro, M., Chiariello, G. A., Dohle, D. S., Kresoja, K.-P., Lin, J., De Angelis, G., Rosch, S., Rommel, K.-P., De Bonis, M., & Lorusso, R. (2025). Long-term outcomes of bioprosthetic tricuspid valves: a systematic review of studies published over the last 20 years. European heart journal. Imaging methods and practice, 3(4), Article 097. https://doi.org/10.1093/ehjimp/qyaf097
    • Makhoul, M., Natour, N., Salmasi, M. Y., Jainandunsing, J. S., Slomka, A., Lorusso, R., Bidar, E., & Natour, E. (2025). Delayed Two-Stage Bentall Procedure: A Safe Technique of Redo Supra-Prosthetic Aortic Root Replacement. Journal of Clinical Medicine, 14(16), Article 5638. https://doi.org/10.3390/jcm14165638
    • Betti, M., Streukens, S. A. F., Kats, S., Maesen, B., Vainer, J., Theunissen, R. A. L. J., van ‘t Hof, A. W. J., & Vriesendorp, P. A. (2025). Mitral Transcatheter Edge-to-Edge Repair for Anterior Leaflet Flail Induced by Transapical Transcatheter Aortic Valve Replacement. JACC. Case reports, 30(22), Article 104653. https://doi.org/10.1016/j.jaccas.2025.104653
    • Heuschkel, M. A., Jaminon, A., Gräber, S., Artati, A., Adamski, J., Jankowski, J., Schurgers, L., Marx, N., Jahnen-Dechent, W., & Goettsch, C. (2025). Hypotaurine Reduces Glucose-Mediated Vascular Calcification. Acta Physiologica, 241(8), Article e70075. https://doi.org/10.1111/apha.70075
    • Heuts, S., Swinnen, B., Oosterlinck, W., & Gollmann-Tepeköylü, C. (2025). Refining the diagnosis of periprocedural myocardial infarction after cardiac surgery: Time to embrace the EACTS algorithm?European Journal of Cardio-Thoracic Surgery, 67(8), Article ezaf251. https://doi.org/10.1093/ejcts/ezaf251
    • Farnir, F., Chaldoupi, S.-M., Hermans, B. J., Farnir, F., Habibi, Z., Jerltorp, K., Verhaert, D., Schotten, U., Maesen, B., Vernooy, K., Luermans, J., & Linz, D. (2025). A tailored substrate-based approach using focal pulsed field catheter ablation in patients with atrial fibrillation and advanced atrial substrate: Procedural data and 6-month success rates. Heart Rhythm, 22(8), 1957-1968. https://doi.org/10.1016/j.hrthm.2025.01.015
    • Deschamps, J., Obanor, O., Clarizia, N., Singh, G., Lobdell, K., Bailey, D., Barnett, C. F., Shaw, A. D., Engelman, D. T., Arora, R. C., PeriOperative Quality Initiative (POQI), Enhanced Recovery After Surgery® (ERAS) Cardiac Society Workgroup, & Lorusso, R. (2025). Best Management Practices on Temporary Mechanical Circulatory Support: Joint Consensus Report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Annals of Thoracic Surgery, 120(2), 225-243. https://doi.org/10.1016/j.athoracsur.2025.01.039
    • Durakiewicz, M., Konings, T. J. A. J., & Mees, B. M. E. (2025). Covered Endovascular Reconstruction of The Coeliac Artery Bifurcation to Treat Hepatic Artery Aneurysm. European Journal of Vascular and Endovascular Surgery, 70(2), 276. https://doi.org/10.1016/j.ejvs.2025.04.021
    • Grant, M. C., Brudney, C. S., Hernandez-Montfort, J., Ibekwe, S. O., Rea, A., Stoppe, C., Zarbock, A., Shaw, A. D., Engelman, D. T., Kanwar, M. K., PeriOperative Quality Initiative (POQI), Enhanced Recovery After Surgery® (ERAS) Cardiac Society Workgroup, & Lorusso, R. (2025). Definitions of Cardiogenic Shock and Indications for Temporary Mechanical Circulatory Support: Joint Consensus Report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Annals of Thoracic Surgery, 120(2), 202-212. https://doi.org/10.1016/j.athoracsur.2025.01.040
    • Spelde, A. E., Barron, L. M., Cangut, B., Hickey, G. W., Lorusso, R., Silvestry, S. C., Tong, M. Z., Engelman, D. T., Shaw, A. D., Chatterjee, S., PeriOperative Quality Initiative (POQI), & Enhanced Recovery After Surgery® (ERAS) Cardiac Society Workgroup (2025). Escalation and De-escalation of Temporary Mechanical Circulatory Support: Joint Consensus Report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Annals of Thoracic Surgery, 120(2), 213-224. https://doi.org/10.1016/j.athoracsur.2025.01.038
    • Veronese, G., Meani, P., Sirico, D., Di Salvo, G., Ammirati, E., Varrica, A., Di Dedda, U., Bianchi, P., Isgro, G., Giamberti, A., Aloisio, T., Dickstein, M., Bonanomi, E., Alsoufi, B., Thiagarajan, R. R., Alexander, P. M. A., Mcmullan, D. M., Barbaro, R. P., Maclaren, G., ... Lorusso, R. (2025). Left ventricular decompression in paediatric veno-arterial extracorporeal life support: Reviewing the evidence. Esc heart failure, 12(4), 2711-2725. https://doi.org/10.1002/ehf2.15325
    • Kawczynski, M. J., Gabrio, A., Maessen, J. G., van 't Hof, A. W. J., Brophy, J. M., Gollmann-Tepeköylü, C., Sardari Nia, P., Vriesendorp, P. A., & Heuts, S. (2025). Percutaneous coronary intervention with drug-eluting stents versus coronary bypass surgery for coronary artery disease: a Bayesian perspective. Journal of Thoracic and Cardiovascular Surgery, 170(2), 558-565.e10. https://doi.org/10.1016/j.jtcvs.2024.08.017
    • Huckriede, J., Keulen, G. M., van de Poll, M. C. G., Wichapong, K., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2025). Proteolytic neutralization of extracellular histones by neutrophil elastase is enhanced by heparin. Journal of Thrombosis and Haemostasis, 23(8), 2483-2493. https://doi.org/10.1016/j.jtha.2025.03.039
    • Grant, M. C., Kanwar, M. K., Spelde, A. E., Chatterjee, S., Deschamps, J., Arora, R. C., Shaw, A. D., Engelman, D. T., PeriOperative Quality Initiative (POQI), Enhanced Recovery After Surgery® (ERAS) Cardiac Society Workgroup, & Lorusso, R. (2025). Temporary Mechanical Circulatory Support in Cardiogenic Shock: Executive Summary of the Joint Consensus Reports of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Annals of Thoracic Surgery, 120(2), 194-201. https://doi.org/10.1016/j.athoracsur.2025.03.024
    • Scheenstra, B., van Susante, L., & Sardari Nia, P. (2025). Reply: Teleprehabilitation Before Cardiac Surgery: Are There Benefits or Biases in Current Metrics?Journal of the American College of Cardiology, 86(4), e31. https://doi.org/10.1016/j.jacc.2025.04.073
    • Nassiri, S., Voordes, G. H. D., van Heerebeek, L., van Raalte, D. H., Verhaar, M. C., Touw, D. J., Krebber, M. M., Duncker, D. J., Eringa, E. C., Handoko, M. L., Voors, A. A., & RECONNEXT Consortium (2025). Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo-controlled, crossover trial. European journal of heart failure. Advance online publication. https://doi.org/10.1002/ejhf.3711
    • Vitali Rosati, B., Dinale, C., Barbaria, A., Di Dedda, U., Aloisio, T., Mondellini, G., Meuwese, C., Giordano, C., Ranucci, M., Van Mieghem, N., Mondino, M., Lorusso, R., & Meani, P. (2025). Ramp-Down/Ramp-Up Protocol for Biventricular Dysfunction Management With ECpella Support. JACC. Case reports, 30(19), Article 104153. https://doi.org/10.1016/j.jaccas.2025.104153
    • Venner, M. F. G. H. M., Gevers, T. J. G., Ploum, F., Habets, J., Raafs, A. G., Weerts, J., Heymans, S. R. B., van der Leij, C., de Haan, M. W., Verdonschot, J. A. J., Kramer, M., & Knackstedt, C. (2025). Diastolic dysfunction as predictive parameter for the development of post-TIPS cardiac decompensation. International Journal of Cardiology, 431, Article 133226. https://doi.org/10.1016/j.ijcard.2025.133226
    • Ganizada, B. H., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M., Maassen, C. F. M., Ramaekers, M. J. F. G., Spronck, B., van der Laan, K., Koenen, R. R., Lorusso, R., Maessen, J. G., Bidar, E., & Schurgers, L. J. (2025). Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants. The Journal of Physiology, 603(14), 3899-3922. https://doi.org/10.1113/JP288734
    • Verolino, G., Mauro, M. D., Calderone, D., & Lorusso, R. (2025). Major Intraprocedural Complications during Transcatheter Aortic Valve Implantation requiring Emergent Cardiac Surgery: an updated Systematic Review. American Journal of Cardiology, 247, 21-28. https://doi.org/10.1016/j.amjcard.2025.03.031
    • Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4
    • Post, M. J., & Dogan, A. (2025). Towards a cultivated ribeye. Trends in Biotechnology, 43(8), 1825-1826. Advance online publication. https://doi.org/10.1016/j.tibtech.2025.06.019
    • Wong, L. Y., Torfs, T., Vanherle, S. J. V., Janssen, J., Claes, G. R. F., Stroeks, S. L. V. M., Willemars, M. M. A., Schianchi, F., Kapsokalyvas, D., Weltjens, E., Swinnen, A., Strzelecka, A., Krapels, I. P. C., Heymans, S. R. B., Glatz, J., van den Wijngaard, A., Brunner, H. G., Broers, J., Luiken, J. F. P., ... Nabben, M. (2025). Clinical and metabolic consequences of a historic pathogenic lamin A/C founder variant. Scientific Reports, 15(1), Article 23842. https://doi.org/10.1038/s41598-025-08495-0
    • Kowalewski, M., Dabrowski, E. J., Kurasz, A., Swieczkowski, M., Raffa, G. M., Kawczynski, M., Aerts, L., Kuzma, L., Wanha, W., Batko, J., Litwinowicz, R., Urbanowicz, T., Stec, S., Lorusso, R., Hanke, T., Maesen, B., Meani, P., Ronco, D., Pilato, M., ... Thoracic Research Centre, endorsed by the ESC Cardiovascular Surgery Working Group (2025). Surgical ablation of atrial fibrillation with concomitant cardiac surgery. A state-of-the-art review. European Journal of Cardio-Thoracic Surgery, 67(7), Article ezaf187. https://doi.org/10.1093/ejcts/ezaf187
    • Corradi, D., Moreno, P. R., Rahouma, M., Abascal, V. M., Guareschi, D., Tafuni, A., Grazioli, V., Palumbo, A., Niccoli, G., & Lorusso, R. (2025). Cardiac tumors: Updated classifications and main clinico-pathologic findings. Trends in Cardiovascular Medicine, 35(5), 297-308. https://doi.org/10.1016/j.tcm.2025.01.005
    • Vacirca, A., Mesnard, T., Huang, Y., Mendes, B. C., Jakimowicz, T., Schneider, D. B., Haulon, S., Sobocinski, J., Beck, A. W., Schanzer, A., Farber, M. A., Timaran, C., Kahlberg, A., Kölbel, T., Gasper, W. J., Mees, B. M. E., Gargiulo, M., Dias, N. V., Woongchae, A. L., ... International Multicenter Aortic Research Group (2025). Predictors of failure to rescue after fenestrated-branched endovascular aortic repair of thoracoabdominal aortic aneurysms. Journal of Vascular Surgery, 82(1), 32-42.e3. https://doi.org/10.1016/j.jvs.2025.02.032
    • Purvis, G. S. D., Chiazza, F., Chen, J., Azevedo-Loiola, R., Martin, L., Kusters, D. H. M., Reutelingsperger, C., Fountoulakis, N., Gnudi, L., Yaqoob, M. M., Collino, M., Thiemermann, C., & Solito, E. (2025). Retraction Note: Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia, 68(7), 1589. https://doi.org/10.1007/s00125-025-06418-2
    • Baudo, M., Sicouri, S., Yamashita, Y., Magouliotis, D., Cabrucci, F., Goldman, S. M., Rodriguez, R., Gnall, E. M., Coady, P. M., Gray, W. A., Gelsomino, S., & Ramlawi, B. (2025). Transcatheter aortic valve-in-valve implantation in failed stentless valves: a single-center experience. Journal of Invasive Cardiology, 37(7), 1-9. https://doi.org/10.25270/jic/25.00006
    • Finke, J., Pasierski, M., Dabrowski, E. J., Kurasz, A., Braczkowski, J., Drzazdzynska, A., Benny, A., Kozlowski, L., Pawelczak, K., Stec, S., Kuzma, L., Urbanowicz, T., Lorusso, R., Suwalski, P., Kowalewski, M., Endorsed By ESC Working Group On Cardiovascular Surgery, & Thoracic Research Centre (2025). Permanent pacemaker implantation following mitral valve surgery. State-of-the-art scoping review. European Journal of Cardio-Thoracic Surgery, 67(7), Article ezaf210. https://doi.org/10.1093/ejcts/ezaf210
    • Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Correction: Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1637511. https://doi.org/10.3389/fimmu.2025.1637511
    • Cannata, S., Sultan, I., Van Mieghem, N., Giordano, A., De Backer, O., Byrne, J., Tchetche, D., Buccheri, S., Nombela-Franco, L., Teles, R. C., Barbanti, M., Barbato, E., Amat Santos, I., Blackman, D. J., Maisano, F., Lorusso, R., La Spina, K., Millin, A., Kliner, D. E., ... Latib, A. (2025). Transcatheter Aortic Valve Replacement With Intra-Annular Self-Expanding or Balloon-Expandable Valves: The Multicenter International NAVULTRA Registry. JACC. Cardiovascular interventions, 18(12), 1557-1568. https://doi.org/10.1016/j.jcin.2025.03.015
    • Kawczynski, M. J., van der Heijden, C. A. J., Maessen, J. G., Schotten, U., Kowalewski, M., Suwalski, P., Bidar, E., & Maesen, B. (2025). Early postoperative atrial fibrillation is associated with late mortality after cardiac surgery: a systematic review and reconstructed individual patient data meta-analysis. Journal of Cardiothoracic Surgery, 20(1), Article 265. https://doi.org/10.1186/s13019-025-03504-9
    • Yu, C., Arjomandi Rad, A., He, H., Yang, Y., Maessen, J. G., & Sardari Nia, P. (2025). The impact of recurrent mitral regurgitation after surgical or transcatheter mitral valve repair: a comprehensive review and a meta-analysis. Interdisciplinary CardioVascular and Thoracic Surgery, 40(6), Article ivaf109. https://doi.org/10.1093/icvts/ivaf109
    • Makhoul, M., Mariani, S., van Bussel, B. C. T., Wiedeman, D., Saeed, D., Di Mauro, M., Pozzi, M., Botta, L., Boeken, U., Samalavicius, R., Bounader, K., Hou, X., Bunge, J. J. H., Buscher, H., Salazar, L., Meyns, B., Mazzeffi, M. A., Sacha Matteucci, M. L., Sponga, S., ... PELS-1 Investigators (2025). Postcardiotomy extracorporeal membrane oxygenation in patients older than 70 years: Characteristics, outcomes, and variables associated with mortality. JTCVS open, 25, 163-172. https://doi.org/10.1016/j.xjon.2025.04.004
    • Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1532250. https://doi.org/10.3389/fimmu.2025.1532250