Publications
- 2025
- ECST 2 investigators (2025). Optimised medical therapy alone versus optimised medical therapy plus revascularisation for asymptomatic or low-to-intermediate risk symptomatic carotid stenosis (ECST-2): 2-year interim results of a multicentre randomised trial. Lancet Neurology, 24(5), 389-399. https://doi.org/10.1016/S1474-4422(25)00107-3
- Brown, S. D., Rodor, J., & Baker, A. H. (2025). Targeted approach for next-generation coronary stents. European Heart Journal, 46(17), 1659-1661. https://doi.org/10.1093/eurheartj/ehaf007
- Kassem, M., Gorissen, T., Albenwan, M., Bierens, J., van Dam-Nolen, D. H. K., Liem, M. I., Hofman, P. A. M., Wildberger, J. E., Hendrikse, J., Mess, W., Nederkoorn, P. J., Bos, D., Nelemans, P., van Oostenbrugge, R. J., & Kooi, M. E. (2025). The relationship between fibrous cap status or plaque surface morphology and intraplaque hemorrhage volume over time: The PARISK Study. Journal of Stroke & Cerebrovascular Diseases, 34(5), Article 108283. https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108283
- op den Kamp-bruls, Y. M. H., op den Kamp, Y. J. M., Veeraiah, P., Perez, R. Z., Phielix, E., Havekes, B., Schaart, G., Kornips, E., Berendsen, B. R. B., Virmani, A., Wildberger, J. E., Houtkooper, R. H., Hesselink, M. K. C., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2025). Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in patients with type 2 diabetes. Diabetes Obesity & Metabolism, 27(5), 2864-2877. https://doi.org/10.1111/dom.16298
- Suthahar, N., Mourmans, S. G. J., Achten, A., Aboumsallem, J. P., Meijers, W. C., Bomer, N., Kardys, I., Gansevoort, R. T., Bakker, S. J. L., Weerts, J., Eringa, E. C., Damman, K., van Empel, V., & de Boer, R. A. (2025). Peroxiredoxin-4, a marker of systemic oxidative stress, is associated with incident heart failure. European journal of heart failure, 27(5), 905-911. Article 3653. https://doi.org/10.1002/ejhf.3653
- Fuchs, C. J., Hermans, W. J. H., van den Hurk, J., Wiggins, C. J., Widholm, P., Dahlqvist Leinhard, O., Veeraiah, P., Wildberger, J. E., Prompers, J. J., & van Loon, L. J. C. (2025). Quantifying Leg Muscle Disuse Atrophy During Bed Rest Using DXA, CT, and MRI. European Journal of Sport Science, 25(5), Article e12299. https://doi.org/10.1002/ejsc.12299
- Chteinberg, E., Kolarova, J., Vogt, J., Macamo, A., Bormann, F., Kretzmer, H., Speel, E. J., van den Oord, J., Schneider, C., Stilgenbauer, S., Becker, J. C., Winnepenninckx, V., Biessen, E., Zenke, M., Kurz, A. K., Siebert, R., & zur Hausen, A. (2025). The significance of PAX5 in Merkel cell carcinoma. Journal of Pathology, 266(1), 81-94. https://doi.org/10.1002/path.6410
- Mourmans, S. G. J., Achten, A., Hermans, R., Scheepers, M. J. E., D'Alessandro, E., Swennen, G., Woudstra, J., Appelman, Y., Goor, H. V., Schalkwijk, C., Knackstedt, C., Weerts, J., Eringa, E. C., & van Empel, V. P. M. (2025). The effect of empagliflozin on peripheral microvascular dysfunction in patients with heart failure with preserved ejection fraction. Cardiovascular Diabetology, 24(1), Article 182. https://doi.org/10.1186/s12933-025-02679-8
- Peters, L., Rakateli, L., Huchzermeier, R., Bonnin-Marquez, A., Maas, S. L., Lin, C., Jans, A., Geng, Y., Gorter, A., Gijbels, M., Rensen, S., Olinga, P., Hendrikx, T., Krawczyk, M., Brisbois, M., Jankowski, J., Bidzhekov, K., Weber, C., Biessen, E. A. L., ... van der Vorst, E. (2025). MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles. Elife, 13. https://doi.org/10.7554/eLife.97165
- Bierens, J., Severens-Rijvers, C., Hildebrand, S., van Zandvoort, M., Al-Nasiry, S., & Kapsokalyvas, D. (2025). Imaging and quantification of placental terminal villi microvasculature and nuclear characteristics in preeclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 308, 181-189. https://doi.org/10.1016/j.ejogrb.2025.03.015
- Psychogios, M., Brehm, A., Ribo, M., Rizzo, F., Strbian, D., Raety, S., Arenillas, J. F., Martinez-Galdamez, M., Hajdu, S. D., Michel, P., Gralla, J., Piechowiak, E. I., Kaiser, D. P. O., Puetz, V., van den Bergh, F., De Raedt, S., Bellante, F., Dusart, A., Hellstern, V., ... Staals, J. (2025). Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels. New England Journal of Medicine, 392(14), 1374-1384. Article NEJMoa2408954. https://doi.org/10.1056/NEJMoa2408954
- Krilis, G., Beqqali, A., & Baker, A. H. (2025). ERC-funded Advanced Grant: creating molecular polypills. European Heart Journal, 46(14), 1288-1290. https://doi.org/10.1093/eurheartj/ehae866
- Vranken, N. P. A., Li, X., Bouman, H., Mourmans, S. G. J., Achten, A., Aizpurua, A. B., Brunner-La Rocca, H.-P., Knackstedt, C., van Empel, V. P. M., & Weerts, J. (2025). Temporal prevalence and prognostic impact of diabetes mellitus and albuminuria in heart failure with preserved ejection fraction. Cardiovascular Diabetology, 24(1), Article 156. https://doi.org/10.1186/s12933-025-02708-6
- Gottschlich, A., Grünmeier, R., Hoffmann, G. V., Nandi, S., Kavaka, V., Müller, P. J., Jobst, J., Oner, A., Kaiser, R., Gärtig, J., Piseddu, I., Frenz-Wiessner, S., Fairley, S. D., Schulz, H., Igl, V., Janert, T. A., Di Fina, L., Mulkers, M., Thomas, M., ... Kobold, S. (2025). Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma. Blood, 145(14), 1536-1552. https://doi.org/10.1182/blood.2023022197
- Sluis, W. M., Venema, S. M. U., van der Hoorn, A., Bot, J. C. J., van Zwam, W. H., Hofmeijer, J., & van der Worp, H. B. (2025). Endovascular treatment in comatose patients with anterior circulation ischemic stroke. Frontiers in Neurology, 16, Article 1524262. https://doi.org/10.3389/fneur.2025.1524262
- van der Vorst, E. P. C., & Lembo, G. (2025). Harnessing the power of the brain to fight metabolic diseases. Cardiovascular Research, 121(5), 685-687. https://doi.org/10.1093/cvr/cvaf061
- Achten, A., Weerts, J., van Koll, J., Ghossein, M., Mourmans, S. G. J., Aizpurua, A. B., van Stipdonk, A. M. W., Vernooy, K., Prinzen, F. W., Rocca, H.-P. B.-L., Knackstedt, C., & van Empel, V. P. M. (2025). Prevalence and prognostic value of ventricular conduction delay in heart failure with preserved ejection fraction. IJC Heart and Vasculature, 57, Article 101622. https://doi.org/10.1016/j.ijcha.2025.101622
- Berends, E., Vangrieken, P., Amiri, N., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Schalkwijk, C. G., & Foulquier, S. (2025). Increased Levels of Circulating Methylglyoxal Have No Consequence for Cerebral Microvascular Integrity and Cognitive Function in Young Healthy Mice. Molecular Neurobiology, 62(4), 4190-4202. Article 101148. https://doi.org/10.1007/s12035-024-04552-3
- Vermeulen, I., Li, M., van Mourik, H., Yadati, T., Eijkel, G., Balluff, B., Godschalk, R., Temmerman, L., Biessen, E. A. L., Kulkarni, A., Theys, J., Houben, T., Cillero-Pastor, B., & Shiri-Sverdlov, R. (2025). Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis. FEBS Journal, 292(7), 1781-1797. https://doi.org/10.1111/febs.17358
- Olthuis, S. G. H., & Van Zwam, W. H. (2025). Endovascular Therapy for NIHSS =5 How Low Should We Go?Neurology, 104(7), Article e213515. https://doi.org/10.1212/WNL.0000000000213515
- Asare, Y., Yan, G., Schlegl, C., Prestel, M., van der Vorst, E. P. C., Teunissen, A. J. P., Aronova, A., Tosato, F., Naser, N., Caputo, J., Prevot, G., Azzun, A., Wefers, B., Wurst, W., Schneider, M., Forne, I., Bidzhekov, K., Naumann, R., van der Laan, S. W., ... Dichgans, M. (2025). A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis. Immunity, 58(3), 555-567.e9. https://doi.org/10.1016/j.immuni.2025.01.003
- El Bounkari, O., Zan, C., Yang, B., Ebert, S., Wagner, J., Bugar, E., Kramer, N., Bourilhon, P., Kontos, C., Zarwel, M., Sinitski, D., Milic, J., Jansen, Y., Kempf, W. E., Sachs, N., Maegdefessel, L., Ji, H., Gokce, O., Riols, F., ... Bernhagen, J. (2025). An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis. Nature Communications, 16(1), Article 2297. https://doi.org/10.1038/s41467-025-57540-z
- Saba, L., Cau, R., Vergallo, R., Kooi, M. E., Staub, D., Faa, G., Congiu, T., Ntaios, G., Wasserman, B. A., Benson, J., Nardi, V., Kawakami, R., Lanzino, G., Virmani, R., & Libby, P. (2025). Carotid artery atherosclerosis: mechanisms of instability and clinical implications. European Heart Journal, 46(10), 904-921. Article ehae933. https://doi.org/10.1093/eurheartj/ehae933
- Ben-Aicha, S., & van der Vorst, E. P. C. (2025). Shaping the future of cardiovascular research: a focus on cardioimmunology. European Heart Journal, 46(9), 778-780. Article ehae783. https://doi.org/10.1093/eurheartj/ehae783
- Frol, S., Benali, F., Rouchaud, A., Knapen, R. R. M. M., van Zwam, W. H., & Research Committee of the European Society of Minimally Invasive Neurological Therapy (ESMINT) (2025). The variable use of heparin through intravenous bolus and flush fluid systems during endovascular stroke treatment, a world-wide survey. CVIR Endovascular, 8(1), Article 17. https://doi.org/10.1186/s42155-025-00532-3
- Tore, E. C., Adriaans, B. C., Olsen, T., Vinknes, K. J., Kooi, M. E., Elshorbagy, A. K., Bastani, N. E., Dagnelie, P. C., Eussen, S. J. P. M., Gundersen, T. E., Kožich, V., Refsum, H., Retterstøl, K., Stolt, E. T. K., & van Greevenbroek, M. M. J. (2025). Estimated stearoyl-CoA desaturase activity mediates the associations of total cysteine with adiposity: The Maastricht Study. Journal of Clinical Lipidology, 19(2), 348-357. https://doi.org/10.1016/j.jacl.2024.11.005
- Lemmens, M.-J. D. K., Heuts, S., Bidar, E., Wildberger, J. E., Mihl, C., & Smulders, M. W. (2025). Integrating Coronary Artery Assessment and Myocardial Late Enhancement Imaging With Photon-Counting Detector CT: Visualizing the Invisible. Circulation-Cardiovascular Imaging, 18(3), e017238. Article e017238. https://doi.org/10.1161/CIRCIMAGING.124.017238
- Taha, A., Nagy, M., Hund, H. M., van Doormaal, P. J., van Noorden, K., Spronk, H. M. H., Ceulemans, A., van Oostenbrugge, R. J., Duncker, D. J., ten Cate, H., Dippel, D., van Es, A. C. G. M., Bobi, J., & van Beusekom, H. M. M. (2025). Vascular injury and occurrence of microthrombi after endovascular therapy for acute ischaemic stroke in a thromboembolic model. BMJ Neurology Open, 7(1), Article e000989. https://doi.org/10.1136/bmjno-2024-000989
- Huchzermeier, R., & van der Vorst, E. P. C. (2025). Aryl hydrocarbon receptor (AHR) and nuclear factor erythroid-derived 2-like 2 (NRF2): An important crosstalk in the gut-liver axis. Biochemical Pharmacology, 233, Article 116785. https://doi.org/10.1016/j.bcp.2025.116785
- Stringer, M. S., Blair, G. W., Kopczak, A., Kerkhofs, D., Thrippleton, M. J., Chappell, F. M., Maniega, S. M., Brown, R., Shuler, K., Hamilton, I., Garcia, D. J., Doubal, F. N., Clancy, U., Sakka, E., Poliakova, T., Janssen, E., Duering, M., Ingrisch, M., Staals, J., ... Wardlaw, J. M. (2025). Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease. Annals of Neurology, 97(3), 483-498. https://doi.org/10.1002/ana.27136
- Voorter, P. H. M., Jansen, J. F. A., van der Thiel, M. M., van Dinther, M., Postma, A. A., van Oostenbrugge, R. J., Gurney-Champion, O. J., Drenthen, G. S., & Backes, W. H. (2025). Diffusion-derived intravoxel-incoherent motion anisotropy relates to CSF and blood flow. Magnetic Resonance in Medicine, 93(3), 930-941. https://doi.org/10.1002/mrm.30294
- Vacante, F., & Baker, A. H. (2025). Effective CRISPR modulation of complex non-coding RNA loci. Nature Reviews Cardiology, 22(3), 145. Article 145. https://doi.org/10.1038/s41569-025-01117-2
- Nagy, M., Bender, M., Poulter, N. S., Pike, J. A., Sickmann, A., Vondenhoff, S., Bielicka, N., van Zandvoort, M. A. M. J., Koenen, R. R., ten Cate, H., Stéphenne, X., Heemskerk, J. W. M., & Baaten, C. C. F. M. J. (2025). Formation of tight junction-like structures of zonula occludens 2 in platelet–platelet interaction. Research and practice in thrombosis and haemostasis, 9(3), Article 102845. https://doi.org/10.1016/j.rpth.2025.102845
- Halmos, B., La Rose, A. M., Methorst, D., Groenen, A. G., Nakládal, D., Bazioti, V., Koster, M. H., Kloosterhuis, N. J., Buiten, A. V., Schouten, E. M., Huijkman, N. C. A., Langelaar-Makkinje, M., Bongiovanni, L., De Neck, S. M., de Bruin, A., Buikema, H., Deelman, L. E., van den Heuvel, M. C., Kuipers, F., ... Westerterp, M. (2025). SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis. Circulation Research, 136(5), 491-507. https://doi.org/10.1161/CIRCRESAHA.124.325103
- Parma, L., Sachs, N., Sobczak, N., Li, Z., Merchant, K., Pauli, J., Depuydt, M. A. C., Wezel, A., Smeets, H. J., Bot, I., Sluetter, B., Maegdefessel, L., Weber, C., Duchene, J., & Megens, R. T. A. (2025). CXCL12 Derived From ACKR1<SUP>+</SUP> Intraplaque Neovessels Mediates CD8<SUP>+</SUP> T Cell Recruitment in Human Atherosclerosis. Circulation, 151(8), 581-584. https://doi.org/10.1161/CIRCULATIONAHA.124.072560
- Fuentes-Cimma, J., Sluijsmans, D., Mejias, P. P., Villagran, I., Riquelme, A., & Heeneman, S. (2025). Psychometric properties of the Feedback Orientation Scale in the clinical workplace of health professions students. International Journal of Medical Education, 16, 36-44. https://doi.org/10.5116/ijme.679e.07de
- Vangrieken, P., Scheijen, J. L. J. M., Schiffers, P. M. H., van de Waarenburg, M. P. H., Foulquier, S., & Schalkwijk, C. C. G. (2025). Modelling the effects of elevated methylglyoxal levels on vascular and metabolic complications. Scientific Reports, 15(1), Article 6025. https://doi.org/10.1038/s41598-025-90661-5
- Hill, M. D., Goyal, M., Demchuk, A. M., Menon, B. K., Field, T. S., Guest, W. C., Berrouschot, J., Bormann, A., Pham, M., Haeusler, K. G., Dippel, D. W. J., van Doormaal, P. J., Dorn, F., Bode, F. J., van Adel, B. A., Sahlas, D. J., Swartz, R. H., Da Costa, L., Ospel, J. M., ... van Zwam, W. (2025). Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial. Lancet, 405(10478), 560-570. https://doi.org/10.1016/S0140-6736(25)00194-1
- Möller-Ramon, Z., Aslani, M., Sobczak, N., Hristov, M., Weber, C., Rot, A., & Duchêne, J. (2025). The 129 strain-derived passenger mutations in ACKR1-deficient mice alter the expression of PYHIN and Fc-gamma receptor genes. Journal of leukocyte biology, 117(2), Article qiae208. https://doi.org/10.1093/jleuko/qiae208
- Achten, A., Muller, S. A., Zwetsloot, P.-P., Michels, M., van der Meer, P., Nienhuis, H. L. A., van der Meer, M. G., van Empel, V. P. M., Oerlemans, M. I. F. J., & Knackstedt, C. (2025). Is transthyretin amyloid cardiomyopathy heading towards losing its rare disease classification?Expert review of cardiovascular therapy, 23(1-2), 1-4. https://doi.org/10.1080/14779072.2025.2463333
- Rodor, J., Klimi, E., Brown, S. D., Krilis, G., Braga, L., Ring, N. A. R., Ballantyne, M. D., Kesidou, D., Dinh Cat, A. N., Miscianinov, V., Vacante, F., Miteva, K., Bennett, M., Beqqali, A., Giacca, M., Zacchigna, S., & Baker, A. H. (2025). Functional screening identifies miRNAs with a novel function inhibiting Vascular Smooth Muscle Cell proliferation. Molecular Therapy, 33(2), 615-630. https://doi.org/10.1016/j.ymthe.2024.12.037
- Hardy, J. C. A., Crombag, G. A. J. C., Peters, N. H. G. M., Hermsen, R., Willigers, J. L., Nobel, J. M., Wildberger, J. E., Flohr, T. G., & Postma, A. A. (2025). Bullet characterization using Photon-Counting detector CT: A phantom study with intact bullets. European Journal of Radiology, 183, Article 111898. https://doi.org/10.1016/j.ejrad.2024.111898
- Stroeks, S. L. V. M., Muller, S., Beelen, N. J., Venner, M. F. G. H. M., Baas, A. F., van Empel, V. P. M., Krapels, I. P. C., Hazebroek, M. R., Te Riele, A. S. J. M., & Verdonschot, J. A. J. (2025). Family Screening in Patients With Dilated and Arrhythmogenic Cardiomyopathy: The Road Toward Gene-Specific Recommendations. Circulation: Genomic and Precision Medicine, 18(1), Article e004778. https://doi.org/10.1161/CIRCGEN.124.004778
- Heuts, S., Kawczynski, M. J., Leus, A., Godinas, L., Belge, C., van Empel, V., Meyns, B., Maessen, J. G., Delcroix, M., & Verbelen, T. (2025). The volume-outcome relationship for pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 65(2), Article 2401865. https://doi.org/10.1183/13993003.01865-2024
- Pinckaers, F. M. E., Grutters, J. P. C., Huijberts, I., Gabrio, A., Boogaarts, H. D., Postma, A. A., van Oostenbrugge, R. J., van Zwam, W. H., & Evers, S. M. A. A. (2025). Author's Response to Letter to the Editor Titled "Potential Biases in Post-stroke Health Utility Estimates by Modified Rankin Scale Scores". Value in Health, 28(2), 320-321. https://doi.org/10.1016/j.jval.2024.10.3854
- Gao, L., Churilov, L., Johns, H., Pujara, D., Hassan, A. E., Abraham, M., Ortega-Gutierrez, S., Hussain, M. S., Chen, M., Blackburn, S., Sitton, C. W., Pinckaers, F. M. E., van Zwam, W. H., Tsivgoulis, G., Hill, M. D., Grotta, J. C., Kasner, S., Ribo, M., Campbell, B. C., ... SELECT2 investigators (2025). Cost-Effectiveness of Endovascular Thrombectomy in Patients with Large Ischemic Stroke. Annals of Neurology, 97(2), 222-231. https://doi.org/10.1002/ana.27119
- Peeters, M. T. J., Postma, A. A., van Oostenbrugge, R. J., Henneman, W. J. P., & Staals, J. (2025). Dual-energy CT angiography in detecting underlying causes of intracerebral hemorrhage: an observational cohort study. Neuroradiology, 67(2), 331-338. https://doi.org/10.1007/s00234-024-03473-1
- van Oeteren, M. A. J., Simons, N., Simons, P. I. H. G., van de Waarenburg, M. P. H., Kooi, M. E., Feskens, E. J. M., van der Ploeg, E. M. C. L., Van den Eynde, M. D. G., Houben, A. J. H. M., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2025). Fructose restriction has beneficial effects on adipose tissue distribution but not on serum adipokine levels: Post-hoc analysis of a double-blind randomized controlled trial. Clinical Obesity, 15(1), Article e12714. https://doi.org/10.1111/cob.12714
- Mourmans, S. G. J., Weerts, J., Baumert, M., Aizpurua, A. B., Achten, A., Knackstedt, C., Linz, D., & van Empel, V. P. M. (2025). Prognostic value of hypoxaemic burden from overnight oximetry in heart failure with preserved ejection fraction. Esc heart failure, 12(1), 622-630. https://doi.org/10.1002/ehf2.15116
- Gan, S., Azzo, J. D., Zhao, L., Pourmussa, B., Dib, M. J., Salman, O., Erten, O., Ebert, C., Richards, A. M., Javaheri, A., Mann, D. L., Rietzschel, E., Zamani, P., van Empel, V., Cappola, T. P., & Chirinos, J. A. (2025). Transferrin Saturation, Serum Iron, and Ferritin in Heart Failure: Prognostic Significance and Proteomic Associations. Circulation-Heart Failure, 18(2), Article e011728. https://doi.org/10.1161/CIRCHEARTFAILURE.124.011728



