PI group Leon Schurgers
- 2026
- Rasiah, M. G., Konings, T. J. A. J., Nio, A., Moriconi, S., Patel, A. S., Smith, A., Gkoutzios, P., Abdelhalim, M. A., Delhaas, T., Cardoso, M. J., Lamata, P., Mees, B. M. E., & Modarai, B. (2026). In silico modelling of changes in spinal cord blood flow after endovascular aortic aneurysm repair. Computer Methods and Programs in Biomedicine, 280, Article 109336. https://doi.org/10.1016/j.cmpb.2026.109336
- Potjewijd, J., Tobal, R., van Doorn, D. P. C., Schurgers, L. J., Heeringa, P., Damoiseaux, J. G. M. C., & van Paassen, P. (2026). Soluble immune checkpoints reflect immune activation and treatment response in high-risk systemic sclerosis patients treated with plasma exchange. Journal of Translational Autoimmunity, 12, Article 100361. https://doi.org/10.1016/j.jtauto.2026.100361
- Pinckaers, N. E. T., Blankesteijn, W. M., Leenders, P., Weltjens, E., Opperhuizen, A., Van Schooten, F.-J., & Vrolijk, M. (2026). Potential Cardiovascular Risks of Phenethylamine Analogues in Food Supplements: Evidence from Vasocontraction of Rat Artery Segments. Cardiovascular Toxicology, 26(4), Article 36. https://doi.org/10.1007/s12012-026-10109-8
- Davies, H., Boalot, A., Howitt, A., Vleugels, M.-J., Tam, S. K. P., Kwan, J. Y., Black, S., Francis, I., Bull, C., Mees, B. M. E., Mitchell, S., & Russell, D. (2026). Analgesic strategies for ischaemic pain in chronic limb-threatening ischaemia: a systematic review and meta-analysis. Pain reports, 11(2), Article e1426. https://doi.org/10.1097/PR9.0000000000001426
- Goossens, S. H., van der Reijden, J. J., Tseng, C. M. E. S. N., Hoogeveen, A. R., Vaes, R., Jan de Borst, G., Schurink, G. W., & Scheltinga, M. R. M. (2026). Short-term analysis of botulinum toxin A for functional popliteal artery entrapment syndrome. Journal of Vascular Surgery Cases and Innovative Techniques, 12(2), Article 102139. https://doi.org/10.1016/j.jvscit.2026.102139
- Atash, A., Mees, B. M. E., Cramer, M. J., Baas, A. F., Schurgers, L. J., Doevendans, P. A., & Stillitano, F. (2026). MYH11 variants in thoracic aortic aneurysm pathophysiology: From bench to bedside. European Journal of Clinical Investigation, 56(4), Article e70196. https://doi.org/10.1111/eci.70196
- van Heeswijk, K., Heijmans, M., van der Cruijsen, M., Schurink, G. W., & Scheltinga, M. (2026). Association Between Number of Positive Pedowitz Criteria and Outcome After a Fasciotomy for Lower Leg Chronic Exertional Compartment Syndrome. Orthopaedic Journal of Sports Medicine, 14(3), Article 23259671251394375. https://doi.org/10.1177/23259671251394375
- Frankort, J., Keszei, A., Doukas, P., Uhl, C., Jacobs, M. J., Mees, B. M. E., Gombert, A., & Elfeky, M. (2026). Outcome following open TAAA repair after TEVAR compared to conventional open type II TAAA repair. Vasa-European Journal of Vascular Medicine, 55(2 Special Issue:Complex aortic pathologies), 114-120. https://doi.org/10.1024/0301-1526/a001247
- Frankort, J., Doukas, P., Krabbe, J., Otte, N., Uhl, C., Schurink, G. W., Gombert, A., Jacobs, M. J., & Mees, B. M. E. (2026). Outcomes Following Contemporary Open Thoracoabdominal Aortic Aneurysm Extent I Repair: A Cross-Border Study. European Journal of Cardio-Thoracic Surgery, 68(3), Article ezag104. https://doi.org/10.1093/ejcts/ezag104
- You, W., Berendschot, T. T. J. M., Benedikter, B. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2026). Potential and value of rescuing dying neurons. Neural Regeneration Research, 21(3), 1013-1022. https://doi.org/10.4103/NRR.NRR-D-24-01134
- van Heeswijk, K., van Essen, B., Kokshoorn, A., Schurink, G. W., & Scheltinga, M. (2026). Pressure-controlled ultrasound is a novel non-invasive technique for detecting anterior chronic exertional compartment syndrome. BJM Open Sport & Exercise Medicine, 12(1), Article e003094. https://doi.org/10.1136/bmjsem-2025-003094
- Francesco Squizzato, U., D'Oria, M., Antonello, M., Trimarchi, S., Mani, K., Holden, A., Kölbel, T., Haulon, S., Verhoeven, E., Böckler, D., Resch, T., Azizzadeh, A., Lombardi, J., Piazza, M., Fargion, A. T., Zimmermann, A., Wanhainen, A., Holden, A., Freyrie, A., ... IDEAAS-IMH/PAU Investigators (2026). Editor's Choice – International Expert Consensus on the Management of Acute Aortic Type B Intramural Haematoma and Penetrating Ulcer. European Journal of Vascular and Endovascular Surgery, 71(3), 402-412. https://doi.org/10.1016/j.ejvs.2025.09.045
- Vleugels, M.-J., Moser, A., van den Beuken-van Everdingen, M., Mees, B., & Hendriks, J. M. (2026). Nurses in the lead: advancement of integrated palliative care and professional autonomy in peripheral arterial disease. European Journal of Cardiovascular Nursing, 25(2), 217-218. https://doi.org/10.1093/eurjcn/zvag005
- Lima, L. S., Ribeiro, M., Cardozo, L. F. M. F., Bittner, R., Ribeiro-Alves, M., Schultz, J., Rosado, A. S., Leite, P. E. C., Nakao, L. S., Schurgers, L. J., & Mafra, D. (2026). Association of poor vitamin K status with inflammation and gut microbiota in hemodialysis patients: A cross-sectional study. Journal of Nutritional Biochemistry, 148, Article 110139. https://doi.org/10.1016/j.jnutbio.2025.110139
- Vidula, M. K., Schurgers, L. J., Zhao, L., Dib, M.-J., Zhao, M., Wang, Z., Ebert, C., Salman, O., Azzo, J. D., Zamani, P., van Empel, V., Richards, A. M., Doughty, R., Javaheri, A., Mann, D. L., Rietzschell, E., Kammerhoff, K., Schafer, P., Seiffert, D. A., ... Chirinos, J. A. (2026). Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure. Circulation-Heart Failure, 19(2), 1-11. Article e012734. https://doi.org/10.1161/CIRCHEARTFAILURE.124.012734
- Wanhainen, A., Gombert, A., Antoniou, G. A., Domingos, L. A. F., Gouveia e Melo, R., Grabenwoger, M., Haulon, S., Katsargyris, A., Kolbel, T., Loftus, I. M., Mani, K., Mees, B. M. E., Melissano, G., Pedro, L. M., Prendes, C. F., Spanos, K., Tsilimparis, N., Van Herzeele, I., Venermo, M., ... Vermassen, F. E. G. (2026). European Society for Vascular Surgery (ESVS) 2026 Clinical Practice Guidelines on the Management of Descending Thoracic and Thoraco-Abdominal Aortic Diseases – Editor's Choice. European Journal of Vascular and Endovascular Surgery, 71(2), 172-270. https://doi.org/10.1016/j.ejvs.2025.12.050
- Greenleaf, E. K., Maximus, S., Oden-Brunson, H., Ferreira, Z. C., Miranda, J., Huang, Y., Mees, B., & Oderich, G. S. (2026). Historical Evolution of Physician-Modified Endografts (PMEGs) for Treatment of Complex Aortic Aneurysms. Annals of Vascular Surgery, 123, 636-652. https://doi.org/10.1016/j.avsg.2025.10.015
- Barb, A., Uhl, C., Bornhak, L., El-Sanosy, E., Fink, M., Böckler, D., Hatzl, J., Zephyr study group collaborators, & Mees, B. (2026). Accuracy of fully automated iliac artery tortuosity measurements in patients with abdominal aortic aneurysm using deep learning. European Journal of Radiology, 195, Article 112609. https://doi.org/10.1016/j.ejrad.2025.112609
- Stenvinkel, P., Kotanko, P., Painer-Gigler, J., Shiels, P. G., Evenepoel, P., Schurgers, L., Natterson-Horowitz, B., Kalogeropoulu, S., Schiffman, J., & Johnson, R. J. (2026). Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?Diabetologia, 69(2), 295-307. https://doi.org/10.1007/s00125-025-06611-3
- Doukas, P., Bassett, C., Hruschka, B., Kuzmanova, E., Wessels, I., Klump, H. J., Schurgers, L. J., Jacobs, M. J., Uhl, C., Gombert, A., & Huang, J. T. J. (2026). Plasma Desmosine Is Elevated in Thoracoabdominal Aortic Aneurysms and Is Associated with Intramural Proteolytic Activity. International Journal of Molecular Sciences, 27(3), Article 1236. https://doi.org/10.3390/ijms27031236
- Frankort, J., Mess, W. H., Krabbe, J., Gombert, A., Mees, B. M. E., & Jacobs, M. J. (2026). Accuracy and Applicability of Motor Evoked Potential Monitoring during Open Thoraco-Abdominal Aortic Aneurysm Repair. European Journal of Vascular and Endovascular Surgery. Advance online publication. https://doi.org/10.1016/j.ejvs.2025.12.058
- Schanzer, A., Schneider, D. B., Timaran, C., Beck, A. W., Schermerhorn, M., Schurink, G. W., van Herwaarden, J., Modarai, B., Moreels, N., Cochennec, F., Resch, T., & Kölbel, T. (2026). Design of the RadFree randomized controlled study comparing LumiGuide, powered by Fiber Optic RealShape Technology, with conventional fluoroscopy guidance in fenestrated endovascular aortic repair. Jvs Vascular Insights, 4, Article 100354. https://doi.org/10.1016/j.jvsvi.2026.100354
- Karelis, A., Adam, D., Piazza, M., Tinelli, G., Gallito, E., Matsagkas, M., Mees, B., Mani, K., D'Oria, M., Mansour, W., Cieri, E., Kolbel, T., Sonesson, B., Dias, N., & PEACE, C. (2026). Parallel Endografting And Chimney Endovascular (PEACE) registry outcomes in emergency repair of complex abdominal aortic aneurysms. British Journal of Surgery, 113(1), Article znaf278. https://doi.org/10.1093/bjs/znaf278
- van der Wilt, C. N., Veltrop, R. J. A., Janssens, M. H., Bakker, I., Stillitano, F., Sluijter, J. P. G., van Laake, L. W., van der Velden, J., Villard, E., Montag, J., Denning, C., van Tintelen, J. P., Te Riele, A. S. J. M., van der Harst, P., Schurgers, L. J., van Steenbeek, F. G., & Harakalova, M. (2026). Setting the stage for cardiomyopathy gene editing trials: a systematic review of isogenic pair use in human induced pluripotent stem cell-derived cardiomyocyte research. European heart journal open, 6(1), Article oeaf161. https://doi.org/10.1093/ehjopen/oeaf161
- Davies, H., Vleugels, M.-J., Kwong, M., Dua, A., Akhtar, N., Mees, B. M. E., Mitchell, S., & Russell, D. (2026). Clinician Attitudes towards Analgesia for Chronic Limb Threatening Ischaemia: A Survey of Vascular Specialists to Inform a Topical Morphine Trial. EJVES vascular forum, 65, 43-48. https://doi.org/10.1016/j.ejvsvf.2025.12.001
- 2025
- Meulendijks, E. R., Fabrizi, B., Bruns, S., Eringa, E. C., Hoebe, R., van den Boogert, T., Wesselink, R., Al-Shama, R. F. M., de Vries, T. A. C., Ernault, A. C., Niessen, H. W. M., van Boven, W. J. P., Driessen, A. H. G., Zbairi, I., Zappala, P., Dey, D., Isgum, I., Planken, R. N., Krul, S. P. J., & de Groot, J. R. (2025). Patients with persistent atrial fibrillation and metabolic comorbidities have an altered inflammatory state of atrial epicardial adipose tissue, which is linked to CT-attenuation. Cardiovascular Diabetology, 25(1), Article 82. https://doi.org/10.1186/s12933-025-02985-1
- Kopytina, V., Marchant, V., Rodrigues-Diez, R., Pascual-Anton, L., Toggweiler, N., Strahl, L., Kane, J., Tejera-Munoz, A., Cortes, M., Sucunza, D., Vaquero, J. J., Vervloet, M., Piecha, D., Eringa, E. C., Ruiz-Ortega, M., Lopez-Cabrera, M., & Gonzalez-Mateo, G. T. (2025). Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions. Nephrology Dialysis Transplantation, Article gfaf249. https://doi.org/10.1093/ndt/gfaf249
- Nassiri, S., Voordes, G. H. D., van Heerebeek, L., van Raalte, D. H., Verhaar, M. C., Touw, D. J., Krebber, M. M., Duncker, D. J., Eringa, E. C., Handoko, M. L., Voors, A. A., & RECONNEXT Consortium (2025). Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo-controlled, crossover trial. European journal of heart failure, 27(12), 3304-3311. https://doi.org/10.1002/ejhf.3711
- Lanzer, P., Schurgers, L., Twarda-Clapa, A., Ferraresi, R., Hui, H., Kamenskiy, A., Chen, Y., Hamana, T., Fok, P.-W., Millán, Á., Virmani, R., & St Hilaire, C. (2025). Medial arterial calcification in ageing and disease: current evidence and knowledge gaps. European Heart Journal, 46(45), 4876-4900. https://doi.org/10.1093/eurheartj/ehaf341
- Al-Chalabi, S., Sinha, S., Kalra, P. A., Evans, D., Green, D., Schurgers, L., & Poulikakos, D. (2025). A Randomised Prospective Crossover Study on the Effects of Medium Cut-Off Membranes on FGF-23 and Inflammatory Mediators in Patients Receiving Regular Haemodialysis. Blood Purification, 54(11), 639-651. https://doi.org/10.1159/000545745
- Ramos, K. S., Nassiri, S., Wijdeveld, L. F. J., van der Palen, R. L., Kuipers, M. F., Hills, M. T., Slijkerman, P., van Raalte, D. H., Handoko, M. L., de Groot, N. M. S., Grewal, N., Klautz, R. J. M., Eringa, E. C., & Brundel, B. J. J. M. (2025). Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY). Cardiovascular Drugs and Therapy, 39(6), 1589-1595. https://doi.org/10.1007/s10557-025-07693-2
- Niederau, C., Maas, S. L., van der Vorst, E. P. C., Schurgers, L. J., Shi, Y., Holzle, F., Wolf, M., & Craveiro, R. B. (2025). Jaw-specific differential kinase activity profiles in human periodontal ligament stem cells under mechanical compression. Stem Cell Research & Therapy, 16(1), Article 624. https://doi.org/10.1186/s13287-025-04778-5
- Frankort, J., Frankort, S., Doukas, P., Uhl, C., Elfeky, M., Mees, B. M. E., Gombert, A., & Jacobs, M. J. (2025). Shift in Patient Demographics of Open Thoracoabdominal Aortic Aneurysm Repair Patients in the Endovascular Era. Journal of Clinical Medicine, 14(19), Article 7088. https://doi.org/10.3390/jcm14197088
- Jin, H., Maas, S. L., Zou, Y., Lu, C., Yu, B., Huchzermeier, R., Nadeau, S., Dos Santos, J., Gijbels, M., Mees, B. M. E., Smirnov, E., Matic, L., Hedin, U., Maffia, P., Monaco, C., Sluimer, J. C., Martins, G. A., van der Vorst, E. P. C., & Biessen, E. A. L. (2025). Identification of a PRDM1-regulated T cell network to regulate atherosclerotic plaque inflammation. Genome Medicine, 17(1), Article 109. https://doi.org/10.1186/s13073-025-01541-6
- Kalaja, I., Smeets, R. R., Wegner, M., Macherey-Meyer, S., Heyne, S., Espinola-Klein, C., Mees, B. M. E., & Meertens, M. M. (2025). Ultrasound Guided Versus Conventional Closure Device Deployment Following Transfemoral Endovascular Procedures: A Systematic Review and Meta-analysis. European Journal of Vascular and Endovascular Surgery, 70(4), 469-479. https://doi.org/10.1016/j.ejvs.2025.06.023
- Miranda, M., Leoni, M., van der Zwaan, C., van Bruggen, R., Reutelingsperger, C. P. M., Fijnvandraat, K., Hoogendijk, A. J., van den Biggelaar, M., Voorberg, J., & Collaborative group: EDUC8 consortium (2025). MHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells. Frontiers in Immunology, 16, Article 1668397. https://doi.org/10.3389/fimmu.2025.1668397
- van Mourik, N., van Amstel, R. B. E., Slim, M. A., van Vught, L. A., van der Poll, T., Huckriede, J., de Vries, F., de Kimpe, S. J., Crabbe, R., van Leeuwen, S. J. M., Ekhart, P. F., Reutelingsperger, C. P. M., Nicolaes, G. A. F., Vlaar, A. P. J., & Mueller, M. C. A. (2025). A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients. Intensive Care Medicine Experimental, 13(1), Article 84. https://doi.org/10.1186/s40635-025-00790-4
- Heuschkel, M. A., Jaminon, A., Gräber, S., Artati, A., Adamski, J., Jankowski, J., Schurgers, L., Marx, N., Jahnen-Dechent, W., & Goettsch, C. (2025). Hypotaurine Reduces Glucose-Mediated Vascular Calcification. Acta Physiologica, 241(8), Article e70075. https://doi.org/10.1111/apha.70075
- Durakiewicz, M., Konings, T. J. A. J., & Mees, B. M. E. (2025). Covered Endovascular Reconstruction of The Coeliac Artery Bifurcation to Treat Hepatic Artery Aneurysm. European Journal of Vascular and Endovascular Surgery, 70(2), 276. https://doi.org/10.1016/j.ejvs.2025.04.021
- Huckriede, J., Keulen, G. M., van de Poll, M. C. G., Wichapong, K., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2025). Proteolytic neutralization of extracellular histones by neutrophil elastase is enhanced by heparin. Journal of Thrombosis and Haemostasis, 23(8), 2483-2493. https://doi.org/10.1016/j.jtha.2025.03.039
- Ganizada, B. H., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M., Maassen, C. F. M., Ramaekers, M. J. F. G., Spronck, B., van der Laan, K., Koenen, R. R., Lorusso, R., Maessen, J. G., Bidar, E., & Schurgers, L. J. (2025). Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants. The Journal of Physiology, 603(14), 3899-3922. https://doi.org/10.1113/JP288734
- Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4
- Vacirca, A., Mesnard, T., Huang, Y., Mendes, B. C., Jakimowicz, T., Schneider, D. B., Haulon, S., Sobocinski, J., Beck, A. W., Schanzer, A., Farber, M. A., Timaran, C., Kahlberg, A., Kölbel, T., Gasper, W. J., Mees, B. M. E., Gargiulo, M., Dias, N. V., Woongchae, A. L., ... International Multicenter Aortic Research Group (2025). Predictors of failure to rescue after fenestrated-branched endovascular aortic repair of thoracoabdominal aortic aneurysms. Journal of Vascular Surgery, 82(1), 32-42.e3. https://doi.org/10.1016/j.jvs.2025.02.032
- Purvis, G. S. D., Chiazza, F., Chen, J., Azevedo-Loiola, R., Martin, L., Kusters, D. H. M., Reutelingsperger, C., Fountoulakis, N., Gnudi, L., Yaqoob, M. M., Collino, M., Thiemermann, C., & Solito, E. (2025). Retraction Note: Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia, 68(7), 1589. https://doi.org/10.1007/s00125-025-06418-2
- Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Correction: Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1637511. https://doi.org/10.3389/fimmu.2025.1637511
- Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1532250. https://doi.org/10.3389/fimmu.2025.1532250
- Janssen-Telders, C., Eringa, E. C., de Groot, J. R., de Man, F. S., & Handoko, M. L. (2025). The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction. Cardiovascular Research, 121(6), 860-870. https://doi.org/10.1093/cvr/cvaf056
- Suthahar, N., Mourmans, S. G. J., Achten, A., Aboumsallem, J. P., Meijers, W. C., Bomer, N., Kardys, I., Gansevoort, R. T., Bakker, S. J. L., Weerts, J., Eringa, E. C., Damman, K., van Empel, V., & de Boer, R. A. (2025). Peroxiredoxin-4, a marker of systemic oxidative stress, is associated with incident heart failure. European journal of heart failure, 27(5), 905-911. Article 3653. https://doi.org/10.1002/ejhf.3653
- Saraber, P., Bica, L., Reesink, K., Mees, B., Bidar, E., Schurger, L., & Heuts, S. (2025). The clinical relevance of the decelerating effect of angiotensin receptor blockers on aortic growth in Marfan patients; a Bayesian perspective. International Journal of Cardiology, 433, Article 133318. https://doi.org/10.1016/j.ijcard.2025.133318
- Mourmans, S. G. J., Achten, A., Hermans, R., Scheepers, M. J. E., D'Alessandro, E., Swennen, G., Woudstra, J., Appelman, Y., Goor, H. V., Schalkwijk, C., Knackstedt, C., Weerts, J., Eringa, E. C., & van Empel, V. P. M. (2025). The effect of empagliflozin on peripheral microvascular dysfunction in patients with heart failure with preserved ejection fraction. Cardiovascular Diabetology, 24(1), Article 182. https://doi.org/10.1186/s12933-025-02679-8




