Boy Houben

Associate professor

Alfons (Boy) Houben is Associate Professor at the Department of Internal Medicine of Maastricht UMC+. He graduated in Biology at the University of Nijmegen, and received his PhD, in Maastricht in 1993, on early microcirculatory changes in patients with type 1 diabetes. He has longstanding expertise in human (non-invasive) micro- and macrovascular function tests in combination with (pharmacological) interventions, and in the epidemiological setting (The Maastricht Study). Using this unique approach, his main research interest is on the role of microvascular dysfunction in cardiometabolic diseases. An additional focus in his present research is the effects of lifestyle modifications in order to improve microvascular function. He is President of the European Society for Microcirculation, chair of the Dutch Society for Microcirculation and Vascular Biology, and member of several other international scientific societies.

The focus of my research for many years has been microvascular dysfunction (MVD) as both a cause and a consequence of (cardio)metabolic diseases. One important function of the microcirculation is to deliver oxygen/nutrients to all tissues and to remove waste products. In normal metabolism this includes the delivery of glucose, which taken up by the gut following a meal, to skeletal muscle in order to be stored as glycogen. For that, insulin plays an important role by stimulating the endothelium to produce nitric oxide (NO), which leads to recruitment of capillaries in skeletal muscle and thus an increase in exchange surface. As a result, both glucose and insulin can reach skeletal muscle cells quickly and easily in order to store glucose in the cells. In our working hypothesis, we state that MVD may disturb this insulin-mediated glucose delivery/uptake, leading to metabolic insulin resistance and contributing to the development of type 2 diabetes. Within the framework of The Maastricht Study (a population-based cohort study), we perform deep phenotyping of the microcirculation. By using this approach, we are looking for (early) determinants of MVD, and study the role of MVD in the development and progression of various diseases (e.g. (pre)diabetes, heart failure, and depression).

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht

  • 2021
    • van der Heide, F. C. T., Zhou, T. L., Henry, R. M. A., Houben, A. J. H. M., Kroon, A. A., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Koster, A., Savelberg, H. H. C. M., Schaper, N. C., Reesink, K. D., & Stehouwer, C. D. A. (2021). Carotid stiffness is associated with retinal microvascular dysfunction- The Maastricht Study. Microcirculation, 28(6), [e12702]. https://doi.org/10.1111/micc.12702
    • Van den Eynde, M. D. G., Kusters, Y. H. A. M., Houben, A. J. H. M., Scheijen, J. L. J. M., van Duynhoven, J., Fazelzadeh, P., Joris, P. J., Plat, J., Mensink, R. P., Hanssen, N. M. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2021). Diet-induced weight loss reduces postprandial dicarbonyl stress in abdominally obese men: Secondary analysis of a randomized controlled trial. Clinical Nutrition, 40(5), 2654-2662. https://doi.org/10.1016/j.clnu.2021.03.042
    • Hanssen, N. M. J., Scheijen, J. L. J. M., Houben, A. J. H. M., van de Waarenburg, M., Berendschot, T. T. J. M., Webers, C. A. B., Reesink, K. D., van Greevenbroek, M. M. J., van der Kallen, C., Schaper, N. C., Schram, M. T., Henry, R. M. A., Stehouwer, C. D. A., & Schalkwijk, C. G. (2021). Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study. Diabetes & Metabolism, 47(1), [101148]. https://doi.org/10.1016/j.diabet.2020.02.002
  • 2020
    • Ginsberg, C., Houben, A. J. H. M., Malhotra, R., Berendschot, T. T. J. M., Kooman, J. P., Webers, C. A. B., Stehouwer, C. D. A., & Ix, J. H. (2020). Urinary Phosphate Excretion and Microvascular Function in a Population-Based Cohort. Kidney Medicine, 2(6), 812-815. https://doi.org/10.1016/j.xkme.2020.08.009
    • Sharma, S., Katz, R., Bullen, A. L., Chaves, P. H. M., de Leeuw, P. W., Kroon, A. A., Houben, A. J. H. M., Shlipak, M. G., & Ix, J. H. (2020). Intact and C-Terminal FGF23 Assays-Do Kidney Function, Inflammation, and Low Iron Influence Relationships With Outcomes?Journal of Clinical Endocrinology & Metabolism, 105(12), [665]. https://doi.org/10.1210/clinem/dgaa665
    • Joris, P. J., Plat, J., Kusters, Y. H. A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Mensink, R. P. (2020). Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal: Results of a randomized controlled trial with abdominally obese men. Clinical Nutrition, 39(10), 2998-3004. https://doi.org/10.1016/j.clnu.2020.01.006
    • Wouters, K., Kusters, Y. H. A. M., Bijnen, M., Wetzels, S., Zhang, X., Linssen, P. B. C., Gaens, K., Houben, A. J. H. M., Joris, P. J., Plat, J., Kooi, M. E., van der Kallen, C. J. H., Mensink, R. P., Verboven, K., Jocken, J., Hansen, D., Blaak, E. E., Ehlers, F. A. I., Wieten, L., ... Schalkwijk, C. G. (2020). NK cells in human visceral adipose tissue contribute to obesity-associated insulin resistance through low-grade inflammation. Clinical and Translational Medicine, 10(6), [192]. https://doi.org/10.1002/ctm2.192
    • Li, W., Schram, M. T., Sörensen, B. M., van Agtmaal, M. J. M., Berendschot, T. T. J. M., Webers, C. A. B., Jansen, J. F. A., Backes, W. H., Gronenschild, E. H. B. M., Schalkwijk, C. G., Stehouwer, C. D. A., & Houben, A. J. H. M. (2020). Microvascular Phenotyping in the Maastricht Study: Design and Main Findings, 2010-2018. American Journal of Epidemiology, 189(9), 873-884. https://doi.org/10.1093/aje/kwaa023
    • Geraets, A. F. J., van Agtmaal, M. J. M., Stehouwer, C. D. A., Sörensen, B. M., Berendschot, T. T. J. M., Webers, C. A. B., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Eussen, S. J. P. M., Koster, A., van Sloten, T. T., Köhler, S., Schram, M. T., & Houben, A. J. H. M. (2020). Association of Markers of Microvascular Dysfunction With Prevalent and Incident Depressive Symptoms: The Maastricht Study. Hypertension, 76(2), 342-349. https://doi.org/10.1161/HYPERTENSIONAHA.120.15260
    • Zhou, T. L., Rensma, S. P., van der Heide, F. C. T., Henry, R. M. A., Kroon, A. A., Houben, A. J. H. M., Jansen, J. F. A., Backes, W. H., Berendschot, T. T. J. M., Schouten, J. S. A. G., van Dongen, M. C. J. M., Eussen, S. J. P. M., Dagnelie, P. C., Webers, C. A. B., Schram, M. T., Schalkwijk, C. G., van Sloten, T. T., & Stehouwer, C. D. A. (2020). Blood pressure variability and microvascular dysfunction: the Maastricht Study. Journal of Hypertension, 38(8), 1541-1550. https://doi.org/10.1097/HJH.0000000000002444
    • Li, W., Schram, M. T., Berendschot, T. T. J. M., Webers, C. A. B., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Schaper, N. C., Huang, F., Dashtbozorg, B., Tan, T., Zhang, J., Abbasi-Sureshjani, S., Ter Haar Romeny, B. M., Stehouwer, C. D. A., & Houben, A. J. H. M. (2020). Type 2 diabetes and HbA1c are independently associated with wider retinal arterioles: the Maastricht study. Diabetologia, 63(7), 1408-1417. https://doi.org/10.1007/s00125-020-05146-z
    • Rensma, S. P., Stehouwer, C. D. A., Van Boxtel, M. P. J., Houben, A. J. H. M., Berendschot, T. T. J. M., Jansen, J. F. A., Schalkwijk, C. G., Verhey, F. R. J., Kroon, A. A., Henry, R. M. A., Backes, W. H., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bosma, H., Köhler, S., Reesink, K. D., Schram, M. T., & van Sloten, T. T. (2020). Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction: The Maastricht Study. Hypertension, 75(6), 1607-1614. https://doi.org/10.1161/hypertensionaha.119.14307
    • Simons, N., Debray, F-G., Schaper, N. C., Feskens, E. J. M., Hollak, C. E. M., Bons, J. A. P., Bierau, J., Houben, A. J. H. M., Schalkwijk, C. G., Stehouwer, C. D. A., Cassiman, D., & Brouwers, M. C. G. J. (2020). Kidney and vascular function in adult patients with hereditary fructose intolerance. Molecular Genetics and Metabolism Reports, 23, [100600]. https://doi.org/10.1016/j.ymgmr.2020.100600
    • Sorensen, B. M., van der Heide, F. C. T., Houben, A. J. H. M., Koster, A., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., van Dongen, M. C. J. M., Eussen, S. J. P. M., Savelberg, H. H. C. M., van der Berg, J. D., Schaper, N. C., Schram, M. T., & Stehouwer, C. D. A. (2020). Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study. Microcirculation, 27(4), [12611]. https://doi.org/10.1111/micc.12611
    • Van den Eynde, M. D. G., Streese, L., Houben, A. J. H. M., Stehouwer, C. D. A., Scheijen, J. L. J. M., Schalkwijk, C. G., Hanssen, N. M. J., & Hanssen, H. (2020). Physical activity and markers of glycation in older individuals: data from a combined cross-sectional and randomized controlled trial (EXAMIN AGE). Clinical Science, 134(9), 1095-1105. https://doi.org/10.1042/CS20200255
    • Marcoccia, A., Klein-Weigel, P. F., Gschwandtner, M. E., Wautrecht, J-C., Matuska, J., Rother, U., & Houben, A. J. H. M. (2020). Microcirculatory assessment of vascular diseases. Vasa-European Journal of Vascular Medicine, 49(3), 175-186. https://doi.org/10.1024/0301-1526/a000851
    • Schutten, M. T. J., Kusters, Y. H. A. M., Houben, A. J. H. M., Niessen, H. E., Roodt, J. O., Scheijen, J. L. J. M., van de Waardenburg, M. P., Schalkwijk, C. G., de Leeuw, P. W., & Stehouwer, C. D. A. (2020). Glucocorticoids affect metabolic but not muscle microvascular insulin sensitivity following high versus low salt intake. JCI INSIGHT, 5(6), [127530]. https://doi.org/10.1172/jci.insight.127530
    • Rensma, S. P., van Sloten, T. T., Houben, A. J. H. M., Koehler, S., van Boxtel, M. P. J., Berendschot, T. T. J. M., Jansen, J. F. A., Verhey, F. R. J., Kroon, A. A., Koster, A., Backes, W. H., Schaper, N., Dinant, G-J., Schalkwijk, C. G., Henry, R. M. A., Wolfs, E. M. L., van Heumen, M. J. A., Schram, M. T., & Stehouwer, C. D. A. (2020). Microvascular Dysfunction Is Associated With Worse Cognitive Performance The Maastricht Study. Hypertension, 75(1), 237-245. https://doi.org/10.1161/hypertensionaha.119.13023
  • 2019
    • Foreman, Y. D., Brouwers, M. C. G. J., Berendschot, T. T. J. M., van Dongen, M. C. J. M., Eussen, S. J. P. M., van Greevenbroek, M. M. J., Henry, R. M. A., Houben, A. J. H. M., van der Kallen, C. J. H., Kroon, A. A., Reesink, K. D., Schram, M. T., Schaper, N. C., & Stehouwer, C. D. A. (2019). The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study. Cardiovascular Diabetology, 18(1), [152]. https://doi.org/10.1186/s12933-019-0950-x
    • Ginsberg, C., Houben, A. J. H. M., Malhotra, R., Berendschot, T. T. J. M., Dagnelie, P. C., Kooman, J. P., Webers, C. A., Stehouwer, C. D. A., & Ix, J. H. (2019). Serum Phosphate and Microvascular Function in a Population-Based Cohort. Clinical journal of the American Society of Nephrology, 14(11), 1626-1633. https://doi.org/10.2215/CJN.02610319
    • Telgenkamp, I., Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., Bons, J. A. P., Schaper, N. C., Joris, P. J., Plat, J., Mensink, R. P., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2019). Contribution of Liver Fat to Weight Loss-Induced Changes in Serum Hepatokines: A Randomized Controlled Trial. Journal of Clinical Endocrinology & Metabolism, 104(7), 2719-2727. https://doi.org/10.1210/jc.2018-02378
    • Sluimer, J. C., & Houben, A. J. H. M. (2019). Joint ESM-EVBO meetings: past, present, and future. Cardiovascular Research, 115(4), E46-E48. https://doi.org/10.1093/cvr/cvz041
    • Rensma, S., van Sloten, T. T., Houben, A. J. H. M., van Boxtel, M. P. J., Berendschot, T. T. J. M., Jansen, J. F. A., Kroon, A. A., Koster, A., Backes, W. H., Schaper, N., Dinant, G. J., Schalkwijk, C. G., Henry, R. M. A., Wolfs, E. M. L., van Heumen, M. J. A., Schram, M. T., & Stehouwer, C. D. A. (2019). Microvascular Dysfunction Is Associated with Worse Cognitive Performance: The Maastricht Study. Journal of Vascular Research, 56(S1), 94-94. https://doi.org/10.1159/000499516
  • 2018
    • van Agtmaal, M. J. M., Houben, A. J. H. M., de Wit, V., Henry, R. M. A., Schaper, N. C., Dagnelie, P. C., van der Kallen, C. J., Koster, A., Sep, S. J., Kroon, A. A., Jansen, J. F. A., Hofman, P. A., Backes, W. H., Schram, M. T., & Stehouwer, C. D. A. (2018). Prediabetes Is Associated With Structural Brain Abnormalities: The Maastricht Study. Diabetes Care, 41(12), 2535-2543. https://doi.org/10.2337/dc18-1132
    • de Waard, E. A. C., de Jong, J. J. A., Koster, A., Savelberg, H. H. C. M., van Geel, T. A., Houben, A. J. H. M., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Berendschot, T. T. J. M., Schouten, J. S. A. G., Geusens, P. P. M. M., & van den Bergh, J. P. W. (2018). The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomography: The Maastricht Study. Osteoporosis International, 29(12), 2725-2738. https://doi.org/10.1007/s00198-018-4678-3
    • van Twist, D. J. L., de Heer, P. W. M., Houben, A. J. H. M., de Haan, M. W., de Leeuw, P. W., & Kroon, A. A. (2018). Differences in renal hemodynamics and renin secretion between patients with unifocal and multifocal fibromuscular dysplasia. Journal of Hypertension, 36(8), 1729-1735. https://doi.org/10.1097/HJH.0000000000001755
    • Martens, R. J. H., Houben, A. J. H. M., Kooman, J. P., Berendschot, T. T. J. M., Dagnelie, P. C., van der Kallen, C. J. H., Kroon, A. A., Leunissen, K. M. L., van der Sande, F. M., Schaper, N. C., Schouten, J. S. A. G., Schram, M. T., Sep, S. J. S., Sörensen, B. M., Henry, R. M. A., & Stehouwer, C. D. A. (2018). Microvascular endothelial dysfunction is associated with albuminuria: the Maastricht Study. Journal of Hypertension, 36(5), 1178-1187. https://doi.org/10.1097/HJH.0000000000001674
    • Schutten, M. T. J., Kusters, Y. H. A. M., Houben, A. J. H. M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Schalkwijk, C. G., Joris, P. J., Plat, J., Mensink, R. P., de Leeuw, P. W., & Stehouwer, C. D. A. (2018). Aldosterone Is Not Associated With Metabolic and Microvascular Insulin Sensitivity in Abdominally Obese Men. Journal of Clinical Endocrinology & Metabolism, 103(2), 759-767. https://doi.org/10.1210/jc.2017-01541
  • 2017
    • Houben, A. J. H. M., Martens, R. J. H., & Stehouwer, C. D. A. (2017). Assessing Microvascular Function in Humans from a Chronic Disease Perspective. Journal of the American Society of Nephrology, 28(12), 3461-3472. https://doi.org/10.1681/ASN.2017020157
    • Sörensen, B. M., Houben, A. J. H. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Dagnelie, P. C., Schaper, N. C., Schram, M. T., & Stehouwer, C. D. A. (2017). Cardiovascular risk factors as determinants of retinal and skin microvascular function: The Maastricht Study. PLOS ONE, 12(10), [e0187324]. https://doi.org/10.1371/journal.pone.0187324
    • Sörensen, B. M., Houben, A. J. H. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Reesink, K. D., Dagnelie, P. C., Schaper, N. C., Schalkwijk, C. G., Schram, M. T., & Stehouwer, C. D. A. (2017). Hyperglycemia Is the Main Mediator of Prediabetes- and Type 2 Diabetes-Associated Impairment of Microvascular Function: The Maastricht Study. Diabetes Care, 40(8), e103-e105. https://doi.org/10.2337/dc17-0574
    • van Twist, D. J. L., Houben, A. J. H. M., de Leeuw, P. W., & Kroon, A. A. (2017). Lateralization of renal blood flow and renin secretion in fibromuscular dysplasia Reply. Journal of Hypertension, 35(8), 1721-1722. https://doi.org/10.1097/HJH.0000000000001387
    • Houben, A. J. H. M., Berendschot, T. T. J. M., & Grassi, G. (2017). Retinal microvascular diameters: normative data and their use in clinical hypertension. Journal of Hypertension, 35(8), 1573-1574. https://doi.org/10.1097/HJH.0000000000001421
    • Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., 't Roodt, J. O., Joris, P. J., Plat, J., Mensink, R. P., Barrett, E. J., & Stehouwer, C. D. A. (2017). Independent tissue contributors to obesity-associated insulin resistance. JCI INSIGHT, 2(13), [e89695]. https://doi.org/10.1172/jci.insight.89695
    • van Agtmaal, M. J. M., Houben, A. J. H. M., Pouwer, F., Stehouwer, C. D. A., & Schram, M. T. (2017). Association of Microvascular Dysfunction With Late-Life Depression A Systematic Review and Meta-analysis. JAMA Psychiatry, 74(7), 729-739. https://doi.org/10.1001/jamapsychiatry.2017.0984
    • Slot, M. C., Kroon, A. A., Damoiseaux, J. G. M. C., Theunissen, R., Houben, A. J. H. M., de Leeuw, P. W., & Tervaert, J. W. C. (2017). CD4+CD28null T Cells are related to previous cytomegalovirus infection but not to accelerated atherosclerosis in ANCA-associated vasculitis. Rheumatology International, 37(5), 791-798. https://doi.org/10.1007/s00296-016-3643-8
    • Snijders, T., Nederveen, J. P., Verdijk, L. B., Houben, A. J. H. M., Goossens, G. H., Parise, G., & van Loon, L. J. C. (2017). Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans. Physiological Reports, 5(10), [e13278]. https://doi.org/10.14814/phy2.13278
    • Schutten, M. T. J., Houben, A. J. H. M., de Leeuw, P. W., & Stehouwer, C. D. A. (2017). The Link Between Adipose Tissue Renin-Angiotensin- Aldosterone System Signaling and Obesity-Associated Hypertension. Physiology, 32(3), 197-209. https://doi.org/10.1152/physiol.00037.2016
    • Sorensen, B. M., Houben, A. J. H. M., Martens, R. J. H., & Stehouwer, C. D. A. (2017). Response by Sorensen et al to Letters Regarding Article, "Prediabetes and Type 2 Diabetes Are Associated With Generalized Microvascular Dysfunction": The Maastricht Study. Circulation, 135(14), E862-E863. https://doi.org/10.1161/CIRCULATIONAHA.117.027475
    • van Twist, D. J. L., Houben, A. J. H. M., de Haan, M. W., de Leeuw, P. W., & Kroon, A. A. (2017). Pathophysiological differences betweenmultifocal fibromuscular dysplasia and atherosclerotic renal artery stenosis. Journal of Hypertension, 35(4), 845-852. https://doi.org/10.1097/HJH.0000000000001243
    • Joris, P. J., Plat, J., Kusters, Y. H. A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Mensink, R. P. (2017). Diet-induced weight loss improves not only cardiometabolic risk markers but also markers of vascular function: a randomized controlled trial in abdominally obese men. American Journal of Clinical Nutrition, 105(1), 23-31. https://doi.org/10.3945/ajcn.116.143552
  • 2016
    • Martens, R. J. H., Henry, R. M. A., Houben, A. J. H. M., van der Kallen, C. J. H., Kroon, A. A., Schalkwijk, C. G., Schram, M. T., Sep, S. J. S., Schaper, N. C., Dagnelie, P. C., Muris, D. M. J., Gronenschild, E. H. B. M., van der Sande, F. M., Leunissen, K. M. L., Kooman, J. P., & Stehouwer, C. D. A. (2016). Capillary Rarefaction Associates with Albuminuria: The Maastricht Study. Journal of the American Society of Nephrology, 27(12), 3748-3757. https://doi.org/10.1681/ASN.2015111219
    • Sörensen, B., Houben, B., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Sep, S. J. S., Dagnelie, P. C., Schaper, N. C., Schram, M. T., & Stehouwer, C. D. A. (2016). Prediabetes and Type 2 Diabetes Are Associated With Generalized Microvascular Dysfunction The Maastricht Study. Circulation, 134(18), 1339-1352. https://doi.org/10.1161/CIRCULATIONAHA.116.023446
    • Schutten, M. T. J., Houben, A. J. H. M., Kroon, A. A., Stehouwer, C. D. A., & de Leeuw, P. W. (2016). Aldosterone-Renin Ratio and Side-Selective Renal Perfusion in Essential Hypertension. American Journal of Hypertension, 29(11), 1311-1316. https://doi.org/10.1093/ajh/hpw077
    • Montero, D., Houben, B., Koster, A., Muris, D. M. J., Schram, M. T., Gronenschild, E. H., Sep, S. J. S., Henry, R. M. A., van der Kallen, C. J. H., Schaper, N. C., Dagnelie, P. C., van Geel, T. A. C. M., Kremers, S. P. J., Savelberg, H. H. C. M., & Stehouwer, C. D. A. (2016). Physical Activity Is Associated With Glucose Tolerance Independent of Microvascular Function: The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 101(9), 3324-3332. https://doi.org/10.1210/jc.2016-1526
    • van Twist, D. J. L., Houben, B., de Haan, M. W., de Leeuw, P. W., & Kroon, A. A. (2016). Renal hemodynamics and renin-angiotensin system activity in humans with multifocal renal artery fibromuscular dysplasia. Journal of Hypertension, 34(6), 1160-1169. https://doi.org/10.1097/HJH.0000000000000917
  • 2015
    • van Sloten, T. T., Czernichow, S., Houben, A. J., Protogerou, A. D., Henry, R. M., Muris, D. M., Schram, M. T., Sep, S. J., Dagnelie, P. C., van der Kallen, C. J., Schaper, N. C., Blacher, J., Hercberg, S., Levy, B. I., & Stehouwer, C. D. (2015). Association Between Arterial Stiffness and Skin Microvascular Function: The SUVIMAX2 Study and The Maastricht Study. American Journal of Hypertension, 28(7), 868-876. https://doi.org/10.1093/ajh/hpu246
    • Touwslager, R. N. H., Houben, A. J. H. M., Tan, F. E. S., Gielen, M., Zeegers, M. P., Stehouwer, C. D. A., Gerver, W. J. M., Westerterp, K. R., Wouters, L., Blanco, C. E., Zimmermann, L. J., & Mulder, A. L. M. (2015). Growth and Endothelial Function in the First 2 Years of Life. Journal of Pediatrics, 166(3), 666-671.e1. https://doi.org/10.1016/j.jpeds.2014.11.059